Abstract:
BACKGROUND:Early detection of capecitabine-resistance could largely increase overall survival of colorectal cancer (CRC) patients. Previous studies suggested examination of immune cells in peripheral blood would help to predict efficacy of chemotherapy. METHODS:We examined the immunological characteristics of peripheral blood in CRC patients with capecitabine treatment. We analyzed the relationships between the abnormal immune cell population in capecitabine-resistance patients and major clinical features. Furthermore, RNA sequencing, analyses of cell surface marker expression and the correlations with other major immune cell populations were performed using this population to explore the possible function of these cells. RESULTS:The expression level of CD16 on neutrophils was down-regulated in capecitabine-resistant CRC patients. Patients with CD16low/-neutrophils after capecitabine therapy had adverse clinical features. What's important, the change of CD16 expression level on neutrophils appeared much earlier than CT scan. RNA sequencing revealed that CD16low/-neutrophils in capecitabine-resistant patients had lower expression level of neutrophil-related genes, compared to CD16+neutrophils in capecitabine-sensitive patients, suggesting this CD16low/-population might be immature neutrophils. Furthermore, the expression level of CD16 on neutrophils in patients with capecitabine treatment was positively correlated with the number of anti-tumor immune cell subsets, such as CD8+T cell, CD4+T cell, NK cell and monocyte. CONCLUSIONS:Our findings indicated that CD16 expression on neutrophils in peripheral blood was a good prognostic marker for predicting efficacy of capecitabine in CRC patients.
journal_name
BMC Immunoljournal_title
BMC immunologyauthors
Lu Y,Huang Y,Huang L,Xu Y,Wang Z,Li H,Zhang T,Zhong M,Gao WQ,Zhang Ydoi
10.1186/s12865-020-00375-8subject
Has Abstractpub_date
2020-08-08 00:00:00pages
46issue
1issn
1471-2172pii
10.1186/s12865-020-00375-8journal_volume
21pub_type
杂志文章相关文献
BMC IMMUNOLOGY文献大全abstract:BACKGROUND:Marginal zone (MZ) B cells play important roles in the early phases of humoral immune responses. In addition to possessing an inherent capacity to rapidly differentiate into antibody secreting cells, MZ B cells also help to regulate the fate of both T-independent and T-dependent blood-borne antigens in the s...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/1471-2172-6-8
更新日期:2005-04-18 00:00:00
abstract:BACKGROUND:Expressed in embryonic development, matrix metalloprotein-9 (MMP-9) is absent in most of developed adult tissues, but recurs in inflammation during tissue injury, wound healing, tumor formation and metastasis. Expression of MMP-9 is tightly controlled by extracellular cues including pro-inflammatory cytokine...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/1471-2172-10-15
更新日期:2009-03-19 00:00:00
abstract:BACKGROUND:Down syndrome (DS) is the most common syndromic immunodeficiency with an increased risk of infection, mortality from sepsis, and autoinflammation. Innate immune function is altered in DS and therefore we examined responses in CD11b and Toll like receptor 4 (TLR-4), which are important immune cell surface mar...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/s12865-018-0270-z
更新日期:2018-11-03 00:00:00
abstract:BACKGROUND:In genetically modified (GM) crops there is a risk that the inserted genes may introduce new allergens and/or adjuvants into the food and feed chain. The MON810 maize, expressing the insecticidal Cry1Ab toxin, is grown in many countries worldwide. In animal models, intranasal and intraperitoneal immunisation...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/s12865-016-0148-x
更新日期:2016-05-04 00:00:00
abstract:BACKGROUND:Interleukin-9 (IL-9) was reported as an active participant in the pathogenesis of allergic asthma. This study aimed to investigate the major source ofIL-9 and its effect on interferon γ (IFN-γ) and immunoglobulin (Ig) secretion by B cells. METHODS:We isolated peripheral blood mononuclear cells from children...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/s12865-017-0220-1
更新日期:2017-07-19 00:00:00
abstract:BACKGROUND:Human Papillomavirus, HPV, is the main etiological factor for cervical cancer. Different studies show that in women infected with HPV there is a positive correlation between lesion grade and number of infiltrating macrophages, as well as with IL-10 higher expression. Using a HPV16 associated tumor model in m...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/1471-2172-11-27
更新日期:2010-06-07 00:00:00
abstract:BACKGROUND:The CXCR3 receptor and its three interferon-inducible ligands (CXCL9, CXCL10 and CXCL11) have been implicated as playing a central role in directing a Th1 inflammatory response. Recent studies strongly support that the CXCR3 receptor is a very attractive therapeutic target for treating autoimmune diseases, s...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/1471-2172-13-2
