Immunophenotype and functional characteristics of human primitive CD34-negative hematopoietic stem cells: the significance of the intra-bone marrow injection.

Abstract:

:The biology of hematopoietic stem cell (HSC) is a current topic of interest which has important implications for clinical HSC transplantation as well as for the basic research of HSC. The most primitive HSCs in mammals, including mice and humans, have long been believed to be CD34 antigen (Ag)-positive (CD34(+)) cells. In fact, bone marrow (BM), peripheral blood (PB), and cord blood (CB) stem cell transplantation studies indicate that a CD34(+) subpopulation in the BM, PB, or CB can provide durable long-term donor-derived lymphohematopoietic reconstitution. Therefore, CD34 Ag was used to identify/purify immature HSCs. However, Osawa et al. reported that murine long-term lymphohematopoietic reconstituting HSCs are lineage marker-negative (Lin(-)) c-kit(+)Sca-1(+)CD34-low/negative (CD34(low/-)), which are called CD34(low/-) KSL cells. Recently, human CB-derived CD34(-) HSCs, a counterpart of murine CD34(low/-) KSL cells, were successfully identified using an intra-bone marrow injection (IBMI) method. This review will update the concept of the immunophenotype and the functional characteristics of human primitive CD34(-) HSCs. In addition, the significance of the application of the IBMI technique in clinical HSC transplantation is also discussed. Recent rapid advances in understanding the biological nature of HSCs may make it possible to fully characterize the most primitive class of human HSCs in the near future.

journal_name

J Autoimmun

journal_title

Journal of autoimmunity

authors

Sonoda Y

doi

10.1016/j.jaut.2007.12.004

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

136-44

issue

3

eissn

0896-8411

issn

1095-9157

pii

S0896-8411(07)00146-1

journal_volume

30

pub_type

杂志文章,评审
  • Intracellular localization of histidyl-tRNA synthetase/Jo-1 antigen in T24 cells and some other cells.

    abstract::Anti-Jo-1 antibody is characteristic of patients suffering from autoimmune-disease myositis. Since the antigen has been identified to be a histidyl-tRNA synthetase (HisRS), it is reasonable to suppose that it localizes mainly in the cytoplasm. However, contradictory results (localization in the nucleus, cytoplasm, or ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/j.jaut.2004.01.004

    authors: Kamei H

    更新日期:2004-05-01 00:00:00

  • Polymyalgia rheumatica--diagnosis and classification.

    abstract::Polymyalgia rheumatica is the most common inflammatory rheumatic disease of the elderly, and shares many pathogenetic and epidemiological features with giant cell arteritis. The typical symptoms are bilateral aching of the shoulder girdle, associated with morning stiffness. The neck and hip girdle may also be involved...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaut.2014.01.016

    authors: Nesher G

    更新日期:2014-02-01 00:00:00

  • Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.

    abstract::The complement component C4 is encoded by two genes: C4A and C4B on human chromosome 6p in the major histocompatibility complex (MHC). Most studies have linked the deficiencies in C4 with systemic lupus erythematosus (SLE) in Angio-Irish, North American, Black American, Mexican American, Australian and Japanese popula...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/j.jaut.2005.04.004

    authors: Ittiprasert W,Kantachuvesiri S,Pavasuthipaisit K,Verasertniyom O,Chaomthum L,Totemchokchyakarn K,Kitiyanant Y

    更新日期:2005-08-01 00:00:00

  • Beyond thrombosis: Anti-β2GPI domain 1 antibodies identify late pregnancy morbidity in anti-phospholipid syndrome.

    abstract::Antibodies against β2 glycoprotein I (anti-β2GPI) have been identified as the main pathogenic autoantibody subset in anti-phospholipid syndrome (APS); the most relevant epitope is a cryptic and conformation-dependent structure on β2GPI domain (D) 1. Anti-β2GPI domain profiling has been investigated in thrombotic APS, ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/j.jaut.2018.02.002

    authors: Chighizola CB,Pregnolato F,Andreoli L,Bodio C,Cesana L,Comerio C,Gerosa M,Grossi C,Kumar R,Lazzaroni MG,Mahler M,Mattia E,Nalli C,Norman GL,Raimondo MG,Ruffatti A,Tonello M,Trespidi L,Tincani A,Borghi MO,Meroni PL

