Abstract：
BACKGROUND:An ideal tumor vaccine should activate both effector and memory immune response against tumor-specific antigens. Beside the CD8+ T cells that play a central role in the generation of a protective immune response and of long-term memory, dendritic cells (DCs) are important for the induction, coordination and regulation of the adaptive immune response. The DCs can conduct all of the elements of the immune orchestra and are therefore a fundamental target and tool for vaccination. The present study was aimed at assessing the ability of tumor vaccine composed of C-class CpG ODNs and irradiated melanoma tumor cells B16F1 followed by two additional injections of CpG ODNs to induce the generation of a functional long-term memory response in experimental tumor model in mice (i.p. B16F1). RESULTS:It has been shown that the functional memory response in vaccinated mice persists for at least 60 days after the last vaccination. Repeated vaccination also improves the survival of experimental animals compared to single vaccination, whereas the proportion of animals totally protected from the development of aggressive i.p. B16F1 tumors after vaccination repeated three times varies between 88.9%-100.0%. Additionally, the long-term immune memory and tumor protection is maintained over a prolonged period of time of at least 8 months. Finally, it has been demonstrated that following the vaccination the tumor-specific memory cells predominantly reside in bone marrow and peritoneal tissue and are in a more active state than their splenic counterparts. CONCLUSIONS:In this study we demonstrated that tumor vaccine composed of C-class CpG ODNs and irradiated tumor cells followed by two additional injections of CpG ODNs induces a long-term immunity against aggressive B16F1 tumors.
journal_name
BMC Immunoljournal_title
BMC immunologyauthors
Cerkovnik P,Novakovic BJ,Stegel V,Novakovic Sdoi
10.1186/1471-2172-11-45subject
Has Abstractpub_date
2010-09-13 00:00:00pages
45issn
1471-2172pii
1471-2172-11-45journal_volume
11pub_type
杂志文章相关文献
BMC IMMUNOLOGY文献大全abstract：BACKGROUND:Immunoglobulin rearrangement involves random and imprecise processes that act to both create and constrain diversity. Two such processes are the loss of nucleotides through the action of unknown exonuclease(s) and the addition of P nucleotides. The study of such processes has been compromised by difficulties...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/1471-2172-5-19
更新日期：2004-09-02 00:00:00
abstract：BACKGROUND:Streptococcus pneumoniae is a human pathogenic bacteria and a major cause of severe invasive diseases, including pneumonia, bacteremia, and meningitis. Infections with S. pneumoniae evoke a strong inflammatory response, which plays a major role in the pathogenesis of pneumococcal disease. RESULTS:In this st...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/1471-2172-9-52
更新日期：2008-09-16 00:00:00
abstract：BACKGROUND:Vascular calcification is often associated with chronic inflammation and is a risk factor for brain arterial stiffness. Our previous results showed that miR32-5p was positively correlated with vascular smooth muscle cells (VSMC) calcification, but it is unclear whether miR32-5p promoted VSMC calcification by...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/s12865-019-0324-x
更新日期：2020-01-17 00:00:00
abstract：BACKGROUND:Regulatory CD4 T cells (Tregs) are critical in maintaining the homeostasis of the immune system. Quantitative or phenotypic alterations and functional impairment of Tregs have been associated with the development of pathologies including those of the central nervous system. Individuals with HIV-1/HTLV-1 co-i...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/s12865-015-0116-x
更新日期：2015-09-02 00:00:00
abstract：BACKGROUND:T-cells extravasation and CNS parenchyma infiltration during autoimmune neurodegenerative disease can be evoked by local antigen presenting cells. Studying the chemoattracting potential of spinal perivascular macrophages (SPM) during experimental allergic encephalomyelitis (EAE), we observed numerous infiltr...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/1471-2172-3-11
更新日期：2002-08-26 00:00:00
abstract：BACKGROUND:Understanding immune mechanisms, particularly the role of innate immune markers during latent TB infection remains elusive. The main objective of this study was to evaluate mRNA gene expression patterns of toll-like receptors (TLRs) as correlates of immunity during latent TB infection and further infer their...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/s12865-021-00400-4
更新日期：2021-01-28 00:00:00
abstract：BACKGROUND:Class I major histocompatibility complex (MHC) molecules bind, and present to T cells, short peptides derived from intracellular processing of proteins. The peptide repertoire of a specific molecule is to a large extent determined by the molecular structure accommodating so-called main anchor positions of th...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/1471-2172-9-1
