abstract：:Retinal vein occlusion (RVO) is an intractable eye disease that results in reduced visual acuity, associated with retinal ischemia, hemorrhage, and edema. RVO results in excessive ROS production in the retina, causing inflammation and retinal edema. A free radical scavenger, 4-(4-acetylpiperazin-1-yl)-2-(1H-imidazole-...

journal_title：Experimental eye research

authors： Yamamoto T,Nitta K,Nishinaka A,Tanaka M,Nakamura S,Shimazawa M,Hara H

更新日期：2021-01-24 00:00:00

abstract：PURPOSE:This study examined the patterned treatment of corneal collagen cross-linking (CXL) for keratoconus to reduce the complications caused by ultraviolet (UV) irradiation. By modifying the method of UV irradiation during the cross-linking process, cross-linking with a special structure is achieved, and the cross-li...

journal_title：Experimental eye research

authors： Hu Y,Huang Y,Chen Y,Ye C,Wei W,Feng Y,Mi S

更新日期：2021-01-23 00:00:00

abstract：:Careful control of iron availability in the retina is central to maintenance of iron homeostasis, as its imbalance is associated with oxidative stress and the progression of several retinopathies. Ferritin, known for its role in iron storage and detoxification, has also been proposed as an iron-transporter protein, th...

journal_title：Experimental eye research

authors： Valença A,Mendes-Jorge L,Bonet A,Catita J,Ramos D,Jose-Cunilleras E,Garcia M,Carretero A,Nacher V,Navarro M,Ruberte J

更新日期：2021-01-01 00:00:00

abstract：:The autonomic innervation in the anterior chamber (AC) structures might play an efferent role in neural intraocular pressure (IOP) regulation, the center of which is thought to be located in the hypothalamus. In this study, we identified the efferent pathway from the hypothalamus to the autonomic innervation in the AC...

journal_title：Experimental eye research

authors： Yang F,Zhu X,Liu X,Ma L,Zhang Z,Pei L,Wang H,Xu F,Liu H

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Indirect traumatic optic neuropathy (ITON) is a major cause of permanent loss of vision after blunt head trauma. Neuroinflammation plays a crucial role in neurodegenerative diseases. The present study concentrated on JNK/c-Jun-driven NLRP3 inflammasome activation in microglia during the degeneration of retin...

journal_title：Experimental eye research

authors： Chu X,Wang C,Wu Z,Fan L,Tao C,Lin J,Chen S,Lin Y,Ge Y

更新日期：2021-01-01 00:00:00

abstract：:The retinoschisin protein is encoded on the short arm of the X-chromosome by RS1, is expressed abundantly in photoreceptor inner segments and in bipolar cells, and is secreted as an octamer that maintains the structural integrity of the retina. Mutations in RS1 lead to X-linked retinoschisis (XLRS), a disease characte...

journal_title：Experimental eye research

authors： Ambrosio L,Williams JS,Gutierrez A,Swanson EA,Munro RJ,Ferguson RD,Fulton AB,Akula JD

更新日期：2021-01-01 00:00:00

abstract：:Neuroretinal diseases are the predominant cause of irreversible blindness worldwide, mainly due to photoreceptor loss. Currently, there are no radical treatments to fully reverse the degeneration or even stop the disease progression. Thus, it is urgent to develop new biological therapeutics for these diseases on the c...

journal_title：Experimental eye research

authors： Zhang CJ,Ma Y,Jin ZB

更新日期：2021-01-01 00:00:00

abstract：:The genetically encoded green fluorescent protein-based calcium sensor, GCaMP, has been used to detect calcium transients and report neuronal activity. We evaluated the specificity of GCaMP3 expression to retinal ganglion cells (RGCs) of the transgenic Thy1-GCaMP3 mouse line in healthy control animals and in those aft...

