听力与言语-语言病理学

行为科学

医学伦理学

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  • Genomic and signalling pathway characterization of the NZM panel of melanoma cell lines: A valuable model for studying the impact of genetic diversity in melanoma.

    abstract::Melanoma is a disease associated with a very high mutation burden and thus the possibility of a diverse range of oncogenic mechanisms that allow it to evade therapeutic interventions and the immune system. Here, we describe the characterization of a panel of 102 cell lines from metastatic melanomas (the NZM lines), in...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12908

    authors: Tran KB,Gimenez G,Tsai P,Kolekar S,Rodger EJ,Chatterjee A,Jabed A,Shih JH,Joseph WR,Marshall ES,Wang Q,Print CG,Eccles MR,Baguley BC,Shepherd PR

    更新日期:2021-01-01 00:00:00

  • NRASQ61K melanoma tumor formation is reduced by p38-MAPK14 activation in zebrafish models and NRAS-mutated human melanoma cells.

    abstract::Oncogenic BRAF and NRAS mutations drive human melanoma initiation. We used transgenic zebrafish to model NRAS-mutant melanoma, and the rapid tumor onset allowed us to study candidate tumor suppressors. We identified P38α-MAPK14 as a potential tumor suppressor in The Cancer Genome Atlas melanoma cohort of NRAS-mutant m...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12925

    authors: Banik I,Cheng PF,Dooley CM,Travnickova J,Merteroglu M,Dummer R,Patton EE,Busch-Nentwich EM,Levesque MP

    更新日期:2020-09-10 00:00:00

  • Premature senescence in human melanocytes after exposure to solar UVR: An exosome and UV-miRNA connection.

    abstract::Ultraviolet radiation (UVR) can play two roles: induce cellular senescence and convert skin melanocytes into melanoma. To assess whether this conversion might rely on melanocytes having to first acquire a senescent phenotype, we studied the effects of physiological doses of UVR (UVA + UVB) on quiescent melanocytes in ...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12888

    authors: Sha J,Arbesman J,Harter ML

    更新日期:2020-09-01 00:00:00

  • Leptomeningeal disease in melanoma patients: An update to treatment, challenges, and future directions.

    abstract::In February 2018, the Melanoma Research Foundation and the Moffitt Cancer Center hosted the Second Summit on Melanoma Central Nervous System Metastases in Tampa, Florida. The meeting included investigators from multiple academic centers and disciplines. A consensus summary of the progress and challenges in melanoma pa...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章,评审

    doi:10.1111/pcmr.12861

    authors: Glitza IC,Smalley KSM,Brastianos PK,Davies MA,McCutcheon I,Liu JKC,Ahmed KA,Arrington JA,Evernden BR,Smalley I,Eroglu Z,Khushalani N,Margolin K,Kluger H,Atkins MB,Tawbi H,Boire A,Forsyth P

    更新日期:2020-07-01 00:00:00

  • Pathogenesis of a variant in the 5' untranslated region of ADAR1 in dyschromatosis symmetrica hereditaria.

    abstract::Dyschromatosis symmetrica hereditaria (DSH) is a pigmentary genodermatosis caused by mutations in ADAR1. In this study, we performed mutation analysis on a family that included typical DSH patients. No mutations were found in any coding regions or exon-intron boundary regions of ADAR1, but a previously unreported non-...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12863

    authors: Suganuma M,Kono M,Yamanaka M,Akiyama M

    更新日期:2020-07-01 00:00:00

  • PLX3397 inhibits the accumulation of intra-tumoral macrophages and improves bromodomain and extra-terminal inhibitor efficacy in melanoma.

    abstract::Bromodomain and extra-terminal inhibitors (BETi) delay tumor growth, in part, through tumor cell intrinsic alterations and initiation of anti-tumor CD8+ T-cell responses. By contrast, BETi effects on pro-tumoral immune responses remain unclear. Here, we show that the next-generation BETi, PLX51107, delayed tumor growt...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12845

    authors: Erkes DA,Rosenbaum SR,Field CO,Chervoneva I,Villanueva J,Aplin AE

    更新日期:2020-03-01 00:00:00

  • Osteoblasts contribute to a protective niche that supports melanoma cell proliferation and survival.

