Abstract：
BACKGROUND:The role of angiotensin converting enzyme inhibitors on the inflammation process has been demonstrated previously. In the present study, the effects of captopril on lung injury induced by lipopolysaccharide (LPS) were investigated. METHODS:Control, LPS, 12.5, 25 and 50 mg/kg captopril-treated before LPS administration and captopril 50 mg/kg before saline administration groups of rats were studied. Total and percentage of differential WBC, the levels of MDA, total thiol groups, the activities of SOD and CAT, the levels of IFN-γ, PGE2, TGF-β1 and IL-4 in the BALF were evaluated. RESULTS:MDA concentration in LPS groups treated with all captopril concentrations, total WBC in LPS + Cap50, percent of neutrophils in LPS + Cap25 and LPS + Cap50, levels of IFN-γ, PGE2, TGF-β1 in LPS + Cap50 and IFN-γ/IL-4 ratio in LPS + Cap25 and LPS + Cap50 were significantly decreased but total thiol groups and activity of SOD in LPS + Cap25 and LPS + Cap50, percent of lymphocyte, CAT activity and concentration of IL-4 only in LPS + Cap50 group were increased in comparison to the LPS group (p < 0.05 to p < 0.001). CONCLUSION:Captopril dose dependently improved oxidant-antioxidant biomarkers, the imbalance between pro-inflammatory and anti-inflammatory cytokines and showed specific immunomodulatory effect on Th1/Th2 balance in the BALF of lung injury induced by LPS.
journal_name
Inflammopharmacologyjournal_title
Inflammopharmacologyauthors
Boskabadi J,Askari VR,Hosseini M,Boskabady MHdoi
10.1007/s10787-018-0535-4subject
Has Abstractpub_date
2019-06-01 00:00:00pages
639-647issue
3eissn
0925-4692issn
1568-5608pii
10.1007/s10787-018-0535-4journal_volume
27pub_type
杂志文章abstract：:Caffeic acid phenethyl ester (CAPE) is the active component of honey bee propolis extracts. The results of the current study demonstrate that CAPE attenuated immunoglobulin (Ig)E-mediated allergic response in mast cells. Oral administration of CAPE inhibited IgE-mediated passive cutaneous anaphylaxis. CAPE effectively...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-012-0138-4
更新日期：2013-04-01 00:00:00
abstract：:Ischemia/reperfusion (I/R) damages gastric mucosa via reactive oxygen species (ROS) activity. ROS was reportedly produced through angiotensin II stimulation in tissues such as kidney, heart and brain. To determine whether AT1 receptor plays a role in gastric mucosal damage, we examined the effect of AT1 receptor block...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-006-1551-3
更新日期：2007-08-01 00:00:00
abstract：:Pioglitazone, a specific ligand for peroxisome proliferator-activated receptor gamma (PPAR-gamma), was recently implicated in the control of inflammatory processes and in the modulation of the expression of various cytokines such as tumor necrosis factor alpha (TNF-alpha), but its role in the mechanism of gastric muco...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856005774423908
更新日期：2005-01-01 00:00:00
abstract：:Mitochondria can interchange morphology due to their dynamic nature. It can exist in either fragmented disconnected arrangement or elongated interconnected mitochondrial networks due to fission and fusion, respectively. The recent studies have revealed the remarkable and unexpected insights into the physiological impa...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-017-0347-y
更新日期：2017-08-01 00:00:00
abstract：:Propolis is a resinous substance collected by honeybees from leaf buds and cracks in the bark of various plants. Propolis has been reported to have immunomodulatory activity. We hypothesized that propolis would be able to reduce the disease severity of rheumatoid arthritis. We evaluated the effect of Brazilian propoli...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-011-0088-2
更新日期：2012-02-01 00:00:00
abstract：:Some B vitamins exhibit activities in models of nociceptive pain, inflammatory pain, and neuropathic pain induced by nerve lesions and also in certain painful conditions in humans. In the present study, we investigated the effects of thiamine, riboflavin, and nicotinamide in a neuropathic pain model induced by the che...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00625-1
更新日期：2020-02-01 00:00:00
abstract：:Since their development and licensing no class of drug has received as much attention both in the scientific and lay press as the cyclo-oxygenase 2 (COX-2) inhibitors. These compounds, also known as coxibs, were developed as a safer alternative to traditional non-steroidal anti-inflammatory drugs (NSAIDs) due to their...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1163/156856005774415619
更新日期：2005-01-01 00:00:00
