abstract：BACKGROUND:The epidemiology of congenital infections is ever changing, with a recent resurgence in syphilis infection rates seen in the UK. Identification of congenital infection is often delayed; early recognition and management of congenital infections is important. Testing modalities and investigations are often lim...

journal_title：Archives of disease in childhood

authors： Penner J,Hernstadt H,Burns JE,Randell P,Lyall H

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Achondroplasia is associated with foramen magnum stenosis (FMS) and significant risk of morbidity and sudden death in infants. A sensitive and reliable method of detecting infants who require decompressive surgery is required. This study aims to describe the incidence and severity of FMS in an unselected, se...

journal_title：Archives of disease in childhood

authors： Cheung MS,Irving M,Cocca A,Santos R,Shaunak M,Dougherty H,Siddiqui A,Gringras P,Thompson D

更新日期：2021-02-01 00:00:00

abstract：PURPOSE:To estimate the minimum incidence of congenital Zika syndrome (CZS) and severe microcephaly in Canada and describe key clinical, epidemiological, aetiological and outcome features of these conditions. METHODS:Two separate national surveillance studies were conducted on CZS and severe microcephaly using the wel...

journal_title：Archives of disease in childhood

authors： Morris SK,Farrar DS,Miller SP,Ofner M,Bitnun A,Nelson CRM,Shevell M,Moore AM,Tataryn J,Evans JA,Zipursky AR,Moore Hepburn C

更新日期：2021-01-08 00:00:00

abstract：INTRODUCTION:UK screening for congenital hypothyroidism (CH) is based on dried blood spot Thyroid Stimulating Hormone (TSH). Scintigraphy may identify CH subtypes classified as dysplasia, gland in situ (GIS) and ectopia, but is not performed in all centres. We retrospectively investigated the role of scintigraphy to id...

journal_title：Archives of disease in childhood

authors： Worth C,Hird B,Tetlow L,Wright N,Patel L,Banerjee I

更新日期：2021-01-01 00:00:00

abstract：:Better understanding of the proportion of children who ever receive special educational needs (SEN) provision or social care services during school years is highly relevant for healthcare as reductions in one or more of these services could impact on healthcare. Using the National Pupil Database linked to the all-of-E...

journal_title：Archives of disease in childhood

authors： Jay MA,Gilbert R

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:Anaphylaxis is a severe, potentially fatal allergic reaction best treated with intramuscular epinephrine via epinephrine auto-injectors (AAIs). Our published concerns over laceration injuries to young children associated with AAIs led to this service evaluation of the two administration methods: swing and jab...

journal_title：Archives of disease in childhood

authors： Pike LC,Tuthill D

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:Use next-generation sequencing (NGS) technology to improve our diagnostic yield in patients with suspected genetic disorders in the Asian setting. DESIGN:A diagnostic study conducted between 2014 and 2019 (and ongoing) under the Singapore Undiagnosed Disease Program. Date of last analysis was 1 July 2019. S...

journal_title：Archives of disease in childhood

authors： Bhatia NS,Lim JY,Bonnard C,Kuan JL,Brett M,Wei H,Cham B,Chin H,Bosso-Lefevre C,Dharuman P,Escande-Beillard N,Devasia AG,Goh CYJ,Kam S,Liew WK,Liew WK,Lin G,Jain K,Ng AY,Subramanian D,Xie M,Tan YM,Tawari NR,T

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:To establish the relationship between serum point-of-care (POC) ketones at triage and moderate-to-severe dehydration based on the validated Gorelick Scales. DESIGN, SETTING AND PATIENTS:Prospective unblinded study from April 2016 to February 2017 in a paediatric emergency department. Patients aged 1 month to...

journal_title：Archives of disease in childhood

authors： Durnin S,Jones J,Ryan E,Howard R,Walsh S,Dawkins I,Blackburn C,O'Donnell SM,Barrett MJ

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVES:To understand the experiences and perceptions of healthcare services of children with life-limiting and life-threatening conditions and their family members, including palliative care. DESIGN:Longitudinal qualitative interview study with children and their family members. Up to three in-depth interviews wer...

journal_title：Archives of disease in childhood

authors： Mitchell S,Slowther AM,Coad J,Dale J

更新日期：2020-11-16 00:00:00

abstract：OBJECTIVE:Early diagnosis and treatment initiation are important factors for successful treatment of mucopolysaccharidosis type I (MPS I). The purpose of this observational study was to assess whether age at diagnosis and time to first treatment for individuals with MPS I have improved over the last 15 years. STUDY DE...

