当前位置： SCI文献检索 > JOURNAL OF AUTOIMMUNITY期刊下所有文献 > Cell and gene therapy using mesenchymal stem cells (MSCs).

Cell and gene therapy using mesenchymal stem cells (MSCs).

Abstract：

:Mesenchymal stem cells (MSCs) are considered to be a promising platform for cell and gene therapy for a variety of diseases. First, in the field of hematopoietic stem cell transplantation, there are two applications of MSCs: 1) the improvement of stem cell engrafting and the acceleration of hematopoietic reconstitution based on the hematopoiesis-supporting ability; and 2) the treatment of severe graft-versus-host disease (GVHD) based on the immunomodulatory ability. Regarding the immunosuppressive ability, we found that nitric oxide (NO) is involved in the MSC-mediated suppression of T cell proliferation. Second, tumor-bearing nude mice were injected with luciferase-expressing MSCs. An in vivo imaging analysis showed the significant accumulation of the MSCs at the site of tumors. The findings suggest that MSCs can be utilized to target metastatic tumors and to deliver anti-cancer molecules locally. As the third application, MSCs may be utilized as a cellular vehicle for protein-supplement gene therapy. When long-term transgene expression is needed, a therapeutic gene should be introduced with a minimal risk of insertional mutagenesis. To this end, site-specific integration into the AAVS1 locus on the chromosome 19 (19q13.4) by using the integration machinery of adeno-associated virus (AAV) would be particularly valuable. There will be wide-ranging applications of MSCs to frontier medical treatments in the near future.

journal_name

J Autoimmun

journal_title

Journal of autoimmunity

authors

Ozawa K,Sato K,Oh I,Ozaki K,Uchibori R,Obara Y,Kikuchi Y,Ito T,Okada T,Urabe M,Mizukami H,Kume A

doi

10.1016/j.jaut.2007.12.008

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

121-7

issue

3

eissn

0896-8411

issn

1095-9157

pii

S0896-8411(07)00150-3

journal_volume

30

pub_type

杂志文章,评审

相关文献

JOURNAL OF AUTOIMMUNITY文献大全
  • Phosphatidylethanolamine binding protein-4 (PEBP4) is increased in IgA nephropathy and is associated with IgA-positive B-cells in affected kidneys.

    abstract：:IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide and a major cause of chronic kidney disease and failure. IgAN is driven by an autoimmune reaction against galactose-deficient IgA1 that results in the generation of autoantibodies and large IgG-IgA immune complexes. Immune complexes accumulate in t...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2019.102309

    authors： Taylor S,Pieri K,Nanni P,Tica J,Barratt J,Didangelos A

    更新日期：2019-12-01 00:00:00

  • In vitro induction of regulatory T cells by anti-CD3 antibody in humans.

    abstract：:Therapy with anti-CD3 antibody is effective in controlling models of autoimmune diseases and can reverse or prevent rejection of grafts. We studied the in vitro immunomodulatory effect of anti-CD3 treated human T cells. CD4(+) T cells were stimulated with plate-bound anti-CD3 and cultured for 12 days after which they ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2007.11.007

    authors： Abraham M,Karni A,Dembinsky A,Miller A,Gandhi R,Anderson D,Weiner HL

    更新日期：2008-02-01 00:00:00

  • Identification of the encephalitogenic epitopes of CNS proteolipid protein in BALB/c mice.

    abstract：:It was previously shown that BALB/c mice were susceptible to experimental autoimmune encephalomyelitis induced by immunization with proteolipid protein (PLP). To determine the encephalitogenic epitopes of PLP in BALB/c mice, mice were immunized with successively smaller pools of 20-mer peptides spanning the PLP molecu...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.2002.0619

    authors： Lyons JA,Ramsbottom MJ,Trotter JL,Cross AH

    更新日期：2002-12-01 00:00:00

  • Do we know which patients with the antiphospholipid syndrome should receive long-term high dose anti-coagulation?

