Abstract:
:Dermatomyositis (DM) is an idiopathic inflammatory myopathy (IIM) characterized by an inflammatory infiltrate primarily affecting the skeletal muscle and skin. Most common and peculiar cutaneous lesions include Gottron's papules, Gottron's sign and heliotrope rash. Different DM subsets have been identified until now encompassing classic DM, amyopathic DM, hypomyopathic DM, post-myopathic DM, and DM sine dermatitis. Patients with DM have a higher incidence rate of malignancy than the normal population. In these patients cancer occurs in about 30% of cases with higher occurrence in men and in elderly people. Bohan and Peter's diagnostic criteria, proposed in 1975, have been widely accepted and used until now. In the last ten years muscle immunopathology, myositis specific autoantibodies testing, and the use of new techniques of muscle imaging such as contrast-enhanced ultrasound or Magnetic Resonance Imaging have been introduced in the diagnostic work-up of patients with DM leading to the development of new diagnostic criteria.
journal_name
J Autoimmunjournal_title
Journal of autoimmunityauthors
Iaccarino L,Ghirardello A,Bettio S,Zen M,Gatto M,Punzi L,Doria Adoi
10.1016/j.jaut.2013.11.005subject
Has Abstractpub_date
2014-02-01 00:00:00pages
122-7eissn
0896-8411issn
1095-9157pii
S0896-8411(14)00034-1journal_volume
48-49pub_type
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