当前位置： SCI文献检索 > JOURNAL OF AUTOIMMUNITY期刊下所有文献 > Different dysregulations of the natural antibody repertoire in treated and untreated HIV-1 patients.

Different dysregulations of the natural antibody repertoire in treated and untreated HIV-1 patients.

Abstract：

:To investigate a possible dysregulation of the autoantibody network in AIDS patients, the relative activity of representative natural antibodies was measured in serum IgG and IgM. These immunoglobulins were purified from two cohorts of 20 HIV-infected patients undergoing, or not, a triple combination therapy. A cohort of 20 normal patients was used as a control. Marked alterations of the natural antibody repertoire were observed, varying according to the isotype and specificity of the antibody studied. For the classical self-protein antigens, human actin and myosin, the changes observed in the untreated cohort were absent in the treated cohort. In contrast, no changes, or even increased changes of the activity of antibodies to special antigens, DNA and TNP, occurred in the treated cohort. The differences were highly significant, indicating that this repertoire is regulated and not randomly modified by the disease. These results suggest the presence of different factors of dysregulation of the B cell repertoire of natural antibodies associated with the disease as well as with the treatment. These major dysregulations may favor the autoimmune phenomena observed during HIV infection.

journal_name

J Autoimmun

journal_title

Journal of autoimmunity

authors

Quan CP,Watanabe S,Pamonsinlapatham P,Bouvet JP

doi

10.1006/jaut.2001.0529

subject

Has Abstract

pub_date

2001-08-01 00:00:00

pages

81-7

issue

1

eissn

0896-8411

issn

1095-9157

pii

S0896-8411(01)90529-3

journal_volume

17

pub_type

杂志文章

相关文献

JOURNAL OF AUTOIMMUNITY文献大全
  • Dysregulation of innate and adaptive serum mediators precedes systemic lupus erythematosus classification and improves prognostic accuracy of autoantibodies.

    abstract：:Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a poorly understood preclinical stage of immune dysregulation and symptom accrual. Accumulation of antinuclear autoantibody (ANA) specificities is a hallmark of impending clinical disease. Yet, many ANA-positive individuals remain healthy, suggest...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2016.06.001

    authors： Lu R,Munroe ME,Guthridge JM,Bean KM,Fife DA,Chen H,Slight-Webb SR,Keith MP,Harley JB,James JA

    更新日期：2016-11-01 00:00:00

  • Comparison of conventional immunosuppressive drugs versus anti-TNF-α agents in non-infectious non-anterior uveitis.

    abstract：OBJECTIVE:To compare the efficacy and safety of Disease-modifying antirheumatic drugs (DMARDs) and anti-TNF-α agents in patients with non-infectious non-anterior uveitis. METHODS:Single center retrospective study including adult patients with non-infectious intermediate, posterior or pan-uveitis. Outcomes were compare...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2020.102481

    authors： Leclercq M,Langlois V,Girszyn N,Le Besnerais M,Benhamou Y,Levesque H,Muraine M,Gueudry J

    更新日期：2020-09-01 00:00:00

  • Intracellular localization of histidyl-tRNA synthetase/Jo-1 antigen in T24 cells and some other cells.

    abstract：:Anti-Jo-1 antibody is characteristic of patients suffering from autoimmune-disease myositis. Since the antigen has been identified to be a histidyl-tRNA synthetase (HisRS), it is reasonable to suppose that it localizes mainly in the cytoplasm. However, contradictory results (localization in the nucleus, cytoplasm, or ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2004.01.004

    authors： Kamei H

    更新日期：2004-05-01 00:00:00

  • E4BP4 overexpression: a protective mechanism in CD4+ T cells from SLE patients.

    abstract：:Systemic lupus erythematosus (SLE) is a prototype autoimmune disease characterized by various immunological abnormalities, including dysregulated activation of T and B lymphocytes, which trigger autoantibody production and immune-complex deposition. E4BP4, also known as NFIL3, has emerged as a major transcription fact...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2013.01.004

    authors： Zhao M,Liu Q,Liang G,Wang L,Luo S,Tang Q,Zhao H,Su Y,Yung S,Chan TM,Lu Q

