Mycobacterial glycolipids di-O-acylated trehalose and tri-O-acylated trehalose downregulate inducible nitric oxide synthase and nitric oxide production in macrophages.

Abstract:

BACKGROUND:Tuberculosis (TB) remains a serious human health problem that affects millions of people in the world. Understanding the biology of Mycobacterium tuberculosis (Mtb) is essential for tackling this devastating disease. Mtb possesses a very complex cell envelope containing a variety of lipid components that participate in the establishment of the infection. We have previously demonstrated that di-O-acylated trehalose (DAT), a non-covalently linked cell wall glycolipid, inhibits the proliferation of T lymphocytes and the production of cytokines. RESULTS:In this work we show that DAT and the closely related tri-O-acylated trehalose (TAT) inhibits nitric oxide (NO) production and the inducible nitric oxide synthase (iNOS) expression in macrophages (MØ). CONCLUSIONS:These findings show that DAT and TAT are cell-wall located virulence factors that downregulate an important effector of the immune response against mycobacteria.

journal_name

BMC Immunol

journal_title

BMC immunology

authors

Espinosa-Cueto P,Escalera-Zamudio M,Magallanes-Puebla A,López-Marín LM,Segura-Salinas E,Mancilla R

doi

10.1186/s12865-015-0102-3

subject

Has Abstract

pub_date

2015-06-23 00:00:00

pages

38

issn

1471-2172

pii

10.1186/s12865-015-0102-3

journal_volume

16

pub_type

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