journal_title：Archives of disease in childhood

authors： Giugliani R,Muschol N,Keenan HA,Dant M,Muenzer J

更新日期：2020-11-02 00:00:00

abstract：OBJECTIVE:To examine the prevalence of dysnatraemias among children admitted for paediatric surgery before and after a change from hypotonic to isotonic intravenous maintenance fluid therapy. DESIGN:Retrospective consecutive time series intervention study. SETTING:Paediatric surgery ward at the Children's Hospital in...

journal_title：Archives of disease in childhood

authors： Chromek M,Jungner Å,Rudolfson N,Ley D,Bockenhauer D,Hagander L

更新日期：2020-10-28 00:00:00

abstract：OBJECTIVE:To determine if administration of oral prednisolone to preschool children with acute wheeze alters respiratory outcomes. DESIGN:Double-blind, randomised, placebo-controlled equivalence trial. SETTING:Three hospitals in New Zealand. PATIENTS:477 children aged 24-59 months with acute wheeze associated with r...

journal_title：Archives of disease in childhood

authors： Wallace A,Sinclair O,Shepherd M,Neutze J,Trenholme A,Tan E,Brabyn C,Bonisch M,Grey N,Johnson DW,McNamara D,Thompson JMD,Asher I,Dalziel SR

更新日期：2020-10-16 00:00:00

abstract：OBJECTIVES:Describe cases of female genital mutilation (FGM) presenting to consultant paediatricians and sexual assault referral centres (SARCs), including demographics, medical symptoms, examination findings and outcome. DESIGN:The well-established epidemiological surveillance study performed through the British Paed...

journal_title：Archives of disease in childhood

authors： Hodes D,Ayadi O'Donnell N,Pall K,Leoni M,Lok W,Debelle G,Armitage AJ,Creighton SM,Lynn RM

更新日期：2020-10-06 00:00:00

abstract：BACKGROUND:The primary aim was to evaluate the efficacy of financial incentives for reducing paediatric tobacco smoke exposures (TSEs) through motivating cigarette usage reduction among low-income maternal caregivers and members of their social network. DESIGN:Randomised control pilot trial over a 6-month study follow...

journal_title：Archives of disease in childhood

authors： Jassal MS,Lewis-Land C,Thompson RE,Butz A

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:To determine the incidence, demography and prognosis of vitamin D deficiency dilated cardiomyopathy (DCM) in Scotland over the last decade. STUDY DESIGN:A retrospective review of cases of vitamin D deficiency DCM presenting to a national paediatric cardiac centre between 1 January 2008 and 1 January 2018. Th...

journal_title：Archives of disease in childhood

authors： Hunter L,Ferguson R,McDevitt H

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Recent research in febrile neutropaenia (FN) has focused on reducing the intensity of treatment for those thought to be at low risk of significant morbidity or mortality. This has not led to a reduced burden of treatment for either families or healthcare systems. An alternative approach is to discharge all p...

journal_title：Archives of disease in childhood

authors： Seneviratne N,Yeomanson D,Phillips R

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:Infections with multidrug-resistant organisms (MDROs) such as Gram-negative bacteria have high morbidity and mortality with limited treatment options. Colistin, an antibiotic active against MDRO, was rarely used due to frequent adverse effects, but its use has now been recommended among adults. In this study,...

journal_title：Archives of disease in childhood

authors： Ambreen G,Salat MS,Hussain K,Raza SS,Ali U,Azam I,Iqbal J,Fatmi Z

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Our current understanding regarding the aetiology of infantile acute liver failure largely derives from studies conducted by regional liver units. This may introduce selection bias and therefore not provide a true reflection of the wider population. METHODS:Every coagulation screen with a prothrombin time ≥...

journal_title：Archives of disease in childhood

authors： Wands D,Tayler R,Kelly D,Pinto F,Simpson JH,Hansen R

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:Due to lack of information on drug use in children, many drugs are used off-label in paediatrics. Increased knowledge of adverse drug reactions (ADRs) would enable a better risk-benefit analysis. Our aim was to characterise drugs causing psychiatric ADRs in children by conducting a descriptive study based on ...

