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Inhibition of the development of spontaneous autoimmune thyroiditis in the obese strain (OS) chickens by in vivo treatment with anti-CD4 or anti-CD8 antibodies.

Abstract：

:The involvement of CD4+ and CD8+ T cells in pathogenesis of spontaneous autoimmune thyroiditis (SAT) in obese strain (OS) chickens has not been studied in depth until now. We depleted CD4+ or CD8+ T cells in OS chickens by treatment with murine monoclonal anti-CD4 or anti-CD8 antibodies at 3 day intervals beginning at hatching. The birds were killed at 19-25 days of age. Treatment with anti-CD4 antibody completely prevented SAT development, while treatment with anti-CD8 antibody partially inhibited SAT. These results show the critical role of CD4+ T cells in the development of SAT in OS chickens, and indicate that CD8+ T cells are also involved in SAT pathogenesis.

journal_name

J Autoimmun

journal_title

Journal of autoimmunity

authors

Cihak J,Hoffmann-Fezer G,Wasl M,Merkle H,Kaspers B,Vainio O,Plachý J,Hála K,Wick G,Stangassinger M,Lösch U

doi

10.1006/jaut.1997.0185

subject

Has Abstract

pub_date

1998-04-01 00:00:00

pages

119-26

issue

2

eissn

0896-8411

issn

1095-9157

pii

S0896-8411(97)90185-2

journal_volume

11

pub_type

杂志文章

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