Differential activities of immunogenic collagen type II peptides in the induction of nasal tolerance to collagen-induced arthritis.

abstract：:Chronic myocarditis often progresses to dilated cardiomyopathy resulting in heart failure or cardiac transplantation. Viral infection is the most common cause of myocarditis and coxsackie B viruses (CBV) are the most frequently cited etiologic agents associated with myocarditis and cardiomyopathy. Additionally, CBV in...

journal_title：Journal of autoimmunity

authors： Horwitz MS,Ilic A,Fine C,Sarvetnick N

更新日期：2005-09-01 00:00:00

abstract：:The involvement of CD4+ and CD8+ T cells in pathogenesis of spontaneous autoimmune thyroiditis (SAT) in obese strain (OS) chickens has not been studied in depth until now. We depleted CD4+ or CD8+ T cells in OS chickens by treatment with murine monoclonal anti-CD4 or anti-CD8 antibodies at 3 day intervals beginning at...

journal_title：Journal of autoimmunity

authors： Cihak J,Hoffmann-Fezer G,Wasl M,Merkle H,Kaspers B,Vainio O,Plachý J,Hála K,Wick G,Stangassinger M,Lösch U

更新日期：1998-04-01 00:00:00

abstract：:University of California at Davis (UCD) lines 200 and 206 chickens develop a hereditary systemic scleroderma-like connective tissue disease characterized by severe lymphocytic infiltration and excessive accumulation of collagen in skin and internal organs. The immune system seems to play an important role in the devel...

journal_title：Journal of autoimmunity

authors： Sgonc R,Dietrich H,Gershwin ME,Colombatti A,Wick G

更新日期：1995-10-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a deadly cancer of the biliary epithelium with limited therapeutic options. It is a heterogeneous group of cancer that could develop at any level from the biliary tree and is currently classified into intrahepatic, perihilar and distal based on its anatomical location. With incidence and mo...

journal_title：Journal of autoimmunity

authors： Rimassa L,Personeni N,Aghemo A,Lleo A

更新日期：2019-06-01 00:00:00

abstract：:To investigate a possible dysregulation of the autoantibody network in AIDS patients, the relative activity of representative natural antibodies was measured in serum IgG and IgM. These immunoglobulins were purified from two cohorts of 20 HIV-infected patients undergoing, or not, a triple combination therapy. A cohort...

journal_title：Journal of autoimmunity

authors： Quan CP,Watanabe S,Pamonsinlapatham P,Bouvet JP

更新日期：2001-08-01 00:00:00

abstract：:Further to define the epitopes of PDC-E2, the major autoantigen in primary biliary cirrhosis (PBC), we have developed and characterized five human monoclonal antibodies. These antibodies were derived by fusing a regional hepatic lymph node from a patient with PBC with the mouse human heterohybrid cell line F3B6. Previ...

journal_title：Journal of autoimmunity

authors： Leung PS,Krams S,Munoz S,Surh CP,Ansari A,Kenny T,Robbins DL,Fung J,Starzl TE,Maddrey W

更新日期：1992-12-01 00:00:00

abstract：:Different cell populations isolated from rats during the period of latency of adjuvant arthritis were injected into the bloodstream of naive rats to test their ability to transfer articular disorders. Synovium-derived cells (synoviocytes) were able to induce arthritis in 3 out of 4 recipient animals, whereas periphera...

journal_title：Journal of autoimmunity

authors： Ramos-Ruiz R,Bernabeu C,Ariza A,Fernández JM,Larraga V,López-Bote JP

更新日期：1992-02-01 00:00:00

abstract：:The removal of beta(1)-adrenergic receptor (beta(1)AR) autoantibodies by immunoadsorption (IA) has been proposed as a potential mechanism for the improvement of the left ventricular function in dilated cardiomyopathy (DCM). In the present study, the possible association between removal of the autoantibodies against th...

