The clinical features, diagnosis and classification of dermatomyositis.

Abstract:

:Dermatomyositis (DM) is an idiopathic inflammatory myopathy (IIM) characterized by an inflammatory infiltrate primarily affecting the skeletal muscle and skin. Most common and peculiar cutaneous lesions include Gottron's papules, Gottron's sign and heliotrope rash. Different DM subsets have been identified until now encompassing classic DM, amyopathic DM, hypomyopathic DM, post-myopathic DM, and DM sine dermatitis. Patients with DM have a higher incidence rate of malignancy than the normal population. In these patients cancer occurs in about 30% of cases with higher occurrence in men and in elderly people. Bohan and Peter's diagnostic criteria, proposed in 1975, have been widely accepted and used until now. In the last ten years muscle immunopathology, myositis specific autoantibodies testing, and the use of new techniques of muscle imaging such as contrast-enhanced ultrasound or Magnetic Resonance Imaging have been introduced in the diagnostic work-up of patients with DM leading to the development of new diagnostic criteria.

journal_name

J Autoimmun

journal_title

Journal of autoimmunity

authors

Iaccarino L,Ghirardello A,Bettio S,Zen M,Gatto M,Punzi L,Doria A

doi

10.1016/j.jaut.2013.11.005

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

122-7

eissn

0896-8411

issn

1095-9157

pii

S0896-8411(14)00034-1

journal_volume

48-49

pub_type

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