当前位置： SCI文献检索 > JOURNAL OF AUTOIMMUNITY期刊下所有文献 > Regulatory T cell defect in APECED patients is associated with loss of naive FOXP3(+) precursors and impaired activated population.

Regulatory T cell defect in APECED patients is associated with loss of naive FOXP3(+) precursors and impaired activated population.

Abstract：

:The pathogenetic mechanisms of organ-specific autoimmune diseases remain obscured by the complexity of the genetic and environmental factors participating in the breakdown of tolerance. A unique opportunity to study the pathogenesis of human autoimmunity is provided by autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), a rare inherited autoimmune disease caused by mutations in Autoimmune Regulator (AIRE) gene. Loss of AIRE function disrupts the deletion of autoreactive T cells and impairs the suppressive function of regulatory T (Treg) cells. Here we show by multiparameter flow cytometry that in healthy controls the peripheral naive Treg cell subset forms a slowly dividing, persistent reservoir of recent thymic emigrants (RTEs). In APECED patients the RTE Treg cells show accelerated turnover and shift to the activated pool and the RTE reservoir is depleted. Moreover, the activated Treg cell population in the patients expresses significantly less Forkhead box protein P3 (FOXP3) than in the healthy controls, consistent with the impairment of peripheral activation. Our results indicate that in addition to their thymic effects, loss-of-function mutations in AIRE disrupt the peripheral homeostasis and activation of Treg cells. This may synergize with failed negative selection to cause APECED.

journal_name

J Autoimmun

journal_title

Journal of autoimmunity

authors

Laakso SM,Laurinolli TT,Rossi LH,Lehtoviita A,Sairanen H,Perheentupa J,Kekäläinen E,Arstila TP

doi

10.1016/j.jaut.2010.07.008

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

351-7

issue

4

eissn

0896-8411

issn

1095-9157

pii

S0896-8411(10)00083-1

journal_volume

35

pub_type

杂志文章

相关文献

JOURNAL OF AUTOIMMUNITY文献大全
  • Anti-CD4 treatment inhibits autoimmunity in scurfy mice through the attenuation of co-stimulatory signals.

    abstract：:A major concept in autoimmunity is that disruption of Foxp3(+) regulatory T cells (Tregs) predisposes to breach of tolerance. This is exemplified by the Foxp3-linked disorder termed IPEX (immunodysregulation, polyendocrinopathy, enteropathy, X-linked) which affects newborn children. There has been considerable clinica...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2013.08.010

    authors： Mayer CT,Tian L,Hesse C,Kühl AA,Swallow M,Kruse F,Thiele M,Gershwin ME,Liston A,Sparwasser T

    更新日期：2014-05-01 00:00:00

  • Differential activities of immunogenic collagen type II peptides in the induction of nasal tolerance to collagen-induced arthritis.

    abstract：:Nasal tolerance has recently been used to modulate immune responses in animal models of autoimmunity. We have compared immunogenic collagen type II (CII) peptides for induction of nasal tolerance in DBA/1 mice to collagen-induced arthritis (CIA). Three synthetic peptides corresponding to T cell-stimulating sequences o...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1998.0255

    authors： Chu CQ,Londei M

    更新日期：1999-02-01 00:00:00

  • Induction of lupus autoantibodies by adjuvants.

    abstract：:Exposure to the hydrocarbon oil pristane induces lupus specific autoantibodies in non-autoimmune mice. We investigated whether the capacity to induce lupus-like autoimmunity is a unique property of pristane or is shared by other adjuvant oils. Seven groups of 3-month-old female BALB/cJ mice received a single intraperi...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/s0896-8411(03)00083-0

    authors： Satoh M,Kuroda Y,Yoshida H,Behney KM,Mizutani A,Akaogi J,Nacionales DC,Lorenson TD,Rosenbauer RJ,Reeves WH

    更新日期：2003-08-01 00:00:00

  • Serum concentrations of IgM, IgG1, IgG2b, IgG3 and IgA in C57BL/6 mice and their congenics at the lpr (lymphoproliferation) locus.

