Immunoglobulin allotypes in myasthenia gravis patients with a thymoma.

abstract：:In 1990 our group reported a patient with autoimmune hemolytic anemia and high titers of IgM anticardiolipin antibodies that cross-reacted with phosphatidylcholine (PTC). These autoantibodies also recognized bromelain-treated erythrocytes (BrE) and in vitro aged erythrocytes. The epitope exposed with this treatment is...

journal_title：Journal of autoimmunity

authors： Cabiedes J,Cabral AR,López-Mendoza AT,Cordero-Esperón HA,Huerta MT,Alarcón-Segovia D

更新日期：2002-03-01 00:00:00

abstract：:Our aim was to investigate presence of tumour necrosis factor (TNF) and interleukin (IL)-10 in serum and their relation to different genotypes as well as to clinical and laboratory phenotypes in patients with polymyositis and dermatomyositis. In 65 patients with poly- or dermatomyositis the inflammatory cytokine balan...

journal_title：Journal of autoimmunity

authors： Hassan AB,Fathi M,Dastmalchi M,Lundberg IE,Padyukov L

更新日期：2006-08-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a prototype autoimmune disease characterized by various immunological abnormalities, including dysregulated activation of T and B lymphocytes, which trigger autoantibody production and immune-complex deposition. E4BP4, also known as NFIL3, has emerged as a major transcription fact...

journal_title：Journal of autoimmunity

authors： Zhao M,Liu Q,Liang G,Wang L,Luo S,Tang Q,Zhao H,Su Y,Yung S,Chan TM,Lu Q

更新日期：2013-03-01 00:00:00

abstract：:We have previously described an SLE-derived human hybridoma autoantibody, 9604, which binds to activated but not to resting platelets, inhibits platelet aggregation, and immunoprecipitates a surface-labelled poly-peptide of 32,000 molecular weight (MW) (p32). In the present study, using a murine monoclonal anti-p32 an...

journal_title：Journal of autoimmunity

authors： Xu H,Frojmovic MM,Wong T,Rauch J

更新日期：1995-02-01 00:00:00

abstract：:The features of autoantibodies (autoAb) to liver fumarylacetoacetate hydrolase (FAH) elicited in mice infected with mouse hepatitis virus (MHV) were studied by ELISA and western-blot competition assays. All sera tested contained Ab to cryptic FAH epitopes according with results from western-blot tests, whereas ELISA d...

journal_title：Journal of autoimmunity

authors： Mathieu PA,Gómez KA,Coutelier JP,Retegui LA

更新日期：2004-09-01 00:00:00

abstract：:To study the expression of protein tyrosine phosphatases (PTPs) in pancreatic islets, a cDNA library from islet cells was constructed and analysed. Twenty-one different PTPs were found to be expressed in islet cells, including three previously unknown PTPs. One of these, IA-2beta, was cloned, sequenced, and found to b...

journal_title：Journal of autoimmunity

authors： Notkins AL,Zhang B,Matsumoto Y,Lan MS

更新日期：1997-06-01 00:00:00

abstract：:Despite a broad clinical spectrum, paraneoplastic enecephalomyelitis/sensory neuronopathy (PEM/SSN) is characterized by the presence of a common autoantibody, referred to as anti-Hu or type I anti-neuronal nuclear antibody (ANNA-1). The target of these antibodies is a family of four Hu antigens: three (Hel-N1, HuC, Hu...

journal_title：Journal of autoimmunity

authors： King PH,Redden D,Palmgren JS,Nabors LB,Lennon VA

更新日期：1999-12-01 00:00:00

abstract：:To study the potential roles of cytokines in development and resolution of granulomatous experimental autoimmune thyroiditis (EAT), the kinetics of in vivo expression of cytokine genes in thyroid infiltrates was analysed using reverse transcriptase-PCR (RT-PCR). Both Th1 (IL-2 and IFN-gamma) and Th2 (IL-4 and IL-10) c...

journal_title：Journal of autoimmunity

authors： Tang H,Sharp GC,Chen K,Braley-Mullen H

更新日期：1998-12-01 00:00:00

abstract：:Interstitial cystitis (IC) is a chronic inflammatory condition of the urinary bladder with a strong autoimmune component. Currently, the major challenge in IC treatment is the development of effective therapies. RDP58 is a novel d-amino acid decapeptide with potent immunosuppressive activity. In this study, we investi...

journal_title：Journal of autoimmunity

authors： Liu W,Deyoung BR,Chen X,Evanoff DP,Luo Y

更新日期：2008-06-01 00:00:00

abstract：:The major targets of the disease-specific autoantibodies to citrullinated proteins (ACPA) in synovium of rheumatoid arthritis (RA) patients are borne by the citrullinated α- and β-chains of fibrin. We demonstrated that ACPA target a limited set of citrullinated fibrin peptides and particularly four multicitrullinated ...

journal_title：Journal of autoimmunity

authors： Iobagiu C,Magyar A,Nogueira L,Cornillet M,Sebbag M,Arnaud J,Hudecz F,Serre G

