abstract：:The initial precipitating injury such as SE progresses to chronic epilepsy through multiple epileptogenic processes. Early epileptogenic events are generally characterized by neuroinflammation, neurodegeneration and abnormal neurogenesis in the hippocampus. Metformin has exhibited anti-inflammatory and neuroprotective...

journal_title：Inflammopharmacology

authors： Bojja SL,Medhi B,Anand S,Bhatia A,Joshi R,Minz RW

更新日期：2021-01-01 00:00:00

abstract：:The aim of this study was to determine whether ethanol extracts of Etlingera pavieana rhizomes (EPE) can inhibit the expression of ICAM-1 and VCAM-1 in TNF-α-stimulated human vascular endothelial cells. EPE significantly reduced ICAM-1 and VCAM-1 expression in a concentration-dependent manner. EPE also suppressed phos...

journal_title：Inflammopharmacology

authors： Srisook K,Potiprasart K,Sarapusit S,Park CS,Srisook E

更新日期：2020-12-01 00:00:00

abstract：:Centella asiatica is claimed to have a neuroprotective effect; however, its ability to protect the cerebrum against damage in diabetes has never been identified. The aims were to identify the possibility that C. asiatica ameliorates inflammation, oxidative stress, and apoptosis in the cerebrum in diabetes. C. asiatica...

journal_title：Inflammopharmacology

authors： Giribabu N,Karim K,Kilari EK,Nelli SR,Salleh N

更新日期：2020-12-01 00:00:00

abstract：:Gout, the most prevalent inflammatory arthritis worldwide, released interleukin-1β (IL-1β) and Cathepsin B inflammatory mediators that constitute the hallmark of the disease. Herein we aimed to investigate whether procyanidin B2 (PCB2), a natural dietary compound, can suppress MSU crystals-stimulated gouty inflammatio...

journal_title：Inflammopharmacology

authors： Qiao CY,Li Y,Shang Y,Jiang M,Liu J,Zhan ZY,Ye H,Lin YC,Jiao JY,Sun RH,Zhang ZH,Piao MH,Wu YL,Nan JX,Lian LH

更新日期：2020-12-01 00:00:00

abstract：:R-phenylpiracetam (R-PhP, (4R)-2-(4-phenyl-2-oxopyrrolidin-1-yl)acetamide) is an optical isomer of phenotropil, a clinically-used nootropic drug that improves physical condition and cognition. Recently, R-PhP was shown to bind to the dopamine transporter (DAT). Since growing evidence suggests that dysfunction of the d...

journal_title：Inflammopharmacology

authors： Zvejniece L,Zvejniece B,Videja M,Stelfa G,Vavers E,Grinberga S,Svalbe B,Dambrova M

更新日期：2020-10-01 00:00:00

abstract：:The therapeutic efficacy of the contemporary anti-inflammatory drugs are well established; however, prolonged use of such can often lead to serious and life-threatening side effects. Natural product-based anti-inflammatory compounds with superior efficacy and minimum toxicity can serve as possible therapeutic alternat...

journal_title：Inflammopharmacology

authors： Jalil J,Attiq A,Hui CC,Yao LJ,Zakaria NA

更新日期：2020-10-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease, which is characterized by a chronic fluctuating course and immune dysfunction, resulting in affecting the health and life quality of RA patients. Methotrexate (MTX), as the standard gold treatment of RA, has received more and more clinical applications and ba...

journal_title：Inflammopharmacology

authors： Yu J,Zhou P

更新日期：2020-10-01 00:00:00

abstract：:Nicotine mediates some of the injurious effects caused by consuming tobacco products. The aim of this work is to investigate the protective effects of Mentha spicata extract (ME) supplementation on the testis and brain of nicotine-induced oxidative damage rats. ME extract showed interesting hydrogen peroxide-scavengin...

