abstract：:Introduction: Muscle impairments are prevalent in COPD and have adverse clinical implications in terms of physical performance capacity, disease burden, quality of life and even mortality. During acute exacerbations of COPD (AECOPDs) the respiratory symptoms worsen and this might also apply to the muscle impairments. ...

journal_title：Expert review of respiratory medicine

authors： Gosker HR,Langen RC,Simons SO

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVES:Anemia is often seen in chronic obstructive pulmonary disease (COPD) patients. However, the implications of anemia on the outcomes of patients with COPD is not clearly known. Therefore, we conducted a systematic review and meta-analysis to evaluate the effects of anemia on the morbidity and mortality of pati...

journal_title：Expert review of respiratory medicine

authors： Xu Y,Hu T,Ding H,Chen R

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Approximately 14% of UK hospital in-patients receive supplemental oxygen therapy, only 57% have valid prescriptions. Oxygen must be optimally prescribed to ensure maximal therapeutic response whilst minimizing adverse outcomes (including fatality). This study investigates prescription compliance. METHODS:Al...

journal_title：Expert review of respiratory medicine

authors： Barrett R,Catangui E,Scott R

更新日期：2020-10-14 00:00:00

abstract：INTRODUCTION:Chronic pulmonary aspergillosis (CPA) is a chronic lung infection caused by Aspergillus fumigatus, that complicates structural lung diseases. Of the different types of CPA, chronic cavitary pulmonary aspergillosis (CCPA) is the most common form. The mainstay of treatment of CCPA is oral triazoles. However,...

journal_title：Expert review of respiratory medicine

authors： Sehgal IS,Dhooria S,Muthu V,Prasad KT,Agarwal R

更新日期：2020-07-01 00:00:00

abstract：:Introduction: Acute respiratory distress syndrome (ARDS) is a severe form of acute lung injury common in critically ill patients and characterized by significant morbidity and mortality. It frequently manifests long-lasting effects beyond hospitalization, from cognitive impairment to physical weakness.Areas covered: S...

journal_title：Expert review of respiratory medicine

authors： Mart MF,Ware LB

更新日期：2020-06-01 00:00:00

abstract：:Objectives: Pleurodesis is an important management option to palliate breathlessness in patients with malignant pleural effusion (MPE). This systematic review aimed to examine available literature for studies investigating factors that predict pleurodesis outcome.Methods: The healthcare databases advanced search (HDAS...

journal_title：Expert review of respiratory medicine

authors： Hassan M,Gadallah M,Mercer RM,Harriss E,Rahman NM

更新日期：2020-06-01 00:00:00

abstract：:Introduction: Neuromotor control of diaphragm muscle and the recovery of diaphragm activity following spinal cord injury have been narrowly focused on ventilation. By contrast, the understanding of neuromotor control for non-ventilatory expulsive/straining maneuvers (including coughing, defecation, and parturition) is...

journal_title：Expert review of respiratory medicine

authors： Fogarty MJ,Sieck GC

更新日期：2020-05-01 00:00:00

abstract：:Introduction: Idiopathic pulmonary fibrosis (IPF), the most common of the idiopathic interstitial pneumonias, is a disease with a poor prognosis, and a highly heterogeneous and unpredictable clinical course. While most patients experience a relatively slow clinical, functional and radiological deterioration, a signifi...

journal_title：Expert review of respiratory medicine

authors： Biondini D,Balestro E,Sverzellati N,Cocconcelli E,Bernardinello N,Ryerson CJ,Spagnolo P

更新日期：2020-04-01 00:00:00

abstract：:Introduction: Knowledge of the pathophysiology of cough has continued to advance over recent decades. Establishing anatomic-diagnostic protocols, based on the anatomy and distribution of vagus nerve pathways regulating the cough reflex, was the first breakthrough in modern clinical medicine for chronic cough. The unme...

journal_title：Expert review of respiratory medicine

authors： Song WJ,Chung KF

更新日期：2020-03-01 00:00:00

abstract：:Introduction: Detection and characterization of pulmonary nodules is an important issue, because the process is the first step in the management of lung cancers.Areas covered: Literature review was performed on May 15 2019 by using the PubMed, US National Library of Medicine National Institutes of Health, and the Nati...

journal_title：Expert review of respiratory medicine

authors： Kim TJ,Kim CH,Lee HY,Chung MJ,Shin SH,Lee KJ,Lee KS

更新日期：2020-02-01 00:00:00

abstract：:Introduction: Lung transplantation is an effective treatment for certain types of end-stage lung disease. Frailty is a complex clinical syndrome associated with decreased physiological reserve and an increased risk for suboptimal health outcomes.Area covered: This article reviews the current literature on frailty in l...