journal_title：Experimental eye research

authors： Yabana T,Hooper ML,Farrell SR,Chauhan BC

更新日期：2021-01-01 00:00:00

abstract：:As a result of longitudinal chromatic aberration (LCA), longer wavelengths are blurred when shorter wavelengths are in focus, and vice versa. As a result, LCA affects the color and temporal aspects of the retinal image with hyperopic defocus. In this experiment, we investigated how the sensitivity to temporal color co...

journal_title：Experimental eye research

authors： Watts NS,Taylor C,Rucker FJ

更新日期：2021-01-01 00:00:00

abstract：:The biosafety and efficiency of transplanting retinal pigment epithelial (RPE) cells derived from both human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) have been evaluated in phase I and phase II clinical trials. For further large-scale application, cryopreserved RPE cells must be used; th...

journal_title：Experimental eye research

authors： Li QY,Zou T,Gong Y,Chen SY,Zeng YX,Gao LX,Weng CH,Xu HW,Yin ZQ

更新日期：2021-01-01 00:00:00

abstract：:Experimental autoimmune uveoretinitis (EAU) in mice provides a useful platform to study the pathogenesis and experimental therapeutics of human uveitis. One often used EAU model employs C57BL/6 (B6) mice sensitized with a peptide residue having 1 to 20 amino acids of human interphotoreceptor retinoid binding protein (...

journal_title：Experimental eye research

authors： Tajiri N,Kato T,Satoh M,Iizuka M,Taniguchi M,Kitaichi N,Iwabuchi K

更新日期：2020-12-19 00:00:00

abstract：BACKGROUND:The laser-induced choroidal neovascularization (CNV) mouse model, as the most classic animal model of age-related macular degeneration (AMD), has been widely used. We designed a hand-held mouse holder to optimize mouse fixation in the laser-induced CNV modelling process, which was inconvenient until now. Thi...

journal_title：Experimental eye research

authors： Xue B,Zhang S,Gan L,Lu W,Li J

更新日期：2020-12-15 00:00:00

abstract：:Our study aimed to investigate metabolites alterations in the blood plasma of central serous chorioretinopathy (CSC) patients and to identify the key biomarkers to increase the understanding of the mechanism of CSC at the molecular level. Quantitative and targeted metabolomics using liquid chromatography tandem-mass s...

journal_title：Experimental eye research

authors： Xu H,Huang L,Jin E,Liang Z,Zhao M

更新日期：2020-12-14 00:00:00

abstract：BACKGROUND:Glaucoma is characterized by the neurodegeneration of retinal ganglion cells (RGCs) and the optic nerve. Numerous studies have reported that S100A4 participates in the metastasis of tumor cells and nerve protection. This study was intended to explore the role of S100A4 on RGCs under retinal ischemia-reperfus...

journal_title：Experimental eye research

authors： Yang J,Yang N,Luo J,Cheng G,Zhang X,He T,Xing Y

更新日期：2020-12-01 00:00:00

abstract：:The causes of vitreous humor (VH) liquefaction remain unclear. Diabetes accelerates this process and other ocular diseases. The weakening of the blood-retina barrier observed with diabetes could enhance the rate of transfer of relatively small molecules such as glucose (Glu) and phospholipids (PLs) from the retina to ...

journal_title：Experimental eye research

authors： Schnepf A,Yappert MC,Borchman D

更新日期：2020-11-01 00:00:00

abstract：PURPOSE:Cellular therapy with mesenchymal stem cells (MSC) is emerging as an effective option to treat optic neuropathies. In models of retinal degeneration, MSC injected in the vitreous body protects injured retinal ganglion cells and stimulate their regeneration, however the mechanism is still unknown. Considering th...

journal_title：Experimental eye research

authors： Teixeira-Pinheiro LC,Toledo MF,Nascimento-Dos-Santos G,Mendez-Otero R,Mesentier-Louro LA,Santiago MF

更新日期：2020-11-01 00:00:00

abstract：:Recent studies have shown that lactate coupled water flux is the underlying mechanism of the corneal endothelial pump, which is highly dependent on the presence of bicarbonate. In this study we test the hypothesis that the increased intracellular pH (pHi) caused by bicarbonate stimulates glycolytic activity and the pr...