journal_title：Archives of disease in childhood

authors： Ekhart C,Vries T,Hunsel FV

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:To investigate the mental health of children and adolescents admitted to neonatal intensive/special care units (NICUs) in infancy. METHODS:This cross-sectional study used a provincially representative cohort from the 2014 Ontario Child Health Study. Parents provided data on psychiatric disorders using the MI...

journal_title：Archives of disease in childhood

authors： Chiorean A,Savoy C,Beattie K,El Helou S,Silmi M,Van Lieshout RJ

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVE:Adherence to attention-deficit/hyperactivity disorder (ADHD) medication treatment is often suboptimal. This can compromise patient outcomes. We aimed to describe the patterns of ADHD medication use in Australian children, and characteristics associated with patterns of use. DESIGN:Dispensing data were analys...

journal_title：Archives of disease in childhood

authors： Efron D,Mulraney M,Sciberras E,Hiscock H,Hearps S,Coghill D

更新日期：2020-06-01 00:00:00

abstract：:Advances in paediatric care mean that more children with complex medical problems (heart disease, neurodevelopmental problems and so on) are surviving their early years. This has important implications for the design and delivery of healthcare given their extensive multidisciplinary requirements and susceptibility to ...

journal_title：Archives of disease in childhood

authors： Aitchison K,McGeown H,Holden B,Watson M,Klaber RE,Hargreaves D

更新日期：2020-05-13 00:00:00

abstract：AIM:To describe the nature and causes of reported patient safety incidents relating to care in the community for children dependent on long-term ventilation with the further aim of improving safety. METHODS:We undertook an analysis of patient safety incident data relating to long-term ventilation in the community usin...

journal_title：Archives of disease in childhood

authors： Nawaz RF,Page B,Harrop E,Vincent CA

更新日期：2020-05-01 00:00:00

abstract：INTRODUCTION:Fetal anticonvulsant syndrome (FACS) describes the pattern of physical and developmental problems seen in those children exposed to certain antiepileptic drugs (AEDs) in utero. The diagnosis of FACS is a clinical one and so excluding alternative diagnoses such as genetic disorders is essential. METHODS:We...

journal_title：Archives of disease in childhood

authors： Jackson A,Ward H,Bromley RL,Deshpande C,Vasudevan P,Scurr I,Dean J,Shannon N,Berg J,Holder S,Baralle D,Clayton-Smith J,DDD Study.

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:To assess differences across educational outcomes in survivors of childhood cancer (CCS) compared with peers. DESIGN:Systematic review and meta-analysis of observational studies. DATA SOURCES AND STUDY SELECTION:Medline, EMBASE, ERIC, CINAHL and PsycInfo from inception to 1st August 2018. Any peer reviewed,...

journal_title：Archives of disease in childhood

authors： Saatci D,Thomas A,Botting B,Sutcliffe AG

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:The National Institute for Health and Care Excellence (NICE) guidance for referral of children with suspected cancer was first published in 2005 and updated in 2015. The updated version relied on sparse primary care evidence and published without input from key stakeholders, for example, acute general paedia...

journal_title：Archives of disease in childhood

authors： Murray MJ,Ruffle A,Lowis S,Howell L,Shanmugavadivel D,Dommett R,Gamble A,Shenton G,Nicholson J

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:To provide the first estimate of the cost-effectiveness of financial incentive for breastfeeding intervention compared with usual care. DESIGN:Within-cluster ('ward'-level) randomised controlled trial cost-effectiveness analysis (trial registration number ISRCTN44898617). SETTING:Five local authority distri...

journal_title：Archives of disease in childhood

authors： Anokye N,Coyle K,Relton C,Walters S,Strong M,Fox-Rushby J

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:To ascertain the relationship between prelacteal feeding, early formula feeding and adverse health outcomes, especially hospitalisation during the first year of life. DESIGN:Multicentre prospective cohort study. SETTING:Six hospitals across three cities in Vietnam. PATIENTS:A total of 2030 pregnant women w...

journal_title：Archives of disease in childhood

authors： Nguyen P,Binns CW,Ha AVV,Chu TK,Nguyen LC,Duong DV,Do DV,Lee AH

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:Urolithiasis in renal transplant (RTx) recipients is a potential cause of allograft loss if obstruction is untreated. It is not clear if paediatric transplant recipients are following the global trend for increased prevalence of urolithiasis over time. DESIGN/SETTING/PATIENTS:A retrospective chart review was...