    abstract：:The serum concentrations of IgM, IgG1, IgG2b, IgG3 and IgA were determined in mice of C57BL/6 background, from weaning to one year of age, by quantitative isotype-specific, indirect double sandwich enzyme-linked immunosorbent assays (ELISAs). Only limited data could be obtained for the IgG2a isotype in the present stu...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(89)90013-9

    authors： Klein-Schneegans AS,Kuntz L,Fonteneau P,Loor F

    更新日期：1989-12-01 00:00:00

  • Evidence for a role of anti-idiotypic antibodies in the induction of remission in Graves' disease.

    abstract：:Serum and Ig samples obtained from a patient with Graves' disease during exacerbation and remission were evaluated in the nu/nu bioassay. Blocking of the exacerbation serum's biological activity was demonstrated by several biological assay parameters after it was mixed with the remission serum. Since this blocking eff...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/s0896-8411(05)80011-3

    authors： Paschke R,Teuber J,Enger I,Schmeidl R,Schwedes U,Usadel KH

    更新日期：1990-08-01 00:00:00

  • Immunoglobulin allotypes in myasthenia gravis patients with a thymoma.

    abstract：:Gm and Km allotypes were examined in 29 myasthenia gravis patients with a thymoma and non-receptor skeletal muscle antibodies. The frequency of the phenotype Gm1,2,3;23;5,21 was significantly higher in the patients than in 292 healthy controls (P less than 0.01). Km allotype frequencies did not differ in patients and ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(90)90148-l

    authors： Gilhus NE,Pandey JP,Gaarder PI,Aarli JA

    更新日期：1990-06-01 00:00:00

  • Arthritis transferred by cells derived from pre-inflammatory rat synovium.

    abstract：:Different cell populations isolated from rats during the period of latency of adjuvant arthritis were injected into the bloodstream of naive rats to test their ability to transfer articular disorders. Synovium-derived cells (synoviocytes) were able to induce arthritis in 3 out of 4 recipient animals, whereas periphera...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：

    authors： Ramos-Ruiz R,Bernabeu C,Ariza A,Fernández JM,Larraga V,López-Bote JP

    更新日期：1992-02-01 00:00:00

  • New insights into non-conventional epitopes as T cell targets: The missing link for breaking immune tolerance in autoimmune disease?

    abstract：:The mechanism by which immune tolerance is breached in autoimmune disease is poorly understood. One possibility is that post-translational modification of self-antigens leads to peripheral recognition of neo-epitopes against which central and peripheral tolerance is inadequate. Accumulating evidence points to multiple...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2017.08.001

    authors： Harbige J,Eichmann M,Peakman M

    更新日期：2017-11-01 00:00:00

  • The mystery of Sneddon syndrome: relationship with antiphospholipid syndrome and systemic lupus erythematosus.

    abstract：:Since its description in 1965, Sneddon syndrome (SNS) is usually characterized by the association of an ischemic cerebrovascular disease and a widespread livedo reticularis. The presence of many other manifestations suggests that it is a systemic syndrome. The prevalence of anti-phospholipid antibodies (aPL) is highly...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1006/jaut.2000.0418

    authors： Francès C,Piette JC

    更新日期：2000-09-01 00:00:00

  • The top ten clues to understand the origin of chronic lymphocytic leukemia (CLL).

    abstract：:The fundamental task of the immune system is to protect the individual from infectious organisms without serious injury to self. The essence of acquired immunity is molecular self/non self discrimination. Chronic lymphocytic leukemia is characterized by a global failure of immune system that begins with the failure of...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2014.10.005

    authors： García-Muñoz R,Feliu J,Llorente L

    更新日期：2015-01-01 00:00:00

  • Dual-Targeted Autoimmune Sword in Fatal Epilepsy: Patient's glutamate receptor AMPA GluR3B peptide autoimmune antibodies bind, induce Reactive Oxygen Species (ROS) in, and kill both human neural cells and T cells.

