Infantile acute liver failure in the West of Scotland.

Abstract:

BACKGROUND:Our current understanding regarding the aetiology of infantile acute liver failure largely derives from studies conducted by regional liver units. This may introduce selection bias and therefore not provide a true reflection of the wider population. METHODS:Every coagulation screen with a prothrombin time ≥18 s in our centre was examined over one calendar year. All patients less than 1 year of age were included and their electronic records retrospectively reviewed. RESULTS:24 patients were identified, from 9989 coagulation screens, that fit the current definition of acute liver failure. Hypoxic birth injury and ischaemic events were the most common aetiologies. Survival was 75%. CONCLUSION:The 'catch-all' methodology employed demonstrated that acute liver failure is more common than previously reported and suggests that current data may exclude large numbers who either have more minor self-resolving disease or conversely have severe disease leading to death prior to transfer.

journal_name

Arch Dis Child

authors

Wands D,Tayler R,Kelly D,Pinto F,Simpson JH,Hansen R

doi

10.1136/archdischild-2019-317360

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

794-796

issue

8

eissn

0003-9888

issn

1468-2044

pii

archdischild-2019-317360

journal_volume

105

pub_type

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