更新日期:2012-01-10 00:00:00
abstract:BACKGROUND:Regulatory T cells (Treg) play a crucial role in maintaining immune homeostasis and self-tolerance. The immune suppressive effects of Tregs should however be limited in case effective immunity is required against pathogens or cancer cells. We previously found that the Toll-like receptor 2 (TLR2) agonist, Pam...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/1471-2172-12-23
更新日期:2011-03-24 00:00:00
abstract:BACKGROUND:Toxic shock syndrome (TSS) is caused by an overwhelming host-mediated response to bacterial superantigens produced mainly by Staphylococcus aureus and Streptococcus pyogenes. TSS is characterized by aberrant activation of T cells and excessive release of pro-inflammatory cytokines ultimately resulting in cap...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/1471-2172-15-1
更新日期:2014-01-14 00:00:00
abstract:BACKGROUND:Although plasmid DNA encoding an antigen from pathogens or tumor cells has been widely studied as vaccine, the use of plasmid vector (without insert) as therapeutic agent requires further investigation. RESULTS:Here, we showed that plasmid DNA (pcDNA3) at low doses inhibits the production of IL-6 and TNF-α ...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/1471-2172-13-59
更新日期:2012-11-08 00:00:00
abstract:BACKGROUND:Allergic skin inflammation such as atopic dermatitis (AD), which is characterized by pruritus and inflammation, is regulated partly through the activity of regulatory T cells (Tregs). Tregs play key roles in the immune response by preventing or suppressing the differentiation, proliferation and function of v...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/1471-2172-13-44
更新日期:2012-08-09 00:00:00
abstract:BACKGROUND:Cryopreservation of peripheral blood mononuclear cells has been used to preserve and standardize immunologic measurements for multicenter studies, however, effects of cryopreservation on cytokine responses are incompletely understood. In designing immunologic studies for a new multicenter birth cohort study ...
journal_title:BMC immunology
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2172-7-29
更新日期:2006-12-12 00:00:00
abstract:BACKGROUND:Extracellular vesicles (EVs) are nano-sized particles secreted by most cells. EVs carry nucleic acids that hold promise as potential biomarkers in various diseases. Human immunodeficiency virus type 1 (HIV) infects CD4+ T cells and induces immune dysfunction, inflammation, and EV secretion, but little is kno...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/s12865-020-00386-5
更新日期:2020-11-11 00:00:00
abstract:BACKGROUND:Adenoviral vectors have provided effective methods for in vivo gene delivery in therapeutic applications. However, these vectors can induce immune responses that may severely affect the ability of vector re-application. There is limited information about the mechanisms and signal transduction pathways involv...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/1471-2172-12-8
更新日期:2011-01-21 00:00:00
abstract:BACKGROUND:The purpose of this study was to characterize specific cytotoxic T-cell (CTL) responses in men who have sex with men (MSM) subjects infected with the human immunodeficiency virus type 1 (HIV-1) CRF01_AE subtype during the first year of infection and impacts on viral control and evolution. RESULTS:Fifteen HI...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/s12865-016-0166-8
更新日期:2016-08-30 00:00:00
abstract:BACKGROUND:Recognition of pathogens by dendritic cells (DCs) through interaction with pattern recognition receptors, including Toll like receptors (TLR), is crucial for the initiation of appropriate polarized T helper (Th) cell responses. Yet, the characteristics and differences in molecular profiles of DCs with differ...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/1471-2172-10-9
更新日期:2009-02-04 00:00:00
abstract:BACKGROUND:The initiation of highly active antiretroviral therapy (HAART) plays a significant role in the clinical management of HIV infected people by preventing morbidity and mortality. This benefit becomes, the most terrible when treatment failure develops. Thus, this research aims to assess the prevalence and assoc...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/s12865-018-0278-4
更新日期:2018-12-17 00:00:00
abstract:BACKGROUND:Parasite-specific IgE levels correlate with human resistance to reinfection with Schistosoma spp. after chemotherapy. Although the role of eosinophils in schistosomiasis has been the focus of a great deal of important research, the involvement of other Fcepsilon receptor-bearing cells, such as mast cells and...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/1471-2172-5-6
更新日期:2004-04-21 00:00:00
