当前位置： SCI文献检索 > JOURNAL OF AUTOIMMUNITY期刊下所有文献 > Multi-peptide coupled-cell tolerance ameliorates ongoing relapsing EAE associated with multiple pathogenic autoreactivities.

Multi-peptide coupled-cell tolerance ameliorates ongoing relapsing EAE associated with multiple pathogenic autoreactivities.

Abstract：

:The probability that epitope spreading occurs in multiple sclerosis (MS) and the fact that patients have been shown to respond to multiple myelin epitopes concurrently makes the use of peptide-specific tolerance therapies targeting single epitopes problematic. To attempt to overcome this limitation, we have employed cocktails of peptides in the ECDI coupled-APC tolerance system in mice to determine if T cell responses to multiple autoepitopes can be targeted simultaneously. Preventative tolerance induced with splenocytes coupled with a peptide cocktail of four distinct encephalitogenic epitopes (PLP(139-151), PLP(178-191), MBP(84-104), and MOG(92-106)) inhibited initiation of active EAE induced with each individual peptide and by a mixture of the four peptides by preventing activation of autoreactive Th1 cells and subsequent infiltration of inflammatory cells into the CNS. Most relevant to treatment of clinical MS, therapeutic tolerance initiated by splenocytes coupled with the peptide cocktail administered at the peak of acute disease prevented clinical relapses due to epitope spreading and ameliorated a diverse disease induced with a mixture of the four peptides. Interestingly, therapeutic tolerance appeared to be mediated by a mechanism distinct from preventative tolerance, i.e. by significantly increasing the levels of production of the anti-inflammatory cytokines TGF-beta and/or IL-10 in both the periphery and the CNS.

journal_name

J Autoimmun

journal_title

Journal of autoimmunity

authors

Smith CE,Miller SD

doi

10.1016/j.jaut.2006.12.002

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

218-31

issue

4

eissn

0896-8411

issn

1095-9157

pii

S0896-8411(06)00115-6

journal_volume

27

pub_type

杂志文章

相关文献

JOURNAL OF AUTOIMMUNITY文献大全
  • The role of NK cell activity in the pathogenesis of poly I:C accelerated and spontaneous diabetes in the diabetes prone BB rat.

    abstract：:The development of insulin dependent diabetes mellitus (IDDM) and diabetes in the diabetes prone (DP) BB rat animal model of IDDM is thought to be due to an autoimmune process. Natural killer (NK) cells have been implicated but not proven to play a pathogenetic role in BB rats due to the increased NK cell number and a...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/s0896-8411(95)80021-2

    authors： Sobel DO,Azumi N,Creswell K,Holterman D,Blair OC,Bellanti JA,Abbassi V,Hiserodt JC

    更新日期：1995-12-01 00:00:00

  • Immunoaugmenting effect of FK 506 on experimental allergic encephalomyelitis in Lewis rats.

    abstract：:The effect of the immunosuppressive drug FK 506 on encephalomyelitis (EAE) in Lewis rats was studied. Treatment that began during EAE induction delayed EAE onset, but when the disease started it was chronic/progressive and of unusual severity and duration, leading to death in many animals. Treatment started after onse...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1998.0205

    authors： Chelmicka-Schorr E,Wiegmann K,Wollmann R,Arnason BG,Kim DH

    更新日期：1998-08-01 00:00:00

  • RDP58 inhibits T cell-mediated bladder inflammation in an autoimmune cystitis model.

    abstract：:Interstitial cystitis (IC) is a chronic inflammatory condition of the urinary bladder with a strong autoimmune component. Currently, the major challenge in IC treatment is the development of effective therapies. RDP58 is a novel d-amino acid decapeptide with potent immunosuppressive activity. In this study, we investi...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2007.10.005

    authors： Liu W,Deyoung BR,Chen X,Evanoff DP,Luo Y

    更新日期：2008-06-01 00:00:00

  • B-cell overexpression of Bcl-2 cooperates with p21 deficiency for the induction of autoimmunity and lymphomas.

