当前位置： SCI文献检索 > JOURNAL OF AUTOIMMUNITY期刊下所有文献 > Phosphorylcholine-tuftsin compound prevents development of dextransulfate-sodium-salt induced murine colitis: implications for the treatment of human inflammatory bowel disease.

Phosphorylcholine-tuftsin compound prevents development of dextransulfate-sodium-salt induced murine colitis: implications for the treatment of human inflammatory bowel disease.

Abstract：

:Improved clinical findings of inflammatory bowel disease (IBD) upon treatment with helminthes and their ova were proven in animal models of IBD and in human clinical studies. The immunomodulatory properties of several helminthes were attributed to the phosphorylcholine (PC) molecule. We assessed the therapeutic potential of tuftsin-PC conjugate (TPC) to attenuate murine colitis. Colitis was induced by Dextransulfate-Sodium-Salt (DSS) in drinking water. TPC was given by daily oral ingestion (50 μg/0.1 ml/mouse or PBS) starting at day -2. Disease activity index (DAI) score was followed daily and histology of the colon was performed by H&E staining. Analysis of the cytokines profile in distal colon lysates was performed by immunoblot. Treatment of DSS induced colitis with TPC prevented the severity of colitis, including a reduction in the DAI score, less shortening of the colon and less inflammatory activity in histology. The immunoblot showed that the colitis preventive activity of TPC was associated with downregulation of colon pro-inflammatory IL-1β, TNFα and IL-17 cytokines expression, and enhancement of anti-inflammatory IL-10 cytokine expression. In the current study, we demonstrated that TPC treatment can prevent significantly experimental colitis induction in naïve mice. We propose the TPC as a novel potential small synthetic molecule to treat colitis.

journal_name

J Autoimmun

journal_title

Journal of autoimmunity

authors

Ben-Ami Shor D,Bashi T,Lachnish J,Fridkin M,Bizzaro G,Barshak I,Blank M,Shoenfeld Y

doi

10.1016/j.jaut.2014.11.001

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

111-7

eissn

0896-8411

issn

1095-9157

pii

S0896-8411(14)00165-6

journal_volume

56

pub_type

杂志文章

相关文献

JOURNAL OF AUTOIMMUNITY文献大全
  • Characterization of regulatory T cells in patients with dermatomyositis.

    abstract：:The purpose of this study was to characterize regulatory T cells (T(reg)) in skin lesions and peripheral blood from patients with dermatomyositis (DM) and to determine the serum levels of regulatory cytokines in the disease. In skin biopsy specimens from patients with DM, immunohistochemistry was performed for CD4(+),...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2010.07.006

    authors： Antiga E,Kretz CC,Klembt R,Massi D,Ruland V,Stumpf C,Baroni G,Hartmann M,Hartschuh W,Volpi W,Del Bianco E,Enk A,Fabbri P,Krammer PH,Caproni M,Kuhn A

    更新日期：2010-12-01 00:00:00

  • The role of intrinsic epithelial activation in the pathogenesis of Sjögren's syndrome.

    abstract：:Sjögren's syndrome (SS) is a chronic autoimmune disorder that is characterized by dysfunction and destruction of the exocrine glands. Exocrinopathy is associated with periductal mononuclear cell infiltrates in the affected exocrine glands and B-cell hyperreactivity. Epithelial cells are thought to play an important pa...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2010.06.011

    authors： Manoussakis MN,Kapsogeorgou EK

    更新日期：2010-11-01 00:00:00

  • Do naturally occurring autoantibodies participate in the constitution of the pathological B-cell repertoire in systemic lupus erythematosus?

    abstract：:Systemic lupus erythematosus (SLE) is the prototype of systemic autoimmune diseases. In both human and mouse SLE diseases, the autoimmune response targets a restricted set of autoantigens. Many of them are nucleic acids and proteins involved in the synthesis and processing of DNA or RNA, a characteristic which should ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1006/jaut.1996.0031

    authors： Gilbert D,Brard F,Jovelin F,Tron F

    更新日期：1996-04-01 00:00:00

  • Genetically determined imbalance between serum levels of tumour necrosis factor (TNF) and interleukin (IL)-10 is associated with anti-Jo-1 and anti-Ro52 autoantibodies in patients with poly- and dermatomyositis.