    更新日期:2018-06-01 00:00:00

  • Increased T lymphocytes bearing the gamma-delta T cell receptor in subjects at high risk for insulin dependent diabetes.

    abstract::The effector mechanisms responsible for autoimmune beta cell destruction in insulin dependent (type 1) diabetes (IDD) remain elusive. In order to investigate whether T lymphocytes bearing the gamma-delta T cell receptor (gamma delta+ T cells) could be involved in this process, we measured percentages of peripheral blo...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/0896-8411(91)90055-h

    authors: Lang FP,Schatz DA,Pollock BH,Riley WJ,Maclaren NK,Dumont-Driscoll M,Barrett DJ

    更新日期:1991-12-01 00:00:00

  • Sjögren's syndrome salivary gland immunopathology: increased laminin expression precedes lymphocytic infiltration.

    abstract::Previous studies have demonstrated increased expression of a laminin-like protein in labial salivary glands from Sjögren's syndrome (SS) patients. The objective of the present study was to verify the identity of this protein and to compare lymphocytic infiltration and laminin expression in minor salivary gland ductal ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1006/jaut.1996.0109

    authors: McArthur CP,Daniels PJ,Kragel P,Howard PF,Julian L

    更新日期:1997-02-01 00:00:00

  • Correction of autophagy impairment inhibits pathology in the NOD.H-2h4 mouse model of primary Sjögren's syndrome.

    abstract::Dysregulation of autophagy has been implicated in the development of various disease indications including autoimmune diseases. Here we identified hitherto unsuspected molecular alterations of autophagy occurring at an early stage of the macroautophagy pathway in the salivary glands and spleen of NOD.H-2h4 mice that d...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/j.jaut.2020.102418

    authors: Voynova E,Lefebvre F,Qadri A,Muller S

    更新日期:2020-03-01 00:00:00

  • T-cell vaccination in experimental myasthenia gravis: a double-edged sword.

    abstract::Immunization with antigen-specific T cells has been used successfully in the treatment of several T cell-mediated experimental autoimmune diseases, including experimental allergic encephalomyelitis, thyroiditis, and adjuvant arthritis. The aim of this study was to determine whether T-cell vaccination could be used to ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/s0896-8411(05)80033-2

    authors: Kahn CR,McIntosh KR,Drachman DB

    更新日期:1990-12-01 00:00:00

  • Autoimmunity: from black water fever to regulatory function.

    abstract::Autoimmunity is a field that has only been around for a little over a century. Initially, it was thought that autoimmunity could not happen, that the body would never turn on itself (i.e. "horror autotoxicus"). It was only around the First World War that autoimmunity was recognized as the pathogenesis of various disea...

    journal_title:Journal of autoimmunity

    pub_type: 社论,历史文章

    doi:10.1016/j.jaut.2013.12.019

    authors: Chang C

    更新日期:2014-02-01 00:00:00

  • Treg-specific IL-2 therapy can reestablish intrahepatic immune regulation in autoimmune hepatitis.

    abstract::Autoimmune hepatitis (AIH) is a chronic autoimmune inflammatory disease that usually requires life-long immunosuppression. Frequent relapses after discontinuation of therapy indicate that intrahepatic immune regulation is not restored by current therapies. As steroid therapy preferentially depletes intrahepatic regula...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/j.jaut.2020.102591

    authors: Buitrago-Molina LE,Pietrek J,Noyan F,Schlue J,Manns MP,Wedemeyer H,Hardtke-Wolenski M,Jaeckel E

    更新日期:2021-02-01 00:00:00

  • Are HLA-DR or TAP genes genetic markers of severity in ulcerative colitis?

    abstract::The pathogeny of ulcerative colitis (UC) is not yet elucidated, but some arguments suggest the implication of genetic factors. Among the candidate genes, those encoding for HLA class II genotypes have been extensively studied in UC; however, discordant data may be imputable to heterogeneity, characterized by immunolog...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1006/jaut.1996.0100

    authors: Heresbach D,Alizadeh M,Reumaux D,Colombel JF,Delamaire M,Danze PM,Gosselin M,Genetet B,Bretagne JF,Semana G