    abstract::Melanoma is the deadliest form of skin cancer; a primary driver of this high level of morbidity is the propensity of melanoma cells to metastasize. When malignant tumours develop distant metastatic lesions the new local tissue niche is known to impact on the biology of the cancer cells. However, little is known about ...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12812

    authors: Ferguson J,Wilcock DJ,McEntegart S,Badrock AP,Levesque M,Dummer R,Wellbrock C,Smith MP

    更新日期:2020-01-01 00:00:00

  • IsomiRs and tRNA-derived fragments are associated with metastasis and patient survival in uveal melanoma.

    abstract::Uveal melanoma (UVM) is the most common primary intraocular malignancy in adults. With over 50% of patients developing metastatic disease, there is an unmet need for improved diagnostic and therapeutic options. Efforts to understand the molecular biology of the disease have revealed several markers that correlate with...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12810

    authors: Londin E,Magee R,Shields CL,Lally SE,Sato T,Rigoutsos I

    更新日期:2020-01-01 00:00:00

  • ABCB5 is activated by MITF and β-catenin and is associated with melanoma differentiation.

    abstract::Defining markers of different phenotypic states in melanoma is important for understanding disease progression, determining the response to therapy, and defining the molecular mechanisms underpinning phenotype-switching driven by the changing intratumor microenvironment. The ABCB5 transporter is implicated in drug-res...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12830

    authors: Louphrasitthiphol P,Chauhan J,Goding CR

    更新日期:2020-01-01 00:00:00

  • MITF controls the TCA cycle to modulate the melanoma hypoxia response.

    abstract::In response to the dynamic intra-tumor microenvironment, melanoma cells adopt distinct phenotypic states associated with differential expression of the microphthalmia-associated transcription factor (MITF). The response to hypoxia is driven by hypoxia-inducible transcription factors (HIFs) that reprogram metabolism an...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12802

    authors: Louphrasitthiphol P,Ledaki I,Chauhan J,Falletta P,Siddaway R,Buffa FM,Mole DR,Soga T,Goding CR

    更新日期:2019-11-01 00:00:00

  • Induced pluripotent stem cell-derived melanocyte precursor cells undergoing differentiation into melanocytes.

    abstract::Induced pluripotent stem cell (iPSC) technology offers a novel approach for conversion of human primary fibroblasts into melanocytes. During attempts to explore various protocols for differentiation of iPSCs into melanocytes, we found a distinct and self-renewing cell lineage that could differentiate into melanocytes,...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12779

    authors: Hosaka C,Kunisada M,Koyanagi-Aoi M,Masaki T,Takemori C,Taniguchi-Ikeda M,Aoi T,Nishigori C

    更新日期:2019-09-01 00:00:00

  • The 308-nm excimer laser treatment does not increase the risk of skin cancer in patients with vitiligo: A population-based retrospective cohort study.

    abstract::A 308-nm excimer laser (EL) has been widely used to treat patients with localized vitiligo. However, data are rare on the influence of EL treatment on the risks of skin cancer. To evaluate the skin cancer risks after long-term EL treatment, we performed a nationwide population-based retrospective cohort study using th...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12781

    authors: Bae JM,Eun SH,Oh SH,Shin JH,Kang HY,Kim KH,Lee SC,Choi CW

    更新日期:2019-09-01 00:00:00

  • Mechanism of action of 4-substituted phenols to induce vitiligo and antimelanoma immunity.

    abstract::Monobenzone is a 4-substituted phenol that can induce vitiligo and antimelanoma immunity. We investigated the influence of the chemical structure on the biological activity of a series of structurally related 4-substituted phenols. All phenols inhibited cellular melanin synthesis, and eight of ten phenols inhibited ty...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12774

    authors: Kammeyer A,Willemsen KJ,Ouwerkerk W,Bakker WJ,Ratsma D,Pronk SD,Smit NPM,Luiten RM

    更新日期:2019-07-01 00:00:00

  • The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma.

    abstract::The deubiquitinating enzyme BAP1 is mutated in a hereditary cancer syndrome with a high risk of mesothelioma and melanocytic tumors. Here, we show that Bap1 deletion in melanocytes cooperates with the constitutively active, oncogenic form of BRAF (BRAFV600E ) and UV to cause melanoma in mice, albeit at very low freque...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12735

    authors: Webster JD,Pham TH,Wu X,Hughes NW,Li Z,Totpal K,Lee HJ,Calses PC,Chaurushiya MS,Stawiski EW,Modrusan Z,Chang MT,Tran C,Lee WP,Chalasani S,Hung J,Sharma N,Chan S,Hotzel K,Talevich E,Shain A,Xu M,Lill J,Dixit

