Evaluation of signal transduction pathways after transient cutaneous adenoviral gene delivery.

abstract：BACKGROUND:Interleukin-9 (IL-9) was reported as an active participant in the pathogenesis of allergic asthma. This study aimed to investigate the major source ofIL-9 and its effect on interferon γ (IFN-γ) and immunoglobulin (Ig) secretion by B cells. METHODS:We isolated peripheral blood mononuclear cells from children...

journal_title：BMC immunology

authors： Jia L,Wang Y,Li J,Li S,Zhang Y,Shen J,Tan W,Wu C

更新日期：2017-07-19 00:00:00

abstract：BACKGROUND:Understanding immune mechanisms, particularly the role of innate immune markers during latent TB infection remains elusive. The main objective of this study was to evaluate mRNA gene expression patterns of toll-like receptors (TLRs) as correlates of immunity during latent TB infection and further infer their...

journal_title：BMC immunology

authors： Alemnew B,Hoff ST,Abebe T,Abebe M,Aseffa A,Howe R,Wassie L

更新日期：2021-01-28 00:00:00

abstract：BACKGROUND:The lymphatic vascular pattern in the head of mice has rarely been studied, due to problems of sectioning and immunostaining of complex bony structures. Therefore, the association of head lymphoid tissues with the lymphatics has remained unknown although the mouse is the most often used species in immunology...

journal_title：BMC immunology

authors： Lohrberg M,Pabst R,Wilting J

更新日期：2018-01-25 00:00:00

abstract：BACKGROUND:Insulin dependent (i.e., "type 1") diabetes mellitus (T1DM) is considered to be a T cell mediated disease in which TH1 and Tc autoreactive cells attack the pancreatic islets. Among the beta-cell antigens implicated in T1DM, glutamic acid decarboxylase (GAD) 65 appears to play a key role in the development of...

journal_title：BMC immunology

authors： Pedotti R,Sanna M,Tsai M,DeVoss J,Steinman L,McDevitt H,Galli SJ

更新日期：2003-02-22 00:00:00

abstract：BACKGROUND:Symptomatic Primary Humoral Immunodeficiency Diseases (PHID) constitute a highly heterogeneous group of diseases characterized by a shared hypogammaglobulinemia, resulting in increased risk of recurrent or severe infections. Associations have been described with a variety of immunological abnormalities invol...

journal_title：BMC immunology

authors： Picat MQ,Thiébaut R,Lifermann F,Delbrel X,Adoue D,Wittkop L,Fauchais AL,Rispal P,Moreau JF,Viallard JF

更新日期：2014-03-12 00:00:00

abstract：BACKGROUND:Dendritic cells (DC) play the key role in directing antigen-specific immune responses and manipulating their function may be a useful tool for immunotherapy. The balance between immune stimulation and tolerance is particularly important at mucosal interfaces, where discrimination between dangerous pathogens ...

journal_title：BMC immunology

authors： Polak ME,Borthwick NJ,Gabriel FG,Jager MJ,Cree IA

更新日期：2008-03-18 00:00:00

abstract：BACKGROUND:Respiratory burst function resulting in the release of reactive oxygen species such as superoxide anion (O2-) from neutrophils is one of the key mechanisms of the innate immune system, and maladaptive control of this mechanism is thought to play a pivotal role in the development of pathologies such as acute ...

journal_title：BMC immunology

authors： Tung JP,Fraser JF,Wood P,Fung YL

更新日期：2009-05-08 00:00:00

abstract：BACKGROUND:Cryopreservation of peripheral blood mononuclear cells (PBMCs) is a common and essential practice in conducting research. There are different reports in the literature as to whether cryopreserved PBMCs need to only be stored ≤ -150 °C or can be stored for a specified time at -80 °C. Therefore, we performed g...

journal_title：BMC immunology

authors： Yang J,Diaz N,Adelsberger J,Zhou X,Stevens R,Rupert A,Metcalf JA,Baseler M,Barbon C,Imamichi T,Lempicki R,Cosentino LM

更新日期：2016-03-15 00:00:00

abstract：BACKGROUND:We sought to compare Pneumovax®23 responses in adults with subnormal IgG subclass concentrations. We studied adults with normal total IgG, frequent/severe respiratory infection, and subnormal IgG1, IgG3, or IgG1 + IgG3 before and after Pneumovax®23. We defined response as serotype-specific IgG > 1.3 μg/mL an...

journal_title：BMC immunology

authors： Parker AR,Skold M,Harding S,Barton JC,Bertoli LF,Barton JC

更新日期：2019-08-20 00:00:00

abstract：BACKGROUND:Most HIV-infected subjects exhibit a progressive rise in CD4 T-cell counts after initiation of highly active antiretroviral therapy (HAART). However, a subset of individuals exhibit very poor CD4 T-cell recovery despite effective control of HIV-RNA viraemia. We evaluated CD4 T-cell proliferation among subopt...

journal_title：BMC immunology

authors： Nakanjako D,Ssewanyana I,Nabatanzi R,Kiragga A,Kamya MR,Cao H,Mayanja-Kizza H

