Abstract:
:In some circumstances cyclosporine (CyA) induces autoimmune phenomena, and a lethal form of syngeneic graft-vs-host disease (SGVHD) can be induced in rats by the administration of CyA. Although several rat strains develop this disease, in this study, we report that of six mouse strains tested, only the DBA/2 strain developed SGVHD. A comparison of the effect of CyA on thymocytic and peripheral T-cell populations revealed that CyA-induced alterations were similar in the two species, although more marked in rats. Notably, CyA-treated syngeneic bone marrow chimeras (SBMC) had transiently increased numbers of peripheral CD4+ CD8+ T-cells, expressing a marker normally limited to thymocytes. Examination of T-cell receptor (TCR) V beta expression in CyA-treated mice revealed a normal pattern of clonal deletion in all strains (including disease-prone DBA/2 mice), suggesting that CyA may induce autoimmunity without blocking intrathymic clonal deletion.
journal_name
J Autoimmunjournal_title
Journal of autoimmunityauthors
Prud'homme GJ,Sanders R,Parfrey NA,Ste-Croix Hdoi
10.1016/0896-8411(91)90030-gsubject
Has Abstractpub_date
1991-04-01 00:00:00pages
357-68issue
2eissn
0896-8411issn
1095-9157pii
0896-8411(91)90030-Gjournal_volume
4pub_type
杂志文章abstract::Previous studies have indicated that blood mononuclear cells from 15-20% of patients with systemic lupus erythematosus (SLE) carry elevated levels of hsp90, a heat shock protein associated with steroid receptors in cells. We analysed surface expression of hsp90 on mononuclear cells (lymphocytes and monocytes) from pat...
journal_title:Journal of autoimmunity
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doi:10.1016/0896-8411(89)90133-9
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journal_title:Journal of autoimmunity
pub_type: 杂志文章
doi:10.1006/jaut.1993.1045
更新日期:1993-10-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/0896-8411(92)90015-i
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journal_title:Journal of autoimmunity
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journal_title:Journal of autoimmunity
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journal_title:Journal of autoimmunity
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journal_title:Journal of autoimmunity
pub_type: 杂志文章
doi:10.1016/j.jaut.2014.01.002
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journal_title:Journal of autoimmunity
pub_type: 杂志文章
doi:10.1006/jaut.1998.0258
更新日期:1999-03-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of autoimmunity
pub_type: 杂志文章
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journal_title:Journal of autoimmunity
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