journal_title：Experimental eye research

authors： Li S,Shyam R,Ogando DG,Bonanno JA

更新日期：2020-10-01 00:00:00

abstract：:Traumatic optic neuropathy (TON) can occur following blunt trauma to the orbit and can lead to permanent vision loss. In this study, we investigated the effectiveness of elamipretide (MTP-131), a small mitochondrially-targeted tetrapeptide, in conjunction with etanercept, a tumor necrosis factor (TNF) inhibitor, as ne...

journal_title：Experimental eye research

authors： Tse BC,Dvoriantchikova G,Tao W,Gallo RA,Lee JY,Ivanov D,Tse DT,Pelaez D

更新日期：2020-10-01 00:00:00

abstract：:Increasing evidence points to inflammation as a key factor in the pathogenesis of diabetic retinopathy (DR). Choroidal inflammatory changes in diabetes have been reported and in vivo choroidal thickness (CT) has been searched as a marker of retinopathy with contradictory results. We aimed to investigate the early stag...

journal_title：Experimental eye research

authors： Campos A,Campos EJ,Martins J,Rodrigues FSC,Silva R,Ambrósio AF

更新日期：2020-10-01 00:00:00

abstract：:Müller cells (MC) represent a key element for the metabolic and functional regulation of the vertebrate retina. The aim of the present study was to test the feasibility of a new method for the in-vivo detection and quantification of extrafoveal MC in human retina. We developed a new approach to isolate and analyse ext...

journal_title：Experimental eye research

authors： Arrigo A,Perra C,Aragona E,Giusto D,Doglioni C,Pierro L,Giordano Resti A,Bandello F,Battaglia Parodi M

更新日期：2020-10-01 00:00:00

abstract：:Ultraviolet A (UVA) light-based photoactivation of riboflavin (Rf) to induce corneal crosslinking (CXL) and mechanical stiffening is now a well-known treatment for corneal ectasia and Keratoconus that is being used in a topographically guided photorefractive intrastromal CXL (PiXL) procedure to treat low degrees of re...

journal_title：Experimental eye research

authors： Bradford S,Mikula E,Juhasz T,Brown DJ,Jester JV

更新日期：2020-10-01 00:00:00

abstract：:Structure and function of the retina mainly rely on its fatty acid (FA) composition. Evidence from epidemiological studies and from animal experiments indicates that FA composition of the retina is influenced by the diet. Mice under chronic high-fat diet (HFD) develop metabolic syndrome, a risk factor for diabetes tha...

journal_title：Experimental eye research

authors： Albouery M,Buteau B,Grégoire S,Martine L,Gambert S,Bron AM,Acar N,Chassaing B,Bringer MA

更新日期：2020-07-01 00:00:00

abstract：:Selective pericyte loss, the histological hallmark of early diabetic retinopathy (DR), enhances the breakdown of the blood-retinal barrier (BRB) in diabetes. However, the role of pericytes on BRB alteration in diabetes and the signaling pathways involved in their effects are currently unknown. To understand the role o...

journal_title：Experimental eye research

authors： Rangasamy S,Monickaraj F,Legendre C,Cabrera AP,Llaci L,Bilagody C,McGuire P,Das A

更新日期：2020-06-01 00:00:00

abstract：:This study aimed to assess the cytotoxic effect of low molecular weight components (LMWC) and conventional silicone oils (SOs) 1000 cSt with different degree of purification (raw, intermediate, and purified) using in vitro cytotoxicity tests. Direct contact cytotoxicity tests were performed in BALB 3T3 and human retin...

journal_title：Experimental eye research

authors： Romano MR,Ferrara M,Gatto C,Giurgola L,Zanoni M,Angi M,Rinaldi M,Borgia A,Sorrentino T,D'Amato Tóthová J