    更新日期:1996-12-01 00:00:00

  • Sex differences and genomics in autoimmune diseases.

    abstract::Autoimmune diseases (AIDs) are believed to be multifactorial diseases that commonly involve multiple organ systems. About three fourth of the patients afflicted with AIDs are women suggesting that sex differences impact the incidence of AID. However, the proportion of females to males suffering from AID varies dependi...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaut.2011.12.001

    authors: Amur S,Parekh A,Mummaneni P

    更新日期:2012-05-01 00:00:00

  • Dual-Targeted Autoimmune Sword in Fatal Epilepsy: Patient's glutamate receptor AMPA GluR3B peptide autoimmune antibodies bind, induce Reactive Oxygen Species (ROS) in, and kill both human neural cells and T cells.

    abstract::Nodding Syndrome (NS) is a fatal pediatric epilepsy of unknown etiology, accompanied by multiple neurological impairments, and associated with Onchocerca volvulus (Ov), malnutrition, war-induced trauma, and other insults. NS patients have neuroinflammation, and ~50% have cross-reactive Ov/Leiomodin-1 neurotoxic autoim...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/j.jaut.2020.102462

    authors: Levite M,Zelig D,Friedman A,Ilouz N,Eilam R,Bromberg Z,Ramadhan Lasu AA,Arbel-Alon S,Edvardson S,Tarshish M,Riek LP,Lako RL,Reubinoff B,Lebendiker M,Yaish D,Stavsky A,Galun E

    更新日期:2020-08-01 00:00:00

  • The mystery of Sneddon syndrome: relationship with antiphospholipid syndrome and systemic lupus erythematosus.

    abstract::Since its description in 1965, Sneddon syndrome (SNS) is usually characterized by the association of an ischemic cerebrovascular disease and a widespread livedo reticularis. The presence of many other manifestations suggests that it is a systemic syndrome. The prevalence of anti-phospholipid antibodies (aPL) is highly...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审

    doi:10.1006/jaut.2000.0418

    authors: Francès C,Piette JC

    更新日期:2000-09-01 00:00:00

  • Geoepidemiology and environmental factors of psoriasis and psoriatic arthritis.

    abstract::Psoriasis and Psoriatic Arthritis (PsA) are chronic inflammatory diseases that have a major impact on health. The prevalence and incidence estimates of these two closely related diseases show ethnic and geographic variations, being generally more common in the colder north than in the tropics. In Europe the prevalence...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaut.2009.12.001

    authors: Chandran V,Raychaudhuri SP

    更新日期:2010-05-01 00:00:00

  • Complete suppression of insulitis and diabetes in NOD mice lacking interferon regulatory factor-1.

    abstract::Interferon regulatory factor-1 (IRF-1), a transcriptional factor, regulates type I interferon and interferon-induced genes. It was reported that IRF-1 regulates important molecules required for inflammation and immune reactions. To investigate the role of IRF-1 in the development of autoimmune diabetes, we established...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1006/jaut.2001.0531

    authors: Nakazawa T,Satoh J,Takahashi K,Sakata Y,Ikehata F,Takizawa Y,Bando SI,Housai T,Li Y,Chen C,Masuda T,Kure S,Kato I,Takasawa S,Taniguchi T,Okamoto H,Toyota T

    更新日期:2001-09-01 00:00:00

  • B cell activating factor is central to bleomycin- and IL-17-mediated experimental pulmonary fibrosis.

    abstract::Idiopathic pulmonary fibrosis (IPF) is a progressive devastating, yet untreatable fibrotic disease of unknown origin. We investigated the contribution of the B-cell activating factor (BAFF), a TNF family member recently implicated in the regulation of pathogenic IL-17-producing cells in autoimmune diseases. The contri...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/j.jaut.2014.08.003

    authors: François A,Gombault A,Villeret B,Alsaleh G,Fanny M,Gasse P,Adam SM,Crestani B,Sibilia J,Schneider P,Bahram S,Quesniaux V,Ryffel B,Wachsmann D,Gottenberg JE,Couillin I