    更新日期:2019-03-01 00:00:00

  • Melasma, a photoaging disorder.

    abstract::Melasma is a common hyperpigmentary disorder. The impact on the quality of life of affected individuals is well demonstrated, demanding new therapeutic strategies. However, the treatment of melasma remains highly challenging. Melasma is often considered as the main consequence of female hormone stimulation on a predis...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章,评审

    doi:10.1111/pcmr.12684

    authors: Passeron T,Picardo M

    更新日期:2018-07-01 00:00:00

  • Giant congenital melanocytic nevus with vascular malformation and epidermal cysts associated with a somatic activating mutation in BRAF.

    abstract::Giant congenital melanocytic nevi may be symptomatically isolated or syndromic. Associations with capillary malformations are exceptional, and development of epidermal cysts has not been described. A 71-year-old patient with a giant congenital melanocytic nevus (CMN) of the lower back, buttocks, and thighs was asympto...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12685

    authors: Etchevers HC,Rose C,Kahle B,Vorbringer H,Fina F,Heux P,Berger I,Schwarz B,Zaffran S,Macagno N,Krengel S

    更新日期:2018-05-01 00:00:00

  • D-tyrosine negatively regulates melanin synthesis by competitively inhibiting tyrosinase activity.

    abstract::Although L-tyrosine is well known for its melanogenic effect, the contribution of D-tyrosine to melanin synthesis was previously unexplored. Here, we reveal that, unlike L-tyrosine, D-tyrosine dose-dependently reduced the melanin contents of human MNT-1 melanoma cells and primary human melanocytes. In addition, 500 μM...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12668

    authors: Park J,Jung H,Kim K,Lim KM,Kim JY,Jho EH,Oh ES

    更新日期:2018-05-01 00:00:00

  • The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival.

    abstract::Evidence on the relationship between the vitamin D pathway and outcomes in melanoma is growing, although it is not always clear. We investigated the impact of measured levels of sun exposure at diagnosis on associations of vitamin D receptor gene (VDR) polymorphisms and melanoma death in 3336 incident primary melanoma...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12653

    authors: Orlow I,Shi Y,Kanetsky PA,Thomas NE,Luo L,Corrales-Guerrero S,Cust AE,Sacchetto L,Zanetti R,Rosso S,Armstrong BK,Dwyer T,Venn A,Gallagher RP,Gruber SB,Marrett LD,Anton-Culver H,Busam K,Begg CB,Berwick M,GEM Study

    更新日期:2018-03-01 00:00:00

  • Genetic variation in IRF4 expression modulates growth characteristics, tyrosinase expression and interferon-gamma response in melanocytic cells.

    abstract::A SNP within intron4 of the interferon regulatory factor4 (IRF4) gene, rs12203592*C/T, has been independently associated with pigmentation and age-specific effects on naevus count in European-derived populations. We have characterized the cis-regulatory activity of this intronic region and using human foreskin-derived...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12620

    authors: Chhabra Y,Yong HXL,Fane ME,Soogrim A,Lim W,Mahiuddin DN,Kim RSQ,Ashcroft M,Beatson SA,Ainger SA,Smit DJ,Jagirdar K,Walker GJ,Sturm RA,Smith AG

    更新日期:2018-01-01 00:00:00

  • The avidity of tumor-specific T cells amplified by a plasmacytoid dendritic cell-based assay can predict the clinical evolution of melanoma patients.

    abstract::The advent of immune checkpoint blockers and targeted therapies has changed the outcome of melanoma. However, many patients experience relapses, emphasizing the need for predictive and prognostic biomarkers. We developed a strategy based on plasmacytoid dendritic cells (pDCs) loaded with melanoma tumor antigens that a...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12618

    authors: Charles J,Chaperot L,Revol B,Baudin M,Mouret S,Hamon A,Leccia MT,Plumas J,Aspord C

    更新日期:2018-01-01 00:00:00

  • Re-evaluation of insect melanogenesis research: Views from the dark side.