    abstract：:The standard treatment of thrombosis related to antiphospholipid antibodies is lifelong high-intensity oral anticoagulation. This standard is primarily based on retrospective evaluations of such patients. In this paper we give a summary of current treatment of deep leg vein thrombosis, pulmonary embolism, ischaemic st...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1006/jaut.2000.0395

    authors： Derksen RH,de Groot PG

    更新日期：2000-09-01 00:00:00

  • Structural characterization of an (NZB x NZW)F1 mouse-derived IgM monoclonal antibody that binds through V region-dependent interactions to murine IgG anti-DNA antibodies.

    abstract：:Among B/W-derived IgM mAb, 12.5H was selected because of its ability to recognize, in solid phase ELISAs, IgG mAb with DNA-binding activity. mAb 12.5H bound preferentially to IgG2a mAb and did not react with B/W- or BALB/c-derived IgG2a mAb with no DNA-binding activity, suggesting V region-mediated interactions. mAb 1...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1994.1056

    authors： Margaritte C,Gilbert D,Brard F,Tron F

    更新日期：1994-12-01 00:00:00

  • The diffuse infiltrative lymphocytosis syndrome (DILS). A comprehensive review.

    abstract：:The Diffuse Infiltrative Lymphocytosis Syndrome (DILS) is a rare multisystemic syndrome described in HIV-infected patients. It is characterised by CD8(+) T-cell lymphocytosis associated with a CD8(+) T-cell infiltration of multiple organs. DILS is usually seen in uncontrolled or untreated HIV infection but can also ma...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2015.01.010

    authors： Ghrenassia E,Martis N,Boyer J,Burel-Vandenbos F,Mekinian A,Coppo P

    更新日期：2015-05-01 00:00:00

  • Dendritic cells tip the balance towards induction of regulatory T cells upon priming in experimental autoimmune encephalomyelitis.

    abstract：:Counter-balancing regulatory mechanisms, such as the induction of regulatory T cells (Treg), limit the effects of autoimmune attack in neuroinflammation. However, the role of dendritic cells (DCs) as the most powerful antigen-presenting cells, which are intriguing therapeutic targets in this context, is not fully unde...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2016.09.008

    authors： Paterka M,Voss JO,Werr J,Reuter E,Franck S,Leuenberger T,Herz J,Radbruch H,Bopp T,Siffrin V,Zipp F

    更新日期：2017-01-01 00:00:00

  • Limited sufficiency of antigen presentation by dendritic cells in models of central nervous system autoimmunity.

    abstract：:Experimental autoimmune encephalomyelitis (EAE), a model for the human disease multiple sclerosis (MS), is dependent upon the activation and effector functions of autoreactive CD4 T cells. Multiple interactions between CD4 T cells and major histocompatibility class II (MHCII)+ antigen presenting cells (APCs) must occu...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2010.10.006

    authors： Wu GF,Shindler KS,Allenspach EJ,Stephen TL,Thomas HL,Mikesell RJ,Cross AH,Laufer TM

    更新日期：2011-02-01 00:00:00

  • Immunosuppressive and anti-inflammatory action of antioxidants in rat autoimmune diabetes.

    abstract：:Oxidative stress makes an important contribution to the development of autoimmune diabetes. We therefore tested the possible therapeutic value of two anti-oxidants, butylated hydroxyanisole (BHA) and pyrrolidine dithiocarbamate (PDTC), in the animal model of diabetes induced in susceptible DA rats by multiple low dose...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2004.01.005

    authors： Stosic-Grujicic SD,Miljkovic DM,Cvetkovic ID,Maksimovic-Ivanic DD,Trajkovic V

    更新日期：2004-06-01 00:00:00

  • Beyond thrombosis: Anti-β2GPI domain 1 antibodies identify late pregnancy morbidity in anti-phospholipid syndrome.