journal_title：Archives of disease in childhood

authors： Ma S,Taher A,Zhu B,Durkan AM

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:To develop waist circumference (WC) centile curves for UK South Asian children, to make comparisons with published centiles for British, indigenous Indian and Pakistani children, as well as to make anthropometric comparisons with their UK white peers. DESIGN:Cross-sectional study. SETTING:School-aged child...

journal_title：Archives of disease in childhood

authors： Shah M,Radia D,McCarthy HD

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Paediatric early warning scores (PEWS) are widely used as an adjunct to support staff in recognising deterioration in hospitalised children. Relatively little is known about how staff use these systems. OBJECTIVE:To examine the completeness and accuracy of PEWS recording in hospitalised children in a tertia...

journal_title：Archives of disease in childhood

authors： Chapman SM,Oulton K,Peters MJ,Wray J

更新日期：2019-12-01 00:00:00

abstract：:The utility of point-of-care lung ultrasound in neonatology is rapidly expanding. This review summarises current evidence of a diagnostic, procedural and observational tool valuable in the management of newborns requiring intensive care. Approaching a patient, probe in-hand with focused clinical question is essential,...

journal_title：Archives of disease in childhood

authors： Woods PL

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between ethnicity and health outcomes among fetuses and infants with congenital left heart obstruction (LHO). DESIGN:A retrospective population-based review was conducted of fetuses and infants with LHO including all terminations, stillbirths and live births from 20 weeks' ges...

journal_title：Archives of disease in childhood

authors： Cloete E,Sadler L,Bloomfield FH,Crengle S,Percival T,Gentles TL

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:Despite decreasing mortality, functional impairments in children with transposition of the great arteries (TGA) are still a concern. This study analyses health-related physical fitness (HRPF), arterial stiffness and health-related quality of life (HRQoL) in children with anatomically repaired TGA regarding co...

journal_title：Archives of disease in childhood

authors： Häcker AL,Reiner B,Oberhoffer R,Hager A,Ewert P,Müller J

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Studies on adolescent drug use are scarce as most studies do not distinguish between children and adolescents. Therefore, we assessed overall drug use in adolescents. METHODS:A retrospective cohort study was conducted using pharmacy dispensing records from 62 community pharmacies in the Netherlands. Dispens...

journal_title：Archives of disease in childhood

authors： Kosse RC,Koster ES,de Vries TW,Bouvy ML

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the views of young people (YP) with gender dysphoria and their parents concerning fertility preservation and reproductive and life priorities. DESIGN:A cross-sectional questionnaire-based study assessed knowledge of potential effects of treatments for gender dysphoria...

journal_title：Archives of disease in childhood

authors： Chiniara LN,Viner C,Palmert M,Bonifacio H

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:The evidence base to guide the pharmacological management of tone and abnormal movements in cerebral palsy (CP) is limited, as is an understanding of routine clinical practice in the UK. We aimed to establish details of motor phenotype and current pharmacological management of a representative cohort across ...

journal_title：Archives of disease in childhood

authors： Lumsden DE,Crowe B,Basu A,Amin S,Devlin A,DeAlwis Y,Kumar R,Lodh R,Lundy CT,Mordekar SR,Smith M,Cadwgan J

更新日期：2019-08-01 00:00:00

abstract：INTRODUCTION:Despite immunisation, antibiotics and intensive care management, infection with Streptococcus pneumoniae remains a major cause of morbidity and mortality in children. The WHO currently recommends vaccinating infants with either a 3+0 schedule (6 weeks, 3-4 and 4-6 months of age) or 2+1 schedule (2 doses be...

journal_title：Archives of disease in childhood

authors： Zimmermann P,Perrett KP,Berbers G,Curtis N

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:Inconsistencies have been reported in health-related quality of life (HRQOL) in postoperative congenital heart disease (CHD). Despite the need for lifelong care due for residual symptoms, only a few studies have explored cardiac-related HRQOL but none in lower middle-income countries (LMIC). This study theref...

journal_title：Archives of disease in childhood

authors： Ladak LA,Hasan BS,Gullick J,Awais K,Abdullah A,Gallagher R

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:We assessed whether maternal mental health problems increased rates for child injury during the preschool years and mid-childhood, and the extent to which associations could be accounted for by a range of potential explanatory factors. DESIGN:We analysed the UK Millennium Cohort Study, a nationally represent...

journal_title：Archives of disease in childhood

authors： Hope S,Deighton J,Micali N,Law C

更新日期：2019-03-01 00:00:00