更新日期：2013-06-20 00:00:00

abstract：BACKGROUND:Besides their prominent role in the elimination of infected or malignantly transformed cells, natural killer (NK) cells serve as modulators of adaptive immune responses. Enhancing bidirectional crosstalk between NK cells and dendritic cells (DC) is considered a promising tool to potentiate cancer vaccines. W...

journal_title：BMC immunology

authors： Oth T,Habets THPM,Germeraad WTV,Zonneveld MI,Bos GMJ,Vanderlocht J

更新日期：2018-02-13 00:00:00

abstract：BACKGROUND:Although plasmid DNA encoding an antigen from pathogens or tumor cells has been widely studied as vaccine, the use of plasmid vector (without insert) as therapeutic agent requires further investigation. RESULTS:Here, we showed that plasmid DNA (pcDNA3) at low doses inhibits the production of IL-6 and TNF-α ...

journal_title：BMC immunology

authors： Malardo T,Batalhão ME,Panunto-Castelo A,Almeida LP,Padilha E,Fontoura IC,Silva CL,Carnio EC,Coelho-Castelo AA

更新日期：2012-11-08 00:00:00

abstract：BACKGROUND:Pattern recognition receptors (PRRs) for double-stranded RNA (dsRNA) are components of innate immunity that recognize the presence of viral infection and initiate efficient defense mechanisms. In addition to previously well-characterized signaling pathways that are mediated by PKR and TLR3, new intracellular...

journal_title：BMC immunology

authors： Yun JJ,Tsao MS,Der SD

更新日期：2011-02-10 00:00:00

abstract：BACKGROUND:Interleukin 7 (IL-7) signals via the IL-7 receptor (IL-7R) and drives homeostatic T-cell proliferation in patients after allogeneic hematopoietic stem cell transplantation (aHSCT). PURPOSE:We performed a prospective study in adults (n = 33) and children (n = 29) undergoing aHSCT measuring plasma IL-7 and so...

journal_title：BMC immunology

authors： Poiret T,Rane L,Remberger M,Omazic B,Gustafsson-Jernberg A,Vudattu NK,Ahmed R,Ernberg I,Winiarski J,Magalhaes I,Ringden O,Maeurer M

更新日期：2014-06-19 00:00:00

abstract：BACKGROUND:Graft-versus-host disease (GVHD) is one of the most complex complications after allogeneic stem cell transplantation. Current standard of grading system is based on clinical symptoms in skin, liver and intestinal. However, it's difficult to differ GVHD and its extent just by clinical manifestation. Here we r...

journal_title：BMC immunology

authors： Zhang P,Yang S,Zou Y,Yan X,Wu H,Zhou M,Sun YC,Zhang Y,Zhu H,Xu K,Wang Y,Sheng LX,Mu Q,Sun L,Ouyang G

更新日期：2019-12-09 00:00:00

abstract：BACKGROUND:Allergic skin inflammation such as atopic dermatitis (AD), which is characterized by pruritus and inflammation, is regulated partly through the activity of regulatory T cells (Tregs). Tregs play key roles in the immune response by preventing or suppressing the differentiation, proliferation and function of v...

journal_title：BMC immunology

authors： Han SC,Kang GJ,Ko YJ,Kang HK,Moon SW,Ann YS,Yoo ES

更新日期：2012-08-09 00:00:00

abstract：BACKGROUND:We have previously reported that ATP treatment of M bovis-BCG infected human macrophages induces P2X7 receptor-dependent killing of intracellular mycobacteria. The mechanism mediating this bactericidal effect has not been full characterized but is known to be Ca2+-dependent and to promote the maturation and ...

journal_title：BMC immunology

authors： Biswas D,Qureshi OS,Lee WY,Croudace JE,Mura M,Lammas DA

更新日期：2008-07-15 00:00:00

abstract：BACKGROUND:Anthrax lethal toxin (LT), produced by the Gram-positive bacterium Bacillus anthracis, is a highly effective zinc dependent metalloprotease that cleaves the N-terminus of mitogen-activated protein kinase kinases (MAPKK or MEKs) and is known to play a role in impairing the host immune system during an inhalat...

journal_title：BMC immunology

authors： Chauncey KM,Lopez MC,Sidhu G,Szarowicz SE,Baker HV,Quinn C,Southwick FS

更新日期：2012-07-02 00:00:00

abstract：BACKGROUND:Burkholderia pseudomallei is the causative agent for melioidosis. For many bacterial infections, cytokine dysregulation is one of the contributing factors to the severe clinical outcomes in the susceptible hosts. The C57BL/6 and BALB/c mice have been established as a differential model of susceptibility in m...

journal_title：BMC immunology

authors： Koo GC,Gan YH

更新日期：2006-08-18 00:00:00

abstract：BACKGROUND:We have previously reported that interleukin-10 (IL-10) deficient dendritic cells (DCs) are potent antigen presenting cells that induced elevated protective immunity against Chlamydia. To further investigate the molecular and biochemical mechanism underlying the superior immunostimulatory property of IL-10 d...

journal_title：BMC immunology

authors： Ryans K,Omosun Y,McKeithen DN,Simoneaux T,Mills CC,Bowen N,Eko FO,Black CM,Igietseme JU,He Q

