Profile and clinical significance of anti-nuclear envelope antibodies found in patients with primary biliary cirrhosis: a multicenter study.

abstract：:Susceptibility to Pemphigus, an autoimmune disease of the skin, has been previously linked to DRB1*0402, 1401/04 and DQB1*0503 in pemphigus vulgaris (PV), to DRB1*0102, 0404, 1402/06 in endemic pemphigus foliaceus in Brazil and to DRB1*04 in Italian patients suffering from pemphigus foliaceus (PF). The disease is caus...

journal_title：Journal of autoimmunity

authors： Loiseau P,Lecleach L,Prost C,Lepage V,Busson M,Bastuji-Garin S,Roujeau JC,Charron D

更新日期：2000-08-01 00:00:00

abstract：:University of California at Davis line 200 (UCD-200) chickens develop a hereditary connective tissue disease characterized by severe lymphocytic infiltration, vascular occlusion and fibrosis of skin and internal organs. To identify cellular immunological abnormalities in the acute inflammatory disease stage of this an...

journal_title：Journal of autoimmunity

authors： Gruschwitz MS,Moormann S,Krömer G,Sgonc R,Dietrich H,Boeck G,Gershwin ME,Boyd R,Wick G

更新日期：1991-08-01 00:00:00

abstract：:Spontaneous idiotype shift of anti-DNA antibodies in systemic lupus erythematosus was shown to be associated with changes in the clinical manifestations of the disease. Characterization of two anti-DNA antibody preparations from the same lupus patient showed that lupus nephritis was associated with antibodies showing ...

journal_title：Journal of autoimmunity

authors： Suenaga R,Munoz PA,Hon SH,Abdou NI

更新日期：1989-06-01 00:00:00

abstract：:Neuropsychiatric disease is one of the most common manifestations of human systemic lupus erythematosus, but the mechanisms remain poorly understood. In human brain microvascular endothelial cells in vitro, TNF-like weak inducer of apoptosis (TWEAK) decreases tight junction ZO-1 expression and increases the permeabili...

journal_title：Journal of autoimmunity

authors： Wen J,Doerner J,Weidenheim K,Xia Y,Stock A,Michaelson JS,Baruch K,Deczkowska A,Gulinello M,Schwartz M,Burkly LC,Putterman C

更新日期：2015-06-01 00:00:00

abstract：:Costimulatory molecules are cell-surface glycoproteins that can direct, modulate and fine tune immune responses. B7-2(CD86) costimulatory molecules are considered as major regulators of T cell responses, acting by appropriate interactions with the stimulatory CD28 or inhibitory CTLA-4 receptors found on T cells. Altho...

journal_title：Journal of autoimmunity

authors： Kapsogeorgou EK,Manoussakis MN

更新日期：2010-11-01 00:00:00

abstract：:New Zealand (NZ) mouse strains comprise both autoimmune and non-autoimmune animals: NZ black (NZB) mice and the F1 hybrid (NZB/W) of NZB and NZ white (NZW) mice show spontaneous autoimmune disease by 6 months of age and die before the first year of age from renal disease, while NZW mice do not show autoimmune disorder...

journal_title：Journal of autoimmunity

authors： Esaguy N,Macedo PM,Castro AP,Aguas AP

更新日期：1992-10-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a model of T-cell mediated autoimmune disease. Active disease is mediated by myelin basic protein specific CD4+ T-cells, whose adoptive transfer can also induce passive disease. In the Lewis rat EAE is a transient disease inducing lasting resistance to rechallenge. Th...

journal_title：Journal of autoimmunity

authors： Lohse AW,Schwerdt A,Herkel J,Spahn T,Meyer zum Büschenfelde KH

更新日期：1995-06-01 00:00:00

abstract：:Most autoimmune diseases occur significantly more frequently in women than men. This female preponderance for abnormal autoimmune function has largely gone unexplained. Many investigations have concentrated on the effects of female and male sex hormones on immune function, by suggesting that estrogens favor the antibo...

journal_title：Journal of autoimmunity

authors： Gleicher N,Barad DH

更新日期：2007-02-01 00:00:00

abstract：:In contrast to several previously published reports, we demonstrate by a variety of antibody assays that bovine serum albumin (BSA) is not antigenically cross-reactive with the 69-kDa islet cell autoantigen (ICA69). Fast protein liquid chromatography purified BSA and highly purified recombinant human ICA69 were used t...

journal_title：Journal of autoimmunity

authors： Rønningen KS,Atrazhev A,Luo L,Luo C,Smith DK,Korbutt G,Rajotte RV,Elliott JF

更新日期：1998-06-01 00:00:00

abstract：:MHC-class II genes determine susceptibility in human type-1 diabetes. In their context, presentation of target antigen(s) results in autoimmunity and beta-cell destruction. An animal model, in which human beta-cell autoantigen(s) are presented to effector cells in the context of human MHC-class II diabetes-susceptibil...

