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Patients with systemic lupus erythematosus have reduced numbers of circulating natural interferon-alpha- producing cells.

Abstract：

:Systemic lupus erythematosus (SLE) patients often have continuous production of interferon-alpha (IFN-alpha), but production of in vitro IFN-alpha by peripheral blood mononuclear cells (PBMC) may be varyingly reduced. We here report that IFN-alpha production induced by Herpes simplex virus (HSV) in PBMC resembling immature dendritic cells and designated natural IFN-alpha producing cells (NIPC), was much more affected than that induced by sendai virus (SV) in monocytes. At the cell level, the frequency of HSV-activated NIPC was reduced 70-fold, but residual NIPC produced normal amounts of IFN-alpha (1-2 U/cell). The NIPC frequency increased 10-fold in SLE-PBMC, but not in control PBMC, when co-stimulated by the combination IFN-alpha-gamma and GM- CSF. No spontaneous IFN-alpha production by PBMCs was detected in SLE patients. While no SLE serum factor inhibiting IFN-alpha production was seen, sera of four out of 11 SLE patients induced IFN-alpha production in healthy control PBMC. We propose that the number of NIPC in SLE are reduced in blood because of recruitment to tissues and activation by an endogenous IFN-alpha inducer, as well as because of lack of co-stimulatory cytokines. IFN-alpha produced in SLE could be of pathogenic significance, because autoimmune diseases develop in patients with infections or tumours during IFN-alpha therapy.

journal_name

J Autoimmun

journal_title

Journal of autoimmunity

authors

Cederblad B,Blomberg S,Vallin H,Perers A,Alm GV,Rönnblom L

doi

10.1006/jaut.1998.0215

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

465-70

issue

5

eissn

0896-8411

issn

1095-9157

pii

S0896-8411(98)90215-3

journal_volume

11

pub_type

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