    abstract：:Genetic abnormalities predisposing to autoimmunity generally act in a cooperative manner affecting one or several mechanisms regulating immunological tolerance. In addition, many of these genetic abnormalities are also involved in the development of lymphoproliferative diseases. In the present study, we have determine...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2010.07.002

    authors： Santiuste I,Buelta L,Iglesias M,Genre F,Mazorra F,Izui S,Merino J,Merino R

    更新日期：2010-12-01 00:00:00

  • The clinical features, diagnosis and classification of dermatomyositis.

    abstract：:Dermatomyositis (DM) is an idiopathic inflammatory myopathy (IIM) characterized by an inflammatory infiltrate primarily affecting the skeletal muscle and skin. Most common and peculiar cutaneous lesions include Gottron's papules, Gottron's sign and heliotrope rash. Different DM subsets have been identified until now e...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2013.11.005

    authors： Iaccarino L,Ghirardello A,Bettio S,Zen M,Gatto M,Punzi L,Doria A

    更新日期：2014-02-01 00:00:00

  • Polymyalgia rheumatica--diagnosis and classification.

    abstract：:Polymyalgia rheumatica is the most common inflammatory rheumatic disease of the elderly, and shares many pathogenetic and epidemiological features with giant cell arteritis. The typical symptoms are bilateral aching of the shoulder girdle, associated with morning stiffness. The neck and hip girdle may also be involved...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2014.01.016

    authors： Nesher G

    更新日期：2014-02-01 00:00:00

  • The classification and diagnosis of cutaneous lupus erythematosus.

    abstract：:Lupus erythematosus (LE) is an inflammatory connective tissue disease of generalized autoimmunity characterized by pathogenic autoantibodies and immune complexes, attributed to loss of immune tolerance. Cutaneous involvement, which appears in the majority of patients with the disease, can present as LE-specific or LE-...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2014.01.021

    authors： Kuhn A,Landmann A

    更新日期：2014-02-01 00:00:00

  • Salivary gland epithelial cells (SGEC): carriers of exquisite B7-2 (CD86) costimulatory molecules.

    abstract：:Costimulatory molecules are cell-surface glycoproteins that can direct, modulate and fine tune immune responses. B7-2(CD86) costimulatory molecules are considered as major regulators of T cell responses, acting by appropriate interactions with the stimulatory CD28 or inhibitory CTLA-4 receptors found on T cells. Altho...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2010.06.006

    authors： Kapsogeorgou EK,Manoussakis MN

    更新日期：2010-11-01 00:00:00

  • Differential activities of immunogenic collagen type II peptides in the induction of nasal tolerance to collagen-induced arthritis.

    abstract：:Nasal tolerance has recently been used to modulate immune responses in animal models of autoimmunity. We have compared immunogenic collagen type II (CII) peptides for induction of nasal tolerance in DBA/1 mice to collagen-induced arthritis (CIA). Three synthetic peptides corresponding to T cell-stimulating sequences o...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1998.0255

    authors： Chu CQ,Londei M

    更新日期：1999-02-01 00:00:00

  • Elimination of infectious antigens and increase of IgG catabolism as possible modes of action of IVIg.

    abstract：:Many mechanisms can explain the mode of action of IVIg in immune disorders. Macrophage blockade and interference in the idiotypic network are supported by some experimental data. Among the other mechanisms, two are considered in greater detail. Firstly, in some disorders, the patients could improve simply because the ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1006/jaut.1993.1057

    authors： Masson PL

    更新日期：1993-12-01 00:00:00

  • B-cell deficiency does not abrogate development of cutaneous hyperplasia in mice inheriting the defective fibrillin-1 gene.