更新日期：2008-01-22 00:00:00
abstract：BACKGROUND:Down syndrome (DS) is the most common syndromic immunodeficiency with an increased risk of infection, mortality from sepsis, and autoinflammation. Innate immune function is altered in DS and therefore we examined responses in CD11b and Toll like receptor 4 (TLR-4), which are important immune cell surface mar...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/s12865-018-0270-z
更新日期：2018-11-03 00:00:00
abstract：BACKGROUND:The gram-negative bacterium Bordetella pertussis is an important causative agent of pertussis, an infectious disease of the respiratory tract. After introduction of whole-cell vaccines (wP) in the 1950's, pertussis incidence has decreased significantly. Because wP were found to be reactogenic, in most develo...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/1471-2172-9-21
更新日期：2008-05-22 00:00:00
abstract：BACKGROUND:Shiga toxin 2 (Stx2), one of two Stx liberated by Stx-producing Escherichia coli, is composed of an A subunit monomer and a B subunit pentamer, and is directly linked with hemolytic uremic syndrome in children. The pentameric B subunit binds to its cell surface receptor Gb3 for toxin internalization, and the...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/1471-2172-11-16
更新日期：2010-03-24 00:00:00
abstract：BACKGROUND:Human memory CD4+ T cells can be either CD300a/c+ or CD300a/c- and subsequent analyses showed that CD4+ effector memory T (T(EM)) cells are mostly CD300a/c+, whereas CD4+ central memory T (T(CM)) cells have similar frequencies of CD300a/c+ and CD300a/c- cells. RESULTS:Extensive phenotypical and functional c...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/1471-2172-12-62
更新日期：2011-11-02 00:00:00
abstract：BACKGROUND:Neutrophils are critical in the defense against potentially harmful microorganisms, but their excessive and inappropriate activation can contribute significantly to tissue damage and a worsening pathology. Through the release of endocrine factors submandibular glands contribute to achieving a balance in neut...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/1471-2172-4-3
更新日期：2003-03-04 00:00:00
abstract：BACKGROUND:CD4+CD25+ regulatory T cells play an essential role in maintaining immune homeostasis and preventing autoimmunity. Therefore, defects in Treg development, maintenance or function have been associated with several human autoimmune diseases including Systemic Lupus Erythematosus (SLE), a systemic autoimmune di...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/1471-2172-10-5
更新日期：2009-01-27 00:00:00
abstract：BACKGROUND:There are three major B-cell compartments in peripheral lymphoid organs: the germinal center (GC), the mantle zone (MNZ) and the marginal zone (MGZ). Unique sets of B-cells reside in these compartments, and they have specific functional roles in humoral immune response. MNZ B cells are naive cells in a quies...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/1471-2172-5-20
更新日期：2004-09-15 00:00:00
abstract：BACKGROUND:In celiac disease gluten, the disease-inducing toxic component in wheat, induces the secretion of autoantibodies which are targeted against transglutaminase 2 (TG2). These autoantibodies are produced in the small-intestinal mucosa, where they can be found deposited extracellularly below the epithelial baseme...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/1471-2172-9-6
更新日期：2008-02-29 00:00:00
abstract：BACKGROUND:Myeloid derived suppressor cells (MDSCs) present a significant obstacle to cancer immunotherapy because they dampen anti-tumor cytotoxic T cell responses. Previous groups, including our own, have reported on the myelo-depletive effects of certain chemotherapy agents. We have shown previously that decitabine ...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/s12865-020-0337-5
更新日期：2020-02-27 00:00:00
abstract：BACKGROUND:Toxic shock syndrome (TSS) is caused by an overwhelming host-mediated response to bacterial superantigens produced mainly by Staphylococcus aureus and Streptococcus pyogenes. TSS is characterized by aberrant activation of T cells and excessive release of pro-inflammatory cytokines ultimately resulting in cap...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/1471-2172-15-1
更新日期：2014-01-14 00:00:00
abstract：BACKGROUND:The role of M2 polarized macrophages (MΦ) during the allergic airway inflammation has been discussed in various animal models. However, their presence and relevance during the chronic and acute phase of allergic airway inflammation in humans has not been fully elucidated so far. In the present study we pheno...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/1471-2172-15-12
更新日期：2014-03-10 00:00:00
