当前位置： SCI文献检索 > JOURNAL OF AUTOIMMUNITY期刊下所有文献 > Epigenetics, autoimmunity and hematologic malignancies: a comprehensive review.

Epigenetics, autoimmunity and hematologic malignancies: a comprehensive review.

Abstract：

:The relationships between immunological dysfunction, loss of tolerance and hematologic malignancies have been a focus of attention in attempts to understand the appearance of a higher degree of autoimmune disease and lymphoma in children with congenital immunodeficiency. Although multiple hypotheses have been offered, it is clear that stochastic processes play an important role in the immunopathology of these issues. In particular, accumulating evidence is defining a role of epigenetic mechanisms as being critical in this continuous spectrum between autoimmunity and lymphoma. In this review, we focus attention predominantly on the relationships between T helper 17 (Th17) and T regulatory populations that alter local microenvironments and ultimately the expression or transcription factors involved in cell activation and differentiation. Abnormal expression in any of the molecules involved in Th17 and/or Treg development alter immune homeostasis and in genetically susceptible hosts may lead to the appearance of autoimmunity and/or lymphoma. These observations have clinical significance in explaining the discordance of autoimmunity in identical twins. They are also particularly important in the relationships between primary immune deficiency syndromes, immune dysregulation and an increased risk of lymphoma. Indeed, defining the factors that determine epigenetic alterations and their relationships to immune homeostasis will be a challenge greater or even equal to the human genome project.

journal_name

J Autoimmun

journal_title

Journal of autoimmunity

authors

Ngalamika O,Zhang Y,Yin H,Zhao M,Gershwin ME,Lu Q

doi

10.1016/j.jaut.2012.09.002

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

451-65

issue

4

eissn

0896-8411

issn

1095-9157

pii

S0896-8411(12)00126-6

journal_volume

39

pub_type

杂志文章,评审

相关文献

JOURNAL OF AUTOIMMUNITY文献大全
  • Evaluation of the percentage of peripheral T cells with two different T cell receptor alpha-chains and of their potential role in autoimmunity.

    abstract：:Approximately 25% of mature T cells possess two distinct cytoplasmic T cell receptor (TCR) alpha-chains, due to productive gene rearrangements of both alleles. Expression of two different alpha-chains at the cell surface is a potential risk factor for development of autoimmunity. However, it has been difficult to dete...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.2001.0504

    authors： Corthay A,Nandakumar KS,Holmdahl R

    更新日期：2001-06-01 00:00:00

  • E4BP4 overexpression: a protective mechanism in CD4+ T cells from SLE patients.

    abstract：:Systemic lupus erythematosus (SLE) is a prototype autoimmune disease characterized by various immunological abnormalities, including dysregulated activation of T and B lymphocytes, which trigger autoantibody production and immune-complex deposition. E4BP4, also known as NFIL3, has emerged as a major transcription fact...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2013.01.004

    authors： Zhao M,Liu Q,Liang G,Wang L,Luo S,Tang Q,Zhao H,Su Y,Yung S,Chan TM,Lu Q

    更新日期：2013-03-01 00:00:00

  • The influence of genetic predisposition and autoimmune hepatitis inducing antigens in disease development.

    abstract：:Autoimmune hepatitis (AIH) is defined as a chronic liver inflammation with loss of tolerance against hepatocytes. The etiology and pathophysiology of AIH are still poorly understood because reliable animal models are limited. Therefore, we recently introduced a model of experimental murine AIH by a self-limited adenov...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2016.12.001

    authors： Hardtke-Wolenski M,Dywicki J,Fischer K,Hapke M,Sievers M,Schlue J,Anderson MS,Taubert R,Noyan F,Manns MP,Jaeckel E

    更新日期：2017-03-01 00:00:00

  • Anti-BSA antibodies do not cross-react with the 69-kDa islet cell autoantigen ICA69.