更新日期：2020-05-01 00:00:00

abstract：:We aim to determine whether lymphatic drainage from the eye changes with age. Using quantitative photoacoustic tomography, groups of young and older mice were studied in the live state. 10 CD-1 mice of 2-3 months (5M/5F) were studied in addition to 13 older mice of 12-13 months (6M/7F). In each of 23 mice, near-infrar...

journal_title：Experimental eye research

authors： Yücel YH,Cheng F,Cardinell K,Zhou X,Irving H,Gupta N

更新日期：2020-05-01 00:00:00

abstract：:Bombina variegata 8 (Bv8), also known as prokineticin-2 (PK-2), is a potent pro-angiogenic factor. However, its role in retinal neovascularization (RNV) remains unknown. In this study, we explored the role of Bv8 in the pathogenesis of RNV. We found that the expression of Bv8 was significantly increased in two differe...

journal_title：Experimental eye research

authors： Yao Y,Yao Y,Demetriades AM,Sui A,Su T,Zhu Y,Shen X,Xie B

更新日期：2020-04-01 00:00:00

abstract：:Porcine models of ophthalmological diseases are often used in pre-clinical translational studies due to pigs' similarities to humans. In particular, the iodoacetic acid (IAA) model of photoreceptor degeneration seems to mimic well the endstage phenotype of human pathologies as retinitis pigmentosa and age-related macu...

journal_title：Experimental eye research

authors： Barone F,Muscatello LV,Ventrella D,Elmi A,Romagnoli N,Mandrioli L,Maya-Vetencourt JF,Bombardi C,Mete M,Sarli G,Benfenati F,Pertile G,Bacci ML

更新日期：2020-04-01 00:00:00

abstract：:Preeclampsia (PE) is a hypertensive complication of pregnancy. Its cause is still unknown and it could be a risk factor for future ophthalmic problems. Retinal vascular bed alterations have been described as a consequence of PE, suggesting a retinopathy. Factors related to angiogenesis and vascular permeability, such ...

journal_title：Experimental eye research

authors： Ramírez-Montero C,Lima-Gómez V,Anguiano-Robledo L,Hernández-Campos ME,López-Sánchez P

更新日期：2020-04-01 00:00:00

abstract：:Optic fissure closure defects result in uveal coloboma, a potentially blinding condition affecting between 0.5 and 2.6 per 10,000 births that may cause up to 10% of childhood blindness. Uveal coloboma is on a phenotypic continuum with microphthalmia (small eye) and anophthalmia (primordial/no ocular tissue), the so-ca...

journal_title：Experimental eye research

authors： George A,Cogliati T,Brooks BP

更新日期：2020-04-01 00:00:00

abstract：:Gene therapy has been proposed as a feasible strategy for RGC survival and optic nerve regeneration. Some preclinical and clinical studies revealed intraocular inflammation after intravitreal injection of adeno-associated virus (AAV) by slit-lamp or indirect ophthalmoscope. Here we evaluate the longitudinal profile of...

journal_title：Experimental eye research

authors： Liu YF,Huang S,Ng TK,Liang JJ,Xu Y,Chen SL,Xu C,Zhang M,Pang CP,Cen LP

更新日期：2020-04-01 00:00:00

abstract：:We studied the early protein profile in the ocular tissue extracted after LASIK and SMILE surgery. SMILE and LASIK was performed in contralateral eyes and stromal tissue samples were collected from 10 eyes of 5 donors. The stromal tissue samples were analyzed using label free quantification approach and ITRAQ labellin...

journal_title：Experimental eye research

authors： Khamar P,Nishtala K,Shetty R,Panigrahi T,Shetty K,Pahuja N,Deshpande V,Ghosh A

更新日期：2020-03-01 00:00:00

abstract：:Familial exudative vitreoretinopathy (FEVR) is a disease exhibits a wide range of clinical signs, ranging mild peripheral retinal vascular anomalies to severe retinal detachments. Individuals with mild FEVR are frequently asymptomatic with good visual function and are often undiagnosed. However, little is known about ...

