Osthole ameliorates neurogenic and inflammatory hyperalgesia by modulation of iNOS, COX-2, and inflammatory cytokines in mice.

abstract：:Triptolide has been widely reported to exhibit potential therapeutic value in multiple inflammatory diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and psoriasis. Although its safety and efficacy as an anti-inflammatory agent have been verified by many studies, the effect of triptolide on osteoar...

journal_title：Inflammopharmacology

authors： Qian K,Zhang L,Shi K

更新日期：2019-02-01 00:00:00

abstract：:Acute lung injury (ALI) and acute kidney injury (AKI) are major causes of sepsis-induced mortality. The objective of the study is to evaluate the effect of tocilizumab (TCZ), an IL-6 receptor inhibitor, in sepsis-induced ALI and AKI using the cecal ligation and puncture (CLP) rat model of sepsis. Clinical and experime...

journal_title：Inflammopharmacology

authors： Ibrahim YF,Moussa RA,Bayoumi AMA,Ahmed AF

更新日期：2020-02-01 00:00:00

abstract：:The central nervous system, one of the most delicate microenvironments of the body, is protected by the blood-brain barrier regulating its homeostasis. Blood-brain barrier is a highly complex structure that tightly regulates the movement of ions of a limited number of small molecules and of an even more restricted num...

journal_title：Inflammopharmacology

authors： Nair KGS,Ramaiyan V,Sukumaran SK

更新日期：2018-06-01 00:00:00

abstract：AIM:The aim of the present study was to evaluate the anti-inflammatory effect of thymol in acetic acid-induced rat colitis through inhibiting the NF-κB signaling pathway. METHODS:Colitis was induced by intra-rectal administration of 2 mL of diluted acetic acid (4%) solution using a flexible plastic rubber catheter in ...

journal_title：Inflammopharmacology

authors： Chamanara M,Abdollahi A,Rezayat SM,Ghazi-Khansari M,Dehpour A,Nassireslami E,Rashidian A

更新日期：2019-12-01 00:00:00

abstract：:Chronic inflammation is a world health problem. There is a need to develop new anti-inflammatory and analgesic drugs with improved activity and reduced side effects. In this context, the aim of this study was to evaluate the antinociceptive and anti-inflammatory effects of the pyrazole compound LQFM-021 after acute an...

journal_title：Inflammopharmacology

authors： Florentino IF,da Silva DP,Martins JL,da Silva TS,Santos FC,Tonussi CR,Vasconcelos GA,Vaz BG,Lião LM,Menegatti R,Costa EA

更新日期：2016-10-01 00:00:00

abstract：:Some B vitamins exhibit activities in models of nociceptive pain, inflammatory pain, and neuropathic pain induced by nerve lesions and also in certain painful conditions in humans. In the present study, we investigated the effects of thiamine, riboflavin, and nicotinamide in a neuropathic pain model induced by the che...

journal_title：Inflammopharmacology

authors： Braga AV,Costa SOAM,Rodrigues FF,Melo ISF,Morais MI,Coelho MM,Machado RR

更新日期：2020-02-01 00:00:00

abstract：:Propolis is a resinous substance collected by honeybees from leaf buds and cracks in the bark of various plants. Propolis has been reported to have immunomodulatory activity. We hypothesized that propolis would be able to reduce the disease severity of rheumatoid arthritis. We evaluated the effect of Brazilian propoli...

journal_title：Inflammopharmacology

authors： Tanaka M,Okamoto Y,Fukui T,Masuzawa T

更新日期：2012-02-01 00:00:00

abstract：:The ulcerogenic effect of rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, on the gastrointestinal mucosa was investigated in the presence of a low dose of indomethacin. Indomethacin at 3 mg/kg did not cause any damage in both the stomach and small intestine, despite inhibiting prostaglandin (PG) production....

journal_title：Inflammopharmacology

authors： Yokota A,Taniguchi M,Tanaka A,Takeuchi K

更新日期：2005-01-01 00:00:00

abstract：:Euphorbia hirta L. (Euphorbiaceae) (E. hirta) is a tree locally used as a traditional medicine in Africa and Australia to treat numerous diseases such as hypertension, respiratory ailments, tumors, wounds, antipyretic, anti-inflammatory activities, etc. Therefore, we undertook to investigate their immunomodulatory eff...

journal_title：Inflammopharmacology

authors： Ahmad SF,Khan B,Bani S,Kaul A,Sultan P,Ali SA,Satti NK,Bakheet SA,Attia SM,Zoheir KM,Abd-Allah AR

更新日期：2013-04-01 00:00:00

abstract：:Genistein is an isoflavone with oestrogenic activity that is present in a variety of soy products as a constituent of complex mixtures of bioactive compounds, whose matrix profiles play an important role in determining the overall oestrogenic bioactivity of genistein. We review data on how the profile of soy bioactive...