journal_title：Journal of autoimmunity

authors： Mobini R,Staudt A,Felix SB,Baumann G,Wallukat G,Deinum J,Svensson H,Hjalmarson A,Fu M

更新日期：2003-06-01 00:00:00

abstract：:The purpose of this study was to characterize regulatory T cells (T(reg)) in skin lesions and peripheral blood from patients with dermatomyositis (DM) and to determine the serum levels of regulatory cytokines in the disease. In skin biopsy specimens from patients with DM, immunohistochemistry was performed for CD4(+),...

journal_title：Journal of autoimmunity

authors： Antiga E,Kretz CC,Klembt R,Massi D,Ruland V,Stumpf C,Baroni G,Hartmann M,Hartschuh W,Volpi W,Del Bianco E,Enk A,Fabbri P,Krammer PH,Caproni M,Kuhn A

更新日期：2010-12-01 00:00:00

abstract：:Exposure to the hydrocarbon oil pristane induces lupus specific autoantibodies in non-autoimmune mice. We investigated whether the capacity to induce lupus-like autoimmunity is a unique property of pristane or is shared by other adjuvant oils. Seven groups of 3-month-old female BALB/cJ mice received a single intraperi...

journal_title：Journal of autoimmunity

authors： Satoh M,Kuroda Y,Yoshida H,Behney KM,Mizutani A,Akaogi J,Nacionales DC,Lorenson TD,Rosenbauer RJ,Reeves WH

更新日期：2003-08-01 00:00:00

abstract：:Lupus erythematosus (LE) is an inflammatory connective tissue disease of generalized autoimmunity characterized by pathogenic autoantibodies and immune complexes, attributed to loss of immune tolerance. Cutaneous involvement, which appears in the majority of patients with the disease, can present as LE-specific or LE-...

journal_title：Journal of autoimmunity

authors： Kuhn A,Landmann A

更新日期：2014-02-01 00:00:00

abstract：:Primary biliary cirrhosis (PBC) sera contain antibodies which recognize various nuclear envelope proteins of which antibody against gp210 has been proven to be diagnostic for disease. In contrast, the clinical significance of another nuclear envelope antibody, anti-p62 antibody has not been well investigated. In the p...

journal_title：Journal of autoimmunity

authors： Miyachi K,Hankins RW,Matsushima H,Kikuchi F,Inomata T,Horigome T,Shibata M,Onozuka Y,Ueno Y,Hashimoto E,Hayashi N,Shibuya A,Amaki S,Miyakawa H

更新日期：2003-05-01 00:00:00

abstract：:In some circumstances cyclosporine (CyA) induces autoimmune phenomena, and a lethal form of syngeneic graft-vs-host disease (SGVHD) can be induced in rats by the administration of CyA. Although several rat strains develop this disease, in this study, we report that of six mouse strains tested, only the DBA/2 strain de...

journal_title：Journal of autoimmunity

authors： Prud'homme GJ,Sanders R,Parfrey NA,Ste-Croix H

更新日期：1991-04-01 00:00:00

abstract：:A major concept in autoimmunity is that disruption of Foxp3(+) regulatory T cells (Tregs) predisposes to breach of tolerance. This is exemplified by the Foxp3-linked disorder termed IPEX (immunodysregulation, polyendocrinopathy, enteropathy, X-linked) which affects newborn children. There has been considerable clinica...

journal_title：Journal of autoimmunity

authors： Mayer CT,Tian L,Hesse C,Kühl AA,Swallow M,Kruse F,Thiele M,Gershwin ME,Liston A,Sparwasser T

更新日期：2014-05-01 00:00:00

abstract：:Cytokine expression was investigated in synovial cell cultures isolated from diseased joints of patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Tumour necrosis factor alpha (TNF alpha) was produced spontaneously at high levels by both RA and OA synovial cells. There was no correlation between cell com...