abstract：BACKGROUND:Non-adherence has been associated with reduced graft survival. The aim of this study was to investigate the immunological mechanisms underlying chronic renal allograft rejection using a model of non-adherence to immunosuppressive therapy. We used a MHC (major histocompatibility complex) -mismatched rat model...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/s12865-017-0236-6
更新日期：2017-12-19 00:00:00
abstract：BACKGROUND:Tuberculosis (TB) remains a serious human health problem that affects millions of people in the world. Understanding the biology of Mycobacterium tuberculosis (Mtb) is essential for tackling this devastating disease. Mtb possesses a very complex cell envelope containing a variety of lipid components that par...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/s12865-015-0102-3
更新日期：2015-06-23 00:00:00
abstract：BACKGROUND:Although plasmid DNA encoding an antigen from pathogens or tumor cells has been widely studied as vaccine, the use of plasmid vector (without insert) as therapeutic agent requires further investigation. RESULTS:Here, we showed that plasmid DNA (pcDNA3) at low doses inhibits the production of IL-6 and TNF-α ...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/1471-2172-13-59
更新日期：2012-11-08 00:00:00
abstract：BACKGROUND:The adaptive immune system maintains a diversity of T cells capable of recognizing a broad array of antigens. Each T cell's specificity for antigens is determined by its T cell receptors (TCRs), which together across all T cells form a repertoire of millions of unique receptors in each individual. Although m...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/s12865-019-0300-5
更新日期：2019-06-21 00:00:00
abstract：BACKGROUND:Inappropriate responses to normal intestinal bacteria may be involved in the development of Inflammatory Bowel Diseases (IBD, e.g. Crohn's Disease (CD), Ulcerative Colitis (UC)) and variations in the host genome may mediate this process. IL-10 gene-deficient (Il10-/-) mice develop CD-like colitis mainly in t...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/1471-2172-11-39
更新日期：2010-07-15 00:00:00
abstract：BACKGROUND:CD33 is a membrane receptor containing a lectin domain and a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) that is able to inhibit cytokine production. CD33 is expressed by monocytes, and reduced expression of CD33 correlates with augmented production of inflammatory cytokines, such as IL...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/1471-2172-13-19
更新日期：2012-04-14 00:00:00
abstract：BACKGROUND:Expressed in embryonic development, matrix metalloprotein-9 (MMP-9) is absent in most of developed adult tissues, but recurs in inflammation during tissue injury, wound healing, tumor formation and metastasis. Expression of MMP-9 is tightly controlled by extracellular cues including pro-inflammatory cytokine...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/1471-2172-10-15
更新日期：2009-03-19 00:00:00
abstract：BACKGROUND:Activation signals can be negatively regulated by cell surface receptors bearing immunoreceptor tyrosine-based inhibitory motifs (ITIMs). CD300a, an ITIM bearing type I transmembrane protein, is expressed on many hematopoietic cells, including subsets of lymphocytes. RESULTS:We have taken two approaches to ...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/1471-2172-13-23
更新日期：2012-04-26 00:00:00
abstract：BACKGROUND:Parasite-specific IgE levels correlate with human resistance to reinfection with Schistosoma spp. after chemotherapy. Although the role of eosinophils in schistosomiasis has been the focus of a great deal of important research, the involvement of other Fcepsilon receptor-bearing cells, such as mast cells and...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/1471-2172-5-6
更新日期：2004-04-21 00:00:00
abstract：BACKGROUND:The need for rapid and accurate comparison of panels of adjuvanted vaccine formulations and subsequent rational down selection, presents several challenges for modern vaccine development. Here we describe a method which may enable vaccine and adjuvant developers to compare antigen/adjuvant combinations in a ...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/s12865-018-0245-0
更新日期：2018-01-31 00:00:00
abstract：BACKGROUND:Pro-inflammatory cytokines can affect intracellular lipid metabolism. A variety of effects have been described for different cell types; hepatocyte lipid turnover pathways are inhibited during inflammation, whereas interleukin-1beta (IL-1beta) reduces intracellular cholesterol levels in fibroblasts. Levels o...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/1471-2172-9-70
更新日期：2008-11-25 00:00:00
abstract：BACKGROUND:The functional immaturity of T cells contributes to the susceptibility of neonates to infections and the less severe graft-versus-host disease associated with cord blood (CB) transplantation. We have previously reported that insulin-like growth factor - I (IGF-I) promotes the phytohaemagglutinin (PHA)-induce...
journal_title：BMC immunology
pub_type： 杂志文章
doi：10.1186/1471-2172-9-74
更新日期：2008-12-17 00:00:00