journal_title：Inflammopharmacology

authors： Helferich WG,Andrade JE,Hoagland MS

更新日期：2008-10-01 00:00:00

abstract：:The ozonised sunflower oil, Bioperoxoil, was tested for its antimicrobial activity against some pathological strains in vitro together with its healing potential against Staphylococcus aureus in vivo. Bioperoxoil was tested against S. aureus, Pseudomonas aeroginosa, Candida albicans, S. typhimurium and Escherichia col...

journal_title：Inflammopharmacology

authors： Rodrigues KL,Cardoso CC,Caputo LR,Carvalho JC,Fiorini JE,Schneedorf JM

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:This pilot study aimed to determine the efficacy of acamprosate (N-acetyl homotaurine) in reducing the pathological features of experimental autoimmune encephalomyelitis (EAE) which is an animal model for multiple sclerosis (MS). BACKGROUND:The amino acid taurine has multiple biological activities including ...

journal_title：Inflammopharmacology

authors： Sternberg Z,Cesario A,Rittenhouse-Olson K,Sobel RA,Leung YK,Pankewycz O,Zhu B,Whitcomb T,Sternberg DS,Munschauer FE

更新日期：2012-02-01 00:00:00

abstract：:Kerabala (CB) is a novel ayurvedic formulation used for treating various inflammatory diseases. This formulation was made from virgin coconut oil and it comprises extracts of Sida cordifolia, coconut milk and sesame oil. The current study was performed to evaluate the anti-inflammatory action of CB on carrageenan-indu...

journal_title：Inflammopharmacology

authors： Ratheesh M,Sandya S,Pramod C,Asha S,Svenia JP,Premlal S,GrishKumar B

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Hydroxychloroquine (HCQ) is a widely prescribed medication to patients with systemic lupus erythematosus (SLE), with potential anti-inflammatory effects. This study was performed to investigate the efficacy of HCQ therapy by serial assessment of disease activity and serum levels of proinflammatory cytokines ...

journal_title：Inflammopharmacology

authors： Monzavi SM,Alirezaei A,Shariati-Sarabi Z,Tavakol Afshari J,Mahmoudi M,Dormanesh B,Jahandoost F,Khoshdel AR,Etemad Rezaie A

更新日期：2018-10-01 00:00:00

abstract：:Methyl gallate is a gallotannin widely distributed in nature. Previous studies have demonstrated its antioxidant, anti-inflammatory, antimicrobial and anti-tumor activities. In the present study, the activity of methyl gallate on experimental models of inflammatory bowel disease has been investigated. Experimental col...

journal_title：Inflammopharmacology

authors： Anzoise ML,Basso AR,Del Mauro JS,Carranza A,Ordieres GL,Gorzalczany S

更新日期：2018-06-01 00:00:00

abstract：:The anti-inflammatory activity of the aqueous extract of Chromolaena odorata was investigated in rats using the carrageenan-induced oedema, cotton pellet granuloma and formalin-induced oedema methods. The extract was administered orally at doses of 25, 50, 100 and 200 mg/kg. In the carrageenan method the paw oedema wa...

journal_title：Inflammopharmacology

authors： Owoyele VB,Adediji JO,Soladoye AO

更新日期：2005-01-01 00:00:00

abstract：:Regular moderate wine consumption is often associated with reduced morbidity and mortality from to a variety of chronic diseases in which inflammation is a root cause. Wine comes in a wide variety of styles that contain quite different ethanol and polyphenol contents. Controversy remains as to whether the alcohol or p...

journal_title：Inflammopharmacology

authors： Walzem RL

更新日期：2008-12-01 00:00:00

abstract：:The present investigation assessed the potential of Prunus cerasoides fruit extract (PCFE) in alleviation of inflammatory stress in response to lipopolysaccharide (LPS) and interferon-γ (IFN-γ)-stimulated murine peritoneal macrophages as well as in concanavalin A (Con A)-activated splenic lymphocytes. We observed a st...

journal_title：Inflammopharmacology

authors： Sharma A,Joshi R,Kumar S,Sharma R,Rajneesh,Padwad Y,Gupta M

更新日期：2018-12-01 00:00:00

abstract：:The Maytenus genus is a member of the Celastraceae family. Numerous medicinal uses were assigned to species of this genus, with the use of roots, bark, and leaves for the treatment of gastric ulcers, as anti-inflammatory, analgesic, antiallergic, antitumor, among others. Several studies have demonstrated that natural ...

journal_title：Inflammopharmacology

authors： Veloso CC,Oliveira MC,Rodrigues VG,Oliveira CC,Duarte LP,Teixeira MM,Ferreira AVM,Perez AC

更新日期：2019-06-01 00:00:00

abstract：:A small GTPase, Rac1, is recognized as an important modulator of the inflammatory responses to bacterial lipopolysaccharide (LPS) by affecting the processes of phospholipase C activation. The activation of Rac1 involves the exchange of GDP for GTP and is catalyzed by the guanine nucleotide exchange factors (GEFs). Her...

