Rheumatoid factor is correlated with disease activity and inflammatory markers in antineutrophil cytoplasmic antibody-associated vasculitis.

abstract：BACKGROUND:Respiratory burst function resulting in the release of reactive oxygen species such as superoxide anion (O2-) from neutrophils is one of the key mechanisms of the innate immune system, and maladaptive control of this mechanism is thought to play a pivotal role in the development of pathologies such as acute ...

journal_title：BMC immunology

authors： Tung JP,Fraser JF,Wood P,Fung YL

更新日期：2009-05-08 00:00:00

abstract：BACKGROUND:Human intestinal epithelial cells (IECs) secrete the chemokine CCL20 in response to infection by various enteropathogenic bacteria or exposure to bacterial flagellin. CCL20 recruits immature dendritic cells and lymphocytes to target sites. Here we investigated IEC responses to various pathogenic and commensa...

journal_title：BMC immunology

authors： Sibartie S,O'Hara AM,Ryan J,Fanning A,O'Mahony J,O'Neill S,Sheil B,O'Mahony L,Shanahan F

更新日期：2009-10-08 00:00:00

abstract：BACKGROUND:To understand the role of genetic factors on chromosome 1 in the regulation of spontaneous arthritis in mice deficient in IL-1 receptor antagonist protein (IL_1RA), we previously used speed congenic breeding to transfer the QTL region from DBA/1(-/-) mice that are resistant to spontaneous arthritis into BALB...

journal_title：BMC immunology

authors： Deng N,Jiao Y,Cao Y,Liu X,Ma Y,Hasty KA,Brand DD,Stuart JM,Gu W

更新日期：2014-12-09 00:00:00

abstract：BACKGROUND:Allergic skin inflammation such as atopic dermatitis (AD), which is characterized by pruritus and inflammation, is regulated partly through the activity of regulatory T cells (Tregs). Tregs play key roles in the immune response by preventing or suppressing the differentiation, proliferation and function of v...

journal_title：BMC immunology

authors： Han SC,Kang GJ,Ko YJ,Kang HK,Moon SW,Ann YS,Yoo ES

更新日期：2012-08-09 00:00:00

abstract：BACKGROUND:We have developed a 12-parameter/10-color flow cytometric staining method for the simultaneous detection and characterization of 21 mouse thymocyte subpopulations that represent discreet stages of T cell development. To demonstrate the utility of this method, we assessed cytokine receptor expression on mouse...

journal_title：BMC immunology

authors： Tan C,Taylor AA,Coburn MZ,Marino JH,Van De Wiele CJ,Teague TK

更新日期：2011-06-20 00:00:00

abstract：BACKGROUND:The lymphatic vascular pattern in the head of mice has rarely been studied, due to problems of sectioning and immunostaining of complex bony structures. Therefore, the association of head lymphoid tissues with the lymphatics has remained unknown although the mouse is the most often used species in immunology...

journal_title：BMC immunology

authors： Lohrberg M,Pabst R,Wilting J

更新日期：2018-01-25 00:00:00

abstract：BACKGROUND:Toxic shock syndrome (TSS) is caused by an overwhelming host-mediated response to bacterial superantigens produced mainly by Staphylococcus aureus and Streptococcus pyogenes. TSS is characterized by aberrant activation of T cells and excessive release of pro-inflammatory cytokines ultimately resulting in cap...

journal_title：BMC immunology

authors： Kim H,Darwish I,Monroy MF,Prockop DJ,Liles WC,Kain KC

更新日期：2014-01-14 00:00:00

abstract：BACKGROUND:An ideal tumor vaccine should activate both effector and memory immune response against tumor-specific antigens. Beside the CD8+ T cells that play a central role in the generation of a protective immune response and of long-term memory, dendritic cells (DCs) are important for the induction, coordination and ...

journal_title：BMC immunology

authors： Cerkovnik P,Novakovic BJ,Stegel V,Novakovic S

更新日期：2010-09-13 00:00:00

abstract：BACKGROUND:The bacterial biofilm at the gingival margin induces a host immune reaction. In this local inflammation epithelial cells defend the host against bacterial challenge. Porphyromonas gingivalis (P. gingivalis), a keystone pathogen, infects epithelial cells. The aim of this study was to investigate the activatio...

journal_title：BMC immunology

authors： Groeger S,Jarzina F,Domann E,Meyle J

更新日期：2017-01-05 00:00:00

abstract：BACKGROUND:Myeloid cells, especially mononuclear phagocytes, which include monocytes, macrophages and dendritic cells (DC), play vital roles in innate immunity, and in the initiation and maintenance of adaptive immunity. While T cell-associated activation pathways and cytokines have been identified and evaluated in inf...

journal_title：BMC immunology

authors： Liu H,Dasgupta S,Fu Y,Bailey B,Roy C,Lightcap E,Faustin B

更新日期：2019-11-12 00:00:00

abstract：BACKGROUND:T-cells extravasation and CNS parenchyma infiltration during autoimmune neurodegenerative disease can be evoked by local antigen presenting cells. Studying the chemoattracting potential of spinal perivascular macrophages (SPM) during experimental allergic encephalomyelitis (EAE), we observed numerous infiltr...