    abstract：:In contrast to several previously published reports, we demonstrate by a variety of antibody assays that bovine serum albumin (BSA) is not antigenically cross-reactive with the 69-kDa islet cell autoantigen (ICA69). Fast protein liquid chromatography purified BSA and highly purified recombinant human ICA69 were used t...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1998.0199

    authors： Rønningen KS,Atrazhev A,Luo L,Luo C,Smith DK,Korbutt G,Rajotte RV,Elliott JF

    更新日期：1998-06-01 00:00:00

  • Autoimmunity to nucleosomes related to viral infection: a focus on hapten-carrier complex formation.

    abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disorder with unknown aetiology. The major hallmark of this disease is the presence of antibodies against nuclear components, including double-stranded (ds)DNA and histones. The disease affects different organs, particularly the skin, kidneys and the nervous system. ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/s0896-8411(02)00110-5

    authors： Van Ghelue M,Moens U,Bendiksen S,Rekvig OP

    更新日期：2003-03-01 00:00:00

  • Profile and clinical significance of anti-nuclear envelope antibodies found in patients with primary biliary cirrhosis: a multicenter study.

    abstract：:Primary biliary cirrhosis (PBC) sera contain antibodies which recognize various nuclear envelope proteins of which antibody against gp210 has been proven to be diagnostic for disease. In contrast, the clinical significance of another nuclear envelope antibody, anti-p62 antibody has not been well investigated. In the p...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,多中心研究

    doi：10.1016/s0896-8411(03)00033-7

    authors： Miyachi K,Hankins RW,Matsushima H,Kikuchi F,Inomata T,Horigome T,Shibata M,Onozuka Y,Ueno Y,Hashimoto E,Hayashi N,Shibuya A,Amaki S,Miyakawa H

    更新日期：2003-05-01 00:00:00

  • Antigen based therapies to prevent diabetes in NOD mice.

    abstract：:Interventional approaches that have been successful in delaying insulin-dependent diabetes mellitus (IDDM) using antigen-based immunotherapies include parenteral immunization. It has potential for clinical application provided that effective adjuvants suitable for human use can be found. We have previously shown that ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1996.0047

    authors： Ramiya VK,Shang XZ,Pharis PG,Wasserfall CH,Stabler TV,Muir AB,Schatz DA,Maclaren NK

    更新日期：1996-06-01 00:00:00

  • Lack of relationship between the Epstein-Barr virus and the antiperinuclear factor/'perinuclear antigen' system in rheumatoid arthritis.

    abstract：:Our purpose was to evaluate the role of Epstein-Barr virus (EBV) in the production of antiperinuclear factor (APF), a rheumatoid arthritis (RA)-specific marker, and the autoimmunogenicity of 'perinuclear antigens' (PNA) found within the buccal mucosa epithelial cells used as a substrate in the APF assay. Fifty APF-pos...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1994.1035

    authors： Buisson M,Berthelot JM,Le Goff P,Chastel C,Lamour A,Seigneurin JM,Youinou P

    更新日期：1994-08-01 00:00:00

  • Induction of antigen specific peripheral humoral tolerance to cardiac myosin does not prevent CB3-mediated autoimmune myocarditis.

    abstract：:Chronic myocarditis often progresses to dilated cardiomyopathy resulting in heart failure or cardiac transplantation. Viral infection is the most common cause of myocarditis and coxsackie B viruses (CBV) are the most frequently cited etiologic agents associated with myocarditis and cardiomyopathy. Additionally, CBV in...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2005.05.007

    authors： Horwitz MS,Ilic A,Fine C,Sarvetnick N

    更新日期：2005-09-01 00:00:00

  • Reactivities to the Sm autoantigenic complex and the synthetic SmD1-aa83-119 peptide in systemic lupus erythematosus and other autoimmune diseases.

    abstract：:The Sm antigenic complex is, besides dsDNA, the most important and specific autoimmune target in systemic lupus erythematosus (SLE). The population of anti-Sm Ab elicited is very heterogeneous in terms of epitope specificity resulting in a strong assay dependent detectability. Based on the description of a new autoant...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.2001.0545

    authors： Jaekel HP,Klopsch T,Benkenstein B,Grobe N,Baldauf A,Schoessler W,Werle E

