Abstract:
:In some circumstances cyclosporine (CyA) induces autoimmune phenomena, and a lethal form of syngeneic graft-vs-host disease (SGVHD) can be induced in rats by the administration of CyA. Although several rat strains develop this disease, in this study, we report that of six mouse strains tested, only the DBA/2 strain developed SGVHD. A comparison of the effect of CyA on thymocytic and peripheral T-cell populations revealed that CyA-induced alterations were similar in the two species, although more marked in rats. Notably, CyA-treated syngeneic bone marrow chimeras (SBMC) had transiently increased numbers of peripheral CD4+ CD8+ T-cells, expressing a marker normally limited to thymocytes. Examination of T-cell receptor (TCR) V beta expression in CyA-treated mice revealed a normal pattern of clonal deletion in all strains (including disease-prone DBA/2 mice), suggesting that CyA may induce autoimmunity without blocking intrathymic clonal deletion.
journal_name
J Autoimmunjournal_title
Journal of autoimmunityauthors
Prud'homme GJ,Sanders R,Parfrey NA,Ste-Croix Hdoi
10.1016/0896-8411(91)90030-gsubject
Has Abstractpub_date
1991-04-01 00:00:00pages
357-68issue
2eissn
0896-8411issn
1095-9157pii
0896-8411(91)90030-Gjournal_volume
4pub_type
杂志文章abstract::Genetic polymorphism in MECP2/IRAK1 on chromosome Xq28 is a confirmed and replicated susceptibility locus for lupus. High linkage disequilibrium in this locus suggests that both MECP2 and IRAK1 are candidate genes for the disease. DNA methylation changes in lupus T cells play a central role in the pathogenesis of lupu...
journal_title:Journal of autoimmunity
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journal_title:Journal of autoimmunity
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journal_title:Journal of autoimmunity
pub_type: 杂志文章,评审
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doi:10.1016/j.jaut.2003.09.006
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更新日期:2017-03-01 00:00:00
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journal_title:Journal of autoimmunity
pub_type: 杂志文章
doi:10.1016/j.jaut.2018.08.004
更新日期:2019-01-01 00:00:00
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journal_title:Journal of autoimmunity
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,评审
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journal_title:Journal of autoimmunity
pub_type: 杂志文章
doi:10.1006/jaut.1996.0122
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journal_title:Journal of autoimmunity
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更新日期:2015-08-01 00:00:00
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journal_title:Journal of autoimmunity
pub_type: 杂志文章
doi:10.1016/0896-8411(89)90172-8
更新日期:1989-08-01 00:00:00
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doi:10.1006/jaut.2001.0545
更新日期:2001-12-01 00:00:00
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journal_title:Journal of autoimmunity
pub_type: 杂志文章
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更新日期:1992-10-01 00:00:00
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journal_title:Journal of autoimmunity
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.jaut.2017.02.003
更新日期:2017-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jaut.2005.01.014
更新日期:2005-05-01 00:00:00