journal_title：BMC immunology

authors： Hofmann N,Lachnit N,Streppel M,Witter B,Neiss WF,Guntinas-Lichius O,Angelov DN

更新日期：2002-08-26 00:00:00

abstract：BACKGROUND:Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by the novel coronavirus SARS-CoV. The T cell epitopes of the SARS CoV spike protein are well known, but no systematic evaluation of the functional and structural roles of each residue has been reported for these antigenic epit...

journal_title：BMC immunology

authors： Huang J,Cao Y,Bu X,Wu C

更新日期：2012-09-10 00:00:00

abstract：BACKGROUND:Shiga toxin 2 (Stx2), one of two Stx liberated by Stx-producing Escherichia coli, is composed of an A subunit monomer and a B subunit pentamer, and is directly linked with hemolytic uremic syndrome in children. The pentameric B subunit binds to its cell surface receptor Gb3 for toxin internalization, and the...

journal_title：BMC immunology

authors： Jeong KI,Chapman-Bonofiglio S,Singh P,Lee J,Tzipori S,Sheoran AS

更新日期：2010-03-24 00:00:00

abstract：BACKGROUND:Parasite-specific IgE levels correlate with human resistance to reinfection with Schistosoma spp. after chemotherapy. Although the role of eosinophils in schistosomiasis has been the focus of a great deal of important research, the involvement of other Fcepsilon receptor-bearing cells, such as mast cells and...

journal_title：BMC immunology

authors： Satti MZ,Cahen P,Skov PS,Joseph S,Jones FM,Fitzsimmons C,Hoffmann KF,Reimert C,Kariuki HC,Kazibwe F,Mwatha JK,Kimani G,Vennervald BJ,Ouma JH,Kabatereine NB,Dunne DW

更新日期：2004-04-21 00:00:00

abstract：BACKGROUND:Inappropriate responses to normal intestinal bacteria may be involved in the development of Inflammatory Bowel Diseases (IBD, e.g. Crohn's Disease (CD), Ulcerative Colitis (UC)) and variations in the host genome may mediate this process. IL-10 gene-deficient (Il10-/-) mice develop CD-like colitis mainly in t...

journal_title：BMC immunology

authors： Barnett MP,McNabb WC,Cookson AL,Zhu S,Davy M,Knoch B,Nones K,Hodgkinson AJ,Roy NC

更新日期：2010-07-15 00:00:00

abstract：BACKGROUND:Macrophages have heterogeneous phenotypes and complex functions within both innate and adaptive immune responses. To date, most experimental studies have been performed on macrophages derived from bone marrow, spleen and peritoneum. However, differences among macrophages from these particular sources remain ...

journal_title：BMC immunology

authors： Wang C,Yu X,Cao Q,Wang Y,Zheng G,Tan TK,Zhao H,Zhao Y,Wang Y,Harris DCh

更新日期：2013-02-05 00:00:00

abstract：BACKGROUND:We sought to compare Pneumovax®23 responses in adults with subnormal IgG subclass concentrations. We studied adults with normal total IgG, frequent/severe respiratory infection, and subnormal IgG1, IgG3, or IgG1 + IgG3 before and after Pneumovax®23. We defined response as serotype-specific IgG > 1.3 μg/mL an...

journal_title：BMC immunology

authors： Parker AR,Skold M,Harding S,Barton JC,Bertoli LF,Barton JC

更新日期：2019-08-20 00:00:00

abstract：BACKGROUND:The initiation of highly active antiretroviral therapy (HAART) plays a significant role in the clinical management of HIV infected people by preventing morbidity and mortality. This benefit becomes, the most terrible when treatment failure develops. Thus, this research aims to assess the prevalence and assoc...

journal_title：BMC immunology

authors： Ayele G,Tessema B,Amsalu A,Ferede G,Yismaw G

更新日期：2018-12-17 00:00:00

abstract：:The immunological roles of B-cells are being revealed as increasingly complex by functions that are largely beyond their commitment to differentiate into plasma cells and produce antibodies, the key molecular protagonists of innate immunity, and also by their compartmentalisation, a more recently acknowledged property...

journal_title：BMC immunology

authors： Garraud O,Borhis G,Badr G,Degrelle S,Pozzetto B,Cognasse F,Richard Y

更新日期：2012-11-29 00:00:00

abstract：BACKGROUND:Vascular calcification is often associated with chronic inflammation and is a risk factor for brain arterial stiffness. Our previous results showed that miR32-5p was positively correlated with vascular smooth muscle cells (VSMC) calcification, but it is unclear whether miR32-5p promoted VSMC calcification by...