更新日期：2011-12-01 00:00:00

abstract：:Interventional approaches that have been successful in delaying insulin-dependent diabetes mellitus (IDDM) using antigen-based immunotherapies include parenteral immunization. It has potential for clinical application provided that effective adjuvants suitable for human use can be found. We have previously shown that ...

journal_title：Journal of autoimmunity

authors： Ramiya VK,Shang XZ,Pharis PG,Wasserfall CH,Stabler TV,Muir AB,Schatz DA,Maclaren NK

更新日期：1996-06-01 00:00:00

abstract：:Dysregulation of autophagy has been implicated in the development of various disease indications including autoimmune diseases. Here we identified hitherto unsuspected molecular alterations of autophagy occurring at an early stage of the macroautophagy pathway in the salivary glands and spleen of NOD.H-2h4 mice that d...

journal_title：Journal of autoimmunity

authors： Voynova E,Lefebvre F,Qadri A,Muller S

更新日期：2020-03-01 00:00:00

abstract：:We evaluated the presence of autoantibodies to glutamic acid decarboxylase (GAD), competitive insulin autoantibodies (IAA) and islet cell antibodies (ICA) in sera from 288 non-diabetic patients with autoimmune thyroid disease (AITD), including 212 patients with Graves' disease and 76 with Hashimoto's thyroiditis, and ...

journal_title：Journal of autoimmunity

authors： Kawasaki E,Abiru N,Yano M,Uotani S,Matsumoto K,Matsuo H,Yamasaki H,Yamamoto H,Yamaguchi Y,Akazawa S

更新日期：1995-10-01 00:00:00

abstract：:Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune disease of the peripheral nerves evolving with diffuse sensory and motor symptoms. Although it is claimed that in neurodegenerative pathologies, a common feature is the failure of proteolytic systems to adequately eliminate aggregated or...

journal_title：Journal of autoimmunity

authors： Brun S,Schall N,Bonam SR,Bigaut K,Mensah-Nyagan AG,de Sèze J,Muller S

更新日期：2018-08-01 00:00:00

abstract：:B cells are involved in immune thrombocytopenia (ITP) pathophysiology by producing antiplatelet auto-antibodies. However more than a half of ITP patients do not respond to B cell depletion induced by rituximab (RTX). The persistence of splenic T follicular helper cells (TFH) that we demonstrated to be expanded during ...

journal_title：Journal of autoimmunity

authors： Audia S,Rossato M,Trad M,Samson M,Santegoets K,Gautheron A,Bekker C,Facy O,Cheynel N,Ortega-Deballon P,Boulin M,Berthier S,Leguy-Seguin V,Martin L,Ciudad M,Janikashvili N,Saas P,Radstake T,Bonnotte B

更新日期：2017-02-01 00:00:00

abstract：:Helper T cells are required for development of the autoantibody responses to native mouse erythrocytes (MRBC) that spontaneously develop in NZB mice. However, the stimulus for these Th is not known. Therefore, we compared the abilities of splenic T cells from actively autoimmune old NZB mice and preautoimmune, young N...

journal_title：Journal of autoimmunity

authors： Calkins CE,Esposito M

更新日期：1996-08-01 00:00:00

abstract：:The Sm antigenic complex is, besides dsDNA, the most important and specific autoimmune target in systemic lupus erythematosus (SLE). The population of anti-Sm Ab elicited is very heterogeneous in terms of epitope specificity resulting in a strong assay dependent detectability. Based on the description of a new autoant...

journal_title：Journal of autoimmunity

authors： Jaekel HP,Klopsch T,Benkenstein B,Grobe N,Baldauf A,Schoessler W,Werle E

更新日期：2001-12-01 00:00:00

abstract：:TREX1 encodes a major cellular DNA exonuclease. Mutations of this gene in human cause cellular accumulation of DNA that triggers autoimmune diseases including Aicardi-Goutieres Syndrome (AGS) and systemic lupus erythematosus (SLE). We created a lupus mouse model by engineering a D18 N mutation in the Trex1 gene which ...

journal_title：Journal of autoimmunity

authors： Xiao N,Wei J,Xu S,Du H,Huang M,Zhang S,Ye W,Sun L,Chen Q

更新日期：2019-06-01 00:00:00

abstract：:Class II antigens of the major histocompatibility complex (MHC) have a well-defined role in restricting cellular interactions and presenting processed antigen to T cells. In addition, a fundamental role for Class II antigens in cellular activation has been suggested, following studies demonstrating that Class II antig...

journal_title：Journal of autoimmunity

authors： Mooney N,Grillot-Courvalin C,Hivroz C,Charron D

更新日期：1989-06-01 00:00:00

abstract：:The obstetric management of women with antiphospholipid (aPL) syndrome remains controversial. Despite recent advances, the controversies have been fueled by our limited understanding of the multi-factorial causes of aPL-associated pregnancy loss and the lack of data from randomized studies. We have escaped from the na...