    更新日期:2015-01-01 00:00:00

  • Serial study of liver-directed autoantibodies and autoreactive T-lymphocytes in acute viral hepatitis B.

    abstract::To explore the mechanisms underlying liver-directed autoimmune reactions in acute Hepatitis B Virus (HBV) infection, we followed five subjects who were identified in the early incubation phase (30-70 days before the first elevation of transaminases). We assessed serially cellular (using a T-lymphocyte migration inhibi...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/0896-8411(88)90034-0

    authors: Vento S,McFarlane BM,Vento TG,Ranieri S,Rondanelli EG,McFarlane IG,Williams R,Eddleston AL

    更新日期:1988-06-01 00:00:00

  • Cardiac dysfunction in murine autoimmune myocarditis.

    abstract::We have investigated the pathophysiological basis of cardiac dysfunction in autoimmune myocarditis and in the resulting dilated cardiomyopathy. To this end we utilized the myosin-induced autoimmune myocarditis model in BALB/c mice. Myocarditis has been found to be associated with massive ventricular lymphocyte infiltr...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1006/jaut.1998.0273

    authors: Less H,Shilkrut M,Rubinstein I,Berke G,Binah O

    更新日期:1999-05-01 00:00:00

  • Epitope specificity of anti-La antibodies from patients with Sjögren's syndrome.

    abstract::To investigate patterns of autoreactivity in Sjögren's syndrome, the epitope specificity of anti-La antibodies was determined using recombinant antigens bearing sequences of the amino, middle, and carboxyl portions of the La molecule. Sera from patients with primary as well as secondary Sjögren's syndrome reacted with...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/0896-8411(89)90161-3

    authors: St Clair EW,Talal N,Moutsopoulos HM,Ballester A,Zerva L,Keene JD,Pisetsky DS

    更新日期:1989-08-01 00:00:00

  • Role of HLA class II genes in susceptibility and resistance to multiple sclerosis: studies using HLA transgenic mice.

    abstract::Multiple sclerosis (MS), an inflammatory and demyelinating autoimmune disease of CNS has both, a genetic and an environmental predisposition. Among all the genetic factors associated with MS susceptibility, HLA class II haplotypes such as DR2/DQ6, DR3/DQ2, and DR4/DQ8 show the strongest association. Although a direct ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaut.2011.05.001

    authors: Luckey D,Bastakoty D,Mangalam AK

    更新日期:2011-09-01 00:00:00

  • The clinical features, diagnosis and classification of dermatomyositis.

    abstract::Dermatomyositis (DM) is an idiopathic inflammatory myopathy (IIM) characterized by an inflammatory infiltrate primarily affecting the skeletal muscle and skin. Most common and peculiar cutaneous lesions include Gottron's papules, Gottron's sign and heliotrope rash. Different DM subsets have been identified until now e...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaut.2013.11.005

    authors: Iaccarino L,Ghirardello A,Bettio S,Zen M,Gatto M,Punzi L,Doria A

    更新日期:2014-02-01 00:00:00

  • Latent autoimmune thyroiditis in untreated patients with HCV chronic hepatitis: a case-control study.

    abstract::In order to establish a relationship between Hepatitis C virus (HCV) chronic infection and autoimmune thyroiditis, 97 untreated patients with biopsy-proven HCV chronic hepatitis and 97 controls were studied. An ultrasound examination of the thyroid and an assay of serum thyroid-stimulating hormone (TSH), thyroid hormo...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1006/jaut.1999.0360

    authors: Ganne-Carrie N,Medini A,Coderc E,Seror O,Christidis C,Grimbert S,Trinchet JC,Beaugrand M

    更新日期:2000-03-01 00:00:00

  • The forces driving autoimmune disease.

    abstract::There are two classes of autoimmune disease, organ-specific and non-organ specific or systemic. That cells producing autoantibodies are selected by antigen is strongly suggested by the presence of mutations and high affinity antibody. T-cells are pivotal in all forms of autoimmunity as evidenced by the therapeutic ben...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审

    doi:10.1016/0896-8411(92)90015-i

    authors: Roitt IM,Hutchings PR,Dawe KI,Sumar N,Bodman KB,Cooke A

    更新日期:1992-04-01 00:00:00

  • Comparison of conventional immunosuppressive drugs versus anti-TNF-α agents in non-infectious non-anterior uveitis.