journal_title：Journal of autoimmunity

authors： Elagin RB,Balijepalli S,Diacovo MJ,Baekkeskov S,Jaume JC

更新日期：2009-08-01 00:00:00

abstract：:Catastrophic antiphospholipid (Asherson's) syndrome (cAPS) was described in the past as a severe variant of the antiphospholipid syndrome (APS). Currently growing evidence suggests it is a unique condition. This statement is based on several clinical and physiopathological features that although not well understood de...

journal_title：Journal of autoimmunity

authors： Ortega-Hernandez OD,Agmon-Levin N,Blank M,Asherson RA,Shoenfeld Y

更新日期：2009-02-01 00:00:00

abstract：:Autoimmune hepatitis (AIH) is a rare, chronic disease that affects both adults and children, including infants. The disease is probably triggered by environmental factors in genetically predisposed individuals. The clinical presentation ranges from asymptomatic patients or patients with non-specific symptoms, such as ...

journal_title：Journal of autoimmunity

authors： Sokollik C,McLin VA,Vergani D,Terziroli Beretta-Piccoli B,Mieli-Vergani G

更新日期：2018-12-01 00:00:00

abstract：:The significant decrease in mortality rates worldwide, the increased proportion of patients achieving a durable remission, and the recent approval of a new drug after several decades are encouraging advances in the tangled history of systemic lupus erythematosus (SLE). However, when data are observed more closely, the...

journal_title：Journal of autoimmunity

authors： Doria A,Gershwin ME,Selmi C

更新日期：2016-11-01 00:00:00

abstract：:Primary warm autoimmune hemolytic anemia (wAIHA) is a rare autoimmune disease in which red blood cells are eliminated by IgG autoantibodies. We analyzed the antibody-secreting cells in the spleen and the peripheral blood of wAIHA patients in various contexts of treatment. Plasmablasts were observed in peripheral blood...

journal_title：Journal of autoimmunity

authors： Mahévas M,Michel M,Vingert B,Moroch J,Boutboul D,Audia S,Cagnard N,Ripa J,Menard C,Tarte K,Mégret J,Le Gallou S,Patin P,Thai L,Galicier L,Bonnotte B,Godeau B,Noizat-Pirenne F,Weill JC,Reynaud CA

更新日期：2015-08-01 00:00:00

abstract：:Physiologically, HLA Class II molecules are primarily expressed on immunoregulatory cells. In recent years, it has been shown that tissues affected by autoimmunity, including beta cells of 'diabetic' pancreases, 'inappropriately' express these glycoproteins. Cytokines are potent Class II inducers on a variety of cells...

journal_title：Journal of autoimmunity

authors： Pujol-Borrell R,Soldevila G,Buscema M,Vives M,Badenas J,Marakian R,Bottazzo GF

更新日期：1989-06-01 00:00:00

abstract：:We assessed the implication of Th (helper)-cells and the modulation of the Th1/Th2 dichotomy by n-3 polyunsaturated fatty acids (PUFA) in type I diabetic pregnancy (DP) and macrosomia. Female gestant rats fed a standard diet or n-3 PUFA regimen were rendered diabetic by administration of five low doses of streptozotoc...

journal_title：Journal of autoimmunity

authors： Khan NA,Yessoufou A,Kim M,Hichami A

更新日期：2006-06-01 00:00:00

abstract：:The antigenic specificity of anti-phospholipid antibodies (APA) is a matter of intensive investigation. To further characterize these antibodies, we attempted to isolate human monoclonal APA. B-cells of patients with at least one positive test for antibodies against cardiolipin, phosphatidylserine, beta2-glycoprotein ...

journal_title：Journal of autoimmunity

authors： von Landenberg C,Lackner KJ,von Landenberg P,Lang B,Schmitz G

更新日期：1999-09-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease primarily afflicting women. The reason for the gender bias is unclear, but genetic susceptibility, estrogen and environmental agents appear to play significant roles in SLE pathogenesis. Environmental agents can contribute to lupus susceptibility through epig...

journal_title：Journal of autoimmunity

authors： Strickland FM,Hewagama A,Lu Q,Wu A,Hinderer R,Webb R,Johnson K,Sawalha AH,Delaney C,Yung R,Richardson BC

更新日期：2012-05-01 00:00:00

abstract：:HLA-DQB1 is widely considered to be the major histocompatibility complex (MHC) susceptibility gene for type 1 diabetes (T1D). However, since inheritance of the gene in T1D is recessive, the presence of the protective HLA-DQB1 0602 allele with normal nucleotide sequence in some patients raises the question of whether H...

journal_title：Journal of autoimmunity

authors： Husain Z,Kelly MA,Eisenbarth GS,Pugliese A,Awdeh ZL,Larsen CE,Alper CA

更新日期：2008-06-01 00:00:00

abstract：:Our aim was to investigate presence of tumour necrosis factor (TNF) and interleukin (IL)-10 in serum and their relation to different genotypes as well as to clinical and laboratory phenotypes in patients with polymyositis and dermatomyositis. In 65 patients with poly- or dermatomyositis the inflammatory cytokine balan...

