Abstract:
BACKGROUND:Tuberculosis (TB) remains a serious human health problem that affects millions of people in the world. Understanding the biology of Mycobacterium tuberculosis (Mtb) is essential for tackling this devastating disease. Mtb possesses a very complex cell envelope containing a variety of lipid components that participate in the establishment of the infection. We have previously demonstrated that di-O-acylated trehalose (DAT), a non-covalently linked cell wall glycolipid, inhibits the proliferation of T lymphocytes and the production of cytokines. RESULTS:In this work we show that DAT and the closely related tri-O-acylated trehalose (TAT) inhibits nitric oxide (NO) production and the inducible nitric oxide synthase (iNOS) expression in macrophages (MØ). CONCLUSIONS:These findings show that DAT and TAT are cell-wall located virulence factors that downregulate an important effector of the immune response against mycobacteria.
journal_name
BMC Immunoljournal_title
BMC immunologyauthors
Espinosa-Cueto P,Escalera-Zamudio M,Magallanes-Puebla A,López-Marín LM,Segura-Salinas E,Mancilla Rdoi
10.1186/s12865-015-0102-3subject
Has Abstractpub_date
2015-06-23 00:00:00pages
38issn
1471-2172pii
10.1186/s12865-015-0102-3journal_volume
16pub_type
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