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  • Ex vivo mRNA expression of toll-like receptors during latent tuberculosis infection.

    abstract:BACKGROUND:Understanding immune mechanisms, particularly the role of innate immune markers during latent TB infection remains elusive. The main objective of this study was to evaluate mRNA gene expression patterns of toll-like receptors (TLRs) as correlates of immunity during latent TB infection and further infer their...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Alemnew B,Hoff ST,Abebe T,Abebe M,Aseffa A,Howe R,Wassie L

    更新日期:2021-01-28 00:00:00

  • The role of CXCR3 and its ligands expression in Brucellar spondylitis.

    abstract:AIM:Brucellar spondylitis (BS) is one of the most serious complications of brucellosis. CXCR3 is closely related to the severity of disease infection. This research aimed to study the degree of BS inflammatory damage through analyzing the expression levels of CXCR3 and its ligands (CXCL9 and CXCL10) in patients with BS...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Hu X,Shang X,Wang L,Fan J,Wang Y,Lv J,Nazierhan S,Wang H,Wang J,Ma X

    更新日期:2020-11-18 00:00:00

  • Small RNA sequencing of extracellular vesicles identifies circulating miRNAs related to inflammation and oxidative stress in HIV patients.

    abstract:BACKGROUND:Extracellular vesicles (EVs) are nano-sized particles secreted by most cells. EVs carry nucleic acids that hold promise as potential biomarkers in various diseases. Human immunodeficiency virus type 1 (HIV) infects CD4+ T cells and induces immune dysfunction, inflammation, and EV secretion, but little is kno...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Chettimada S,Lorenz DR,Misra V,Wolinsky SM,Gabuzda D

    更新日期:2020-11-11 00:00:00

  • CD16 expression on neutrophils predicts treatment efficacy of capecitabine in colorectal cancer patients.

    abstract:BACKGROUND:Early detection of capecitabine-resistance could largely increase overall survival of colorectal cancer (CRC) patients. Previous studies suggested examination of immune cells in peripheral blood would help to predict efficacy of chemotherapy. METHODS:We examined the immunological characteristics of peripher...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Lu Y,Huang Y,Huang L,Xu Y,Wang Z,Li H,Zhang T,Zhong M,Gao WQ,Zhang Y

    更新日期:2020-08-08 00:00:00

  • Characteristics and reference ranges of CD4+T cell subpopulations among healthy adult Han Chinese in Shanxi Province, North China.

    abstract:BACKGROUND:Immunophenotyping of blood lymphocytes is an essential tool to evaluate the immune function of patients with immunodeficiency or autoimmunity. Predominately identified CD4+T cell subsets, Th1, Th2, Th17, as well as regulatory T (Treg) cells, play crucial roles in several immunological and pathological condit...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Niu HQ,Zhao XC,Li W,Xie JF,Liu XQ,Luo J,Zhao WP,Li XF

    更新日期:2020-08-03 00:00:00

  • EGR2 is elevated and positively regulates inflammatory IFNγ production in lupus CD4+ T cells.

    abstract:BACKGROUND:Recent studies have shown that early growth response 2 (EGR2) is highly induced in activated T cells and regulates T cell functions. In normal C57BL/6 (B6) mice, deletion of EGR2 in lymphocytes results in the development of lupus-like systemic autoimmune disease, which implies indirectly an autoimmune protec...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Dai R,Heid B,Xu X,Xie H,Reilly CM,Ahmed SA

    更新日期:2020-07-09 00:00:00

  • The DNA methyltransferase inhibitor, guadecitabine, targets tumor-induced myelopoiesis and recovers T cell activity to slow tumor growth in combination with adoptive immunotherapy in a mouse model of breast cancer.

    abstract:BACKGROUND:Myeloid derived suppressor cells (MDSCs) present a significant obstacle to cancer immunotherapy because they dampen anti-tumor cytotoxic T cell responses. Previous groups, including our own, have reported on the myelo-depletive effects of certain chemotherapy agents. We have shown previously that decitabine ...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Luker AJ,Graham LJ,Smith TM Jr,Camarena C,Zellner MP,Gilmer JS,Damle SR,Conrad DH,Bear HD,Martin RK