journal_title：Journal of autoimmunity

authors： Hassan AB,Fathi M,Dastmalchi M,Lundberg IE,Padyukov L

更新日期：2006-08-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a progressive devastating, yet untreatable fibrotic disease of unknown origin. We investigated the contribution of the B-cell activating factor (BAFF), a TNF family member recently implicated in the regulation of pathogenic IL-17-producing cells in autoimmune diseases. The contri...

journal_title：Journal of autoimmunity

authors： François A,Gombault A,Villeret B,Alsaleh G,Fanny M,Gasse P,Adam SM,Crestani B,Sibilia J,Schneider P,Bahram S,Quesniaux V,Ryffel B,Wachsmann D,Gottenberg JE,Couillin I

更新日期：2015-01-01 00:00:00

abstract：:The presence or absence of autoimmune disease is a qualitative outcome resulting from the combined influences of genetic, environmental and stochastic factors that interact in complex ways. Because of the nature of these interactions, the effects of risk factors that contribute to the aetiology of disease cannot be ad...

journal_title：Journal of autoimmunity

authors： Baxter AG

更新日期：2001-05-01 00:00:00

abstract：:Exposure to the hydrocarbon oil pristane induces lupus specific autoantibodies in non-autoimmune mice. We investigated whether the capacity to induce lupus-like autoimmunity is a unique property of pristane or is shared by other adjuvant oils. Seven groups of 3-month-old female BALB/cJ mice received a single intraperi...

journal_title：Journal of autoimmunity

authors： Satoh M,Kuroda Y,Yoshida H,Behney KM,Mizutani A,Akaogi J,Nacionales DC,Lorenson TD,Rosenbauer RJ,Reeves WH

更新日期：2003-08-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disorder with unknown aetiology. The major hallmark of this disease is the presence of antibodies against nuclear components, including double-stranded (ds)DNA and histones. The disease affects different organs, particularly the skin, kidneys and the nervous system. ...

journal_title：Journal of autoimmunity

authors： Van Ghelue M,Moens U,Bendiksen S,Rekvig OP

更新日期：2003-03-01 00:00:00

abstract：:Interstitial cystitis (IC) is a chronic inflammatory condition of the urinary bladder with a strong autoimmune component. Currently, the major challenge in IC treatment is the development of effective therapies. RDP58 is a novel d-amino acid decapeptide with potent immunosuppressive activity. In this study, we investi...

journal_title：Journal of autoimmunity

authors： Liu W,Deyoung BR,Chen X,Evanoff DP,Luo Y

更新日期：2008-06-01 00:00:00

abstract：:Chronic myocarditis often progresses to dilated cardiomyopathy resulting in heart failure or cardiac transplantation. Viral infection is the most common cause of myocarditis and coxsackie B viruses (CBV) are the most frequently cited etiologic agents associated with myocarditis and cardiomyopathy. Additionally, CBV in...

journal_title：Journal of autoimmunity

authors： Horwitz MS,Ilic A,Fine C,Sarvetnick N

更新日期：2005-09-01 00:00:00

abstract：:The question of a connection between vaccination and autoimmune illness (or phenomena) is surrounded by controversy. A heated debate is going on regarding the causality between vaccines, such as measles and anti-hepatitis B virus (HBV), and multiple sclerosis (MS). Brain antibodies as well as clinical symptoms have be...

journal_title：Journal of autoimmunity

authors： Shoenfeld Y,Aron-Maor A

更新日期：2000-02-01 00:00:00

abstract：:It has been known for many years that bacteria can induce autoimmune responses in humans resulting in serious disease. Recent work has shown that a number of bacteria that colonize human mucosal surfaces exclusively express antigens on their surfaces which are molecular mimics of glycosphingolipids found on human cell...

journal_title：Journal of autoimmunity

authors： Harvey HA,Swords WE,Apicella MA

更新日期：2001-05-01 00:00:00

abstract：:CD8(+) cytotoxic T lymphocytes (CTL) can rapidly kill beta-cells and therefore contribute to the development of type 1 diabetes (T1D). CTL-mediated beta-cell killing can occur via perforin-mediated lysis, Fas-Fas-L interaction, and the secretion of TNF-alpha or IFN-gamma. The secretion of IFN-gamma can contribute to b...

journal_title：Journal of autoimmunity

authors： Barral AM,Thomas HE,Ling EM,Darwiche R,Rodrigo E,Christen U,Ejrnaes M,Wolfe T,Kay TW,von Herrath MG

更新日期：2006-11-01 00:00:00

abstract：:Nasal tolerance has recently been used to modulate immune responses in animal models of autoimmunity. We have compared immunogenic collagen type II (CII) peptides for induction of nasal tolerance in DBA/1 mice to collagen-induced arthritis (CIA). Three synthetic peptides corresponding to T cell-stimulating sequences o...

journal_title：Journal of autoimmunity

authors： Chu CQ,Londei M

更新日期：1999-02-01 00:00:00