journal_title：Journal of autoimmunity

authors： Rai R

更新日期：2000-09-01 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19) can progress to cytokine storm that is associated with organ dysfunction and death. The purpose of the present study is to determine clinical characteristics associated with 28 day in-hospital survival in patients with coronavirus disease 2019 (COVID-19) that received tocilizumab. T...

journal_title：Journal of autoimmunity

authors： Morrison AR,Johnson JM,Griebe KM,Jones MC,Stine JJ,Hencken LN,To L,Bianchini ML,Vahia AT,Swiderek J,Ramesh MS,Peters MA,Smith ZR

更新日期：2020-11-01 00:00:00

abstract：:Type 1 diabetes is the result of an ongoing autoimmune response to specific proteins expressed by the insulin producing beta cells. Recently, a number of beta cell autoantigens have been identified. However, their role in mediating the diabetogenic response is not known. Here we assess the relative importance of a pan...

journal_title：Journal of autoimmunity

authors： Tisch R,Yang XD,Liblau RS,McDevitt HO

更新日期：1994-12-01 00:00:00

abstract：:The role of the innate immune system has been established in the initiation and perpetuation of inflammatory disease, but less attention has been paid to its role in the resolution of inflammation and return to homeostasis. Toll-like receptor (TLR) expression profiles were analysed in tissues with differing disease st...

journal_title：Journal of autoimmunity

authors： Clanchy FIL,Borghese F,Bystrom J,Balog A,Penn H,Hull DN,Wells GMA,Kiriakidis S,Taylor PC,Sacre SM,Williams LM,Stone TW,Mageed RA,Williams RO

更新日期：2021-01-22 00:00:00

abstract：:B-cell depletion therapy (BCDT) based on rituximab (RTX) induces clinical remission in a majority of seropositive patients with Rheumatoid arthritis (RA). However, all patients eventually relapse. The aim of this study was to determine whether dynamic changes in combinations of serological measures of B-cell activatio...

journal_title：Journal of autoimmunity

authors： Cambridge G,Perry HC,Nogueira L,Serre G,Parsons HM,De La Torre I,Dickson MC,Leandro MJ,Edwards JC

更新日期：2014-05-01 00:00:00

abstract：:In this study, we assessed the expression of activation markers on gammadelta T cells in central nervous system (CNS) lesions of SJL mice adoptively sensitized to develop experimental autoimmune encephalomyelitis (EAE) using myelin basic protein-reactive T cells. Although disease expression is known to be dependent up...

journal_title：Journal of autoimmunity

authors： Gao YL,Rajan AJ,Raine CS,Brosnan CF

更新日期：2001-12-01 00:00:00

abstract：:Serum and Ig samples obtained from a patient with Graves' disease during exacerbation and remission were evaluated in the nu/nu bioassay. Blocking of the exacerbation serum's biological activity was demonstrated by several biological assay parameters after it was mixed with the remission serum. Since this blocking eff...

journal_title：Journal of autoimmunity

authors： Paschke R,Teuber J,Enger I,Schmeidl R,Schwedes U,Usadel KH

更新日期：1990-08-01 00:00:00

abstract：:Interleukin-2 (IL-2) gene regulation was investigated in primary cultures of highly purified human peripheral blood CD28+ T cells. Two discrete mechanisms for induction of T-cell proliferation could be distinguished by examining cell cycle progression and the expression of the IL-2 gene. Stimulation of cells by CD3 Mo...

journal_title：Journal of autoimmunity

authors： June CH,Jackson KM,Ledbetter JA,Leiden JM,Lindsten T,Thompson CB

更新日期：1989-06-01 00:00:00

abstract：:Very little is known about the cellular immune response in c-ANCA (classical anti-neutrophil cytoplasm antibodies) positive vasculitides or Wegener's granulomatosis (WG). The present review is mainly based on published and unpublished observations of the Cattegat Study Group of Wegener's Granulomatosis. Immunohistoche...

journal_title：Journal of autoimmunity

authors： Rasmussen N,Petersen J

更新日期：1993-04-01 00:00:00

abstract：:The question of a connection between vaccination and autoimmune illness (or phenomena) is surrounded by controversy. A heated debate is going on regarding the causality between vaccines, such as measles and anti-hepatitis B virus (HBV), and multiple sclerosis (MS). Brain antibodies as well as clinical symptoms have be...

journal_title：Journal of autoimmunity

authors： Shoenfeld Y,Aron-Maor A

更新日期：2000-02-01 00:00:00

abstract：:Immunoglobulins (Ig) or antibodies are heavy plasma proteins, with sugar chains added to amino acid residues by N-linked glycosylation and occasionally by O-linked glycosylation. The versatility of antibodies is demonstrated by the various functions that they mediate such as neutralization, agglutination, fixation wit...

journal_title：Journal of autoimmunity

authors： Wootla B,Lacroix-Desmazes S,Warrington AE,Bieber AJ,Kaveri SV,Rodriguez M

更新日期：2011-09-01 00:00:00