    abstract::Melanins (eumelanin and pheomelanin) are synthesized in insects for several purposes including cuticle sclerotization and color patterning, clot formation, organogenesis, and innate immunity. Traditional views of insect immunity detail the storage of pro-phenoloxidases inside specialized blood cells (hemocytes) and th...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章,评审

    doi:10.1111/pcmr.12590

    authors: Whitten MMA,Coates CJ

    更新日期:2017-07-01 00:00:00

  • UV-induced somatic mutations elicit a functional T cell response in the YUMMER1.7 mouse melanoma model.

    abstract::Human melanomas exhibit relatively high somatic mutation burden compared to other malignancies. These somatic mutations may produce neoantigens that are recognized by the immune system, leading to an antitumor response. By irradiating a parental mouse melanoma cell line carrying three driver mutations with UVB and exp...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12591

    authors: Wang J,Perry CJ,Meeth K,Thakral D,Damsky W,Micevic G,Kaech S,Blenman K,Bosenberg M

    更新日期:2017-07-01 00:00:00

  • MicroRNA-125a promotes resistance to BRAF inhibitors through suppression of the intrinsic apoptotic pathway.

    abstract::Melanoma patients with BRAFV600E -mutant tumors display striking responses to BRAF inhibitors (BRAFi); however, almost all invariably relapse with drug-resistant disease. Here, we report that microRNA-125a (miR-125a) expression is upregulated in human melanoma cells and patient tissues upon acquisition of BRAFi resist...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12578

    authors: Koetz-Ploch L,Hanniford D,Dolgalev I,Sokolova E,Zhong J,Díaz-Martínez M,Bernstein E,Darvishian F,Flaherty KT,Chapman PB,Tawbi H,Hernando E

    更新日期:2017-05-01 00:00:00

  • Novel regulation of melanogenesis by adiponectin via the AMPK/CRTC pathway.

    abstract::Several studies observed that adiponectin, an important adipokine that improves glucose metabolism by regulating AMP-activated protein kinase (AMPK) signaling, is dermatologically beneficial. In our recent microarray data, we found that adiponectin expression was lower in lesional skin than in non-lesional skin of mel...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12596

    authors: Bang S,Won KH,Moon HR,Yoo H,Hong A,Song Y,Chang SE

    更新日期:2017-01-01 00:00:00

  • Oculocutaneous albinism type 1: link between mutations, tyrosinase conformational stability, and enzymatic activity.

    abstract::Oculocutaneous albinism type 1 (OCA1) is an autosomal recessive disorder caused by mutations in the tyrosinase gene. Two subtypes of OCA1 have been described: severe OCA1A with complete absence of tyrosinase activity and less severe OCA1B with residual tyrosinase activity. Here, we characterize the recombinant human t...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12546

    authors: Dolinska MB,Kus NJ,Farney SK,Wingfield PT,Brooks BP,Sergeev YV

    更新日期:2017-01-01 00:00:00

  • Two light-activated neuroendocrine circuits arising in the eye trigger physiological and morphological pigmentation.

    abstract::Two biological processes regulate light-induced skin colour change. A fast 'physiological pigmentation change' (i.e. circadian variations or camouflage) involves alterations in the distribution of pigment containing granules in the cytoplasm of chromatophores, while a slower 'morphological pigmentation change' (i.e. s...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12531

    authors: Bertolesi GE,Hehr CL,Munn H,McFarlane S

    更新日期:2016-11-01 00:00:00

  • NGS-based 100-gene panel of hypopigmentation identifies mutations in Chinese Hermansky-Pudlak syndrome patients.

    abstract::Hermansky-Pudlak syndrome (HPS) is a rare recessive disorder characterized by hypopigmentation, bleeding diathesis, and other symptoms due to multiple defects in lysosome-related organelles. Ten HPS subtypes have been identified with mutations in HPS1 to HPS10. Only four patients with HPS-1 have been reported in Chine...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12534

    authors: Wei A,Yuan Y,Bai D,Ma J,Hao Z,Zhang Y,Yu J,Zhou Z,Yang L,Yang X,Li L,Li W

    更新日期:2016-11-01 00:00:00

  • Melanoma central nervous system metastases: current approaches, challenges, and opportunities.