    abstract：:Our aim was to investigate presence of tumour necrosis factor (TNF) and interleukin (IL)-10 in serum and their relation to different genotypes as well as to clinical and laboratory phenotypes in patients with polymyositis and dermatomyositis. In 65 patients with poly- or dermatomyositis the inflammatory cytokine balan...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2006.06.003

    authors： Hassan AB,Fathi M,Dastmalchi M,Lundberg IE,Padyukov L

    更新日期：2006-08-01 00:00:00

  • Differential activities of immunogenic collagen type II peptides in the induction of nasal tolerance to collagen-induced arthritis.

    abstract：:Nasal tolerance has recently been used to modulate immune responses in animal models of autoimmunity. We have compared immunogenic collagen type II (CII) peptides for induction of nasal tolerance in DBA/1 mice to collagen-induced arthritis (CIA). Three synthetic peptides corresponding to T cell-stimulating sequences o...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1998.0255

    authors： Chu CQ,Londei M

    更新日期：1999-02-01 00:00:00

  • B-cell overexpression of Bcl-2 cooperates with p21 deficiency for the induction of autoimmunity and lymphomas.

    abstract：:Genetic abnormalities predisposing to autoimmunity generally act in a cooperative manner affecting one or several mechanisms regulating immunological tolerance. In addition, many of these genetic abnormalities are also involved in the development of lymphoproliferative diseases. In the present study, we have determine...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2010.07.002

    authors： Santiuste I,Buelta L,Iglesias M,Genre F,Mazorra F,Izui S,Merino J,Merino R

    更新日期：2010-12-01 00:00:00

  • Polyreactive autoantibodies in systemic lupus erythematosus have pathogenic potential.

    abstract：:The present study was undertaken to determine whether germline encoded and polyreactive antibodies might be pathogenic and whether the breach of early tolerance checkpoints in systemic lupus erythematosus (SLE) might lead to a population of B cells expressing germline encoded antibodies that become pathogenic merely b...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2009.03.011

    authors： Zhang J,Jacobi AM,Wang T,Berlin R,Volpe BT,Diamond B

    更新日期：2009-11-01 00:00:00

  • The diagnosis and classification of polymyositis.

    abstract：:Polymyositis is classified as a separate entity among idiopathic inflammatory myopathies but it is considered as the least common since it is an exclusion diagnosis. This myopathy usually presents with subacute-chronic symmetric proximal limb weakness, although some extramuscular manifestations are common. Creatine ki...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2014.01.025

    authors： Milisenda JC,Selva-O'Callaghan A,Grau JM

    更新日期：2014-02-01 00:00:00

  • Isolation and characterization of apoptotic nucleosomes, free and complexed with lupus autoantibody generated during hybridoma B-cell apoptosis.

    abstract：:Increasing evidence suggests that immune complexes made of anti-nuclear antibodies bound to nucleosomes released from dead cells play an important role in the pathogenesis of lupus nephritis. However, the nature and composition of apoptotic nucleosomes still remain elusive. Since large amounts of nucleosomes are relea...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1997.0172

    authors： Cabrespines A,Laderach D,Lebossé C,Bach JF,Koutouzov S

    更新日期：1998-02-01 00:00:00

  • Immunosuppressive and anti-inflammatory action of antioxidants in rat autoimmune diabetes.

    abstract：:Oxidative stress makes an important contribution to the development of autoimmune diabetes. We therefore tested the possible therapeutic value of two anti-oxidants, butylated hydroxyanisole (BHA) and pyrrolidine dithiocarbamate (PDTC), in the animal model of diabetes induced in susceptible DA rats by multiple low dose...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2004.01.005

    authors： Stosic-Grujicic SD,Miljkovic DM,Cvetkovic ID,Maksimovic-Ivanic DD,Trajkovic V

    更新日期：2004-06-01 00:00:00

  • Two discreet subsets of CD8 T cells modulate PLP(91-110) induced experimental autoimmune encephalomyelitis in HLA-DR3 transgenic mice.