    更新日期：2013-03-01 00:00:00

  • Subepidermal blistering induced by human autoantibodies to BP180 requires innate immune players in a humanized bullous pemphigoid mouse model.

    abstract：:Bullous pemphigoid (BP) is a cutaneous autoimmune inflammatory disease associated with subepidermal blistering and autoantibodies against BP180, a transmembrane collagen and major component of the hemidesmosome. Numerous inflammatory cells infiltrate the upper dermis in BP. IgG autoantibodies in BP fix complement and ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2008.08.009

    authors： Liu Z,Sui W,Zhao M,Li Z,Li N,Thresher R,Giudice GJ,Fairley JA,Sitaru C,Zillikens D,Ning G,Marinkovich MP,Diaz LA

    更新日期：2008-12-01 00:00:00

  • Anti-acetylcholine receptor antibodies decrease after thymectomy in patients with myasthenia gravis. Clinical correlations.

    abstract：:Clinical course and changes in serum levels of antibodies to the acetylcholine receptor (a-AChR) were followed in 82 patients with myasthenia gravis during a period of 1-8 years after thymectomy. Decrease in a-AChR immediately after thymectomy was influenced by changes in a total IgG. Immunosuppressive medication affe...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(91)90018-8

    authors： Kuks JB,Oosterhuis HJ,Limburg PC,The TH

    更新日期：1991-04-01 00:00:00

  • Low levels of vitamin-D are associated with neuropathy and lymphoma among patients with Sjögren's syndrome.

    abstract：BACKGROUND/PURPOSE:Primary Sjögren's syndrome (SS) is a chronic autoimmune disease primarily involving the exocrine glands. The clinical picture of SS ranges from exocrinopathy to systemic disease affecting the lung, kidney, liver, skin, musculockeletal and nervous systems. The morbidity of SS is mainly determined by e...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2012.05.018

    authors： Agmon-Levin N,Kivity S,Tzioufas AG,López Hoyos M,Rozman B,Efes I,Shapira Y,Shamis A,Amital H,Youinou P,Shoenfeld Y

    更新日期：2012-09-01 00:00:00

  • Differences in self-peptide binding between T1D-related susceptible and protective DR4 subtypes.

    abstract：:HLA-DR0401, 0403 and 0405 are associated with variable T1D susceptibilities when linked with a common HLA-DQ8 (DQA1∗0301/DQB1∗0302). It is unknown how the modest differences within the peptide binding regions of DR4 subtypes lead to distinct autoimmune risks. Since all Class II HLA molecules share the same intracellul...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2010.12.004

    authors： Ge X,James EA,Reijonen H,Kwok WW

    更新日期：2011-03-01 00:00:00

  • The physiopathology of the catastrophic antiphospholipid (Asherson's) syndrome: compelling evidence.

    abstract：:Catastrophic antiphospholipid (Asherson's) syndrome (cAPS) was described in the past as a severe variant of the antiphospholipid syndrome (APS). Currently growing evidence suggests it is a unique condition. This statement is based on several clinical and physiopathological features that although not well understood de...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2008.10.003

    authors： Ortega-Hernandez OD,Agmon-Levin N,Blank M,Asherson RA,Shoenfeld Y

    更新日期：2009-02-01 00:00:00

  • Antigen based therapies to prevent diabetes in NOD mice.

    abstract：:Interventional approaches that have been successful in delaying insulin-dependent diabetes mellitus (IDDM) using antigen-based immunotherapies include parenteral immunization. It has potential for clinical application provided that effective adjuvants suitable for human use can be found. We have previously shown that ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1996.0047

    authors： Ramiya VK,Shang XZ,Pharis PG,Wasserfall CH,Stabler TV,Muir AB,Schatz DA,Maclaren NK

    更新日期：1996-06-01 00:00:00

  • Immunophenotype and functional characteristics of human primitive CD34-negative hematopoietic stem cells: the significance of the intra-bone marrow injection.