journal_title：BMC immunology

authors： Cao J,Chen L,Zhong X,Shen Y,Gao Y,Chen Q,Zu X,Liu J

更新日期：2020-01-17 00:00:00

abstract：BACKGROUND:Anthrax lethal toxin (LT), produced by the Gram-positive bacterium Bacillus anthracis, is a highly effective zinc dependent metalloprotease that cleaves the N-terminus of mitogen-activated protein kinase kinases (MAPKK or MEKs) and is known to play a role in impairing the host immune system during an inhalat...

journal_title：BMC immunology

authors： Chauncey KM,Lopez MC,Sidhu G,Szarowicz SE,Baker HV,Quinn C,Southwick FS

更新日期：2012-07-02 00:00:00

abstract：BACKGROUND:Dendritic cells (DC) play the key role in directing antigen-specific immune responses and manipulating their function may be a useful tool for immunotherapy. The balance between immune stimulation and tolerance is particularly important at mucosal interfaces, where discrimination between dangerous pathogens ...

journal_title：BMC immunology

authors： Polak ME,Borthwick NJ,Gabriel FG,Jager MJ,Cree IA

更新日期：2008-03-18 00:00:00

abstract：BACKGROUND:Macrophages are key players in the initiation, perpetuation and regulation of both innate and adaptive immune responses. They largely perform these roles through modulation of the expression of genes, especially those encoding cytokines. Murine bone marrow derived macrophages (BMDMs) are commonly used as a m...

journal_title：BMC immunology

authors： Tanaka A,To J,O'Brien B,Donnelly S,Lund M

更新日期：2017-10-03 00:00:00

abstract：BACKGROUND:Pattern recognition receptors (PRRs) for double-stranded RNA (dsRNA) are components of innate immunity that recognize the presence of viral infection and initiate efficient defense mechanisms. In addition to previously well-characterized signaling pathways that are mediated by PKR and TLR3, new intracellular...

journal_title：BMC immunology

authors： Yun JJ,Tsao MS,Der SD

更新日期：2011-02-10 00:00:00

abstract：BACKGROUND:Understanding immune mechanisms, particularly the role of innate immune markers during latent TB infection remains elusive. The main objective of this study was to evaluate mRNA gene expression patterns of toll-like receptors (TLRs) as correlates of immunity during latent TB infection and further infer their...

journal_title：BMC immunology

authors： Alemnew B,Hoff ST,Abebe T,Abebe M,Aseffa A,Howe R,Wassie L

更新日期：2021-01-28 00:00:00

abstract：BACKGROUND:Bv8, prokineticin-1, or endocrine gland-vascular endothelial growth factor, and prokineticin-2 are recently isolated peptide agonists of two G protein-coupled receptors, prokineticin receptor-1 (PROKR 1) and PROKR 2, and have been described as affecting a number of myeloid cell functions. We evaluated the im...

journal_title：BMC immunology

authors： Franchi S,Giannini E,Lattuada D,Lattanzi R,Tian H,Melchiorri P,Negri L,Panerai AE,Sacerdote P

更新日期：2008-10-28 00:00:00

abstract：BACKGROUND:Adenoviral vectors have provided effective methods for in vivo gene delivery in therapeutic applications. However, these vectors can induce immune responses that may severely affect the ability of vector re-application. There is limited information about the mechanisms and signal transduction pathways involv...

journal_title：BMC immunology

authors： Steinstraesser L,Sorkin M,Jacobsen F,Al-Benna S,Kesting MR,Niederbichler AD,Otte JM,Hirsch T,Stupka J,Steinau HU,Schulte M

更新日期：2011-01-21 00:00:00

abstract：BACKGROUND:Pro-inflammatory cytokines can affect intracellular lipid metabolism. A variety of effects have been described for different cell types; hepatocyte lipid turnover pathways are inhibited during inflammation, whereas interleukin-1beta (IL-1beta) reduces intracellular cholesterol levels in fibroblasts. Levels o...

journal_title：BMC immunology

authors： Persson J,Nilsson J,Lindholm MW

更新日期：2008-11-25 00:00:00

abstract：BACKGROUND:Streptococcus pneumoniae is a human pathogenic bacteria and a major cause of severe invasive diseases, including pneumonia, bacteremia, and meningitis. Infections with S. pneumoniae evoke a strong inflammatory response, which plays a major role in the pathogenesis of pneumococcal disease. RESULTS:In this st...

journal_title：BMC immunology

authors： Mogensen TH,Berg RS,Ostergaard L,Paludan SR

更新日期：2008-09-16 00:00:00

abstract：BACKGROUND:Most HIV-infected subjects exhibit a progressive rise in CD4 T-cell counts after initiation of highly active antiretroviral therapy (HAART). However, a subset of individuals exhibit very poor CD4 T-cell recovery despite effective control of HIV-RNA viraemia. We evaluated CD4 T-cell proliferation among subopt...

journal_title：BMC immunology

authors： Nakanjako D,Ssewanyana I,Nabatanzi R,Kiragga A,Kamya MR,Cao H,Mayanja-Kizza H

更新日期：2013-06-20 00:00:00