journal_title：Inflammopharmacology

authors： Saad AB,Rjeibi I,Brahmi N,Elaloui E,Zouari N

更新日期：2020-08-01 00:00:00

abstract：INTRODUCTION:Retinoic Acid Related Orphan Nuclear Receptor gamma T (RORγT) is a lineage specifying transcription factor for IL-17 expressing cells, which may contribute to the pathogenesis of Inflammatory Bowel Disease (IBD). VPR-254 is a selective in vitro inhibitor of RORγT. AIMS:The main goals of our study were two...

journal_title：Inflammopharmacology

authors： Fitzpatrick LR,Small J,O'Connell R,Talbott G,Alton G,Zapf J

更新日期：2020-04-01 00:00:00

abstract：:Alzheimer's disease (AD) is prevalent in old age people and is one of the most common brain diseases. Brain insulin resistance, neuroinflammation, oxidative stress, and mitochondrial and cholinergic dysfunction are key features of the disease. In our study, streptozotocin (STZ) in a dose of 3 mg/kg was injected in mal...

journal_title：Inflammopharmacology

authors： Akhtar A,Dhaliwal J,Saroj P,Uniyal A,Bishnoi M,Sah SP

更新日期：2020-04-01 00:00:00

abstract：:Tovophyllin A (TA) is a xanthone isolated from Garcinia mangostana L. (GM, Guttiferae) pericarps that possesses various beneficial bioactivities. However, its protective effects on acute lung injury (ALI) and lung carcinoma have not yet been explored. The current work was designed to investigate the protective potenti...

journal_title：Inflammopharmacology

authors： El-Agamy DS,Mohamed GA,Ahmed N,Elkablawy MA,Elfaky MA,Elsaed WM,Mohamed SGA,Ibrahim SRM

更新日期：2020-02-01 00:00:00

abstract：:Some B vitamins exhibit activities in models of nociceptive pain, inflammatory pain, and neuropathic pain induced by nerve lesions and also in certain painful conditions in humans. In the present study, we investigated the effects of thiamine, riboflavin, and nicotinamide in a neuropathic pain model induced by the che...

journal_title：Inflammopharmacology

authors： Braga AV,Costa SOAM,Rodrigues FF,Melo ISF,Morais MI,Coelho MM,Machado RR

更新日期：2020-02-01 00:00:00

abstract：:Acute lung injury (ALI) and acute kidney injury (AKI) are major causes of sepsis-induced mortality. The objective of the study is to evaluate the effect of tocilizumab (TCZ), an IL-6 receptor inhibitor, in sepsis-induced ALI and AKI using the cecal ligation and puncture (CLP) rat model of sepsis. Clinical and experime...

journal_title：Inflammopharmacology

authors： Ibrahim YF,Moussa RA,Bayoumi AMA,Ahmed AF

更新日期：2020-02-01 00:00:00

abstract：:Rhynchosia minima root, a folk herbal medicine in southern China, is used to relieve itch and swelling. In this study, we examined the anti-inflammatory property of an ethanol fraction (EEF6) from R. minima root on lipopolysaccharide (LPS)-induced RAW 264.7 cells, as well as its underlying mechanism. The compound comp...

journal_title：Inflammopharmacology

authors： Jia X,Zhang C,Bao J,Wang K,Tu Y,Wan JB,He C

更新日期：2020-02-01 00:00:00

abstract：:Bioactivity-guided investigation of the methanol extract of Crepis sancta aerial parts, collected off Al-Tafilah, South Jordan, was applied, and in this study, the extract was explored for its phytochemical components and in vivo antiulcer activity. In addition, a docking study involving the purified compounds with th...

journal_title：Inflammopharmacology

authors： Ebada SS,Al-Jawabri NA,Youssef FS,Albohy A,Aldalaien SM,Disi AM,Proksch P

更新日期：2020-02-01 00:00:00

abstract：:P38 mitogen-activated protein kinase (p38 MAPK), a tissue inflammatory factor can be activated under oxidative stress and in conditions associated with hyperglycemia. Gingerol containing various natural herbs has been extensively studied for its pharmacological actions both in reducing the inflammation and as immunity...