    abstract::Melanoma central nervous system metastases are increasing, and the challenges presented by this patient population remain complex. In December 2015, the Melanoma Research Foundation and the Wistar Institute hosted the First Summit on Melanoma Central Nervous System (CNS) Metastases in Philadelphia, Pennsylvania. Here,...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章,评审

    doi:10.1111/pcmr.12538

    authors: Cohen JV,Tawbi H,Margolin KA,Amravadi R,Bosenberg M,Brastianos PK,Chiang VL,de Groot J,Glitza IC,Herlyn M,Holmen SL,Jilaveanu LB,Lassman A,Moschos S,Postow MA,Thomas R,Tsiouris JA,Wen P,White RM,Turnham T,Davies M

    更新日期:2016-11-01 00:00:00

  • The state of melanoma: challenges and opportunities.

    abstract::The Melanoma Research Foundation (MRF) has charted a comprehensive assessment of the current state of melanoma research and care. Intensive discussions among members of the MRF Scientific Advisory Council and Breakthrough Consortium, a group that included clinicians and scientists, focused on four thematic areas - dia...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12475

    authors: Merlino G,Herlyn M,Fisher DE,Bastian BC,Flaherty KT,Davies MA,Wargo JA,Curiel-Lewandrowski C,Weber MJ,Leachman SA,Soengas MS,McMahon M,Harbour JW,Swetter SM,Aplin AE,Atkins MB,Bosenberg MW,Dummer R,Gershenwald JE,Ha

    更新日期:2016-07-01 00:00:00

  • Insights into genetic alterations of liver metastases from uveal melanoma.

    abstract::The liver is the organ usually affected by metastatic uveal melanoma (MUM). Current treatments are almost always ineffective and mortality remains high. In this study, copy number variations (CNVs) were identified in 12 metastatic and five matched primary UMs (PUMs). Our data revealed a wide spectrum of genetic altera...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12433

    authors: McCarthy C,Kalirai H,Lake SL,Dodson A,Damato BE,Coupland SE

    更新日期:2016-01-01 00:00:00

  • NF1 loss induces senescence during human melanocyte differentiation in an iPSC-based model.

    abstract::Neurofibromatosis type 1 (NF1) is a frequent genetic disease leading to the development of Schwann cell-derived neurofibromas or melanocytic lesions called café-au-lait macules (CALMs). The molecular mechanisms involved in CALMs formation remain largely unknown. In this report, we show for the first time pathophysiolo...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12369

    authors: Larribere L,Wu H,Novak D,Galach M,Bernhardt M,Orouji E,Weina K,Knappe N,Sachpekidis C,Umansky L,Beckhove P,Umansky V,De Schepper S,Kaufmann D,Ballotti R,Bertolotto C,Utikal J

    更新日期:2015-07-01 00:00:00

  • Tyrosinase-catalyzed metabolism of rhododendrol (RD) in B16 melanoma cells: production of RD-pheomelanin and covalent binding with thiol proteins.

    abstract::RS-4-(4-Hydroxyphenyl)-2-butanol (rhododendrol, RD) was reported to induce leukoderma of the skin. To explore the mechanism underlying that effect, we previously showed that oxidation of RD with mushroom tyrosinase produces RD-quinone, which is converted to secondary quinone products, and we suggested that those quino...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12363

    authors: Ito S,Okura M,Nakanishi Y,Ojika M,Wakamatsu K,Yamashita T

    更新日期:2015-05-01 00:00:00

  • Is it time to test biguanide metformin in the treatment of melanoma?

    abstract::Metformin is the most widely used antidiabetic drug that belongs to the biguanide class. It is very well tolerated and has the major clinical advantage of not inducing hypoglycemia. Metformin decreases hepatic glucose production via a mechanism requiring liver kinase B1, which controls the metabolic checkpoint, AMP-ac...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章,评审

    doi:10.1111/pcmr.12267

    authors: Cerezo M,Tomic T,Ballotti R,Rocchi S

    更新日期:2015-01-01 00:00:00

  • Distinct microRNA expression signatures are associated with melanoma subtypes and are regulated by HIF1A.

    abstract::The complex genetic changes underlying metastatic melanoma need to be deciphered to develop new and effective therapeutics. Previously, genome-wide microarray analyses of human melanoma identified two reciprocal gene expression programs, including transcripts regulated by either transforming growth factor, beta 1 (TGF...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12255

    authors: Hwang HW,Baxter LL,Loftus SK,Cronin JC,Trivedi NS,Borate B,Pavan WJ

    更新日期:2014-09-01 00:00:00

  • High frequency of PTEN mutations in nevi and melanomas from xeroderma pigmentosum patients.