    abstract：:Previously we showed that transgenic mice expressing human HLA-DR3 gene are susceptible to PLP(91-110) induced experimental autoimmune encephalomyelitis (EAE) and can serve as an animal model of multiple sclerosis (MS). HLA-DR3 mice with EAE showed increased number of CD8 T cells indicating their important role in dis...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2012.02.004

    authors： Mangalam AK,Luckey D,Giri S,Smart M,Pease LR,Rodriguez M,David CS

    更新日期：2012-06-01 00:00:00

  • Induction of experimental anti-phospholipid syndrome associated with SLE following immunization with human monoclonal pathogenic anti-DNA idiotype.

    abstract：:MIV-7 is a human monoclonal antibody that binds to DNA and carries a pathogenic anti-DNA idiotype 16/6. The antibody was generated by fusing peripheral blood lymphocytes of a healthy donor which were stimulated with an anti-idiotypic antibody to B11 (a human mAb anti-mouse mammary tumor virus-MMTV). The MIV-7, in addi...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(92)90008-e

    authors： Blank M,Krause I,Ben-Bassat M,Shoenfeld Y

    更新日期：1992-08-01 00:00:00

  • Treatment with antibody reactive with the nephritogenic idiotype, IdLNF1, suppresses its production and leads to prolonged survival of (NZB x SWR)F1 mice.

    abstract：:The F1 progeny of the cross between SWR and NZB mice (SNF1) develop severe immune complex glomerulonephritis, similar to that seen in human SLE. An idiotypically-related family of nephritic antibodies (IdLNF1) has been shown to be important in the pathogenesis of autoimmune glomerulonephritis in these mice. Interestin...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1994.1003

    authors： Uner AH,Knupp CJ,Tatum AH,Gavalchin J

    更新日期：1994-02-01 00:00:00

  • A functional and phenotypic study on immune accessory cells isolated from the thyroids of Wistar and autoimmune-prone BB-DP rats.

    abstract：:Dendritic cells (DCs) comprise a small population of cells in the normal thyroid. These excellent antigen-presenting cells (APCs) are thought to be involved in the initiation of thyroid autoimmune reactions. However it is not known whether the APCs involved in this process are indeed DCs, or thyrocytes. Our aims were ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.2000.0438

    authors： Simons PJ,Delemarre FG,Drexhage HA

    更新日期：2000-12-01 00:00:00

  • Recombinant thrombomodulin ameliorates autoimmune vasculitis via immune response regulation and tissue injury protection.

    abstract：:Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterized by necrotizing vasculitis with the presence of pathogenic ANCA. ANCA can potentially cause neutrophil activation and induce neutrophil extracellular traps (NETs), resulting in endothelial damage as well as activation of autoreacti...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2019.102390

    authors： Watanabe-Kusunoki K,Nakazawa D,Kusunoki Y,Kudo T,Hattanda F,Nishio S,Masuda S,Tomaru U,Kondo T,Atsumi T,Ishizu A

    更新日期：2020-03-01 00:00:00

  • Role of TWEAK in lupus nephritis: a bench-to-bedside review.

    abstract：:There is significant unmet need in the treatment of lupus nephritis (LN) patients. In this review, we highlight the role of the TWEAK/Fn14 pathway in mediating key pathologic processes underlying LN involving both glomerular and tubular injury, and thus the potential for renal protection via blockade of this pathway. ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2012.05.003

    authors： Michaelson JS,Wisniacki N,Burkly LC,Putterman C

    更新日期：2012-09-01 00:00:00

  • Latent autoimmune thyroiditis in untreated patients with HCV chronic hepatitis: a case-control study.

    abstract：:In order to establish a relationship between Hepatitis C virus (HCV) chronic infection and autoimmune thyroiditis, 97 untreated patients with biopsy-proven HCV chronic hepatitis and 97 controls were studied. An ultrasound examination of the thyroid and an assay of serum thyroid-stimulating hormone (TSH), thyroid hormo...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1006/jaut.1999.0360

    authors： Ganne-Carrie N,Medini A,Coderc E,Seror O,Christidis C,Grimbert S,Trinchet JC,Beaugrand M

    更新日期：2000-03-01 00:00:00

  • Novel genetic loci associated HLA-B*08:01 positive myasthenia gravis.

