Abstract：
:Triptolide has been widely reported to exhibit potential therapeutic value in multiple inflammatory diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and psoriasis. Although its safety and efficacy as an anti-inflammatory agent have been verified by many studies, the effect of triptolide on osteoarthritis (OA) was not clearly understood. In this study, we found that triptolide prevented OA development in a surgical destabilization of the medial meniscus (DMM) mouse model. In addition, triptolide inhibited both DMM-induced and LPS-induced expression of pro-inflammatory cytokines in the human monocytic cell line THP-1. Further mechanistic studies showed that the reduction of pro-inflammatory cytokines by triptolide was mediated by the upregulation of nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 (NLRP3) and downregulation of caspase-1. Finally, we identified that hsa-miR-20b, a microRNA targeting the NLRP3 gene, was downregulated by triptolide. This study provides a novel insight into the effect on triptolide in preventing OA pathogenesis.
journal_name
Inflammopharmacologyjournal_title
Inflammopharmacologyauthors
Qian K,Zhang L,Shi Kdoi
10.1007/s10787-018-0509-6subject
Has Abstractpub_date
2019-02-01 00:00:00pages
109-119issue
1eissn
0925-4692issn
1568-5608pii
10.1007/s10787-018-0509-6journal_volume
27pub_type
杂志文章abstract：OBJECTIVE AND DESIGN:The objective of this study was to investigate the leucocyte-related antiinflammatory properties of rose hip. MATERIALS AND METHODS:The effect of rose hip on a number of inflammatory parameters was evaluated using the following models: (1) The effect of rose hip extract on chemotaxis and chemilumi...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-999-0031-y
更新日期：1999-01-01 00:00:00
abstract：AIM AND OBJECTIVE:6-hydroxy dopamine (6-OHDA) is a neurotoxin which on intranigral administration produces severe nigrostriatal damage with motor and cognitive deficit in animals. Curcumin (CMN) in combination with bioenhancer piperine (PP) in 6-hydroxydopamine-induced Parkinsonian rats was used to investigate the anti...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-016-0297-9
更新日期：2017-02-01 00:00:00
abstract：:The effect of lupeol, a natural pentacyclic triterpene on ethanol-induced gastric damage in mice was evaluated. The gastroprotection was assessed by determination of changes in mean gastric lesion area, quantification of mucosal non-protein sulfhydryls (NP-SH), and characterized using drugs that influence the endogeno...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-009-0009-9
更新日期：2009-08-01 00:00:00
abstract：:Since their development and licensing no class of drug has received as much attention both in the scientific and lay press as the cyclo-oxygenase 2 (COX-2) inhibitors. These compounds, also known as coxibs, were developed as a safer alternative to traditional non-steroidal anti-inflammatory drugs (NSAIDs) due to their...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1163/156856005774415619
更新日期：2005-01-01 00:00:00
abstract：:The aim of this study was to investigate the effect of the nitric oxide donor isosorbide-5-mononitrate (5-ISMN) alone or in combination with the natural hepatoprotectant with anti-oxidant activity silymarin on the carbon tetrachloride (CCl(4))-induced hepatic injury in rats. 5-ISMN (1.8, 3.6 or 7.2 mg/kg), silymarin (...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-009-0027-7
更新日期：2010-04-01 00:00:00
abstract：:Paracetamol-induced toxicity is mainly due to the accumulation of its CYP450-mediated N-hydroxylation product - N-acetylimidoquinone. We examined cell viability, proliferation rates and intracellular calcium in PC12 cells and in a PC12 cell line transfected with cytochrome P4502E1 exposed to paracetamol. This drug had...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-998-0030-4
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND:The role of angiotensin converting enzyme inhibitors on the inflammation process has been demonstrated previously. In the present study, the effects of captopril on lung injury induced by lipopolysaccharide (LPS) were investigated. METHODS:Control, LPS, 12.5, 25 and 50 mg/kg captopril-treated before LPS adm...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0535-4
更新日期：2019-06-01 00:00:00
abstract：OBJECTIVE:The present study aimed to evaluate the anti-inflammatory and analgesic activities of the ginsenoside metabolite compound K (CK) and its mechanisms. METHODS:Mice model of xylene-induced ear swelling and rat model of carrageenan-induced paw swelling were used to evaluate the effect of CK on acute inflammation...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0504-y