    更新日期:2020-02-27 00:00:00

  • miR32-5p promoted vascular smooth muscle cell calcification by upregulating TNFα in the microenvironment.

    abstract:BACKGROUND:Vascular calcification is often associated with chronic inflammation and is a risk factor for brain arterial stiffness. Our previous results showed that miR32-5p was positively correlated with vascular smooth muscle cells (VSMC) calcification, but it is unclear whether miR32-5p promoted VSMC calcification by...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Cao J,Chen L,Zhong X,Shen Y,Gao Y,Chen Q,Zu X,Liu J

    更新日期:2020-01-17 00:00:00

  • NK cell predicts the severity of acute graft-versus-host disease in patients after allogeneic stem cell transplantation using antithymocyte globulin (ATG) in pretreatment scheme.

    abstract:BACKGROUND:Graft-versus-host disease (GVHD) is one of the most complex complications after allogeneic stem cell transplantation. Current standard of grading system is based on clinical symptoms in skin, liver and intestinal. However, it's difficult to differ GVHD and its extent just by clinical manifestation. Here we r...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Zhang P,Yang S,Zou Y,Yan X,Wu H,Zhou M,Sun YC,Zhang Y,Zhu H,Xu K,Wang Y,Sheng LX,Mu Q,Sun L,Ouyang G

    更新日期:2019-12-09 00:00:00

  • Subsets of mononuclear phagocytes are enriched in the inflamed colons of patients with IBD.

    abstract:BACKGROUND:Myeloid cells, especially mononuclear phagocytes, which include monocytes, macrophages and dendritic cells (DC), play vital roles in innate immunity, and in the initiation and maintenance of adaptive immunity. While T cell-associated activation pathways and cytokines have been identified and evaluated in inf...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Liu H,Dasgupta S,Fu Y,Bailey B,Roy C,Lightcap E,Faustin B

    更新日期:2019-11-12 00:00:00

  • Pneumococcal vaccination responses in adults with subnormal IgG subclass concentrations.

    abstract:BACKGROUND:We sought to compare Pneumovax®23 responses in adults with subnormal IgG subclass concentrations. We studied adults with normal total IgG, frequent/severe respiratory infection, and subnormal IgG1, IgG3, or IgG1 + IgG3 before and after Pneumovax®23. We defined response as serotype-specific IgG > 1.3 μg/mL an...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Parker AR,Skold M,Harding S,Barton JC,Bertoli LF,Barton JC

    更新日期:2019-08-20 00:00:00

  • Association of proinflammatory genes expression with serum interleukin 1β and free fatty acids in metabolically healthy and unhealthy abdominally obese individuals: a case-control study.

    abstract:BACKGROUND:Proinflammatory genes are highly expressed in several metabolic disorders associated with obesity. But it is not clarified whether gene expression levels and downstream inflammatory markers are related to the metabolic state or the presence of obesity. Hence, the present study aimed to compare Toll-Like Rece...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Amiri P,Baradaran B,Saghafi-Asl M,Naghizadeh M,Shanehbandi D,Karamzad N,Vahed SZ

    更新日期:2019-07-04 00:00:00

  • Longitudinal immunosequencing in healthy people reveals persistent T cell receptors rich in highly public receptors.

    abstract:BACKGROUND:The adaptive immune system maintains a diversity of T cells capable of recognizing a broad array of antigens. Each T cell's specificity for antigens is determined by its T cell receptors (TCRs), which together across all T cells form a repertoire of millions of unique receptors in each individual. Although m...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Chu ND,Bi HS,Emerson RO,Sherwood AM,Birnbaum ME,Robins HS,Alm EJ

    更新日期:2019-06-21 00:00:00

  • Prevalence and associated factors of treatment failure among HIV/AIDS patients on HAART attending University of Gondar Referral Hospital Northwest Ethiopia.