journal_title：Inflammopharmacology

authors： Song S,Dang M,Kumar M

更新日期：2019-12-01 00:00:00

abstract：:Previous reports suggest flavonoids as potent analgesic compounds. Based on these observations, the present study investigated the antinociceptive action of flavonol, 3', 4'-dimethoxy flavonol, 6, 3'-dimethoxy flavonol, 7, 2'-dimethoxy flavonol, and 7, 3'-dimethoxy flavonol and the possible mechanisms involved in thes...

journal_title：Inflammopharmacology

authors： Sayeli V,Nadipelly J,Kadhirvelu P,Cheriyan BV,Shanmugasundaram J,Subramanian V

更新日期：2019-12-01 00:00:00

abstract：AIM:The aim of the present study was to evaluate the anti-inflammatory effect of thymol in acetic acid-induced rat colitis through inhibiting the NF-κB signaling pathway. METHODS:Colitis was induced by intra-rectal administration of 2 mL of diluted acetic acid (4%) solution using a flexible plastic rubber catheter in ...

journal_title：Inflammopharmacology

authors： Chamanara M,Abdollahi A,Rezayat SM,Ghazi-Khansari M,Dehpour A,Nassireslami E,Rashidian A

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Osthole is a bioactive component reported in medicinal plants such as Angelica pubescens and Cnidium monnieri, known for analgesic activity. However, the toxicity, median effective dose (ED50), and dual modulation of nitric oxide and cyclooxygenase pathways along with inflammatory cytokines of osthole are ye...

journal_title：Inflammopharmacology

authors： Singh G,Bhatti R,Mannan R,Singh D,Kesavan A,Singh P

更新日期：2019-10-01 00:00:00

abstract：:Propolis has been extensively used to improve health and prevent inflammatory diseases. Different types of Cuban propolis (red, brown and yellow) have been documented. The purpose of this research was to investigate the cytotoxic effects of Cuban red propolis (CP) on MDA MB-231 cell line, since breast cancer is consid...

journal_title：Inflammopharmacology

authors： Frión-Herrera Y,Díaz-García A,Ruiz-Fuentes J,Rodríguez-Sánchez H,Sforcin JM

更新日期：2019-10-01 00:00:00

abstract：:Colorectal cancer (CRC) remains the most cancer type related to chronic inflammation; however, the mechanisms that link inflammation to CRC development and progression are still poorly understood. Our study aimed to investigate one of the prominent inflammatory response in cancers, iNOS/NO system. In this regard, we e...

journal_title：Inflammopharmacology

authors： Benkhelifa S,Rafa H,Belhadef S,Ait-Kaci H,Medjeber O,Belkhelfa M,Hetit S,Ait-Younes S,De Launoit Y,Moralès O,Mahfouf H,Delhem N,Touil-Boukoffa C

更新日期：2019-08-01 00:00:00

abstract：:The Maytenus genus is a member of the Celastraceae family. Numerous medicinal uses were assigned to species of this genus, with the use of roots, bark, and leaves for the treatment of gastric ulcers, as anti-inflammatory, analgesic, antiallergic, antitumor, among others. Several studies have demonstrated that natural ...

journal_title：Inflammopharmacology

authors： Veloso CC,Oliveira MC,Rodrigues VG,Oliveira CC,Duarte LP,Teixeira MM,Ferreira AVM,Perez AC

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:The role of angiotensin converting enzyme inhibitors on the inflammation process has been demonstrated previously. In the present study, the effects of captopril on lung injury induced by lipopolysaccharide (LPS) were investigated. METHODS:Control, LPS, 12.5, 25 and 50 mg/kg captopril-treated before LPS adm...