abstract：:Tumour necrosis factor (TNF) and kinins have been associated with neuropathic pain-like behaviour in numerous animal models. However, the way that they interact to cause neuron sensitisation remains unclear. This study assessed the interaction of kinin receptors and TNF receptor TNFR1/p55 in mechanical hypersensitivit...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00578-5
更新日期：2019-06-01 00:00:00
abstract：:The intestinal mucosa is subject to a variety of physical forces in a complex manner during normal gut function and in disease. Intestinal mucosal atrophy during some disease states is a troubling phenomenon that is only partially explained by nutritional parameters. Increasing evidence suggests the possibility that r...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-007-1562-8
更新日期：2007-06-01 00:00:00
abstract：:Excess eicosanoid formation during inflammation has been attributed to the expression of the gene coding for the inducible isoform of prostaglandin G/H synthase (PGHS-2). Human and murine PGHS-2 proteins differ in 73 out of the 604 amino acids. When comparing the inhibitory effects of a panel of PGHS-inhibitors in a w...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-997-0020-y
更新日期：1997-01-01 00:00:00
abstract：:In the process of the oxygen reduction, NADPH oxidase is the enzyme that produces superoxide anion, which subsequently produces reactive oxygen species (ROS) and causes damage in various tissues and microorganisms. NADPH oxidase is demonstrated to exist in several types of cells such as endothelial cells and vascular ...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-007-1587-z
更新日期：2007-12-01 00:00:00
abstract：:The side effects of NSAIDs are equally evident in the stomach and the small bowel. The latter is increasingly seen as being clinically significant, contributing substantially to the iron-deficiency anaemia that is so common in patients with rheumatoid arthritis. Furthermore, NSAID-enteropathy may be associated with li...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856003322699546
更新日期：2003-01-01 00:00:00
abstract：:The initial precipitating injury such as SE progresses to chronic epilepsy through multiple epileptogenic processes. Early epileptogenic events are generally characterized by neuroinflammation, neurodegeneration and abnormal neurogenesis in the hippocampus. Metformin has exhibited anti-inflammatory and neuroprotective...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-020-00782-8
更新日期：2021-01-01 00:00:00
abstract：:There is a growing body of evidence that plant polyphenols such as resveratrol, anthocyanins, catechins, and terpenes like taxol are effectively used in the treatment of chronic conditions including cancer, Alzheimer, Parkinsonism, diabetes, aging, etc. The link between oxidative stress and inflammation is well accept...
journal_title：Inflammopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s10787-015-0236-1
更新日期：2015-08-01 00:00:00
abstract：AIMS:To compare methodological aspects of the impact of different classification procedures used in three phases of a twin study examining genetic factors in the aetiopathogenesis of rheumatoid arthritis (RA). METHODS:We have previously reported the results of a study of the aetiopathogenesis of RA based on the Austra...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-998-0009-1
更新日期：1998-01-01 00:00:00
abstract：:Allanblackia gabonensis (Guttiferae) is a plant used in the African traditional medicine as remedies against pain, rheumatism, inflammations. In the present work, the analgesic effect of aqueous extract has been evaluated using acetic acid, formalin, hot-plate test, tail immersion and paw-pressure test. The anti-infla...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-011-0096-2
更新日期：2013-02-01 00:00:00
abstract：:The present investigation assessed the potential of Prunus cerasoides fruit extract (PCFE) in alleviation of inflammatory stress in response to lipopolysaccharide (LPS) and interferon-γ (IFN-γ)-stimulated murine peritoneal macrophages as well as in concanavalin A (Con A)-activated splenic lymphocytes. We observed a st...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0448-2
更新日期：2018-12-01 00:00:00
abstract：:Previous reports suggest flavonoids as potent analgesic compounds. Based on these observations, the present study investigated the antinociceptive action of flavonol, 3', 4'-dimethoxy flavonol, 6, 3'-dimethoxy flavonol, 7, 2'-dimethoxy flavonol, and 7, 3'-dimethoxy flavonol and the possible mechanisms involved in thes...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00579-4
更新日期：2019-12-01 00:00:00
abstract：:The ulcerogenic effect of rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, on the gastrointestinal mucosa was investigated in the presence of a low dose of indomethacin. Indomethacin at 3 mg/kg did not cause any damage in both the stomach and small intestine, despite inhibiting prostaglandin (PG) production....