    abstract：:Antibodies against β2 glycoprotein I (anti-β2GPI) have been identified as the main pathogenic autoantibody subset in anti-phospholipid syndrome (APS); the most relevant epitope is a cryptic and conformation-dependent structure on β2GPI domain (D) 1. Anti-β2GPI domain profiling has been investigated in thrombotic APS, ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2018.02.002

    authors： Chighizola CB,Pregnolato F,Andreoli L,Bodio C,Cesana L,Comerio C,Gerosa M,Grossi C,Kumar R,Lazzaroni MG,Mahler M,Mattia E,Nalli C,Norman GL,Raimondo MG,Ruffatti A,Tonello M,Trespidi L,Tincani A,Borghi MO,Meroni PL

    更新日期：2018-06-01 00:00:00

  • Increased T lymphocytes bearing the gamma-delta T cell receptor in subjects at high risk for insulin dependent diabetes.

    abstract：:The effector mechanisms responsible for autoimmune beta cell destruction in insulin dependent (type 1) diabetes (IDD) remain elusive. In order to investigate whether T lymphocytes bearing the gamma-delta T cell receptor (gamma delta+ T cells) could be involved in this process, we measured percentages of peripheral blo...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(91)90055-h

    authors： Lang FP,Schatz DA,Pollock BH,Riley WJ,Maclaren NK,Dumont-Driscoll M,Barrett DJ

    更新日期：1991-12-01 00:00:00

  • Cytokine production in culture by cells isolated from the synovial membrane.

    abstract：:Cytokine expression was investigated in synovial cell cultures isolated from diseased joints of patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Tumour necrosis factor alpha (TNF alpha) was produced spontaneously at high levels by both RA and OA synovial cells. There was no correlation between cell com...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(89)90129-7

    authors： Brennan FM,Chantry D,Jackson AM,Maini RN,Feldmann M

    更新日期：1989-06-01 00:00:00

  • Autoantibodies to glutamic acid decarboxylase in patients with autoimmune thyroid disease: relation to competitive insulin autoantibodies.

    abstract：:We evaluated the presence of autoantibodies to glutamic acid decarboxylase (GAD), competitive insulin autoantibodies (IAA) and islet cell antibodies (ICA) in sera from 288 non-diabetic patients with autoimmune thyroid disease (AITD), including 212 patients with Graves' disease and 76 with Hashimoto's thyroiditis, and ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1995.0047

    authors： Kawasaki E,Abiru N,Yano M,Uotani S,Matsumoto K,Matsuo H,Yamasaki H,Yamamoto H,Yamaguchi Y,Akazawa S

    更新日期：1995-10-01 00:00:00

  • Autoimmunity to nucleosomes related to viral infection: a focus on hapten-carrier complex formation.

    abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disorder with unknown aetiology. The major hallmark of this disease is the presence of antibodies against nuclear components, including double-stranded (ds)DNA and histones. The disease affects different organs, particularly the skin, kidneys and the nervous system. ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/s0896-8411(02)00110-5

    authors： Van Ghelue M,Moens U,Bendiksen S,Rekvig OP

    更新日期：2003-03-01 00:00:00

  • Idiotope-specific CD4(+) T cells induce apoptosis of human oligodendrocytes.

    abstract：:CD4(+) T cells specific for immunologic non-self determinants on self-IgG, idiotopes (Id), can be raised from cerebrospinal fluid (CSF) and blood of patients with multiple sclerosis (MS). To test if Id-specific CD4(+) T cells have the potential to destroy oligodendrocytes (ODCs), we analyzed their ability to induce ap...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2009.01.004

    authors： Hestvik AL,Skorstad G,Vartdal F,Holmøy T

    更新日期：2009-03-01 00:00:00

  • Subepidermal blistering induced by human autoantibodies to BP180 requires innate immune players in a humanized bullous pemphigoid mouse model.

    abstract：:Bullous pemphigoid (BP) is a cutaneous autoimmune inflammatory disease associated with subepidermal blistering and autoantibodies against BP180, a transmembrane collagen and major component of the hemidesmosome. Numerous inflammatory cells infiltrate the upper dermis in BP. IgG autoantibodies in BP fix complement and ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2008.08.009

    authors： Liu Z,Sui W,Zhao M,Li Z,Li N,Thresher R,Giudice GJ,Fairley JA,Sitaru C,Zillikens D,Ning G,Marinkovich MP,Diaz LA

