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The diagnosis and classification of polymyositis.

Abstract：

:Polymyositis is classified as a separate entity among idiopathic inflammatory myopathies but it is considered as the least common since it is an exclusion diagnosis. This myopathy usually presents with subacute-chronic symmetric proximal limb weakness, although some extramuscular manifestations are common. Creatine kinase values may be increased up to 50-fold in active disease. Muscle biopsy is characterized by endomysial inflammatory infiltrate consisting predominantly of CD8+ T cells that invade healthy muscle fibres expressing the MHC-I antigen. Although serum autoantibodies, EMG and imaging techniques can help in diagnosis, muscle histopathology is a pivotal value. The clinical picture together with the pathological findings confers the also called PM pattern. A broad differential diagnosis is needed before concluding a diagnosis of pure PM. Sporadic inclusion-body myositis, toxic, endocrine and metabolic myopathies as well as muscular dystrophies are the major categories to be ruled out. Finally, a diagnostic algorithm for suspected cases of PM is also proposed.

journal_name

J Autoimmun

journal_title

Journal of autoimmunity

authors

Milisenda JC,Selva-O'Callaghan A,Grau JM

doi

10.1016/j.jaut.2014.01.025

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

118-21

eissn

0896-8411

issn

1095-9157

pii

S0896-8411(14)00028-6

journal_volume

48-49

pub_type

杂志文章,评审

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