journal_title：Experimental eye research

authors： Chen C,Sun L,Li S,Huang L,Zhang T,Wang Z,Yu B,Ding X

更新日期：2020-03-01 00:00:00

abstract：:This study was conducted to evaluate the impact of varying scleral material properties on the biomechanical response of the cornea under air-puff induced deformation. Twenty pairs of human donor eyes were obtained for this study. One eye from each pair had its sclera stiffened using 4% glutaraldehyde, while the fellow...

journal_title：Experimental eye research

authors： Nguyen BA,Reilly MA,Roberts CJ

更新日期：2020-02-01 00:00:00

abstract：:The interaction of keratocytes with extracellular matrix components plays an important role in the maintenance of corneal transparency and shape as well as in the healing of corneal wounds. In particular, the interaction of these cells with collagen and cell-mediated collagen contraction contribute to wound closure. E...

journal_title：Experimental eye research

authors： Nishida K,Sugioka K,Murakami J,Kodama-Takahashi A,Nanri I,Mishima H,Nishida T,Kusaka S

更新日期：2020-02-01 00:00:00

abstract：:The present study was designed to investigate the effect of topical erythropoietin on the healing process of induced necrotizing scleritis and to evaluate the ocular side effects of this treatment modality in a rabbit model. Necrotizing scleritis was induced in 8 New Zealand albino rabbits. The animals were then rando...

journal_title：Experimental eye research

authors： Feizi S,Kanavi MR,Safari S,Ebrahimi H,Javadi MA

更新日期：2020-01-01 00:00:00

abstract：:Childhood glaucoma is an important cause of blindness world-wide. Eleven genes are currently known to cause inherited forms of glaucoma with onset before age 20. While all the early-onset glaucoma genes cause severe disease, considerable phenotypic variability is observed among mutations carriers. In particular, FOXC1...

journal_title：Experimental eye research

authors： Gauthier AC,Wiggs JL

更新日期：2020-01-01 00:00:00

abstract：:The bird retina offers an excellent model to investigate the mechanisms that coordinate the morphogenesis, histogenesis, and differentiation of neuron and glial cells. Although these developmental features have been intensively studied in the chicken (Gallus gallus, Linnaeus 1758), a precocial bird species, little is ...

journal_title：Experimental eye research

authors： Álvarez-Hernán G,Hernández-Núñez I,Rico-Leo EM,Marzal A,de Mera-Rodríguez JA,Rodríguez-León J,Martín-Partido G,Francisco-Morcillo J

更新日期：2020-01-01 00:00:00

abstract：:Ocular rigidity (OR) is thought to play a role in the pathogenesis of glaucoma, but the lack of reliable non-invasive measurements has been a major technical challenge. We recently developed a clinical method using optical coherence tomography time-lapse imaging and automated choroidal segmentation to measure the puls...

journal_title：Experimental eye research

authors： Sayah DN,Mazzaferri J,Ghesquière P,Duval R,Rezende F,Costantino S,Lesk MR

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:To investigate the potential protective effect of novel G protein coupled estrogen receptor (GPER1) against the neurotoxicity induced by NMDA in the mouse retina. METHODS:We induce retinal ganglion cells (RGCs) toxic injury through intravitreal injection of NMDA or acute ocular hypertension (AOH) induced by an...

journal_title：Experimental eye research

authors： Jiang M,Ma X,Zhao Q,Li Y,Xing Y,Deng Q,Shen Y

更新日期：2019-12-01 00:00:00

abstract：:Several lines of evidence support the existence of a renin-angiotensin system (RAS) in the retina that is separated from the blood stream by the retinal pigment epithelium (RPE). Under physiological conditions, increased activity of intraretinal RAS regulates neuronal activity of the retina but patho-physiologically p...

journal_title：Experimental eye research

authors： Martins JR,Reichhart N,Kociok N,Stindl J,Foeckler R,Lachmann P,Todorov V,Castrop H,Strauß O

更新日期：2019-12-01 00:00:00