journal_title：Inflammopharmacology

authors： Slomiany BL,Slomiany A

更新日期：2015-06-01 00:00:00

abstract：:Kynurenate, a metabolite of tryptophan formed serially from kynurenine, inhibits N-methyl-D-aspartate (NMDA) receptor responses. Non-steroidal anti-inflammatory drugs (NSAIDs) may produce anti-hyperalgesic effects by altering tryptophan metabolism to increase kynurenate concentrations. We examined whether the NSAID di...

journal_title：Inflammopharmacology

authors： Edwards SR,Mather LE

更新日期：2003-01-01 00:00:00

abstract：:Prompted by the findings that smokers have lowered brain and blood platelet monoamine oxidase-A and -B activities compared to non-smokers and that smokers have a lowered incidence of Parkinson's disease, we have examined the neuroprotective properties of an MAO inhibitor, 2,3,6-trimethyl-1,4-naphthoquinone (TMN), whic...

journal_title：Inflammopharmacology

authors： Castagnoli K,Petzer JB,Steyn SJ,van der Schyf CJ,Castagnoli N Jr

更新日期：2003-01-01 00:00:00

abstract：:Caffeic acid phenethyl ester (CAPE) is the active component of honey bee propolis extracts. The results of the current study demonstrate that CAPE attenuated immunoglobulin (Ig)E-mediated allergic response in mast cells. Oral administration of CAPE inhibited IgE-mediated passive cutaneous anaphylaxis. CAPE effectively...

journal_title：Inflammopharmacology

authors： Nader MA

更新日期：2013-04-01 00:00:00

abstract：AIM:The capture, analysis and utilisation of health status information are attended by logistic considerations and interpretation challenges. We report a preliminary evaluation of cellular technology in capturing WOMAC NRS 3.1 Index data. METHODS:A Java midlet for delivering the WOMAC NRS3.1 Index on Nokia-6300, Motor...

journal_title：Inflammopharmacology

authors： Bellamy N,Wilson C,Hendrikz J,Patel B,Dennison S

更新日期：2009-04-01 00:00:00

abstract：:Ischemia/reperfusion (I/R) damages gastric mucosa via reactive oxygen species (ROS) activity. ROS was reportedly produced through angiotensin II stimulation in tissues such as kidney, heart and brain. To determine whether AT1 receptor plays a role in gastric mucosal damage, we examined the effect of AT1 receptor block...

journal_title：Inflammopharmacology

authors： Nakagiri A,Sunamoto M,Murakami M

更新日期：2007-08-01 00:00:00

abstract：:The therapeutic efficacy of the contemporary anti-inflammatory drugs are well established; however, prolonged use of such can often lead to serious and life-threatening side effects. Natural product-based anti-inflammatory compounds with superior efficacy and minimum toxicity can serve as possible therapeutic alternat...

journal_title：Inflammopharmacology

authors： Jalil J,Attiq A,Hui CC,Yao LJ,Zakaria NA

更新日期：2020-10-01 00:00:00

abstract：:Allanblackia gabonensis (Guttiferae) is a plant used in the African traditional medicine as remedies against pain, rheumatism, inflammations. In the present work, the analgesic effect of aqueous extract has been evaluated using acetic acid, formalin, hot-plate test, tail immersion and paw-pressure test. The anti-infla...

journal_title：Inflammopharmacology

authors： Ymele EV,Dongmo AB,Dimo T

更新日期：2013-02-01 00:00:00

abstract：:Pioglitazone, a specific ligand for peroxisome proliferator-activated receptor gamma (PPAR-gamma), was recently implicated in the control of inflammatory processes and in the modulation of the expression of various cytokines such as tumor necrosis factor alpha (TNF-alpha), but its role in the mechanism of gastric muco...

journal_title：Inflammopharmacology

authors： Brzozowski T,Konturek PC,Pajdo R,Kwiecień SN,Konturek S,Targosz A,Burnat G,Cieszkowski J,Pawlik WW,Hahn EG

更新日期：2005-01-01 00:00:00

abstract：:The idea that microbes induce disease has steered medical research toward the discovery of antibacterial products for the prevention and treatment of microbial infections. The twentieth century saw increasing dependency on antimicrobials as mainline therapy accentuating the notion that bacterial interactions with huma...

journal_title：Inflammopharmacology

authors： Vitetta L,Briskey D,Hayes E,Shing C,Peake J

更新日期：2012-10-01 00:00:00

abstract：:Centella asiatica is claimed to have a neuroprotective effect; however, its ability to protect the cerebrum against damage in diabetes has never been identified. The aims were to identify the possibility that C. asiatica ameliorates inflammation, oxidative stress, and apoptosis in the cerebrum in diabetes. C. asiatica...

journal_title：Inflammopharmacology

authors： Giribabu N,Karim K,Kilari EK,Nelli SR,Salleh N

更新日期：2020-12-01 00:00:00