更新日期：2019-02-01 00:00:00
abstract：:Stress is a reflex response, both psychological and physiological, of the body to a difficult situation that requires adaptation. Stress is at the intersection of the objective event and the subjective event. The physiological mechanisms involved in chronic stress are numerous and can contribute to a wide variety of d...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-018-0546-1
更新日期：2019-02-01 00:00:00
abstract：:Pain is recognized as a multifactorial sensory experience that is wholly unpleasant. It can vary in intensity from mild to severe and its duration can be anything from transient to persistent. Today we know so much more about the peripheral nociceptor as the primary detection apparatus for painful stimuli. We also und...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-009-0006-z
更新日期：2009-06-01 00:00:00
abstract：:Inflammatory bowel diseases are associated with reduced colonic contractility and induction of cyclooxygenase-2. In this study a possible role of cyclooxygenase-2 in and the underlying mechanism of the reduced contractility were investigated in experimental colitis. The effects of meloxicam, a cyclooxygenase-2 selecti...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-006-1507-7
更新日期：2006-03-01 00:00:00
abstract：:Tovophyllin A (TA) is a xanthone isolated from Garcinia mangostana L. (GM, Guttiferae) pericarps that possesses various beneficial bioactivities. However, its protective effects on acute lung injury (ALI) and lung carcinoma have not yet been explored. The current work was designed to investigate the protective potenti...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00609-1
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Hydroxychloroquine (HCQ) is a widely prescribed medication to patients with systemic lupus erythematosus (SLE), with potential anti-inflammatory effects. This study was performed to investigate the efficacy of HCQ therapy by serial assessment of disease activity and serum levels of proinflammatory cytokines ...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0512-y
更新日期：2018-10-01 00:00:00
abstract：:A small GTPase, Rac1, is recognized as an important modulator of the inflammatory responses to bacterial lipopolysaccharide (LPS) by affecting the processes of phospholipase C activation. The activation of Rac1 involves the exchange of GDP for GTP and is catalyzed by the guanine nucleotide exchange factors (GEFs). Her...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-015-0235-2
更新日期：2015-06-01 00:00:00
abstract：AIMS:To compare methodological aspects of the impact of different classification procedures used in three phases of a twin study examining genetic factors in the aetiopathogenesis of rheumatoid arthritis (RA). METHODS:We have previously reported the results of a study of the aetiopathogenesis of RA based on the Austra...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-998-0009-1
更新日期：1998-01-01 00:00:00
abstract：:TRP channels have been discovered as a specialized group of somatosensory neurons involved in the detection of noxious stimuli. Desensitization of TRPV1 located on dorsal root and trigeminal ganglia exhibits analgesic effect and makes it potential therapeutic target for treatment of neuropathic pain. With this backgro...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-016-0285-0
更新日期：2016-12-01 00:00:00
abstract：:The idea that microbes induce disease has steered medical research toward the discovery of antibacterial products for the prevention and treatment of microbial infections. The twentieth century saw increasing dependency on antimicrobials as mainline therapy accentuating the notion that bacterial interactions with huma...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-012-0126-8
更新日期：2012-10-01 00:00:00
abstract：:Helicobacter pylori infection, as well as NSAIDs induce oxidative stress on gastric mucosa, thereby causing mucosal damage and retarding mucosal repair. Cells can survive against chronic oxidative stress by enhancing activities of anti-oxidant enzymes, thereby protecting cells from DNA damage. Recent studies have clea...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1163/156856005774423863
更新日期：2005-01-01 00:00:00
abstract：:Silver and silver oxides are gaining interest in medical applications for their prominent antibacterial and antimicrobial potentials. Recent studies suggest that nanosilver oxide has remarkable anti-inflammatory effects and enhances wound healing. Nevertheless, its effect on gastric ulcer has not yet been illustrated....