journal_title：Expert review of respiratory medicine

authors： Montgomery E,Macdonald PS,Newton PJ,Jha SR,Malouf M

更新日期：2020-02-01 00:00:00

abstract：:Introduction: Cystic fibrosis (CF) is a complex, multi-system, genetic disease affecting over 70,000 people worldwide. The underlying defect is a mutation in the CFTR gene. Dysfunctional CFTR protein results in abnormal anion movement across epithelial membranes in affected organs. There has been a paradigm shift in C...

journal_title：Expert review of respiratory medicine

authors： Paterson SL,Barry PJ,Horsley AR

更新日期：2020-01-01 00:00:00

abstract：:Introduction: The forced expiratory flow between 25% and 75% of forced vital capacity (FEF25-75) is a spirometry parameter that may be useful in many clinical settings. Values <65% of predicted have been defined as abnormal.Areas covered: The current report discusses the clinical value of FEF25-75 in different setting...

journal_title：Expert review of respiratory medicine

authors： Ciprandi G,Cirillo I

更新日期：2019-12-01 00:00:00

abstract：:Background: Few studies have provided real-world evidence of mepolizumab efficacy and safety. We aimed to evaluate mepolizumab for severe eosinophilic asthma in daily clinical practice.Research design and methods: Patients included in the RINOVA (Interdisciplinary Network for the management of severe asthma in Veneto ...

journal_title：Expert review of respiratory medicine

authors： Caminati M,Cegolon L,Vianello A,Chieco Bianchi F,Festi G,Marchi MR,Micheletto C,Mazza F,Tognella S,Senna G

更新日期：2019-12-01 00:00:00

abstract：:Introduction: Amongst allergic asthmatics, high allergen exposure increases asthma severity. However, there is no consensus on the role of mite allergen avoidance in the management of asthma, and various guidelines differ in their recommendations. Areas covered: Several systematic reviews/meta-analyses on mite avoidan...

journal_title：Expert review of respiratory medicine

authors： Custovic A,Murray CS,Simpson A

更新日期：2019-10-01 00:00:00

abstract：:Introduction: Bronchopulmonary dysplasia (BPD) is a common long-term adverse complication of very premature delivery. Affected infants can suffer chronic respiratory morbidities including lung function abnormalities and reduced exercise capacity even as young adults. Many studies have investigated possible preventativ...

journal_title：Expert review of respiratory medicine

authors： Williams E,Greenough A

更新日期：2019-08-01 00:00:00

abstract：:Introduction. Optimizing nutrition remains the cornerstone of therapy for patients with cystic fibrosis (CF) since it is associated with better pulmonary function and survival. However, a significant proportion of patients still fail to achieve normal growth and nutritional status. Areas covered. This review describes...

journal_title：Expert review of respiratory medicine

authors： Colombo C,Nobili RM,Alicandro G

更新日期：2019-06-01 00:00:00

abstract：:Introduction: There is an unmet clinical need for improved diagnostic tests for active tuberculosis (TB) to provide high sensitivity for all cases, accelerate time to diagnosis and ensure timely and appropriate treatment. Whilst the measurement of M.tb-specific immune responses is widely used for detecting infection i...

journal_title：Expert review of respiratory medicine

authors： Halliday A,Masonou T,Tolosa-Wright M,Mandagere V,Lalvani A

更新日期：2019-06-01 00:00:00

abstract：INTRODUCTION:Idiopathic pulmonary fibrosis (IPF) is a chronic, debilitating, fibrotic lung disease leading to respiratory failure, and ultimately to death. It is characterized by marked heterogeneity regarding its clinical course. Despite significant progress in the understanding of its pathogenesis, the course of the ...

journal_title：Expert review of respiratory medicine

authors： Inchingolo R,Varone F,Sgalla G,Richeldi L

更新日期：2019-01-01 00:00:00

abstract：:Introduction: Obstructive sleep apnea (OSA) is highly prevalent and constitutes a major health hazard. Current pharmacotherapy is ineffective in correcting sleep-disordered breathing and is used adjunctively to address residual sleepiness. A new drug, solriamfetol, a selective norepinephrine-dopamine reuptake inhibito...