journal_title：Inflammopharmacology

authors： Boskabadi J,Askari VR,Hosseini M,Boskabady MH

更新日期：2019-06-01 00:00:00

abstract：:Tumour necrosis factor (TNF) and kinins have been associated with neuropathic pain-like behaviour in numerous animal models. However, the way that they interact to cause neuron sensitisation remains unclear. This study assessed the interaction of kinin receptors and TNF receptor TNFR1/p55 in mechanical hypersensitivit...

journal_title：Inflammopharmacology

authors： Quintão NLM,Rocha LW,da Silva GF,Paszcuk AF,Manjavachi MN,Bento AF,da Silva KABS,Campos MM,Calixto JB

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:There is considerable interest in the possible importance of the gut microflora in the pathophysiology of the inflammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn's disease (CD). Probiotics offer a potential adjuvant treatment in these patients by modifying the intestinal milieu, but reports o...

journal_title：Inflammopharmacology

authors： Bjarnason I,Sission G,Hayee B

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:The present study aimed to evaluate the anti-inflammatory and analgesic activities of the ginsenoside metabolite compound K (CK) and its mechanisms. METHODS:Mice model of xylene-induced ear swelling and rat model of carrageenan-induced paw swelling were used to evaluate the effect of CK on acute inflammation...

journal_title：Inflammopharmacology

authors： Chen J,Si M,Wang Y,Liu L,Zhang Y,Zhou A,Wei W

更新日期：2019-02-01 00:00:00

abstract：:Triptolide has been widely reported to exhibit potential therapeutic value in multiple inflammatory diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and psoriasis. Although its safety and efficacy as an anti-inflammatory agent have been verified by many studies, the effect of triptolide on osteoar...

journal_title：Inflammopharmacology

authors： Qian K,Zhang L,Shi K

更新日期：2019-02-01 00:00:00

abstract：:The authors would like to inform you that Jie Yu and Haimei Lu contributed equally to this study and should be considered as co-first authors. ...

journal_title：Inflammopharmacology

authors： Yu J,Lu H,Zhou J,Xie Z,Wen C,Xu Z

更新日期：2019-02-01 00:00:00

abstract：:Stress is a reflex response, both psychological and physiological, of the body to a difficult situation that requires adaptation. Stress is at the intersection of the objective event and the subjective event. The physiological mechanisms involved in chronic stress are numerous and can contribute to a wide variety of d...

journal_title：Inflammopharmacology

authors： Nessaibia I,Fouache A,Lobaccaro JA,Tahraoui A,Trousson A,Souidi M

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Resveratrol exerts an anti-inflammatory effect on collagen-induced arthritis and osteoarthritis in rats via activation of sirtuin 1 (SIRT1). Autophagy can be induced by resveratrol and leads to amelioration of interleukin-1 beta (IL-1β) release in vitro. We aimed to determine the anti-inflammatory mechanisms...

journal_title：Inflammopharmacology

authors： Yang QB,He YL,Zhong XW,Xie WG,Zhou JG

更新日期：2019-02-01 00:00:00

abstract：:The present investigation assessed the potential of Prunus cerasoides fruit extract (PCFE) in alleviation of inflammatory stress in response to lipopolysaccharide (LPS) and interferon-γ (IFN-γ)-stimulated murine peritoneal macrophages as well as in concanavalin A (Con A)-activated splenic lymphocytes. We observed a st...

journal_title：Inflammopharmacology

authors： Sharma A,Joshi R,Kumar S,Sharma R,Rajneesh,Padwad Y,Gupta M

更新日期：2018-12-01 00:00:00

abstract：:A series of quinazoline clubbed 1,3,5-triazine derivatives (QCT) were synthesized and evaluated for their in vitro anticancer activity against HeLa (human cervical cancer), MCF-7 (human breast cancer cell), HL-60 (human promyelocytic leukemia cell), HepG2 (human Hepatocellular carcinoma cell), and one normal cell line...