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-017-0424-2
更新日期：2018-08-01 00:00:00
abstract：AIM:Experimental autoimmune encephalomyelitis (EAE) is a CD4(+)-mediated autoimmune pathology of the central nervous system (CNS) that is used as a model for the study of the human neuroinflammatory disease, multiple sclerosis. During the development of EAE, auto-reactive Th1 and Th17 CD4(+) T cells infiltrate the CNS ...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-015-0252-1
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVE:This pilot study aimed to determine the efficacy of acamprosate (N-acetyl homotaurine) in reducing the pathological features of experimental autoimmune encephalomyelitis (EAE) which is an animal model for multiple sclerosis (MS). BACKGROUND:The amino acid taurine has multiple biological activities including ...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-011-0097-1
更新日期：2012-02-01 00:00:00
abstract：:The inflamed mucosa in ulcerative colitis produces high amount of prostaglandin (PG) and nitric oxide (NO) through inducible enzymes: cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), respectively, implicating them as potential anti-inflammatory drug targets. COX-2 or iNOS-related treatments in diff...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-007-1603-3
更新日期：2007-10-01 00:00:00
abstract：:Pioglitazone, a specific ligand for peroxisome proliferator-activated receptor gamma (PPAR-gamma), was recently implicated in the control of inflammatory processes and in the modulation of the expression of various cytokines such as tumor necrosis factor alpha (TNF-alpha), but its role in the mechanism of gastric muco...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856005774423908
更新日期：2005-01-01 00:00:00
abstract：:The present investigation assessed the potential of Prunus cerasoides fruit extract (PCFE) in alleviation of inflammatory stress in response to lipopolysaccharide (LPS) and interferon-γ (IFN-γ)-stimulated murine peritoneal macrophages as well as in concanavalin A (Con A)-activated splenic lymphocytes. We observed a st...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0448-2
更新日期：2018-12-01 00:00:00
abstract：:Centella asiatica is claimed to have a neuroprotective effect; however, its ability to protect the cerebrum against damage in diabetes has never been identified. The aims were to identify the possibility that C. asiatica ameliorates inflammation, oxidative stress, and apoptosis in the cerebrum in diabetes. C. asiatica...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-020-00733-3
更新日期：2020-12-01 00:00:00
abstract：:Genistein is an isoflavone with oestrogenic activity that is present in a variety of soy products as a constituent of complex mixtures of bioactive compounds, whose matrix profiles play an important role in determining the overall oestrogenic bioactivity of genistein. We review data on how the profile of soy bioactive...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-008-8020-0
更新日期：2008-10-01 00:00:00
abstract：:Kerabala (CB) is a novel ayurvedic formulation used for treating various inflammatory diseases. This formulation was made from virgin coconut oil and it comprises extracts of Sida cordifolia, coconut milk and sesame oil. The current study was performed to evaluate the anti-inflammatory action of CB on carrageenan-indu...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-016-0298-8
更新日期：2017-02-01 00:00:00
abstract：:Kynurenate, a metabolite of tryptophan formed serially from kynurenine, inhibits N-methyl-D-aspartate (NMDA) receptor responses. Non-steroidal anti-inflammatory drugs (NSAIDs) may produce anti-hyperalgesic effects by altering tryptophan metabolism to increase kynurenate concentrations. We examined whether the NSAID di...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856003322315622
更新日期：2003-01-01 00:00:00
abstract：:Methyl gallate is a gallotannin widely distributed in nature. Previous studies have demonstrated its antioxidant, anti-inflammatory, antimicrobial and anti-tumor activities. In the present study, the activity of methyl gallate on experimental models of inflammatory bowel disease has been investigated. Experimental col...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-017-0412-6
更新日期：2018-06-01 00:00:00
abstract：:Euphorbia hirta L. (Euphorbiaceae) (E. hirta) is a tree locally used as a traditional medicine in Africa and Australia to treat numerous diseases such as hypertension, respiratory ailments, tumors, antipyretic, anti-inflammatory activities. In the present study, we investigated the anti-arthritic activity of fresh lea...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-012-0161-5
更新日期：2013-10-01 00:00:00