    更新日期：2008-12-01 00:00:00

  • Two distinct mechanisms of interleukin-2 gene expression in human T lymphocytes.

    abstract：:Interleukin-2 (IL-2) gene regulation was investigated in primary cultures of highly purified human peripheral blood CD28+ T cells. Two discrete mechanisms for induction of T-cell proliferation could be distinguished by examining cell cycle progression and the expression of the IL-2 gene. Stimulation of cells by CD3 Mo...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(89)90117-0

    authors： June CH,Jackson KM,Ledbetter JA,Leiden JM,Lindsten T,Thompson CB

    更新日期：1989-06-01 00:00:00

  • Infections as risk factor for autoimmune diseases - A nationwide study.

    abstract：:Viruses, bacteria and other infectious pathogens are the major postulated environmental triggers of autoimmunity. In the present nation-wide study we describe the association between infections and 29 autoimmune diseases. We used the Danish Civil Registration System to identify 4.5 million persons born between 1945 an...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2016.05.013

    authors： Nielsen PR,Kragstrup TW,Deleuran BW,Benros ME

    更新日期：2016-11-01 00:00:00

  • Finding genes for SLE: complex interactions and complex populations.

    abstract：:Many years of work, multiplex family collection and endless genotyping finally give fruit. The original aim cannot be lost. The aim is not only to identify mutations involved in susceptibility for systemic lupus erythematosus (SLE) but to elucidate the disease pathogenesis as well. After genetics comes the biology. We...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/s0896-8411(03)00093-3

    authors： Alarcón-Riquelme ME,Prokunina L

    更新日期：2003-09-01 00:00:00

  • The immune milieu of cholangiocarcinoma: From molecular pathogenesis to precision medicine.

    abstract：:Cholangiocarcinoma (CCA) is a deadly cancer of the biliary epithelium with limited therapeutic options. It is a heterogeneous group of cancer that could develop at any level from the biliary tree and is currently classified into intrahepatic, perihilar and distal based on its anatomical location. With incidence and mo...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2019.03.007

    authors： Rimassa L,Personeni N,Aghemo A,Lleo A

    更新日期：2019-06-01 00:00:00

  • Apoptosis of T cells and macrophages in the central nervous system of intact and adrenalectomized Lewis rats during experimental allergic encephalomyelitis.

    abstract：:The adrenocortical response is central to recovery from experimental allergic encephalomyelitis (EAE) in the Lewis rat, as reflected by the increased severity of the disease in adrenalectomized animals. The protection conferred by glucocorticoids is related to the immunosuppressive effects of the steroid, which may in...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1996.0020

    authors： Smith T,Schmied M,Hewson AK,Lassmann H,Cuzner ML

    更新日期：1996-04-01 00:00:00

  • Characterization of two anti-DNA antibodies bearing distinct idiotypes. Correlation with clinical manifestations.

    abstract：:Spontaneous idiotype shift of anti-DNA antibodies in systemic lupus erythematosus was shown to be associated with changes in the clinical manifestations of the disease. Characterization of two anti-DNA antibody preparations from the same lupus patient showed that lupus nephritis was associated with antibodies showing ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(89)90271-0

    authors： Suenaga R,Munoz PA,Hon SH,Abdou NI

    更新日期：1989-06-01 00:00:00

  • Serial study of liver-directed autoantibodies and autoreactive T-lymphocytes in acute viral hepatitis B.

    abstract：:To explore the mechanisms underlying liver-directed autoimmune reactions in acute Hepatitis B Virus (HBV) infection, we followed five subjects who were identified in the early incubation phase (30-70 days before the first elevation of transaminases). We assessed serially cellular (using a T-lymphocyte migration inhibi...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(88)90034-0

    authors： Vento S,McFarlane BM,Vento TG,Ranieri S,Rondanelli EG,McFarlane IG,Williams R,Eddleston AL