    abstract：:Tight-skin (TSK) mouse, the experimental model for scleroderma, develops cutaneous hyperplasia, cardiac hypertrophy, pulmonary emphysema and autoimmunity against scleroderma target autoantigens. The cutaneous hyperplasia is associated with the accumulation of microfibrils and elastic fibers in the middle and deep derm...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1997.0158

    authors： Kasturi KN,Hatakeyama A,Murai C,Gordon R,Phelps RG,Bona CA

    更新日期：1997-12-01 00:00:00

  • A novel function of IL-2: chemokine/chemoattractant/retention receptor genes induction in Th subsets for skin and lung inflammation.

    abstract：:The Foxp3(+)CD4(+) regulatory T-cell (Treg)-deficient Scurfy (Sf) mice rapidly develop severe inflammation in the skin and lungs with expanded Th subsets bearing increased expression of various chemokine/chemoattractant/retention receptor genes (CRG). Nine different double mutants were generated to elucidate their rol...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2012.02.001

    authors： Sharma R,Sung SS,Gaskin F,Fu SM,Ju ST

    更新日期：2012-06-01 00:00:00

  • Do we know which patients with the antiphospholipid syndrome should receive long-term high dose anti-coagulation?

    abstract：:The standard treatment of thrombosis related to antiphospholipid antibodies is lifelong high-intensity oral anticoagulation. This standard is primarily based on retrospective evaluations of such patients. In this paper we give a summary of current treatment of deep leg vein thrombosis, pulmonary embolism, ischaemic st...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1006/jaut.2000.0395

    authors： Derksen RH,de Groot PG

    更新日期：2000-09-01 00:00:00

  • Autostimulatory factor produced by B-cell lines from patients with Sjögren's syndrome.

    abstract：:Sjögren's syndrome (SS) is an autoimmune disease with a predisposition to transform into a B-cell lymphoma. Stable B-cell lines were established (without exogenous stimulation other than fetal bovine serum) from the peripheral blood of three SS patients. These cell lines secreted immunoglobulin (either IgG, IgM or bot...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(89)90172-8

    authors： Takei M,Dang H,Dauphinée MJ,Talal N

    更新日期：1989-08-01 00:00:00

  • Two distinct mechanisms of interleukin-2 gene expression in human T lymphocytes.

    abstract：:Interleukin-2 (IL-2) gene regulation was investigated in primary cultures of highly purified human peripheral blood CD28+ T cells. Two discrete mechanisms for induction of T-cell proliferation could be distinguished by examining cell cycle progression and the expression of the IL-2 gene. Stimulation of cells by CD3 Mo...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(89)90117-0

    authors： June CH,Jackson KM,Ledbetter JA,Leiden JM,Lindsten T,Thompson CB

    更新日期：1989-06-01 00:00:00

  • Autoimmunity: from black water fever to regulatory function.

    abstract：:Autoimmunity is a field that has only been around for a little over a century. Initially, it was thought that autoimmunity could not happen, that the body would never turn on itself (i.e. "horror autotoxicus"). It was only around the First World War that autoimmunity was recognized as the pathogenesis of various disea...

    journal_title：Journal of autoimmunity

    pub_type： 社论,历史文章

    doi：10.1016/j.jaut.2013.12.019

    authors： Chang C

    更新日期：2014-02-01 00:00:00

  • The role of thrombospondin-1 in the pathogenesis of antiphospholipid syndrome.

    abstract：OBJECTIVE:Antiphospholipid syndrome (APS) is an acquired thrombophilia characterized by recurrent thrombosis and/or pregnancy morbidity, in the presence of antibodies to β2 glycoprotein-I (β2GPI), prothrombin or Lupus anticoagulant (LA). Anti-β2GPI antibodies recognize complexes of β2GPI dimers with CXCL4 chemokine and...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2020.102527

    authors： Patsouras M,Tsiki E,Karagianni P,Vlachoyiannopoulos PG

    更新日期：2020-12-01 00:00:00

  • Immune potentiation of ultrafine dietary particles in normal subjects and patients with inflammatory bowel disease.