    更新日期：2001-12-01 00:00:00

  • Effects of anti-B7 monoclonal antibodies on humoral immune responses.

    abstract：:The costimulatory interaction between CD28 on T cells and B7-related molecules on antigen presenting cells plays an important role in a broad range of functions of the immune system, including protective immunity, tolerance induction, allograft rejection, and the development of autoimmune diseases. Monoclonal antibodi...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1998.0258

    authors： Daikh DI,Wofsy D

    更新日期：1999-03-01 00:00:00

  • Hemodynamic improvement and removal of autoantibodies against beta1-adrenergic receptor by immunoadsorption therapy in dilated cardiomyopathy.

    abstract：:The removal of beta(1)-adrenergic receptor (beta(1)AR) autoantibodies by immunoadsorption (IA) has been proposed as a potential mechanism for the improvement of the left ventricular function in dilated cardiomyopathy (DCM). In the present study, the possible association between removal of the autoantibodies against th...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/s0896-8411(03)00042-8

    authors： Mobini R,Staudt A,Felix SB,Baumann G,Wallukat G,Deinum J,Svensson H,Hjalmarson A,Fu M

    更新日期：2003-06-01 00:00:00

  • The limitations and hidden gems of the epidemiology of primary biliary cirrhosis.

    abstract：:Epidemiology is expected to provide important clues to our understanding of the enigmatic etiopathogenesis of primary biliary cirrhosis (PBC). First, a systematic review of population based studies indicated a wide range in the yearly incidence (0.33-5.8/100.000) and point prevalence (1.91-40.2/100.000) rates. Though ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2013.06.015

    authors： Podda M,Selmi C,Lleo A,Moroni L,Invernizzi P

    更新日期：2013-10-01 00:00:00

  • Efficacy, safety and pharmacokinetics of biosimilars of anti-tumor necrosis factor-α agents in rheumatic diseases; A systematic review and meta-analysis.

    abstract：OBJECTIVE:To evaluate the efficacy and safety of biosimilars of anti-tumor necrosis factor (TNF)-α agents compared to their reference agents in immune mediated diseases. METHODS:Electronic databases were searched for randomized controlled trials (RCTs) assessing the efficacy and safety of biosimilars of anti-TNF-α age...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.jaut.2017.02.003

    authors： Komaki Y,Yamada A,Komaki F,Kudaravalli P,Micic D,Ido A,Sakuraba A

    更新日期：2017-05-01 00:00:00

  • Monoclonal anti-La antibody derived from a mouse with experimental SLE is similar to human anti-La antibodies.

    abstract：:The La antigen is a highly conserved protein, originally defined by sera of patients with Sjögren's syndrome or systemic lupus erythematosus (SLE). In the present study, we have produced and characterized a monoclonal anti-la antibody derived from mice with experimental SLE. The induction of SLE in these mice was achi...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/s0896-8411(05)80037-x

    authors： Offen D,Mendlovic S,Fricke H,Sperling R,Sperling J,Mozes E

    更新日期：1990-12-01 00:00:00

  • Functional characterization of the MECP2/IRAK1 lupus risk haplotype in human T cells and a human MECP2 transgenic mouse.

    abstract：:Genetic polymorphism in MECP2/IRAK1 on chromosome Xq28 is a confirmed and replicated susceptibility locus for lupus. High linkage disequilibrium in this locus suggests that both MECP2 and IRAK1 are candidate genes for the disease. DNA methylation changes in lupus T cells play a central role in the pathogenesis of lupu...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2012.12.012

    authors： Koelsch KA,Webb R,Jeffries M,Dozmorov MG,Frank MB,Guthridge JM,James JA,Wren JD,Sawalha AH

    更新日期：2013-03-01 00:00:00

  • In vitro induction of regulatory T cells by anti-CD3 antibody in humans.