abstract:BACKGROUND:Understanding immune mechanisms, particularly the role of innate immune markers during latent TB infection remains elusive. The main objective of this study was to evaluate mRNA gene expression patterns of toll-like receptors (TLRs) as correlates of immunity during latent TB infection and further infer their...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/s12865-021-00400-4
更新日期:2021-01-28 00:00:00
abstract:BACKGROUND:Pro-inflammatory cytokines can affect intracellular lipid metabolism. A variety of effects have been described for different cell types; hepatocyte lipid turnover pathways are inhibited during inflammation, whereas interleukin-1beta (IL-1beta) reduces intracellular cholesterol levels in fibroblasts. Levels o...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/1471-2172-9-70
更新日期:2008-11-25 00:00:00
abstract:BACKGROUND:Macrophages are key players in the initiation, perpetuation and regulation of both innate and adaptive immune responses. They largely perform these roles through modulation of the expression of genes, especially those encoding cytokines. Murine bone marrow derived macrophages (BMDMs) are commonly used as a m...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/s12865-017-0223-y
更新日期:2017-10-03 00:00:00
abstract:BACKGROUND:Most in vivo studies that have addressed the role of actin dynamics in NADPH oxidase function in phagocytes have used toxins to modulate the polymerization state of actin and mostly effects on actin has been evaluated by end point measurements of filamentous actin, which says little about actin dynamics, and...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/1471-2172-11-44
更新日期:2010-09-08 00:00:00
abstract:BACKGROUND:Neutrophils are critical in the defense against potentially harmful microorganisms, but their excessive and inappropriate activation can contribute significantly to tissue damage and a worsening pathology. Through the release of endocrine factors submandibular glands contribute to achieving a balance in neut...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/1471-2172-4-3
更新日期:2003-03-04 00:00:00
abstract:BACKGROUND:Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by the novel coronavirus SARS-CoV. The T cell epitopes of the SARS CoV spike protein are well known, but no systematic evaluation of the functional and structural roles of each residue has been reported for these antigenic epit...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/1471-2172-13-50
更新日期:2012-09-10 00:00:00
abstract:BACKGROUND:Immunoglobulin rearrangement involves random and imprecise processes that act to both create and constrain diversity. Two such processes are the loss of nucleotides through the action of unknown exonuclease(s) and the addition of P nucleotides. The study of such processes has been compromised by difficulties...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/1471-2172-5-19
更新日期:2004-09-02 00:00:00
abstract:BACKGROUND:Immunophenotyping of blood lymphocytes is an essential tool to evaluate the immune function of patients with immunodeficiency or autoimmunity. Predominately identified CD4+T cell subsets, Th1, Th2, Th17, as well as regulatory T (Treg) cells, play crucial roles in several immunological and pathological condit...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/s12865-020-00374-9
更新日期:2020-08-03 00:00:00
abstract:BACKGROUND:Streptococcus sanguinis (S.sanguinis), a predominant bacterium in the human oral cavity, has been widely associated with the development of infective endocarditis. Platelets play both a haemostatic function and can influence both innate and adaptive immune responses. Previous studies have shown that S.sangui...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/1471-2172-15-15
更新日期:2014-04-22 00:00:00
abstract:BACKGROUND:Human intestinal epithelial cells (IECs) secrete the chemokine CCL20 in response to infection by various enteropathogenic bacteria or exposure to bacterial flagellin. CCL20 recruits immature dendritic cells and lymphocytes to target sites. Here we investigated IEC responses to various pathogenic and commensa...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/1471-2172-10-54
更新日期:2009-10-08 00:00:00
abstract:BACKGROUND:The extracellular domains of cytokine receptors are released during inflammation, but little is known about the shedding of Toll-like receptors (TLR) and whether they can be used as diagnostic biomarkers. METHODS:The release of sTLR2 and sTLR4 was studied in in-vitro stimulations, as well as in-vivo during ...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/s12865-014-0055-y
更新日期:2014-11-19 00:00:00
abstract:BACKGROUND:Burkholderia pseudomallei is the causative agent of melioidosis, an emerging bacterial infectious disease in tropical and subtropical areas. We recently showed that NADPH oxidase but not nitric oxide (NO) contributes to resistance in innately resistant C57BL/6 mice in a B. pseudomallei respiratory infection ...
journal_title:BMC immunology
pub_type: 杂志文章
doi:10.1186/1471-2172-12-20
更新日期:2011-03-16 00:00:00