    abstract：:Various specific and non-specific environmental factors have been associated with the induction and/or exacerbation of disease activity in patients with Crohn's disease and ulcerative colitis. One such factor is the potential role of ingested ultrafine particles. In fact, based on a Western diet, recent data suggest t...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1999.0342

    authors： Powell JJ,Harvey RS,Ashwood P,Wolstencroft R,Gershwin ME,Thompson RP

    更新日期：2000-02-01 00:00:00

  • Evidence that a putative anti-idiotypic monoclonal antibody may actually be recognizing circulating immune complexes.

    abstract：:Murine monoclonal antibodies (mAb) reacting with affinity-purified antihistone antibodies (AHA) from serum of a patient with systemic lupus erythematosus (SLE) were obtained. One of them, 8B3, was initially considered to recognize idiotypic (Id) determinants in AHA since (a) it reacted with AHA but not with control Ig...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(92)90149-k

    authors： Subiza JL,Caturla A,Pereira LF,Camargo MC,Bustos A,Boimorto R,de la Concha EG

    更新日期：1992-06-01 00:00:00

  • Cell and gene therapy using mesenchymal stem cells (MSCs).

    abstract：:Mesenchymal stem cells (MSCs) are considered to be a promising platform for cell and gene therapy for a variety of diseases. First, in the field of hematopoietic stem cell transplantation, there are two applications of MSCs: 1) the improvement of stem cell engrafting and the acceleration of hematopoietic reconstitutio...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2007.12.008

    authors： Ozawa K,Sato K,Oh I,Ozaki K,Uchibori R,Obara Y,Kikuchi Y,Ito T,Okada T,Urabe M,Mizukami H,Kume A

    更新日期：2008-05-01 00:00:00

  • Clinical features and biochemical data of Caucasian children at diagnosis of autoimmune hepatitis.

    abstract：OBJECTIVE:Evaluation of systematic epidemiological data regarding clinical characteristics, sex distribution and autoantibody pattern in Caucasian children with autoimmune hepatitis (AIH). STUDY DESIGN:Data of 142 children presenting with AIH (97 girls and 45 boys) have been analysed for their clinical, serological, a...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2004.11.009

    authors： Oettinger R,Brunnberg A,Gerner P,Wintermeyer P,Jenke A,Wirth S

    更新日期：2005-02-01 00:00:00

  • Thermolabile and calcium-dependent serum factor interferes with polymerized actin, and impairs anti-actin antibody detection.

    abstract：:The detection of anti-actin (AAA) by immunofluorescence is hindered by the presence of a serum factor. To better understand how it interferes with AAA detection, we tested sera from 20 patients with autoimmune hepatitis, and from 21 healthy adults, diluted 1:10 and prepared as follows: (A) diluted with PBS; (B) inacti...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.2001.0540

    authors： Cançado EL,Abrantes-Lemos CP,Vilas-Boas LS,Novo NF,Carrilho FJ,Laudanna AA

    更新日期：2001-11-01 00:00:00

  • Prevention of diabetes in the BB rat by early immunotherapy using Freund's adjuvant.

    abstract：:The BB rat spontaneously develops an insulin-dependent diabetes mellitus (IDDM) that closely resembles this disease in man. The pathogenesis involves autoimmune destruction of pancreatic islet beta-cells. In the present study, a single intraperitoneal injection of complete Freund's adjuvant (CFA) in diabetes-prone (DP...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/s0896-8411(05)80034-4

    authors： Sadelain MW,Qin HY,Sumoski W,Parfrey N,Singh B,Rabinovitch A

    更新日期：1990-12-01 00:00:00

  • Autoantibodies from Sjögren's syndrome induce activation of both the intrinsic and extrinsic apoptotic pathways in human salivary gland cell line A-253.

    abstract：:Sjögren's syndrome (SS) is an autoimmune rheumatic disease that targets salivary and lachrymal glands, characterized by a high concentration of serum autoantibodies directed against nuclear and cytoplasmic antigens. It is known that autoantibodies can enter viable cells and this phenomenon has functional consequences ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2006.05.001

    authors： Sisto M,Lisi S,Castellana D,Scagliusi P,D'Amore M,Caprio S,Scagliusi A,Acquafredda A,Panaro MA,Mitolo V

