Abstract:
BACKGROUND:There is considerable interest in the possible importance of the gut microflora in the pathophysiology of the inflammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn's disease (CD). Probiotics offer a potential adjuvant treatment in these patients by modifying the intestinal milieu, but reports of their efficacy are conflicting. AIMS:To assess the efficacy of a multi-strain probiotic (Symprove™, Symprove Ltd, Farnham, United Kingdom) in quality of life issues and intestinal inflammation in patients with asymptomatic UC and CD. METHODS:A single-centre, randomised, double-blind, placebo-controlled trial of adult patients with asymptomatic IBD. Patients received 4 weeks of treatment with the probiotic or placebo (1 ml/kg/day). The primary efficacy measure was the difference in change in the IBD Quality of Life Questionnaire results (QOL) between probiotic vs. placebo at week 4. Secondary outcome measures included analyses of the change in laboratory findings, including faecal calprotectin (FCAL). RESULTS:Over 500 patients were recruited to the study and 81 and 61 patients with UC and CD, respectively were randomised and completed the study. There were no significant differences in IBD-QOL scores between placebo and the probiotic groups. Similarly, there were no significant changes observed in the laboratory data. However, the differences in FCAL between patients with UC before and after probiotics versus placebo approached statistical significance with a p value of 0.076. Post-hoc analyses showed that the FCAL levels were significantly (p < 0.015) reduced in the UC patients receiving the probiotic as opposed to placebo. No significant changes were seen in CD. No serious adverse events were observed. CONCLUSION:This multi-strain probiotic is associated with decreased intestinal inflammation in patients with UC, but not in CD and is well tolerated. Further research is required to see if the probiotic reduces the incidence of clinical relapses in asymptomatic IBD patients.
journal_name
Inflammopharmacologyjournal_title
Inflammopharmacologyauthors
Bjarnason I,Sission G,Hayee Bdoi
10.1007/s10787-019-00595-4subject
Has Abstractpub_date
2019-06-01 00:00:00pages
465-473issue
3eissn
0925-4692issn
1568-5608pii
10.1007/s10787-019-00595-4journal_volume
27pub_type
杂志文章,随机对照试验abstract::Ischemia/reperfusion (I/R) damages gastric mucosa via reactive oxygen species (ROS) activity. ROS was reportedly produced through angiotensin II stimulation in tissues such as kidney, heart and brain. To determine whether AT1 receptor plays a role in gastric mucosal damage, we examined the effect of AT1 receptor block...
journal_title:Inflammopharmacology
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journal_title:Inflammopharmacology
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pub_type: 杂志文章,评审
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更新日期:2007-06-01 00:00:00
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journal_title:Inflammopharmacology
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doi:10.1163/156856004773121383
更新日期:2004-01-01 00:00:00
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journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
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journal_title:Inflammopharmacology
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更新日期:2006-03-01 00:00:00
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journal_title:Inflammopharmacology
pub_type: 杂志文章
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更新日期:2012-02-01 00:00:00
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journal_title:Inflammopharmacology
pub_type: 杂志文章
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更新日期:2007-12-01 00:00:00
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更新日期:2019-12-01 00:00:00