journal_title：Journal of autoimmunity

authors： Brennan FM,Chantry D,Jackson AM,Maini RN,Feldmann M

更新日期：1989-06-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disorder with unknown aetiology. The major hallmark of this disease is the presence of antibodies against nuclear components, including double-stranded (ds)DNA and histones. The disease affects different organs, particularly the skin, kidneys and the nervous system. ...

journal_title：Journal of autoimmunity

authors： Van Ghelue M,Moens U,Bendiksen S,Rekvig OP

更新日期：2003-03-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease primarily afflicting women. The reason for the gender bias is unclear, but genetic susceptibility, estrogen and environmental agents appear to play significant roles in SLE pathogenesis. Environmental agents can contribute to lupus susceptibility through epig...

journal_title：Journal of autoimmunity

authors： Strickland FM,Hewagama A,Lu Q,Wu A,Hinderer R,Webb R,Johnson K,Sawalha AH,Delaney C,Yung R,Richardson BC

更新日期：2012-05-01 00:00:00

abstract：:Systemic lupus (SLE) is characterized by a break of B cell tolerance that plays a central role in disease pathophysiology. An early checkpoint defect occurs at the transitional stage leading to the survival of autoreactive B cells and consequently the production of pathogenic autoantibodies. The main purpose of our wo...

journal_title：Journal of autoimmunity

authors： Dieudonné Y,Gies V,Guffroy A,Keime C,Bird AK,Liesveld J,Barnas JL,Poindron V,Douiri N,Soulas-Sprauel P,Martin T,Meffre E,Anolik JH,Korganow AS

更新日期：2019-08-01 00:00:00

abstract：:Nowadays, pharmacologic treatments of autoinflammatory diseases are largely palliative rather than curative. Most of them result in non-specific immunosuppression, which can be associated with broad disruption of natural and induced immunity with significant and sometimes serious unwanted injuries. Among the novel str...

journal_title：Journal of autoimmunity

authors： Bonam SR,Wang F,Muller S

更新日期：2018-11-01 00:00:00

abstract：:Previous studies on Spanish patients with Primary Biliary Cirrhosis (PBC) have shown extensive, disease-specific cross-reactivity between the 65-kDa heat shock protein (hsp65) of Mycobacterium gordonae and pyruvate dehydrogenase complex-E2 (PDC-E2), the major target of anti-mitochondrial antibody (AMA). Studies on a B...

journal_title：Journal of autoimmunity

authors： Bogdanos DP,Pares A,Baum H,Caballeria L,Rigopoulou EI,Ma Y,Burroughs AK,Rodes J,Vergani D

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:The aberrant recognition of self-nucleic acids by the innate immune system contributes to the pathology of several autoimmune diseases. Although microbial DNA and, in certain instances, self-DNA that is released from damaged cells are primarily recognized by Toll-like receptor 9 (TLR9), recent evidence sugge...

journal_title：Journal of autoimmunity

authors： Zentsova I,Parackova Z,Kayserova J,Palova-Jelinkova L,Vrabcova P,Volfova N,Sumnik Z,Pruhova S,Petruzelkova L,Sediva A

更新日期：2019-12-01 00:00:00

abstract：:Primary warm autoimmune hemolytic anemia (wAIHA) is a rare autoimmune disease in which red blood cells are eliminated by IgG autoantibodies. We analyzed the antibody-secreting cells in the spleen and the peripheral blood of wAIHA patients in various contexts of treatment. Plasmablasts were observed in peripheral blood...

journal_title：Journal of autoimmunity

authors： Mahévas M,Michel M,Vingert B,Moroch J,Boutboul D,Audia S,Cagnard N,Ripa J,Menard C,Tarte K,Mégret J,Le Gallou S,Patin P,Thai L,Galicier L,Bonnotte B,Godeau B,Noizat-Pirenne F,Weill JC,Reynaud CA

更新日期：2015-08-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE), a model for the human disease multiple sclerosis (MS), is dependent upon the activation and effector functions of autoreactive CD4 T cells. Multiple interactions between CD4 T cells and major histocompatibility class II (MHCII)+ antigen presenting cells (APCs) must occu...