    abstract：:Nodding Syndrome (NS) is a fatal pediatric epilepsy of unknown etiology, accompanied by multiple neurological impairments, and associated with Onchocerca volvulus (Ov), malnutrition, war-induced trauma, and other insults. NS patients have neuroinflammation, and ~50% have cross-reactive Ov/Leiomodin-1 neurotoxic autoim...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2020.102462

    authors： Levite M,Zelig D,Friedman A,Ilouz N,Eilam R,Bromberg Z,Ramadhan Lasu AA,Arbel-Alon S,Edvardson S,Tarshish M,Riek LP,Lako RL,Reubinoff B,Lebendiker M,Yaish D,Stavsky A,Galun E

    更新日期：2020-08-01 00:00:00

  • Chimeric antigen receptor (CAR) T cells targeting a pathogenic MHC class II:peptide complex modulate the progression of autoimmune diabetes.

    abstract：:A primary initiating epitope in the NOD mouse model of Type 1 Diabetes (T1D) lies between residues 9 and 23 of the insulin B chain. The B:9-23 peptide can bind to the NOD MHC class II molecule (I-Ag7) in multiple registers, but only one, (register 3, R3), creates complexes able to stimulate the majority of pathogenic ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2018.08.004

    authors： Zhang L,Sosinowski T,Cox AR,Cepeda JR,Sekhar NS,Hartig SM,Miao D,Yu L,Pietropaolo M,Davidson HW

    更新日期：2019-01-01 00:00:00

  • Identification of a primary antigenic target of epitope spreading in endemic pemphigus foliaceus.

    abstract：:Epitope spreading is an important mechanism for the development of autoantibodies (autoAbs) in autoimmune diseases. The study of epitope spreading in human autoimmune diseases is limited due to the major challenge of identifying the initial/primary target epitopes on autoantigens in autoimmune diseases. We have been s...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2020.102561

    authors： Peng B,Temple BR,Yang J,Geng S,Culton DA,Qian Y

    更新日期：2021-01-01 00:00:00

  • Prevention of diabetes in the BB rat by early immunotherapy using Freund's adjuvant.

    abstract：:The BB rat spontaneously develops an insulin-dependent diabetes mellitus (IDDM) that closely resembles this disease in man. The pathogenesis involves autoimmune destruction of pancreatic islet beta-cells. In the present study, a single intraperitoneal injection of complete Freund's adjuvant (CFA) in diabetes-prone (DP...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/s0896-8411(05)80034-4

    authors： Sadelain MW,Qin HY,Sumoski W,Parfrey N,Singh B,Rabinovitch A

    更新日期：1990-12-01 00:00:00

  • Effect of IVIg on human dendritic cell-mediated antigen uptake and presentation: role of lipid accumulation.

    abstract：:Intravenous immunoglobulin (IVIg) is a therapeutic preparation consisting of pools of normal, polyspecific IgG antibodies obtained from plasma of several thousand healthy individuals. In addition to its use in primary and secondary immune deficiency, IVIg is increasingly used in the therapy of a large number of autoim...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2012.05.013

    authors： Othy S,Bruneval P,Topçu S,Dugail I,Delers F,Lacroix-Desmazes S,Bayry J,Kaveri SV

    更新日期：2012-09-01 00:00:00

  • Epigenetics, autoimmunity and hematologic malignancies: a comprehensive review.

    abstract：:The relationships between immunological dysfunction, loss of tolerance and hematologic malignancies have been a focus of attention in attempts to understand the appearance of a higher degree of autoimmune disease and lymphoma in children with congenital immunodeficiency. Although multiple hypotheses have been offered,...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2012.09.002

    authors： Ngalamika O,Zhang Y,Yin H,Zhao M,Gershwin ME,Lu Q

    更新日期：2012-12-01 00:00:00

  • Therapeutic trials of biologics in primary biliary cholangitis: An open label study of abatacept and review of the literature.