    abstract:BACKGROUND:The initiation of highly active antiretroviral therapy (HAART) plays a significant role in the clinical management of HIV infected people by preventing morbidity and mortality. This benefit becomes, the most terrible when treatment failure develops. Thus, this research aims to assess the prevalence and assoc...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Ayele G,Tessema B,Amsalu A,Ferede G,Yismaw G

    更新日期:2018-12-17 00:00:00

  • Altered endotoxin responsiveness in healthy children with Down syndrome.

    abstract:BACKGROUND:Down syndrome (DS) is the most common syndromic immunodeficiency with an increased risk of infection, mortality from sepsis, and autoinflammation. Innate immune function is altered in DS and therefore we examined responses in CD11b and Toll like receptor 4 (TLR-4), which are important immune cell surface mar...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Huggard D,McGrane F,Lagan N,Roche E,Balfe J,Leahy TR,Franklin O,Moreno A,Melo AM,Doherty DG,Molloy EJ

    更新日期:2018-11-03 00:00:00

  • MiR-18a and miR-17 are positively correlated with circulating PD-1+ICOS+ follicular helper T cells after hepatitis B vaccination in a chinese population.

    abstract:BACKGROUND:While vaccination remains the most effective method to control hepatitis B virus (HBV) infection, 5-10% of recipients exhibit non-responsiveness to the HB vaccine. Immunological analysis of strong, weak or absent protective antibody responses to the HB vaccine should provide insights into the mechanisms that...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Xu X,Li Y,Liang Y,Yin M,Yu Z,Zhang Y,Huang L,Ni J

    更新日期:2018-07-28 00:00:00

  • Pathogen recognition by NK cells amplifies the pro-inflammatory cytokine production of monocyte-derived DC via IFN-γ.

    abstract:BACKGROUND:Besides their prominent role in the elimination of infected or malignantly transformed cells, natural killer (NK) cells serve as modulators of adaptive immune responses. Enhancing bidirectional crosstalk between NK cells and dendritic cells (DC) is considered a promising tool to potentiate cancer vaccines. W...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Oth T,Habets THPM,Germeraad WTV,Zonneveld MI,Bos GMJ,Vanderlocht J

    更新日期:2018-02-13 00:00:00

  • Down selecting adjuvanted vaccine formulations: a comparative method for harmonized evaluation.

    abstract:BACKGROUND:The need for rapid and accurate comparison of panels of adjuvanted vaccine formulations and subsequent rational down selection, presents several challenges for modern vaccine development. Here we describe a method which may enable vaccine and adjuvant developers to compare antigen/adjuvant combinations in a ...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Younis SY,Barnier-Quer C,Heuking S,Sommandas V,Brunner L,Vd Werff N,Dubois P,Friede M,Kocken C,Collin N,Remarque E

    更新日期:2018-01-31 00:00:00

  • Co-localization of lymphoid aggregates and lymphatic networks in nose- (NALT) and lacrimal duct-associated lymphoid tissue (LDALT) of mice.

    abstract:BACKGROUND:The lymphatic vascular pattern in the head of mice has rarely been studied, due to problems of sectioning and immunostaining of complex bony structures. Therefore, the association of head lymphoid tissues with the lymphatics has remained unknown although the mouse is the most often used species in immunology...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Lohrberg M,Pabst R,Wilting J

    更新日期:2018-01-25 00:00:00

  • Rheumatoid factor is correlated with disease activity and inflammatory markers in antineutrophil cytoplasmic antibody-associated vasculitis.

    abstract:BACKGROUND:Some patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) also have positivity of rheumatoid factor (RF). However, the clinical significance of this occurrence remains unknown in AAV patients. The aim of this study was to clarify an association between the presence of RF and c...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Watanabe S,Gono T,Nishina K,Sugitani N,Watanabe E,Yabe H,Terai C

    更新日期:2017-12-20 00:00:00

  • Renal allograft rejection, lymphocyte infiltration, and de novo donor-specific antibodies in a novel model of non-adherence to immunosuppressive therapy.