    更新日期：1988-06-01 00:00:00

  • Epigenetics, autoimmunity and hematologic malignancies: a comprehensive review.

    abstract：:The relationships between immunological dysfunction, loss of tolerance and hematologic malignancies have been a focus of attention in attempts to understand the appearance of a higher degree of autoimmune disease and lymphoma in children with congenital immunodeficiency. Although multiple hypotheses have been offered,...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2012.09.002

    authors： Ngalamika O,Zhang Y,Yin H,Zhao M,Gershwin ME,Lu Q

    更新日期：2012-12-01 00:00:00

  • Heritability versus the role of the environment in autoimmunity.

    abstract：:The higher concordant occurrence of autoimmune diseases in monozygotic twins compared to dizygotic or sibling pairs supports the role for genetic susceptibility. For most conditions, however, concordance rates are considerably below 100% and lead to the estimate of the weight of genetics coined "heritability". In the ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2012.07.011

    authors： Selmi C,Lu Q,Humble MC

    更新日期：2012-12-01 00:00:00

  • Phosphorylation abnormalities: NZB mice exhibit a B-cell signalling defect.

    abstract：:NZB mice demonstrate common and consistent abnormalities in B-cell activation and signalling. One of the hallmark characteristics of lupus disease is the prevalent hypergammaglobulinaemia, composed primarily of anti-nuclear antibodies. In addition to the hyperproliferation seen in mice exhibiting disease, the B cells ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.2002.0607

    authors： Tuscano JM,Hsu TC,McKnight H,Ansari AA,Gershwin ME

    更新日期：2002-11-01 00:00:00

  • Differences in self-peptide binding between T1D-related susceptible and protective DR4 subtypes.

    abstract：:HLA-DR0401, 0403 and 0405 are associated with variable T1D susceptibilities when linked with a common HLA-DQ8 (DQA1∗0301/DQB1∗0302). It is unknown how the modest differences within the peptide binding regions of DR4 subtypes lead to distinct autoimmune risks. Since all Class II HLA molecules share the same intracellul...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2010.12.004

    authors： Ge X,James EA,Reijonen H,Kwok WW

    更新日期：2011-03-01 00:00:00

  • Monoclonal anti-La antibody derived from a mouse with experimental SLE is similar to human anti-La antibodies.

    abstract：:The La antigen is a highly conserved protein, originally defined by sera of patients with Sjögren's syndrome or systemic lupus erythematosus (SLE). In the present study, we have produced and characterized a monoclonal anti-la antibody derived from mice with experimental SLE. The induction of SLE in these mice was achi...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/s0896-8411(05)80037-x

    authors： Offen D,Mendlovic S,Fricke H,Sperling R,Sperling J,Mozes E

    更新日期：1990-12-01 00:00:00

  • Low levels of IgM antibodies to phosphorylcholine predict cardiovascular disease in 60-year old men: effects on uptake of oxidized LDL in macrophages as a potential mechanism.

    abstract：OBJECTIVE:We here determine the role of IgM antibodies against phosphorylcholine (anti-PC) in prediction of cardiovascular disease (CVD) and on macrophage uptake of Oxidized LDL (OxLDL). METHODS:From a screening of 4232 subjects, 60-year-old (2039 men and 2193 women), 211 incident cases of CVD (myocardial infarction, ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2009.05.003

    authors： de Faire U,Su J,Hua X,Frostegård A,Halldin M,Hellenius ML,Wikström M,Dahlbom I,Grönlund H,Frostegård J

    更新日期：2010-03-01 00:00:00

  • T-cell reactivity in myasthenia gravis.

    abstract：:In a proliferation assay, peripheral blood lymphocytes (PBL) from a relatively small proportion of myasthenia gravis (MG) patients and from controls responded to Torpedo acetylcholine receptor (T-AChR), which shows approximately 75% homology with the human AChR. Over 50% of MG patients responded to recombinant human A...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(89)90121-2

    authors： Newsom-Davis J,Harcourt G,Sommer N,Beeson D,Willcox N,Rothbard JB

    更新日期：1989-06-01 00:00:00