    abstract：:Therapy with anti-CD3 antibody is effective in controlling models of autoimmune diseases and can reverse or prevent rejection of grafts. We studied the in vitro immunomodulatory effect of anti-CD3 treated human T cells. CD4(+) T cells were stimulated with plate-bound anti-CD3 and cultured for 12 days after which they ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2007.11.007

    authors： Abraham M,Karni A,Dembinsky A,Miller A,Gandhi R,Anderson D,Weiner HL

    更新日期：2008-02-01 00:00:00

  • Administering glutamic acid decarboxylase to NOD mice prevents diabetes.

    abstract：:Type 1 diabetes is the result of an ongoing autoimmune response to specific proteins expressed by the insulin producing beta cells. Recently, a number of beta cell autoantigens have been identified. However, their role in mediating the diabetogenic response is not known. Here we assess the relative importance of a pan...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1994.1067

    authors： Tisch R,Yang XD,Liblau RS,McDevitt HO

    更新日期：1994-12-01 00:00:00

  • TNF-alpha mediated modulation of T cell development and exacerbation of in vitro T1DM in fetal thymus organ culture.

    abstract：:TNF-alpha is a pleiotropic cytokine that is constitutively expressed in the thymus. This cytokine has opposing effects on type 1 diabetes mellitus (T1DM) as non-obese diabetic (NOD) mice administered TNF-alpha early in life experience an acceleration in disease onset while TNF-alpha administered to adult NOD mice are ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2007.06.002

    authors： Middlebrook AJ,Lebsack T,DeLuca D

    更新日期：2007-09-01 00:00:00

  • Immunoglobulin allotypes in myasthenia gravis patients with a thymoma.

    abstract：:Gm and Km allotypes were examined in 29 myasthenia gravis patients with a thymoma and non-receptor skeletal muscle antibodies. The frequency of the phenotype Gm1,2,3;23;5,21 was significantly higher in the patients than in 292 healthy controls (P less than 0.01). Km allotype frequencies did not differ in patients and ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(90)90148-l

    authors： Gilhus NE,Pandey JP,Gaarder PI,Aarli JA

    更新日期：1990-06-01 00:00:00

  • The forces driving autoimmune disease.

    abstract：:There are two classes of autoimmune disease, organ-specific and non-organ specific or systemic. That cells producing autoantibodies are selected by antigen is strongly suggested by the presence of mutations and high affinity antibody. T-cells are pivotal in all forms of autoimmunity as evidenced by the therapeutic ben...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/0896-8411(92)90015-i

    authors： Roitt IM,Hutchings PR,Dawe KI,Sumar N,Bodman KB,Cooke A

    更新日期：1992-04-01 00:00:00

  • Multi-peptide coupled-cell tolerance ameliorates ongoing relapsing EAE associated with multiple pathogenic autoreactivities.

    abstract：:The probability that epitope spreading occurs in multiple sclerosis (MS) and the fact that patients have been shown to respond to multiple myelin epitopes concurrently makes the use of peptide-specific tolerance therapies targeting single epitopes problematic. To attempt to overcome this limitation, we have employed c...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2006.12.002

    authors： Smith CE,Miller SD

    更新日期：2006-12-01 00:00:00

  • Chimeric antigen receptor (CAR) T cells targeting a pathogenic MHC class II:peptide complex modulate the progression of autoimmune diabetes.

    abstract：:A primary initiating epitope in the NOD mouse model of Type 1 Diabetes (T1D) lies between residues 9 and 23 of the insulin B chain. The B:9-23 peptide can bind to the NOD MHC class II molecule (I-Ag7) in multiple registers, but only one, (register 3, R3), creates complexes able to stimulate the majority of pathogenic ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2018.08.004

    authors： Zhang L,Sosinowski T,Cox AR,Cepeda JR,Sekhar NS,Hartig SM,Miao D,Yu L,Pietropaolo M,Davidson HW

    更新日期：2019-01-01 00:00:00

  • Intravenous immunoglobulin induces proliferation and immunoglobulin synthesis from B cells of patients with common variable immunodeficiency: a mechanism underlying the beneficial effect of IVIg in primary immunodeficiencies.