    abstract:OBJECTIVE:To compare the efficacy and safety of Disease-modifying antirheumatic drugs (DMARDs) and anti-TNF-α agents in patients with non-infectious non-anterior uveitis. METHODS:Single center retrospective study including adult patients with non-infectious intermediate, posterior or pan-uveitis. Outcomes were compare...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/j.jaut.2020.102481

    authors: Leclercq M,Langlois V,Girszyn N,Le Besnerais M,Benhamou Y,Levesque H,Muraine M,Gueudry J

    更新日期:2020-09-01 00:00:00

  • The heterogeneity of whole islet cell cytoplasmic antibodies evidenced by absorption test with glutamic acid decarboxylase.

    abstract::A recent report identified two islet cell cytoplasmic antibody subclasses using an immunohistochemical method. The islet cell cytoplasmic antibody subclass which reacts with only Beta-cells was termed 'Beta-cell islet cell cytoplasmic antibodies' and another islet cell cytoplasmic antibody subclass which reacts with B...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1006/jaut.1994.1028

    authors: Takino H,Kawasaki E,Yano M,Matsumoto K,Uotani S,Okuno S,Takao Y,Yamasaki H,Yamaguchi Y,Akazawa S

    更新日期:1994-06-01 00:00:00

  • B cell depleting therapy regulates splenic and circulating T follicular helper cells in immune thrombocytopenia.

    abstract::B cells are involved in immune thrombocytopenia (ITP) pathophysiology by producing antiplatelet auto-antibodies. However more than a half of ITP patients do not respond to B cell depletion induced by rituximab (RTX). The persistence of splenic T follicular helper cells (TFH) that we demonstrated to be expanded during ...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章

    doi:10.1016/j.jaut.2016.11.002

    authors: Audia S,Rossato M,Trad M,Samson M,Santegoets K,Gautheron A,Bekker C,Facy O,Cheynel N,Ortega-Deballon P,Boulin M,Berthier S,Leguy-Seguin V,Martin L,Ciudad M,Janikashvili N,Saas P,Radstake T,Bonnotte B

    更新日期:2017-02-01 00:00:00

  • Systemic lupus erythematosus: Diagnosis and clinical management.

    abstract::Systemic lupus erythematosus (SLE) is a worldwide chronic autoimmune disease which may affect every organ and tissue. Genetic predisposition, environmental triggers, and the hormonal milieu, interplay in disease development and activity. Clinical manifestations and the pattern of organ involvement are widely heterogen...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaut.2018.11.001

    authors: Fava A,Petri M

    更新日期:2019-01-01 00:00:00

  • The mimicry of human glycolipids and glycosphingolipids by the lipooligosaccharides of pathogenic neisseria and haemophilus.

    abstract::It has been known for many years that bacteria can induce autoimmune responses in humans resulting in serious disease. Recent work has shown that a number of bacteria that colonize human mucosal surfaces exclusively express antigens on their surfaces which are molecular mimics of glycosphingolipids found on human cell...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,评审

    doi:10.1006/jaut.2000.0477

    authors: Harvey HA,Swords WE,Apicella MA

    更新日期:2001-05-01 00:00:00

  • Therapeutic trials of biologics in primary biliary cholangitis: An open label study of abatacept and review of the literature.

    abstract::Primary biliary cholangitis (PBC) is a classic autoimmune disease in which humoral, cytotoxic, and innate immune responses have been implicated with the specific targeting of a mitochondrial antigen. The mainstay of treatment remains the bile acid ursodeoxycholic acid (UDCA). Corticosteroids may have some benefits, bu...

    journal_title:Journal of autoimmunity

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.jaut.2019.04.005

    authors: Bowlus CL,Yang GX,Liu CH,Johnson CR,Dhaliwal SS,Frank D,Levy C,Peters MG,Vierling JM,Gershwin ME

    更新日期:2019-07-01 00:00:00