    abstract：:The biology of hematopoietic stem cell (HSC) is a current topic of interest which has important implications for clinical HSC transplantation as well as for the basic research of HSC. The most primitive HSCs in mammals, including mice and humans, have long been believed to be CD34 antigen (Ag)-positive (CD34(+)) cells...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2007.12.004

    authors： Sonoda Y

    更新日期：2008-05-01 00:00:00

  • Anti-CD4 treatment inhibits autoimmunity in scurfy mice through the attenuation of co-stimulatory signals.

    abstract：:A major concept in autoimmunity is that disruption of Foxp3(+) regulatory T cells (Tregs) predisposes to breach of tolerance. This is exemplified by the Foxp3-linked disorder termed IPEX (immunodysregulation, polyendocrinopathy, enteropathy, X-linked) which affects newborn children. There has been considerable clinica...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2013.08.010

    authors： Mayer CT,Tian L,Hesse C,Kühl AA,Swallow M,Kruse F,Thiele M,Gershwin ME,Liston A,Sparwasser T

    更新日期：2014-05-01 00:00:00

  • Clinical characteristics and predictors of survival in adults with coronavirus disease 2019 receiving tocilizumab.

    abstract：:Coronavirus disease 2019 (COVID-19) can progress to cytokine storm that is associated with organ dysfunction and death. The purpose of the present study is to determine clinical characteristics associated with 28 day in-hospital survival in patients with coronavirus disease 2019 (COVID-19) that received tocilizumab. T...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jaut.2020.102512

    authors： Morrison AR,Johnson JM,Griebe KM,Jones MC,Stine JJ,Hencken LN,To L,Bianchini ML,Vahia AT,Swiderek J,Ramesh MS,Peters MA,Smith ZR

    更新日期：2020-11-01 00:00:00

  • Autophagy dysfunction in autoinflammatory diseases.

    abstract：:Autoinflammatory diseases (AUIDs) are a genetically heterogeneous group of rheumatic diseases characterized by episodic inflammation linked with dysregulated innate immune responses. In this review, we summarize the molecular mechanisms altered by disease-associated variants in several AUIDs, including NOD2-associated...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2017.10.012

    authors： Hua Y,Shen M,McDonald C,Yao Q

    更新日期：2018-03-01 00:00:00

  • Analysis of the PD-1/PD-L1 axis in human autoimmune thyroid disease: Insights into pathogenesis and clues to immunotherapy associated thyroid autoimmunity.

    abstract：:Autoimmune thyroid diseases (AITDs), i.e., Graves' disease (GD) and Hashimoto thyroiditis (HT), are the most prevalent organ-specific autoimmune diseases, but their pathogenesis is still incompletely understood. The PD-1/PD-L1 pathway is an important mechanism of peripheral tolerance that has not been investigated in ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2019.05.013

    authors： Álvarez-Sierra D,Marín-Sánchez A,Ruiz-Blázquez P,de Jesús Gil C,Iglesias-Felip C,González Ó,Casteras A,Costa RF,Nuciforo P,Colobran R,Pujol-Borrell R

    更新日期：2019-09-01 00:00:00

  • Obstetric management of antiphospholipid syndrome.

    abstract：:The obstetric management of women with antiphospholipid (aPL) syndrome remains controversial. Despite recent advances, the controversies have been fueled by our limited understanding of the multi-factorial causes of aPL-associated pregnancy loss and the lack of data from randomized studies. We have escaped from the na...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1006/jaut.2000.0417

    authors： Rai R

    更新日期：2000-09-01 00:00:00

  • gammadelta T cells express activation markers in the central nervous system of mice with chronic-relapsing experimental autoimmune encephalomyelitis.

    abstract：:In this study, we assessed the expression of activation markers on gammadelta T cells in central nervous system (CNS) lesions of SJL mice adoptively sensitized to develop experimental autoimmune encephalomyelitis (EAE) using myelin basic protein-reactive T cells. Although disease expression is known to be dependent up...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.2001.0547

    authors： Gao YL,Rajan AJ,Raine CS,Brosnan CF

    更新日期：2001-12-01 00:00:00

  • Autoimmunity to the glutamate receptor in mice--a model for Rasmussen's encephalitis?

