Abstract:
:Previous reports suggest flavonoids as potent analgesic compounds. Based on these observations, the present study investigated the antinociceptive action of flavonol, 3', 4'-dimethoxy flavonol, 6, 3'-dimethoxy flavonol, 7, 2'-dimethoxy flavonol, and 7, 3'-dimethoxy flavonol and the possible mechanisms involved in these effects. The antinociceptive effect of the investigated compounds in doses of 25, 50, 100, and 200 mg/kg was evaluated in male Swiss albino mice using the acetic acid test, formalin-induced nociception, and hot water tail immersion test. The role of opioid, tryptaminergic, adrenergic, dopaminergic, GABAergic, and K+ATP channels in producing the antinociceptive effect was also studied using appropriate interacting agents. Treatment with flavonol and dimethoxy flavonols resulted in a significant reduction in the number of abdominal constrictions in the acetic acid test, a significant inhibition of the paw-licking/biting response time in both the phases of formalin nociception and also a significant increase in mean reaction time in the hot water tail immersion test. These observations revealed the antinociceptive effect of dimethoxy flavonols. The role of opioid, serotonergic (5HT3), and dopaminergic system was identified in the antinociceptive effect of flavonol and all dimethoxy derivatives investigated. In addition, the role of GABAergic, K+ATP channel, and α-2 adrenergic mechanisms were also observed in the antinociceptive action of some of the investigated compounds. The present study identified the antinociceptive effect of flavonol and dimethoxy flavonols in mice acting through different neuronal pathways.
journal_name
Inflammopharmacologyjournal_title
Inflammopharmacologyauthors
Sayeli V,Nadipelly J,Kadhirvelu P,Cheriyan BV,Shanmugasundaram J,Subramanian Vdoi
10.1007/s10787-019-00579-4subject
Has Abstractpub_date
2019-12-01 00:00:00pages
1155-1167issue
6eissn
0925-4692issn
1568-5608pii
10.1007/s10787-019-00579-4journal_volume
27pub_type
杂志文章abstract::Rhynchosia minima root, a folk herbal medicine in southern China, is used to relieve itch and swelling. In this study, we examined the anti-inflammatory property of an ethanol fraction (EEF6) from R. minima root on lipopolysaccharide (LPS)-induced RAW 264.7 cells, as well as its underlying mechanism. The compound comp...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-019-00632-2
更新日期:2020-02-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a systemic autoimmune disease, which is characterized by a chronic fluctuating course and immune dysfunction, resulting in affecting the health and life quality of RA patients. Methotrexate (MTX), as the standard gold treatment of RA, has received more and more clinical applications and ba...
journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s10787-020-00741-3
更新日期:2020-10-01 00:00:00
abstract::Chronic inflammation is a world health problem. There is a need to develop new anti-inflammatory and analgesic drugs with improved activity and reduced side effects. In this context, the aim of this study was to evaluate the antinociceptive and anti-inflammatory effects of the pyrazole compound LQFM-021 after acute an...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-016-0282-3
更新日期:2016-10-01 00:00:00
abstract::The intestinal mucosa is subject to a variety of physical forces in a complex manner during normal gut function and in disease. Intestinal mucosal atrophy during some disease states is a troubling phenomenon that is only partially explained by nutritional parameters. Increasing evidence suggests the possibility that r...
journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s10787-007-1562-8
更新日期:2007-06-01 00:00:00
abstract::Methyl gallate is a gallotannin widely distributed in nature. Previous studies have demonstrated its antioxidant, anti-inflammatory, antimicrobial and anti-tumor activities. In the present study, the activity of methyl gallate on experimental models of inflammatory bowel disease has been investigated. Experimental col...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-017-0412-6
更新日期:2018-06-01 00:00:00
abstract::Allanblackia gabonensis (Guttiferae) is a plant used in the African traditional medicine as remedies against pain, rheumatism, inflammations. In the present work, the analgesic effect of aqueous extract has been evaluated using acetic acid, formalin, hot-plate test, tail immersion and paw-pressure test. The anti-infla...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-011-0096-2
更新日期:2013-02-01 00:00:00
abstract:AIMS:To compare methodological aspects of the impact of different classification procedures used in three phases of a twin study examining genetic factors in the aetiopathogenesis of rheumatoid arthritis (RA). METHODS:We have previously reported the results of a study of the aetiopathogenesis of RA based on the Austra...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-998-0009-1
更新日期:1998-01-01 00:00:00
abstract::Tovophyllin A (TA) is a xanthone isolated from Garcinia mangostana L. (GM, Guttiferae) pericarps that possesses various beneficial bioactivities. However, its protective effects on acute lung injury (ALI) and lung carcinoma have not yet been explored. The current work was designed to investigate the protective potenti...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-019-00609-1
更新日期:2020-02-01 00:00:00
abstract::A new compound derivative of glycoside 19-α-hydroxy-ursolic acid glucoside (19-α-hydroxyurs-12(13)-ene-28-oic acid-3-O-β-D-glucopyranoside (HEG) was isolated from whole plant of Wedelia calendulacea (Compositae). The structure was elucidated and established by standard spectroscopy approaches. Diethylnitrosamine (DEN)...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-017-0310-y
更新日期:2017-02-01 00:00:00
abstract::Regular moderate wine consumption is often associated with reduced morbidity and mortality from to a variety of chronic diseases in which inflammation is a root cause. Wine comes in a wide variety of styles that contain quite different ethanol and polyphenol contents. Controversy remains as to whether the alcohol or p...
journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s10787-008-8027-6
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE AND DESIGN:The objective of this study was to investigate the leucocyte-related antiinflammatory properties of rose hip. MATERIALS AND METHODS:The effect of rose hip on a number of inflammatory parameters was evaluated using the following models: (1) The effect of rose hip extract on chemotaxis and chemilumi...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-999-0031-y
更新日期:1999-01-01 00:00:00
abstract::The central nervous system, one of the most delicate microenvironments of the body, is protected by the blood-brain barrier regulating its homeostasis. Blood-brain barrier is a highly complex structure that tightly regulates the movement of ions of a limited number of small molecules and of an even more restricted num...
journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s10787-018-0468-y
更新日期:2018-06-01 00:00:00
abstract::Triptolide has been widely reported to exhibit potential therapeutic value in multiple inflammatory diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and psoriasis. Although its safety and efficacy as an anti-inflammatory agent have been verified by many studies, the effect of triptolide on osteoar...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-018-0509-6
更新日期:2019-02-01 00:00:00
abstract::- The use of the non-steroidal anti-inflammatory drug, diclofenac, is associated with occasional serious side effects in the gastrointestinal (GI) tract. We examined the effect of altering the site of release of diclofenac sodium on GI tract side effects. Dissolution and pharmacokinetic studies were carried out to sub...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1163/156856004773121383
更新日期:2004-01-01 00:00:00
abstract::We clarified the roles of histamine H(1)-, H(2)-, H(3)-receptors and oxyradicals in the exacerbation of acid-induced gastric haemorrhage and stomach ulcer in endotoxaemic rats by measuring changes in gastric mucosal glutathione concentrations, lipid peroxide generation and histamine levels as well as in luminal electr...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-998-0017-1
更新日期:1998-01-01 00:00:00
abstract::Helicobacter pylori infection, as well as NSAIDs induce oxidative stress on gastric mucosa, thereby causing mucosal damage and retarding mucosal repair. Cells can survive against chronic oxidative stress by enhancing activities of anti-oxidant enzymes, thereby protecting cells from DNA damage. Recent studies have clea...
journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
doi:10.1163/156856005774423863
更新日期:2005-01-01 00:00:00
abstract::Prompted by the findings that smokers have lowered brain and blood platelet monoamine oxidase-A and -B activities compared to non-smokers and that smokers have a lowered incidence of Parkinson's disease, we have examined the neuroprotective properties of an MAO inhibitor, 2,3,6-trimethyl-1,4-naphthoquinone (TMN), whic...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1163/156856003765764353
更新日期:2003-01-01 00:00:00
abstract::Euphorbia hirta L. (Euphorbiaceae) (E. hirta) is a tree locally used as a traditional medicine in Africa and Australia to treat numerous diseases such as hypertension, respiratory ailments, tumors, antipyretic, anti-inflammatory activities. In the present study, we investigated the anti-arthritic activity of fresh lea...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-012-0161-5
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Osthole is a bioactive component reported in medicinal plants such as Angelica pubescens and Cnidium monnieri, known for analgesic activity. However, the toxicity, median effective dose (ED50), and dual modulation of nitric oxide and cyclooxygenase pathways along with inflammatory cytokines of osthole are ye...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-018-0486-9
更新日期:2019-10-01 00:00:00
abstract::Inflammatory bowel diseases are associated with reduced colonic contractility and induction of cyclooxygenase-2. In this study a possible role of cyclooxygenase-2 in and the underlying mechanism of the reduced contractility were investigated in experimental colitis. The effects of meloxicam, a cyclooxygenase-2 selecti...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-006-1507-7
更新日期:2006-03-01 00:00:00
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journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-019-00676-4
更新日期:2020-12-01 00:00:00
abstract::Kerabala (CB) is a novel ayurvedic formulation used for treating various inflammatory diseases. This formulation was made from virgin coconut oil and it comprises extracts of Sida cordifolia, coconut milk and sesame oil. The current study was performed to evaluate the anti-inflammatory action of CB on carrageenan-indu...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-016-0298-8
更新日期:2017-02-01 00:00:00
abstract::Since their development and licensing no class of drug has received as much attention both in the scientific and lay press as the cyclo-oxygenase 2 (COX-2) inhibitors. These compounds, also known as coxibs, were developed as a safer alternative to traditional non-steroidal anti-inflammatory drugs (NSAIDs) due to their...
journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
doi:10.1163/156856005774415619
更新日期:2005-01-01 00:00:00
abstract::The ulcerogenic effect of rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, on the gastrointestinal mucosa was investigated in the presence of a low dose of indomethacin. Indomethacin at 3 mg/kg did not cause any damage in both the stomach and small intestine, despite inhibiting prostaglandin (PG) production....
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1163/156856005774423755
更新日期:2005-01-01 00:00:00
abstract::The authors would like to inform you that Jie Yu and Haimei Lu contributed equally to this study and should be considered as co-first authors. ...
journal_title:Inflammopharmacology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s10787-018-0518-5
更新日期:2019-02-01 00:00:00
abstract::Stress is a reflex response, both psychological and physiological, of the body to a difficult situation that requires adaptation. Stress is at the intersection of the objective event and the subjective event. The physiological mechanisms involved in chronic stress are numerous and can contribute to a wide variety of d...
journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s10787-018-0546-1
更新日期:2019-02-01 00:00:00
abstract::The idea that microbes induce disease has steered medical research toward the discovery of antibacterial products for the prevention and treatment of microbial infections. The twentieth century saw increasing dependency on antimicrobials as mainline therapy accentuating the notion that bacterial interactions with huma...
journal_title:Inflammopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s10787-012-0126-8
更新日期:2012-10-01 00:00:00
abstract:INTRODUCTION:Retinoic Acid Related Orphan Nuclear Receptor gamma T (RORγT) is a lineage specifying transcription factor for IL-17 expressing cells, which may contribute to the pathogenesis of Inflammatory Bowel Disease (IBD). VPR-254 is a selective in vitro inhibitor of RORγT. AIMS:The main goals of our study were two...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-019-00643-z
更新日期:2020-04-01 00:00:00
abstract::The safety of the cyclo-oxygenase-2 (COX-2) selective NSAID, nimesulide, has been evaluated from information (a) in clinical trials in osteoarthritis that have been performed in Europe as well as in earlier pilot studies that were performed in patients with rheumatoid arthritis in the USA, and (b) in post-marketing st...
journal_title:Inflammopharmacology
pub_type: 杂志文章
doi:10.1007/s10787-998-0020-6
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:There is considerable interest in the possible importance of the gut microflora in the pathophysiology of the inflammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn's disease (CD). Probiotics offer a potential adjuvant treatment in these patients by modifying the intestinal milieu, but reports o...
journal_title:Inflammopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10787-019-00595-4
更新日期:2019-06-01 00:00:00