    abstract:BACKGROUND:Non-adherence has been associated with reduced graft survival. The aim of this study was to investigate the immunological mechanisms underlying chronic renal allograft rejection using a model of non-adherence to immunosuppressive therapy. We used a MHC (major histocompatibility complex) -mismatched rat model...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Kühne L,Jung B,Poth H,Schuster A,Wurm S,Ruemmele P,Banas B,Bergler T

    更新日期:2017-12-19 00:00:00

  • Selection of reliable reference genes for the normalisation of gene expression levels following time course LPS stimulation of murine bone marrow derived macrophages.

    abstract:BACKGROUND:Macrophages are key players in the initiation, perpetuation and regulation of both innate and adaptive immune responses. They largely perform these roles through modulation of the expression of genes, especially those encoding cytokines. Murine bone marrow derived macrophages (BMDMs) are commonly used as a m...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Tanaka A,To J,O'Brien B,Donnelly S,Lund M

    更新日期:2017-10-03 00:00:00

  • Detection of IL-9 producing T cells in the PBMCs of allergic asthmatic patients.

    abstract:BACKGROUND:Interleukin-9 (IL-9) was reported as an active participant in the pathogenesis of allergic asthma. This study aimed to investigate the major source ofIL-9 and its effect on interferon γ (IFN-γ) and immunoglobulin (Ig) secretion by B cells. METHODS:We isolated peripheral blood mononuclear cells from children...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Jia L,Wang Y,Li J,Li S,Zhang Y,Shen J,Tan W,Wu C

    更新日期:2017-07-19 00:00:00

  • The immunoregulatory role of alpha enolase in dendritic cell function during Chlamydia infection.

    abstract:BACKGROUND:We have previously reported that interleukin-10 (IL-10) deficient dendritic cells (DCs) are potent antigen presenting cells that induced elevated protective immunity against Chlamydia. To further investigate the molecular and biochemical mechanism underlying the superior immunostimulatory property of IL-10 d...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Ryans K,Omosun Y,McKeithen DN,Simoneaux T,Mills CC,Bowen N,Eko FO,Black CM,Igietseme JU,He Q

    更新日期:2017-05-19 00:00:00

  • Tumor necrosis factor alpha inhibitors have no effect on a human T-lymphotropic virus type-I (HTLV-I)-infected cell line from patients with HTLV-I-associated myelopathy.

    abstract:BACKGROUND:While tumor necrosis factor alpha (TNF-α) inhibitors (TNFi) and other biologics are very effective against autoimmune diseases, they can also cause infectious diseases. Therefore, it is important to clarify whether the TNFi sometimes used to treat patients with rheumatoid arthritis (RA) complicated with huma...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Fukui S,Nakamura H,Takahashi Y,Iwamoto N,Hasegawa H,Yanagihara K,Nakamura T,Okayama A,Kawakami A

    更新日期:2017-02-03 00:00:00

  • Porphyromonas gingivalis activates NFκB and MAPK pathways in human oral epithelial cells.

    abstract:BACKGROUND:The bacterial biofilm at the gingival margin induces a host immune reaction. In this local inflammation epithelial cells defend the host against bacterial challenge. Porphyromonas gingivalis (P. gingivalis), a keystone pathogen, infects epithelial cells. The aim of this study was to investigate the activatio...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Groeger S,Jarzina F,Domann E,Meyle J

    更新日期:2017-01-05 00:00:00

  • Multi-layered Gag-specific immunodominant responses contribute to improved viral control in the CRF01_AE subtype of HIV-1-infected MSM subjects.

    abstract:BACKGROUND:The purpose of this study was to characterize specific cytotoxic T-cell (CTL) responses in men who have sex with men (MSM) subjects infected with the human immunodeficiency virus type 1 (HIV-1) CRF01_AE subtype during the first year of infection and impacts on viral control and evolution. RESULTS:Fifteen HI...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Jiang F,Han X,Zhang H,Zhao B,An M,Xu J,Chu Z,Dong T,Shang H

    更新日期:2016-08-30 00:00:00

  • Expression of lymphocyte activation markers of preterm neonates is associated with perinatal complications.