    abstract：:We investigated the in vivo pathogenic potential of murine autoimmunity to peptides of the glutamate/AMPA receptor subunit 3 (GluR3). Antibodies to GluR3 are found in human epilepsy, Rasmussen's encephalitis (RE). In our accompanying paper in this issue we found that murine antibodies to the GluR3B peptide (amino acid...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1999.0297

    authors： Levite M,Hermelin A

    更新日期：1999-08-01 00:00:00

  • Idiotope-specific CD4(+) T cells induce apoptosis of human oligodendrocytes.

    abstract：:CD4(+) T cells specific for immunologic non-self determinants on self-IgG, idiotopes (Id), can be raised from cerebrospinal fluid (CSF) and blood of patients with multiple sclerosis (MS). To test if Id-specific CD4(+) T cells have the potential to destroy oligodendrocytes (ODCs), we analyzed their ability to induce ap...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2009.01.004

    authors： Hestvik AL,Skorstad G,Vartdal F,Holmøy T

    更新日期：2009-03-01 00:00:00

  • Frequency, mutual exclusivity and clinical associations of myositis autoantibodies in a combined European cohort of idiopathic inflammatory myopathy patients.

    abstract：OBJECTIVES:To determine prevalence and co-existence of myositis specific autoantibodies (MSAs) and myositis associated autoantibodies (MAAs) and associated clinical characteristics in a large cohort of idiopathic inflammatory myopathy (IIM) patients. METHODS:Adult patients with confirmed IIM recruited to the EuroMyosi...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2019.04.001

    authors： Betteridge Z,Tansley S,Shaddick G,Chinoy H,Cooper RG,New RP,Lilleker JB,Vencovsky J,Chazarain L,Danko K,Nagy-Vincze M,Bodoki L,Dastmalchi M,Ekholm L,Lundberg IE,McHugh N,UKMyonet contributors.

    更新日期：2019-07-01 00:00:00

  • Insulin-secretory-granule specific T cell clones in human IDDM.

    abstract：:T cell clones reactive to beta-cell antigens prepared from different species were established in order to identify putative pathogenic T cells in human IDDM. We were able to generate T cell clones from patients, but not from controls, reactive specifically to the insulin secretory enriched fraction (ISG) of a rat insu...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1995.0017

    authors： Chang JC,Linarelli LG,Laxer JA,Froning KJ,Caralli LL,Brostoff SW,Carlo DJ

    更新日期：1995-04-01 00:00:00

  • A common epitope on human tumor necrosis factor alpha and the autoantigen 'S-antigen/arrestin' induces TNF-alpha production.

    abstract：:A common epitope on S-antigen (arrestin), a potent autoantigen inducing experimental autoimmune uveoretinitis (EAU), and on human tumor necrosis factor alpha (hTNF alpha) was revealed using two monoclonal antibodies to S-antigen which inhibit EAU induction. The minimal common sequence for monoclonal antibody recogniti...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/s0896-8411(05)80048-4

    authors： Stiemer RH,Westenfelder U,Gausepohl H,Mirshahi M,Gundt A,Frank RW,Männel DN

    更新日期：1992-02-01 00:00:00

  • Comparative study of GAD65-specific CD4+ T cells in healthy and type 1 diabetic subjects.

    abstract：:Glutamic acid decarboxylase 65 (GAD65) is a putative autoantigen associated with the pathogenesis of type 1 diabetes (T1D). The prevalence of autoreactive CD4+ T cells towards the immunodominant GAD65(555-567) epitope in DR4 healthy and T1D subjects was investigated with class II tetramers. A slightly higher percentag...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2005.08.007

    authors： Danke NA,Yang J,Greenbaum C,Kwok WW

    更新日期：2005-12-01 00:00:00

  • Transitional B cells in quiescent SLE: An early checkpoint imprinted by IFN.