    abstract::We examined nevi and melanomas in 10 xeroderma pigmentosum (XP) patients with defective DNA repair. The lesions had a lentiginous appearance with markedly increased numbers of melanocytes. Using laser capture microdissection, we performed DNA sequencing of 18 benign and atypical nevi and 75 melanomas (melanoma in situ...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12226

    authors: Masaki T,Wang Y,DiGiovanna JJ,Khan SG,Raffeld M,Beltaifa S,Hornyak TJ,Darling TN,Lee CC,Kraemer KH

    更新日期:2014-05-01 00:00:00

  • Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors.

    abstract::BRAF inhibitors improve melanoma patient survival, but resistance invariably develops. Here we report the discovery of a novel BRAF mutation that confers resistance to PLX4032 employing whole-exome sequencing of drug-resistant BRAF(V600K) melanoma cells. We further describe a new screening approach, a genome-wide pigg...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12197

    authors: Choi J,Landrette SF,Wang T,Evans P,Bacchiocchi A,Bjornson R,Cheng E,Stiegler AL,Gathiaka S,Acevedo O,Boggon TJ,Krauthammer M,Halaban R,Xu T

    更新日期:2014-03-01 00:00:00

  • Genetic variation in regulatory DNA elements: the case of OCA2 transcriptional regulation.

    abstract::Mutations within the OCA2 gene or the complete absence of the OCA2 protein leads to oculocutaneous albinism type 2. The OCA2 protein plays a central role in melanosome biogenesis, and it is a strong determinant of the eumelanin content in melanocytes. Transcript levels of the OCA2 gene are strongly correlated with pig...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章,评审

    doi:10.1111/pcmr.12210

    authors: Visser M,Kayser M,Grosveld F,Palstra RJ

    更新日期:2014-03-01 00:00:00

  • Increasing the complexity: new genes and new types of albinism.

    abstract::Albinism is a rare genetic condition globally characterized by a number of specific deficits in the visual system, resulting in poor vision, in association with a variable hypopigmentation phenotype. This lack or reduction in pigment might affect the eyes, skin, and hair (oculocutaneous albinism, OCA), or only the eye...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章,评审

    doi:10.1111/pcmr.12167

    authors: Montoliu L,Grønskov K,Wei AH,Martínez-García M,Fernández A,Arveiler B,Morice-Picard F,Riazuddin S,Suzuki T,Ahmed ZM,Rosenberg T,Li W

    更新日期:2014-01-01 00:00:00

  • High-resolution array-CGH in patients with oculocutaneous albinism identifies new deletions of the TYR, OCA2, and SLC45A2 genes and a complex rearrangement of the OCA2 gene.

    abstract::Oculocutaneous albinism (OCA) is caused by mutations in six different genes, and their molecular diagnosis encompasses the search for point mutations and intragenic rearrangements. Here, we used high-resolution array-comparative genome hybridization (CGH) to search for rearrangements across exons, introns and regulato...

    journal_title:Pigment cell & melanoma research

    pub_type: 临床试验,杂志文章

    doi:10.1111/pcmr.12173

    authors: Morice-Picard F,Lasseaux E,Cailley D,Gros A,Toutain J,Plaisant C,Simon D,François S,Gilbert-Dussardier B,Kaplan J,Rooryck C,Lacombe D,Arveiler B

    更新日期:2014-01-01 00:00:00

  • T-type calcium channel blockers inhibit autophagy and promote apoptosis of malignant melanoma cells.

    abstract::We have recently reported that human melanoma cells express a variety of voltage-gated calcium (Ca(2+) ) channel types, including low-voltage-activated T-type channels that play a significant role in melanoma cell cycle progression. Here, we challenged melanoma metastatic cells with T-type channel blockers of clinical...

    journal_title:Pigment cell & melanoma research

    pub_type: 杂志文章

    doi:10.1111/pcmr.12155

    authors: Das A,Pushparaj C,Herreros J,Nager M,Vilella R,Portero M,Pamplona R,Matias-Guiu X,Martí RM,Cantí C

    更新日期:2013-11-01 00:00:00

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