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856005774423755
更新日期：2005-01-01 00:00:00
abstract：:Prolonged stimulation of newborn mice by intraperitoneal injections with inactivated staphylococci induces a chronic neonatal inflammatory reaction and an associated oxidative-stress response. The chronically stimulated animals exhibit anorexy. show a reduction in their body weight and undergo a depression in both ant...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/BF02918381
更新日期：1999-01-01 00:00:00
abstract：:The authors would like to inform you that Jie Yu and Haimei Lu contributed equally to this study and should be considered as co-first authors. ...
journal_title：Inflammopharmacology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s10787-018-0518-5
更新日期：2019-02-01 00:00:00
abstract：AIM AND OBJECTIVE:6-hydroxy dopamine (6-OHDA) is a neurotoxin which on intranigral administration produces severe nigrostriatal damage with motor and cognitive deficit in animals. Curcumin (CMN) in combination with bioenhancer piperine (PP) in 6-hydroxydopamine-induced Parkinsonian rats was used to investigate the anti...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-016-0297-9
更新日期：2017-02-01 00:00:00
abstract：INTRODUCTION:Retinoic Acid Related Orphan Nuclear Receptor gamma T (RORγT) is a lineage specifying transcription factor for IL-17 expressing cells, which may contribute to the pathogenesis of Inflammatory Bowel Disease (IBD). VPR-254 is a selective in vitro inhibitor of RORγT. AIMS:The main goals of our study were two...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00643-z
更新日期：2020-04-01 00:00:00
abstract：:A methanol extract of the seeds of Adenanthera pavonina was evaluated for pharmacological effects in animal models. The extract (50-200 mg/kg) produced statistically significant (P < 0.05) inhibition of the carrageenan-induced paw oedema in the rat, as well as the acetic-acid-induced vascular permeability in mice. At ...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/1568560041352310
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND:Osthole is a bioactive component reported in medicinal plants such as Angelica pubescens and Cnidium monnieri, known for analgesic activity. However, the toxicity, median effective dose (ED50), and dual modulation of nitric oxide and cyclooxygenase pathways along with inflammatory cytokines of osthole are ye...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0486-9
更新日期：2019-10-01 00:00:00
abstract：:Propolis has been extensively used to improve health and prevent inflammatory diseases. Different types of Cuban propolis (red, brown and yellow) have been documented. The purpose of this research was to investigate the cytotoxic effects of Cuban red propolis (CP) on MDA MB-231 cell line, since breast cancer is consid...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0492-y
更新日期：2019-10-01 00:00:00
abstract：:Acute lung injury (ALI) and acute kidney injury (AKI) are major causes of sepsis-induced mortality. The objective of the study is to evaluate the effect of tocilizumab (TCZ), an IL-6 receptor inhibitor, in sepsis-induced ALI and AKI using the cecal ligation and puncture (CLP) rat model of sepsis. Clinical and experime...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-019-00628-y
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVE:To evaluate the potential of Azadirachta indica leaf extracts against Salmonella typhimurium-induced inflammation in BALB/c mice. DESIGN:Qualitative tests of A. indica leaf extracts were conducted for screening of various phytochemicals. The antiinflammatory potential of A. indica leaf extracts on S. typhimu...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-008-8032-9
更新日期：2009-02-01 00:00:00
abstract：:Kynurenate, a metabolite of tryptophan formed serially from kynurenine, inhibits N-methyl-D-aspartate (NMDA) receptor responses. Non-steroidal anti-inflammatory drugs (NSAIDs) may produce anti-hyperalgesic effects by altering tryptophan metabolism to increase kynurenate concentrations. We examined whether the NSAID di...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1163/156856003322315622
更新日期：2003-01-01 00:00:00
abstract：:A series of quinazoline clubbed 1,3,5-triazine derivatives (QCT) were synthesized and evaluated for their in vitro anticancer activity against HeLa (human cervical cancer), MCF-7 (human breast cancer cell), HL-60 (human promyelocytic leukemia cell), HepG2 (human Hepatocellular carcinoma cell), and one normal cell line...
journal_title：Inflammopharmacology
pub_type： 杂志文章
doi：10.1007/s10787-018-0471-3
更新日期：2018-12-01 00:00:00