    abstract：:Common variable immunodeficiency (CVID) is associated with low serum immunoglobulin concentrations and an increased susceptibility to infections and autoimmune diseases. The treatment of choice for CVID patients is replacement intravenous immunoglobulin (IVIg) therapy. IVIg has been beneficial in preventing or allevia...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2010.09.006

    authors： Bayry J,Fournier EM,Maddur MS,Vani J,Wootla B,Sibéril S,Dimitrov JD,Lacroix-Desmazes S,Berdah M,Crabol Y,Oksenhendler E,Lévy Y,Mouthon L,Sautès-Fridman C,Hermine O,Kaveri SV

    更新日期：2011-02-01 00:00:00

  • Autophagy: A new concept in autoimmunity regulation and a novel therapeutic option.

    abstract：:Nowadays, pharmacologic treatments of autoinflammatory diseases are largely palliative rather than curative. Most of them result in non-specific immunosuppression, which can be associated with broad disruption of natural and induced immunity with significant and sometimes serious unwanted injuries. Among the novel str...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2018.08.009

    authors： Bonam SR,Wang F,Muller S

    更新日期：2018-11-01 00:00:00

  • Serum concentrations of IgM, IgG1, IgG2b, IgG3 and IgA in C57BL/6 mice and their congenics at the lpr (lymphoproliferation) locus.

    abstract：:The serum concentrations of IgM, IgG1, IgG2b, IgG3 and IgA were determined in mice of C57BL/6 background, from weaning to one year of age, by quantitative isotype-specific, indirect double sandwich enzyme-linked immunosorbent assays (ELISAs). Only limited data could be obtained for the IgG2a isotype in the present stu...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(89)90013-9

    authors： Klein-Schneegans AS,Kuntz L,Fonteneau P,Loor F

    更新日期：1989-12-01 00:00:00

  • A functional and phenotypic study on immune accessory cells isolated from the thyroids of Wistar and autoimmune-prone BB-DP rats.

    abstract：:Dendritic cells (DCs) comprise a small population of cells in the normal thyroid. These excellent antigen-presenting cells (APCs) are thought to be involved in the initiation of thyroid autoimmune reactions. However it is not known whether the APCs involved in this process are indeed DCs, or thyrocytes. Our aims were ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.2000.0438

    authors： Simons PJ,Delemarre FG,Drexhage HA

    更新日期：2000-12-01 00:00:00

  • Second-generation peptidomimetic inhibitors of antigen presentation effectively treat autoimmune diseases in HLA-DR-transgenic mouse models.

    abstract：:Peptidomimetic compounds that bind to major histocompatibility complex class II molecules and are resistant to cathepsins can competitively inhibit the presentation of processed protein antigens. Therefore, compounds that bind to autoimmune disease-associated class II molecules are expected to compete with autoantigen...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2006.09.005

    authors： Rosloniec EF,Brandstetter T,Leyer S,Schwaiger FW,Nagy ZA

    更新日期：2006-11-01 00:00:00

  • Human retrovirus-5 in rheumatic disease.

    abstract：:It has long been suggested that retroviral infection may play a role in the pathogenesis of autoimmune rheumatic disease. Particles resembling retroviruses have been reported in tissue from patients with Sjögren's syndrome, lupus and rheumatoid arthritis, and molecular mimicry between retroviral antigens and host prot...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1999.0307

    authors： Brand A,Griffiths DJ,Herve C,Mallon E,Venables PJ

    更新日期：1999-08-01 00:00:00

  • T-cell clone anti-clone interactions. Effects on suppressor and helper activities.

    abstract：:An experimental model of two interacting clones of T cells is described, which may be used for defining and exploring the T-cell immunoregulatory network. Mx9/9 is a CD4 clone bearing an antigen receptor recognized by the Mx9 anti-V beta 8 monoclonal antibody (MoAb). Anti-V beta 8 MoAbs activate and induce cell prolif...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(89)90112-1

    authors： Naor D,Essery G,Kahan M,Feldmann M

    更新日期：1989-06-01 00:00:00