    abstract:BACKGROUND:Inappropriate activation of T lymphocytes plays an important role in perinatal complications. However, data on T lymphocyte activation markers of preterm infants is scarce. We investigated the association between gender, gestational and postnatal age, preeclampsia (PE), premature rupture of membranes (PROM) ...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Sava F,Toldi G,Treszl A,Hajdú J,Harmath Á,Tulassay T,Vásárhelyi B

    更新日期:2016-06-21 00:00:00

  • Eosinophils may play regionally disparate roles in influencing IgA(+) plasma cell numbers during large and small intestinal inflammation.

    abstract:BACKGROUND:Eosinophils are innate immune cells present in the intestine during steady state conditions. An intestinal eosinophilia is a hallmark of many infections and an accumulation of eosinophils is also observed in the intestine during inflammatory disorders. Classically the function of eosinophils has been associa...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Forman R,Bramhall M,Logunova L,Svensson-Frej M,Cruickshank SM,Else KJ

    更新日期:2016-05-31 00:00:00

  • Investigations of immunogenic, allergenic and adjuvant properties of Cry1Ab protein after intragastric exposure in a food allergy model in mice.

    abstract:BACKGROUND:In genetically modified (GM) crops there is a risk that the inserted genes may introduce new allergens and/or adjuvants into the food and feed chain. The MON810 maize, expressing the insecticidal Cry1Ab toxin, is grown in many countries worldwide. In animal models, intranasal and intraperitoneal immunisation...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Andreassen M,Bøhn T,Wikmark OG,Bodin J,Traavik T,Løvik M,Nygaard UC

    更新日期:2016-05-04 00:00:00

  • The effects of storage temperature on PBMC gene expression.

    abstract:BACKGROUND:Cryopreservation of peripheral blood mononuclear cells (PBMCs) is a common and essential practice in conducting research. There are different reports in the literature as to whether cryopreserved PBMCs need to only be stored ≤ -150 °C or can be stored for a specified time at -80 °C. Therefore, we performed g...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Yang J,Diaz N,Adelsberger J,Zhou X,Stevens R,Rupert A,Metcalf JA,Baseler M,Barbon C,Imamichi T,Lempicki R,Cosentino LM

    更新日期:2016-03-15 00:00:00

  • CD4(+)CD25(High) Treg cells in HIV/HTLV co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factor.

    abstract:BACKGROUND:Regulatory CD4 T cells (Tregs) are critical in maintaining the homeostasis of the immune system. Quantitative or phenotypic alterations and functional impairment of Tregs have been associated with the development of pathologies including those of the central nervous system. Individuals with HIV-1/HTLV-1 co-i...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Matavele Chissumba R,Silva-Barbosa SD,Augusto Â,Maueia C,Mabunda N,Gudo ES Jr,Bhatt N,Jani I,Savino W

    更新日期:2015-09-02 00:00:00

  • Mycobacterial glycolipids di-O-acylated trehalose and tri-O-acylated trehalose downregulate inducible nitric oxide synthase and nitric oxide production in macrophages.

    abstract:BACKGROUND:Tuberculosis (TB) remains a serious human health problem that affects millions of people in the world. Understanding the biology of Mycobacterium tuberculosis (Mtb) is essential for tackling this devastating disease. Mtb possesses a very complex cell envelope containing a variety of lipid components that par...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Espinosa-Cueto P,Escalera-Zamudio M,Magallanes-Puebla A,López-Marín LM,Segura-Salinas E,Mancilla R

    更新日期:2015-06-23 00:00:00

  • Genomic locus on chromosome 1 regulates susceptibility to spontaneous arthritis in mice deficiency of IL-1RA.

    abstract:BACKGROUND:To understand the role of genetic factors on chromosome 1 in the regulation of spontaneous arthritis in mice deficient in IL-1 receptor antagonist protein (IL_1RA), we previously used speed congenic breeding to transfer the QTL region from DBA/1(-/-) mice that are resistant to spontaneous arthritis into BALB...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Deng N,Jiao Y,Cao Y,Liu X,Ma Y,Hasty KA,Brand DD,Stuart JM,Gu W