    abstract：:Primary biliary cholangitis (PBC) is a classic autoimmune disease in which humoral, cytotoxic, and innate immune responses have been implicated with the specific targeting of a mitochondrial antigen. The mainstay of treatment remains the bile acid ursodeoxycholic acid (UDCA). Corticosteroids may have some benefits, bu...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.jaut.2019.04.005

    authors： Bowlus CL,Yang GX,Liu CH,Johnson CR,Dhaliwal SS,Frank D,Levy C,Peters MG,Vierling JM,Gershwin ME

    更新日期：2019-07-01 00:00:00

  • GAD65-Reactive T cells in a non-diabetic stiff-man syndrome patient.

    abstract：:GAD65 (glutamic acid decarboxylase) is an important autoantigen in both type 1 (insulin-dependent) diabetes mellitus (IDDM) and the neurological autoimmune disease stiff-man syndrome (SMS), and is expressed in pancreatic islets as well as the nervous system. Still, only 30% of SMS patients also have type 1 diabetes. T...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1999.0280

    authors： Schloot NC,Batstra MC,Duinkerken G,De Vries RR,Dyrberg T,Chaudhuri A,Behan PO,Roep BO

    更新日期：1999-06-01 00:00:00

  • Cellular immune responses and pathogenesis in c-ANCA positive vasculitides.

    abstract：:Very little is known about the cellular immune response in c-ANCA (classical anti-neutrophil cytoplasm antibodies) positive vasculitides or Wegener's granulomatosis (WG). The present review is mainly based on published and unpublished observations of the Cattegat Study Group of Wegener's Granulomatosis. Immunohistoche...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1006/jaut.1993.1020

    authors： Rasmussen N,Petersen J

    更新日期：1993-04-01 00:00:00

  • Autostimulatory factor produced by B-cell lines from patients with Sjögren's syndrome.

    abstract：:Sjögren's syndrome (SS) is an autoimmune disease with a predisposition to transform into a B-cell lymphoma. Stable B-cell lines were established (without exogenous stimulation other than fetal bovine serum) from the peripheral blood of three SS patients. These cell lines secreted immunoglobulin (either IgG, IgM or bot...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(89)90172-8

    authors： Takei M,Dang H,Dauphinée MJ,Talal N

    更新日期：1989-08-01 00:00:00

  • Expression and functional conservation of the human La (SS-B) nuclear autoantigen in murine cell lines.

    abstract：:We have studied the cellular expression and functional conservation of the human La autoantigen across species by introducing genes encoding human La antigen into cultured murine cell lines. In transfected murine fibroblasts and lymphoid cell lines human La was expressed as a predominantly nuclear antigen, with a typi...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1993.1045

    authors： Keech CL,Gordon TP,Reynolds P,McCluskey J

    更新日期：1993-10-01 00:00:00

  • Elimination of infectious antigens and increase of IgG catabolism as possible modes of action of IVIg.

    abstract：:Many mechanisms can explain the mode of action of IVIg in immune disorders. Macrophage blockade and interference in the idiotypic network are supported by some experimental data. Among the other mechanisms, two are considered in greater detail. Firstly, in some disorders, the patients could improve simply because the ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1006/jaut.1993.1057

    authors： Masson PL

    更新日期：1993-12-01 00:00:00

  • Phosphorylcholine-tuftsin compound prevents development of dextransulfate-sodium-salt induced murine colitis: implications for the treatment of human inflammatory bowel disease.

    abstract：:Improved clinical findings of inflammatory bowel disease (IBD) upon treatment with helminthes and their ova were proven in animal models of IBD and in human clinical studies. The immunomodulatory properties of several helminthes were attributed to the phosphorylcholine (PC) molecule. We assessed the therapeutic potent...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2014.11.001

    authors： Ben-Ami Shor D,Bashi T,Lachnish J,Fridkin M,Bizzaro G,Barshak I,Blank M,Shoenfeld Y

    更新日期：2015-01-01 00:00:00

  • Isolation and characterization of apoptotic nucleosomes, free and complexed with lupus autoantibody generated during hybridoma B-cell apoptosis.