journal_title：Journal of autoimmunity

authors： Wu GF,Shindler KS,Allenspach EJ,Stephen TL,Thomas HL,Mikesell RJ,Cross AH,Laufer TM

更新日期：2011-02-01 00:00:00

abstract：:B-cell depletion therapy (BCDT) based on rituximab (RTX) induces clinical remission in a majority of seropositive patients with Rheumatoid arthritis (RA). However, all patients eventually relapse. The aim of this study was to determine whether dynamic changes in combinations of serological measures of B-cell activatio...

journal_title：Journal of autoimmunity

authors： Cambridge G,Perry HC,Nogueira L,Serre G,Parsons HM,De La Torre I,Dickson MC,Leandro MJ,Edwards JC

更新日期：2014-05-01 00:00:00

abstract：:Neuropsychiatric disease is one of the most common manifestations of human systemic lupus erythematosus, but the mechanisms remain poorly understood. In human brain microvascular endothelial cells in vitro, TNF-like weak inducer of apoptosis (TWEAK) decreases tight junction ZO-1 expression and increases the permeabili...

journal_title：Journal of autoimmunity

authors： Wen J,Doerner J,Weidenheim K,Xia Y,Stock A,Michaelson JS,Baruch K,Deczkowska A,Gulinello M,Schwartz M,Burkly LC,Putterman C

更新日期：2015-06-01 00:00:00

abstract：:Women with antiphospholipid antibodies (aPL) are at high risk for pregnancy complications, such as preeclampsia. We previously demonstrated that aPL recognizing β2GPI promote an extravillous trophoblast pro-inflammatory, anti-migratory and anti-angiogenic profile similar to that seen in preeclampsia. Since preeclampsi...

journal_title：Journal of autoimmunity

authors： Mulla MJ,Pasternak MC,Salmon JE,Chamley LW,Abrahams VM

更新日期：2019-03-01 00:00:00

abstract：:Autoimmune thyroid diseases (AITDs), i.e., Graves' disease (GD) and Hashimoto thyroiditis (HT), are the most prevalent organ-specific autoimmune diseases, but their pathogenesis is still incompletely understood. The PD-1/PD-L1 pathway is an important mechanism of peripheral tolerance that has not been investigated in ...

journal_title：Journal of autoimmunity

authors： Álvarez-Sierra D,Marín-Sánchez A,Ruiz-Blázquez P,de Jesús Gil C,Iglesias-Felip C,González Ó,Casteras A,Costa RF,Nuciforo P,Colobran R,Pujol-Borrell R

更新日期：2019-09-01 00:00:00

abstract：:The probability that epitope spreading occurs in multiple sclerosis (MS) and the fact that patients have been shown to respond to multiple myelin epitopes concurrently makes the use of peptide-specific tolerance therapies targeting single epitopes problematic. To attempt to overcome this limitation, we have employed c...

journal_title：Journal of autoimmunity

authors： Smith CE,Miller SD

更新日期：2006-12-01 00:00:00

abstract：:The presence or absence of autoimmune disease is a qualitative outcome resulting from the combined influences of genetic, environmental and stochastic factors that interact in complex ways. Because of the nature of these interactions, the effects of risk factors that contribute to the aetiology of disease cannot be ad...

journal_title：Journal of autoimmunity

authors： Baxter AG

更新日期：2001-05-01 00:00:00

abstract：:Many years of work, multiplex family collection and endless genotyping finally give fruit. The original aim cannot be lost. The aim is not only to identify mutations involved in susceptibility for systemic lupus erythematosus (SLE) but to elucidate the disease pathogenesis as well. After genetics comes the biology. We...

journal_title：Journal of autoimmunity

authors： Alarcón-Riquelme ME,Prokunina L

更新日期：2003-09-01 00:00:00