    abstract：OBJECTIVE:To identify potential causative markers involved in the development of early-onset myasthenia gravis (EOMG) in the MHC and non-MHC regions that may interact with the HLA-B*08:01 allele. METHODS:We analyzed 583 MG patients and identified 5 patients homozygous for the disease-associated ancestral haplotype 8.1...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2017.10.002

    authors： Varade J,Wang N,Lim CK,Zhang T,Zhang Y,Liu X,Piehl F,Matell R,Cao H,Xu X,Hammarström L

    更新日期：2018-03-01 00:00:00

  • The antigen specificity of the rheumatoid arthritis-associated ACPA directed to citrullinated fibrin is very closely restricted.

    abstract：:The major targets of the disease-specific autoantibodies to citrullinated proteins (ACPA) in synovium of rheumatoid arthritis (RA) patients are borne by the citrullinated α- and β-chains of fibrin. We demonstrated that ACPA target a limited set of citrullinated fibrin peptides and particularly four multicitrullinated ...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2011.07.003

    authors： Iobagiu C,Magyar A,Nogueira L,Cornillet M,Sebbag M,Arnaud J,Hudecz F,Serre G

    更新日期：2011-12-01 00:00:00

  • Regulatory dendritic cells in autoimmunity: A comprehensive review.

    abstract：:Dendritic cells (DCs) are professional antigen-presenting cells (APC) with significant phenotypic heterogeneity and functional plasticity. DCs play crucial roles in initiating effective adaptive immune responses for elimination of invading pathogens and also in inducing immune tolerance toward harmless components to m...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2015.07.011

    authors： Liu J,Cao X

    更新日期：2015-09-01 00:00:00

  • Serum concentrations of IgM, IgG1, IgG2b, IgG3 and IgA in C57BL/6 mice and their congenics at the lpr (lymphoproliferation) locus.

    abstract：:The serum concentrations of IgM, IgG1, IgG2b, IgG3 and IgA were determined in mice of C57BL/6 background, from weaning to one year of age, by quantitative isotype-specific, indirect double sandwich enzyme-linked immunosorbent assays (ELISAs). Only limited data could be obtained for the IgG2a isotype in the present stu...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/0896-8411(89)90013-9

    authors： Klein-Schneegans AS,Kuntz L,Fonteneau P,Loor F

    更新日期：1989-12-01 00:00:00

  • Autophagy: A new concept in autoimmunity regulation and a novel therapeutic option.

    abstract：:Nowadays, pharmacologic treatments of autoinflammatory diseases are largely palliative rather than curative. Most of them result in non-specific immunosuppression, which can be associated with broad disruption of natural and induced immunity with significant and sometimes serious unwanted injuries. Among the novel str...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.jaut.2018.08.009

    authors： Bonam SR,Wang F,Muller S

    更新日期：2018-11-01 00:00:00

  • Dendritic cells tip the balance towards induction of regulatory T cells upon priming in experimental autoimmune encephalomyelitis.

    abstract：:Counter-balancing regulatory mechanisms, such as the induction of regulatory T cells (Treg), limit the effects of autoimmune attack in neuroinflammation. However, the role of dendritic cells (DCs) as the most powerful antigen-presenting cells, which are intriguing therapeutic targets in this context, is not fully unde...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2016.09.008

    authors： Paterka M,Voss JO,Werr J,Reuter E,Franck S,Leuenberger T,Herz J,Radbruch H,Bopp T,Siffrin V,Zipp F

    更新日期：2017-01-01 00:00:00

  • The mimicry of human glycolipids and glycosphingolipids by the lipooligosaccharides of pathogenic neisseria and haemophilus.

    abstract：:It has been known for many years that bacteria can induce autoimmune responses in humans resulting in serious disease. Recent work has shown that a number of bacteria that colonize human mucosal surfaces exclusively express antigens on their surfaces which are molecular mimics of glycosphingolipids found on human cell...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1006/jaut.2000.0477

    authors： Harvey HA,Swords WE,Apicella MA

    更新日期：2001-05-01 00:00:00

  • Regulatory T cell defect in APECED patients is associated with loss of naive FOXP3(+) precursors and impaired activated population.

    abstract：:The pathogenetic mechanisms of organ-specific autoimmune diseases remain obscured by the complexity of the genetic and environmental factors participating in the breakdown of tolerance. A unique opportunity to study the pathogenesis of human autoimmunity is provided by autoimmune polyendocrinopathy-candidiasis-ectoder...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2010.07.008

    authors： Laakso SM,Laurinolli TT,Rossi LH,Lehtoviita A,Sairanen H,Perheentupa J,Kekäläinen E,Arstila TP