    更新日期:2014-12-09 00:00:00

  • The discriminative capacity of soluble Toll-like receptor (sTLR)2 and sTLR4 in inflammatory diseases.

    abstract:BACKGROUND:The extracellular domains of cytokine receptors are released during inflammation, but little is known about the shedding of Toll-like receptors (TLR) and whether they can be used as diagnostic biomarkers. METHODS:The release of sTLR2 and sTLR4 was studied in in-vitro stimulations, as well as in-vivo during ...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Ten Oever J,Kox M,van de Veerdonk FL,Mothapo KM,Slavcovici A,Jansen TL,Tweehuysen L,Giamarellos-Bourboulis EJ,Schneeberger PM,Wever PC,Stoffels M,Simon A,van der Meer JW,Johnson MD,Kullberg BJ,Pickkers P,Pachot A,Jooste

    更新日期:2014-11-19 00:00:00

  • Reduced plasma levels of soluble interleukin-7 receptor during graft-versus-host disease (GVHD) in children and adults.

    abstract:BACKGROUND:Interleukin 7 (IL-7) signals via the IL-7 receptor (IL-7R) and drives homeostatic T-cell proliferation in patients after allogeneic hematopoietic stem cell transplantation (aHSCT). PURPOSE:We performed a prospective study in adults (n = 33) and children (n = 29) undergoing aHSCT measuring plasma IL-7 and so...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Poiret T,Rane L,Remberger M,Omazic B,Gustafsson-Jernberg A,Vudattu NK,Ahmed R,Ernberg I,Winiarski J,Magalhaes I,Ringden O,Maeurer M

    更新日期:2014-06-19 00:00:00

  • Depigmented-polymerised allergoids favour regulatory over effector T cells: enhancement by 1α, 25-dihydroxyvitamin D3.

    abstract:BACKGROUND:Allergen immunotherapy (SIT) is the only treatment for allergic disease capable of modifying disease long term. To reduce the risk of anaphylaxis from SIT, allergen-extracts have been modified by polymerisation with glutaraldehyde to reduce IgE binding. It is suggested that these allergoid extracts also have...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Urry ZL,Richards DF,Black C,Morales M,Carnés J,Hawrylowicz CM,Robinson DS

    更新日期:2014-05-29 00:00:00

  • Streptococcus sanguinis-induced cytokine and matrix metalloproteinase-1 release from platelets.

    abstract:BACKGROUND:Streptococcus sanguinis (S.sanguinis), a predominant bacterium in the human oral cavity, has been widely associated with the development of infective endocarditis. Platelets play both a haemostatic function and can influence both innate and adaptive immune responses. Previous studies have shown that S.sangui...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Cognasse F,Hamzeh-Cognasse H,Chabert A,Jackson E,Arthaud CA,Garraud O,McNicol A

    更新日期:2014-04-22 00:00:00

  • T-cell activation discriminates subclasses of symptomatic primary humoral immunodeficiency diseases in adults.

    abstract:BACKGROUND:Symptomatic Primary Humoral Immunodeficiency Diseases (PHID) constitute a highly heterogeneous group of diseases characterized by a shared hypogammaglobulinemia, resulting in increased risk of recurrent or severe infections. Associations have been described with a variety of immunological abnormalities invol...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Picat MQ,Thiébaut R,Lifermann F,Delbrel X,Adoue D,Wittkop L,Fauchais AL,Rispal P,Moreau JF,Viallard JF

    更新日期:2014-03-12 00:00:00

  • Impact of endobronchial allergen provocation on macrophage phenotype in asthmatics.

    abstract:BACKGROUND:The role of M2 polarized macrophages (MΦ) during the allergic airway inflammation has been discussed in various animal models. However, their presence and relevance during the chronic and acute phase of allergic airway inflammation in humans has not been fully elucidated so far. In the present study we pheno...

    journal_title:BMC immunology

    pub_type: 杂志文章


    authors: Winkler C,Witte L,Moraw N,Faulenbach C,Müller M,Holz O,Schaumann F,Hohlfeld JM

    更新日期:2014-03-10 00:00:00

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