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Apoptosis in feathers of Smyth line chickens with autoimmune vitiligo.

Abstract：

:Vitiligo is an acquired dermatological disorder characterized by a loss of epidermal melanocytes resulting in depigmentation of the skin. Mechanisms underlying the destruction of melanocytes in vitiligo remain unclear. An animal model to study spontaneously occurring autoimmune vitiligo is the mutant Smyth line (SL) of chickens. This investigation was designed to determine whether the pathogenesis of depigmentation in Smyth line chicken vitiligo (SLV) involves an apoptotic mechanism. Terminal deoxynucleotide transferase-mediated fluorescein-dUTP nick end labeling (TUNEL) was used to detect in situ cell apoptosis in cryostat sections of 2-week-old regenerating feathers. Two-week-old regenerating feathers were obtained from SL chickens and their normally pigmented controls including the parental Brown line (BL) and Light Brown Leghorn (LBL) chickens at 6, 8, 10 and 12 weeks of age. In feathers from vitiliginous SL chickens, the number of TUNEL+ cells was significantly (P

journal_name

J Autoimmun

journal_title

Journal of autoimmunity

authors

Wang X,Erf GF

doi

10.1016/j.jaut.2003.09.006

subject

Has Abstract

pub_date

2004-02-01 00:00:00

pages

21-30

issue

1

eissn

0896-8411

issn

1095-9157

pii

S0896841103001501

journal_volume

22

pub_type

杂志文章

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