    更新日期：2006-08-01 00:00:00

  • Serum SmD autoantibody proteomes are clonally restricted and share variable-region peptides.

    abstract：:Recent advances in mass spectrometry-based proteomic methods have allowed variable (V)-region peptide signatures to be derived from human autoantibodies present in complex serum mixtures. Here, we analysed the clonality and V-region composition of immunoglobulin (Ig) proteomes specific for the immunodominant SmD prote...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2014.12.005

    authors： Al Kindi MA,Chataway TK,Gilada GA,Jackson MW,Goldblatt FM,Walker JG,Colella AD,Gordon TP

    更新日期：2015-02-01 00:00:00

  • Heritability versus the role of the environment in autoimmunity.

    abstract：:The higher concordant occurrence of autoimmune diseases in monozygotic twins compared to dizygotic or sibling pairs supports the role for genetic susceptibility. For most conditions, however, concordance rates are considerably below 100% and lead to the estimate of the weight of genetics coined "heritability". In the ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2012.07.011

    authors： Selmi C,Lu Q,Humble MC

    更新日期：2012-12-01 00:00:00

  • Autoantibodies to glutamic acid decarboxylase in patients with autoimmune thyroid disease: relation to competitive insulin autoantibodies.

    abstract：:We evaluated the presence of autoantibodies to glutamic acid decarboxylase (GAD), competitive insulin autoantibodies (IAA) and islet cell antibodies (ICA) in sera from 288 non-diabetic patients with autoimmune thyroid disease (AITD), including 212 patients with Graves' disease and 76 with Hashimoto's thyroiditis, and ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1995.0047

    authors： Kawasaki E,Abiru N,Yano M,Uotani S,Matsumoto K,Matsuo H,Yamasaki H,Yamamoto H,Yamaguchi Y,Akazawa S

    更新日期：1995-10-01 00:00:00

  • Identification of the encephalitogenic epitopes of CNS proteolipid protein in BALB/c mice.

    abstract：:It was previously shown that BALB/c mice were susceptible to experimental autoimmune encephalomyelitis induced by immunization with proteolipid protein (PLP). To determine the encephalitogenic epitopes of PLP in BALB/c mice, mice were immunized with successively smaller pools of 20-mer peptides spanning the PLP molecu...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.2002.0619

    authors： Lyons JA,Ramsbottom MJ,Trotter JL,Cross AH

    更新日期：2002-12-01 00:00:00

  • Genetically determined imbalance between serum levels of tumour necrosis factor (TNF) and interleukin (IL)-10 is associated with anti-Jo-1 and anti-Ro52 autoantibodies in patients with poly- and dermatomyositis.

    abstract：:Our aim was to investigate presence of tumour necrosis factor (TNF) and interleukin (IL)-10 in serum and their relation to different genotypes as well as to clinical and laboratory phenotypes in patients with polymyositis and dermatomyositis. In 65 patients with poly- or dermatomyositis the inflammatory cytokine balan...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2006.06.003

    authors： Hassan AB,Fathi M,Dastmalchi M,Lundberg IE,Padyukov L

    更新日期：2006-08-01 00:00:00

  • Treatment of experimental autoimmune encephalomyelitis with engineered bi-specific Foxp3+ regulatory CD4+ T cells.

    abstract：:The use of autoantigen-specific regulatory T cells (Tregs) as a cellular therapy for autoimmune diseases is appealing. However, it is challenging to isolate and expand large quantity of Tregs expressing disease-relevant T-cell receptors (TCR). To overcome this problem, we used an approach aiming at redirecting the spe...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2020.102401

    authors： Malviya M,Saoudi A,Bauer J,Fillatreau S,Liblau R

    更新日期：2020-03-01 00:00:00