Abstract：
OBJECTIVE:Evaluation of systematic epidemiological data regarding clinical characteristics, sex distribution and autoantibody pattern in Caucasian children with autoimmune hepatitis (AIH). STUDY DESIGN:Data of 142 children presenting with AIH (97 girls and 45 boys) have been analysed for their clinical, serological, and histological profile. RESULTS:Clinical findings were jaundice (58%), unspecific weakness (57%), anorexia (47%), abdominal pain (38%) and paleness (26%). One hundred and three children (73%) (68 girls, 35 boys, 1.9:1) had AIH type 1 and 35 patients (25%) (27 girls, 8 boys, 3.4:1) type 2 due to specific autoantibodies. Four children could not be classified. Histology of 122 children revealed active hepatitis in 64 (52%), cirrhosis in 46 (38%), and mild inflammatory activity in 12 individuals (10%). The most prevalent HLA type was B8. CONCLUSION:In our cohort the prevalence of AIH was half as frequent in boys as in girls. Type 1 was the most frequent diagnosis (73%) and was more prevalent in older children. Type 2 was equally age distributed. The clinical presentation of AIH in children was unspecific and type I and type II could only be differentiated by the determination of the specific autoantibodies. Ninety percent of patients presented with high inflammatory activity or liver cirrhosis.
journal_name
J Autoimmunjournal_title
Journal of autoimmunityauthors
Oettinger R,Brunnberg A,Gerner P,Wintermeyer P,Jenke A,Wirth Sdoi
10.1016/j.jaut.2004.11.009subject
Has Abstractpub_date
2005-02-01 00:00:00pages
79-84issue
1eissn
0896-8411issn
1095-9157pii
S0896-8411(04)00136-2journal_volume
24pub_type
杂志文章abstract：:Interleukin-2 (IL-2) gene regulation was investigated in primary cultures of highly purified human peripheral blood CD28+ T cells. Two discrete mechanisms for induction of T-cell proliferation could be distinguished by examining cell cycle progression and the expression of the IL-2 gene. Stimulation of cells by CD3 Mo...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/0896-8411(89)90117-0
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
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journal_title：Journal of autoimmunity
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
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更新日期：2000-02-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章,评审
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/s0896-8411(05)80048-4
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pub_type： 杂志文章
doi：10.1016/j.jaut.2017.10.002
更新日期：2018-03-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章,评审
doi：10.1016/j.jaut.2010.06.011
更新日期：2010-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.jaut.2018.05.009
更新日期：2018-08-01 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：2020-11-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1006/jaut.1996.0020
更新日期：1996-04-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/0896-8411(91)90018-8
更新日期：1991-04-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章,评审
doi：10.1006/jaut.1993.1057
更新日期：1993-12-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 社论,历史文章
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更新日期：2014-02-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章,评审
doi：10.1016/j.jaut.2013.11.005
更新日期：2014-02-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2006.12.002
更新日期：2006-12-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2006.09.005
更新日期：2006-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0896-8411(88)90078-9
更新日期：1988-02-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2007.07.003
更新日期：2007-09-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1006/jaut.1993.1040
更新日期：1993-08-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1006/jaut.2000.0395
更新日期：2000-09-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2007.11.011
更新日期：2008-02-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1006/jaut.1998.0255
更新日期：1999-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0896-8411(89)90161-3
更新日期：1989-08-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章,评审
doi：10.1016/j.jaut.2014.08.002
更新日期：2014-11-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2004.01.005
更新日期：2004-06-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2010.09.006
更新日期：2011-02-01 00:00:00
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journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1016/j.jaut.2019.05.013
更新日期：2019-09-01 00:00:00
abstract：:The costimulatory interaction between CD28 on T cells and B7-related molecules on antigen presenting cells plays an important role in a broad range of functions of the immune system, including protective immunity, tolerance induction, allograft rejection, and the development of autoimmune diseases. Monoclonal antibodi...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
doi：10.1006/jaut.1998.0258
更新日期：1999-03-01 00:00:00
abstract：:Malathion administration at non-cholinergical doses was shown to elevate macrophage, proliferative and humoral immune responses. This study examined the effects of malathion on autoimmunity, autoantibody formation, macrophage function and mitogenic responses in MRL-lpr mice (genetically predisposed to autoimmune disea...
journal_title：Journal of autoimmunity
pub_type： 杂志文章
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更新日期：1997-08-01 00:00:00