journal_title：Inflammopharmacology

authors： Pathak P,Shukla PK,Kumar V,Kumar A,Verma A

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Hydroxychloroquine (HCQ) is a widely prescribed medication to patients with systemic lupus erythematosus (SLE), with potential anti-inflammatory effects. This study was performed to investigate the efficacy of HCQ therapy by serial assessment of disease activity and serum levels of proinflammatory cytokines ...

journal_title：Inflammopharmacology

authors： Monzavi SM,Alirezaei A,Shariati-Sarabi Z,Tavakol Afshari J,Mahmoudi M,Dormanesh B,Jahandoost F,Khoshdel AR,Etemad Rezaie A

更新日期：2018-10-01 00:00:00

abstract：:Silver and silver oxides are gaining interest in medical applications for their prominent antibacterial and antimicrobial potentials. Recent studies suggest that nanosilver oxide has remarkable anti-inflammatory effects and enhances wound healing. Nevertheless, its effect on gastric ulcer has not yet been illustrated....

journal_title：Inflammopharmacology

authors： Salem NA,Wahba MA,Eisa WH,El-Shamarka M,Khalil W

更新日期：2018-08-01 00:00:00

abstract：:Methyl gallate is a gallotannin widely distributed in nature. Previous studies have demonstrated its antioxidant, anti-inflammatory, antimicrobial and anti-tumor activities. In the present study, the activity of methyl gallate on experimental models of inflammatory bowel disease has been investigated. Experimental col...

journal_title：Inflammopharmacology

authors： Anzoise ML,Basso AR,Del Mauro JS,Carranza A,Ordieres GL,Gorzalczany S

更新日期：2018-06-01 00:00:00

abstract：:The central nervous system, one of the most delicate microenvironments of the body, is protected by the blood-brain barrier regulating its homeostasis. Blood-brain barrier is a highly complex structure that tightly regulates the movement of ions of a limited number of small molecules and of an even more restricted num...

journal_title：Inflammopharmacology

authors： Nair KGS,Ramaiyan V,Sukumaran SK

更新日期：2018-06-01 00:00:00

abstract：:Pulmonary fibrosis is a result of an abnormal wound healing in lung tissue triggered by an excessive accumulation of extracellular matrix proteins, loss of tissue elasticity, and debit of ventilatory function. NKT cells are a major source of Th1 and Th2 cytokines and may be crucial in the polarization of M1/M2 macroph...

journal_title：Inflammopharmacology

authors： Grabarz F,Aguiar CF,Correa-Costa M,Braga TT,Hyane MI,Andrade-Oliveira V,Landgraf MA,Câmara NOS

更新日期：2018-04-01 00:00:00

abstract：:2-(4-phenylquinoline-2-yl)phenol derivatives (4a-l) with COX-2 enzyme inhibition, analgesic, anti-inflammatory and antipyretic potentials were executed and reported. From the in vitro COX-2 enzyme inhibition assay, compounds 4 h (IC50 0.026 µM) and 4j (IC50 0.102 µM) were found as most potent COX-2 inhibitors. Consequ...

journal_title：Inflammopharmacology

authors： Manikandan A,Ravichandran S,Sathiyanarayanan KI,Sivakumar A

更新日期：2017-12-01 00:00:00

abstract：:Mitochondria can interchange morphology due to their dynamic nature. It can exist in either fragmented disconnected arrangement or elongated interconnected mitochondrial networks due to fission and fusion, respectively. The recent studies have revealed the remarkable and unexpected insights into the physiological impa...

journal_title：Inflammopharmacology

authors： Singh S,Sharma S

更新日期：2017-08-01 00:00:00

abstract：AIM AND OBJECTIVE:6-hydroxy dopamine (6-OHDA) is a neurotoxin which on intranigral administration produces severe nigrostriatal damage with motor and cognitive deficit in animals. Curcumin (CMN) in combination with bioenhancer piperine (PP) in 6-hydroxydopamine-induced Parkinsonian rats was used to investigate the anti...

journal_title：Inflammopharmacology

authors： Singh S,Kumar P

更新日期：2017-02-01 00:00:00