    更新日期：2010-12-01 00:00:00

  • PBC screen: an IgG/IgA dual isotype ELISA detecting multiple mitochondrial and nuclear autoantibodies specific for primary biliary cirrhosis.

    abstract：:A dual isotype (IgG, IgA) enzyme-linked immunosorbent assay (ELISA) designed to provide enhanced detection of primary biliary cirrhosis (PBC)-specific autoantibodies against both major mitochondrial and nuclear antigens has been developed and recently become commercially available. The assay (PBC Screen) simultaneousl...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2010.09.005

    authors： Liu H,Norman GL,Shums Z,Worman HJ,Krawitt EL,Bizzaro N,Vergani D,Bogdanos DP,Dalekos GN,Milkiewicz P,Czaja AJ,Heathcote EJ,Hirschfield GM,Tan EM,Miyachi K,Bignotto M,Battezzati PM,Lleo A,Leung PS,Podda M,Gershwin

    更新日期：2010-12-01 00:00:00

  • Disease-specific cross-reactivity between mimicking peptides of heat shock protein of Mycobacterium gordonae and dominant epitope of E2 subunit of pyruvate dehydrogenase is common in Spanish but not British patients with primary biliary cirrhosis.

    abstract：:Previous studies on Spanish patients with Primary Biliary Cirrhosis (PBC) have shown extensive, disease-specific cross-reactivity between the 65-kDa heat shock protein (hsp65) of Mycobacterium gordonae and pyruvate dehydrogenase complex-E2 (PDC-E2), the major target of anti-mitochondrial antibody (AMA). Studies on a B...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2004.03.002

    authors： Bogdanos DP,Pares A,Baum H,Caballeria L,Rigopoulou EI,Ma Y,Burroughs AK,Rodes J,Vergani D

    更新日期：2004-06-01 00:00:00

  • Dual-Targeted Autoimmune Sword in Fatal Epilepsy: Patient's glutamate receptor AMPA GluR3B peptide autoimmune antibodies bind, induce Reactive Oxygen Species (ROS) in, and kill both human neural cells and T cells.

    abstract：:Nodding Syndrome (NS) is a fatal pediatric epilepsy of unknown etiology, accompanied by multiple neurological impairments, and associated with Onchocerca volvulus (Ov), malnutrition, war-induced trauma, and other insults. NS patients have neuroinflammation, and ~50% have cross-reactive Ov/Leiomodin-1 neurotoxic autoim...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2020.102462

    authors： Levite M,Zelig D,Friedman A,Ilouz N,Eilam R,Bromberg Z,Ramadhan Lasu AA,Arbel-Alon S,Edvardson S,Tarshish M,Riek LP,Lako RL,Reubinoff B,Lebendiker M,Yaish D,Stavsky A,Galun E

    更新日期：2020-08-01 00:00:00

  • Salivary gland epithelial cells (SGEC): carriers of exquisite B7-2 (CD86) costimulatory molecules.

    abstract：:Costimulatory molecules are cell-surface glycoproteins that can direct, modulate and fine tune immune responses. B7-2(CD86) costimulatory molecules are considered as major regulators of T cell responses, acting by appropriate interactions with the stimulatory CD28 or inhibitory CTLA-4 receptors found on T cells. Altho...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章

    doi：10.1016/j.jaut.2010.06.006

    authors： Kapsogeorgou EK,Manoussakis MN

    更新日期：2010-11-01 00:00:00

  • Do we know which patients with the antiphospholipid syndrome should receive long-term high dose anti-coagulation?

    abstract：:The standard treatment of thrombosis related to antiphospholipid antibodies is lifelong high-intensity oral anticoagulation. This standard is primarily based on retrospective evaluations of such patients. In this paper we give a summary of current treatment of deep leg vein thrombosis, pulmonary embolism, ischaemic st...

    journal_title：Journal of autoimmunity

    pub_type： 杂志文章,评审

    doi：10.1006/jaut.2000.0395

    authors： Derksen RH,de Groot PG

    更新日期：2000-09-01 00:00:00