    abstract：:Increasing evidence suggests that immune complexes made of anti-nuclear antibodies bound to nucleosomes released from dead cells play an important role in the pathogenesis of lupus nephritis. However, the nature and composition of apoptotic nucleosomes still remain elusive. Since large amounts of nucleosomes are relea...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1997.0172

    authors： Cabrespines A,Laderach D,Lebossé C,Bach JF,Koutouzov S

    更新日期：1998-02-01 00:00:00

  • Autoimmunity to nucleosomes related to viral infection: a focus on hapten-carrier complex formation.

    abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disorder with unknown aetiology. The major hallmark of this disease is the presence of antibodies against nuclear components, including double-stranded (ds)DNA and histones. The disease affects different organs, particularly the skin, kidneys and the nervous system. ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/s0896-8411(02)00110-5

    authors： Van Ghelue M,Moens U,Bendiksen S,Rekvig OP

    更新日期：2003-03-01 00:00:00

  • Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice.

    abstract：:MHC-class II genes determine susceptibility in human type-1 diabetes. In their context, presentation of target antigen(s) results in autoimmunity and beta-cell destruction. An animal model, in which human beta-cell autoantigen(s) are presented to effector cells in the context of human MHC-class II diabetes-susceptibil...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2009.02.004

    authors： Elagin RB,Balijepalli S,Diacovo MJ,Baekkeskov S,Jaume JC

    更新日期：2009-08-01 00:00:00

  • Isolation and characterization of two human monoclonal anti-phospholipid IgG from patients with autoimmune disease.

    abstract：:The antigenic specificity of anti-phospholipid antibodies (APA) is a matter of intensive investigation. To further characterize these antibodies, we attempted to isolate human monoclonal APA. B-cells of patients with at least one positive test for antibodies against cardiolipin, phosphatidylserine, beta2-glycoprotein ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1999.0316

    authors： von Landenberg C,Lackner KJ,von Landenberg P,Lang B,Schmitz G

    更新日期：1999-09-01 00:00:00

  • A novel function of IL-2: chemokine/chemoattractant/retention receptor genes induction in Th subsets for skin and lung inflammation.

    abstract：:The Foxp3(+)CD4(+) regulatory T-cell (Treg)-deficient Scurfy (Sf) mice rapidly develop severe inflammation in the skin and lungs with expanded Th subsets bearing increased expression of various chemokine/chemoattractant/retention receptor genes (CRG). Nine different double mutants were generated to elucidate their rol...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2012.02.001

    authors： Sharma R,Sung SS,Gaskin F,Fu SM,Ju ST

    更新日期：2012-06-01 00:00:00

  • The role of thrombospondin-1 in the pathogenesis of antiphospholipid syndrome.

    abstract：OBJECTIVE:Antiphospholipid syndrome (APS) is an acquired thrombophilia characterized by recurrent thrombosis and/or pregnancy morbidity, in the presence of antibodies to β2 glycoprotein-I (β2GPI), prothrombin or Lupus anticoagulant (LA). Anti-β2GPI antibodies recognize complexes of β2GPI dimers with CXCL4 chemokine and...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2020.102527

    authors： Patsouras M,Tsiki E,Karagianni P,Vlachoyiannopoulos PG

    更新日期：2020-12-01 00:00:00

  • Neuronal PAD4 expression and protein citrullination: possible role in production of autoantibodies associated with neurodegenerative disease.

    abstract：:Peptidyl arginine deiminases (PADs) catalyze a post-translational protein modification reaction called citrullination, where arginine is converted to citrulline. This modification has been linked to the pathogenesis of autoimmune diseases including rheumatoid arthritis (RA). More recently, several studies have suggest...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2012.03.004

    authors： Acharya NK,Nagele EP,Han M,Coretti NJ,DeMarshall C,Kosciuk MC,Boulos PA,Nagele RG

    更新日期：2012-06-01 00:00:00