    abstract：:Systemic lupus (SLE) is characterized by a break of B cell tolerance that plays a central role in disease pathophysiology. An early checkpoint defect occurs at the transitional stage leading to the survival of autoreactive B cells and consequently the production of pathogenic autoantibodies. The main purpose of our wo...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2019.05.002

    authors： Dieudonné Y,Gies V,Guffroy A,Keime C,Bird AK,Liesveld J,Barnas JL,Poindron V,Douiri N,Soulas-Sprauel P,Martin T,Meffre E,Anolik JH,Korganow AS

    更新日期：2019-08-01 00:00:00

  • Pathogenic conversion of regulatory B10 cells into osteoclast-priming cells in rheumatoid arthritis.

    abstract：:Regulatory B10 cells were functionally impaired in rheumatoid arthritis (RA), yet the mechanisms were unclear. B cells are recently recognized as important participants in osteoclastogenesis by producing RANKL. In this study, we investigated whether regulatory B10 cells could convert into RANKL-producing cells, thus i...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2016.09.002

    authors： Hu F,Liu H,Liu X,Zhang X,Xu L,Zhu H,Li Y,Shi L,Ren L,Zhang J,Li Z,Jia Y

    更新日期：2017-01-01 00:00:00

  • Identification of a primary antigenic target of epitope spreading in endemic pemphigus foliaceus.

    abstract：:Epitope spreading is an important mechanism for the development of autoantibodies (autoAbs) in autoimmune diseases. The study of epitope spreading in human autoimmune diseases is limited due to the major challenge of identifying the initial/primary target epitopes on autoantigens in autoimmune diseases. We have been s...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2020.102561

    authors： Peng B,Temple BR,Yang J,Geng S,Culton DA,Qian Y

    更新日期：2021-01-01 00:00:00

  • T-cell vaccination in experimental myasthenia gravis: a double-edged sword.

    abstract：:Immunization with antigen-specific T cells has been used successfully in the treatment of several T cell-mediated experimental autoimmune diseases, including experimental allergic encephalomyelitis, thyroiditis, and adjuvant arthritis. The aim of this study was to determine whether T-cell vaccination could be used to ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/s0896-8411(05)80033-2

    authors： Kahn CR,McIntosh KR,Drachman DB

    更新日期：1990-12-01 00:00:00

  • Genetically determined imbalance between serum levels of tumour necrosis factor (TNF) and interleukin (IL)-10 is associated with anti-Jo-1 and anti-Ro52 autoantibodies in patients with poly- and dermatomyositis.

    abstract：:Our aim was to investigate presence of tumour necrosis factor (TNF) and interleukin (IL)-10 in serum and their relation to different genotypes as well as to clinical and laboratory phenotypes in patients with polymyositis and dermatomyositis. In 65 patients with poly- or dermatomyositis the inflammatory cytokine balan...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2006.06.003

    authors： Hassan AB,Fathi M,Dastmalchi M,Lundberg IE,Padyukov L

    更新日期：2006-08-01 00:00:00

  • T-cell clone anti-clone interactions. Effects on suppressor and helper activities.

    abstract：:An experimental model of two interacting clones of T cells is described, which may be used for defining and exploring the T-cell immunoregulatory network. Mx9/9 is a CD4 clone bearing an antigen receptor recognized by the Mx9 anti-V beta 8 monoclonal antibody (MoAb). Anti-V beta 8 MoAbs activate and induce cell prolif...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(89)90112-1

    authors： Naor D,Essery G,Kahan M,Feldmann M

    更新日期：1989-06-01 00:00:00

  • Two distinct mechanisms of interleukin-2 gene expression in human T lymphocytes.

    abstract：:Interleukin-2 (IL-2) gene regulation was investigated in primary cultures of highly purified human peripheral blood CD28+ T cells. Two discrete mechanisms for induction of T-cell proliferation could be distinguished by examining cell cycle progression and the expression of the IL-2 gene. Stimulation of cells by CD3 Mo...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(89)90117-0

    authors： June CH,Jackson KM,Ledbetter JA,Leiden JM,Lindsten T,Thompson CB

    更新日期：1989-06-01 00:00:00