更新日期：2017-05-19 00:00:00

abstract：BACKGROUND:The role of M2 polarized macrophages (MΦ) during the allergic airway inflammation has been discussed in various animal models. However, their presence and relevance during the chronic and acute phase of allergic airway inflammation in humans has not been fully elucidated so far. In the present study we pheno...

journal_title：BMC immunology

authors： Winkler C,Witte L,Moraw N,Faulenbach C,Müller M,Holz O,Schaumann F,Hohlfeld JM

更新日期：2014-03-10 00:00:00

abstract：BACKGROUND:An ideal tumor vaccine should activate both effector and memory immune response against tumor-specific antigens. Beside the CD8+ T cells that play a central role in the generation of a protective immune response and of long-term memory, dendritic cells (DCs) are important for the induction, coordination and ...

journal_title：BMC immunology

authors： Cerkovnik P,Novakovic BJ,Stegel V,Novakovic S

更新日期：2010-09-13 00:00:00

abstract：BACKGROUND:Immunoglobulin rearrangement involves random and imprecise processes that act to both create and constrain diversity. Two such processes are the loss of nucleotides through the action of unknown exonuclease(s) and the addition of P nucleotides. The study of such processes has been compromised by difficulties...

journal_title：BMC immunology

authors： Jackson KJ,Gaeta B,Sewell W,Collins AM

更新日期：2004-09-02 00:00:00

abstract：BACKGROUND:Activation signals can be negatively regulated by cell surface receptors bearing immunoreceptor tyrosine-based inhibitory motifs (ITIMs). CD300a, an ITIM bearing type I transmembrane protein, is expressed on many hematopoietic cells, including subsets of lymphocytes. RESULTS:We have taken two approaches to ...

journal_title：BMC immunology

authors： DeBell KE,Simhadri VR,Mariano JL,Borrego F

更新日期：2012-04-26 00:00:00

abstract：BACKGROUND:The CXCR3 receptor and its three interferon-inducible ligands (CXCL9, CXCL10 and CXCL11) have been implicated as playing a central role in directing a Th1 inflammatory response. Recent studies strongly support that the CXCR3 receptor is a very attractive therapeutic target for treating autoimmune diseases, s...

journal_title：BMC immunology

authors： Jenh CH,Cox MA,Cui L,Reich EP,Sullivan L,Chen SC,Kinsley D,Qian S,Kim SH,Rosenblum S,Kozlowski J,Fine JS,Zavodny PJ,Lundell D

更新日期：2012-01-10 00:00:00

abstract：BACKGROUND:Shiga toxin 2 (Stx2), one of two Stx liberated by Stx-producing Escherichia coli, is composed of an A subunit monomer and a B subunit pentamer, and is directly linked with hemolytic uremic syndrome in children. The pentameric B subunit binds to its cell surface receptor Gb3 for toxin internalization, and the...

journal_title：BMC immunology

authors： Jeong KI,Chapman-Bonofiglio S,Singh P,Lee J,Tzipori S,Sheoran AS

更新日期：2010-03-24 00:00:00

abstract：BACKGROUND:Vascular calcification is often associated with chronic inflammation and is a risk factor for brain arterial stiffness. Our previous results showed that miR32-5p was positively correlated with vascular smooth muscle cells (VSMC) calcification, but it is unclear whether miR32-5p promoted VSMC calcification by...

journal_title：BMC immunology

authors： Cao J,Chen L,Zhong X,Shen Y,Gao Y,Chen Q,Zu X,Liu J

更新日期：2020-01-17 00:00:00

abstract：BACKGROUND:Down syndrome (DS) is the most common syndromic immunodeficiency with an increased risk of infection, mortality from sepsis, and autoinflammation. Innate immune function is altered in DS and therefore we examined responses in CD11b and Toll like receptor 4 (TLR-4), which are important immune cell surface mar...

journal_title：BMC immunology

authors： Huggard D,McGrane F,Lagan N,Roche E,Balfe J,Leahy TR,Franklin O,Moreno A,Melo AM,Doherty DG,Molloy EJ

更新日期：2018-11-03 00:00:00

abstract：BACKGROUND:Tuberculous pleural effusion (TPE) is one of the most common forms of extrapulmonary tuberculosis. Because most studies of TPE focused on the pleural space, little information regarding lung parenchyma is available. We therefore aimed to investigate immune responses in the lung parenchyma of TPE patients wit...

journal_title：BMC immunology

authors： Qama D,Choi WI,Kwon KY

更新日期：2012-08-13 00:00:00

abstract：BACKGROUND:Proinflammatory genes are highly expressed in several metabolic disorders associated with obesity. But it is not clarified whether gene expression levels and downstream inflammatory markers are related to the metabolic state or the presence of obesity. Hence, the present study aimed to compare Toll-Like Rece...

journal_title：BMC immunology

authors： Amiri P,Baradaran B,Saghafi-Asl M,Naghizadeh M,Shanehbandi D,Karamzad N,Vahed SZ

更新日期：2019-07-04 00:00:00