journal_title：Expert review of respiratory medicine

authors： Abad VC,Guilleminault C

更新日期：2018-12-01 00:00:00

abstract：INTRODUCTION:Survival after lung transplantation lags behind outcomes of other solid organ transplants, and complications from lung transplant are the second most common cause of death in cystic fibrosis. Evolving surgical techniques, therapeutics, and perioperative management have improved short-term survival after lu...

journal_title：Expert review of respiratory medicine

authors： Li SS,Tumin D,Krone KA,Boyer D,Kirkby SE,Mansour HM,Hayes D Jr

更新日期：2018-11-01 00:00:00

abstract：INTRODUCTION:Positive airway pressure (PAP) devices are generally considered to be the first-line treatment of choice for most adults with obstructive sleep apnea (OSA). However, there are several alternatives. It is important for patients and their sleep providers to be aware of the most up-to-date information regardi...

journal_title：Expert review of respiratory medicine

authors： Camacho M,Chang ET,Neighbors CLP,Noller MW,Mack D,Capasso R,Kushida CA

更新日期：2018-11-01 00:00:00

abstract：INTRODUCTION:Acute exacerbations of chronic lung disease account for substantial morbidity and health costs. Repeated inflammatory episodes and attendant bronchoconstriction cause structural remodeling of the airway. Remodeling is a multicellular response to mucosal injury that results in epithelial cell-state changes,...

journal_title：Expert review of respiratory medicine

authors： Brasier AR

更新日期：2018-11-01 00:00:00

abstract：INTRODUCTION:A growing number of immunocompromised (IC) patients with acute hypoxemic respiratory failure (ARF) is admitted to the intensive care unit (ICU) worldwide. Areas covered: This review provides an overview of the current knowledge of the ways to prevent intubation in IC patients with ARF. Expert commentary: S...

journal_title：Expert review of respiratory medicine

authors： De Jong A,Calvet L,Lemiale V,Demoule A,Mokart D,Darmon M,Jaber S,Azoulay E

更新日期：2018-10-01 00:00:00

abstract：INTRODUCTION:Cystic fibrosis (CF) is an autosomal dominant chloride channelopathy caused by mutations in the CF transmembrane conductance regulator (CFTR) gene that results clinically in a multisystem disorder. The major source of morbidity and mortality in CF is lung disease, which is characterized by recurrent cycles...

journal_title：Expert review of respiratory medicine

authors： McElvaney OJ,Gunaratnam C,McElvaney OF,Bagwe I,Reeves EP,McElvaney NG

更新日期：2018-10-01 00:00:00

abstract：INTRODUCTION:N-acetyl-l-cysteine (NAC), a derivative of the naturally occurring amino acid l-cysteine, is a mucolytic agent that may also act as an antioxidant by providing cysteine intracellularly for increased production of glutathione. It is also used for the treatment of acetaminophen overdose. Areas covered: The r...

journal_title：Expert review of respiratory medicine

authors： Calzetta L,Matera MG,Rogliani P,Cazzola M

更新日期：2018-08-01 00:00:00

abstract：INTRODUCTION:Exercise intolerance is a common and often significant limitation in pulmonary arterial hypertension (PAH). This intolerance greatly affects the quality of life and function of the individual with PAH, irrespective of its etiology. In PAH associated with connective tissue disorders (PAH-CTD), exercise into...

journal_title：Expert review of respiratory medicine

authors： Babu AS,Morris NR,Arena R,Myers J

更新日期：2018-07-01 00:00:00

abstract：INTRODUCTION:In sarcoidosis, muscle involvement is common, but mostly asymptomatic. Currently, little is known about respiratory muscle and diaphragm involvement and function in patients with sarcoidosis. Reduced inspiratory muscle strength and/or a reduced diaphragm function may contribute to exertional dyspnea, fatig...

journal_title：Expert review of respiratory medicine

authors： Schreiber T,Windisch W

更新日期：2018-07-01 00:00:00

abstract：INTRODUCTION:Cystic fibrosis (CF) outcomes and survival have improved over the last century primarily due to advancements in antibiotics, nutritional, and pulmonary therapies. Reviewed here are the significant unmet needs that exist for individuals with CF. Areas covered: With the recent development of medications that...

journal_title：Expert review of respiratory medicine

authors： West NE,Flume PA

更新日期：2018-07-01 00:00:00

abstract：INTRODUCTION:The management of infected pleural effusion is complex. Therapeutic resolution requires determining the following: appropriate antibiotic regimen, the need for pleural drainage, the optimal drainage tube size, and the need for intrapleural therapy or surgery. Areas covered: An updating of the latest advanc...

journal_title：Expert review of respiratory medicine

authors： Ferreiro L,Porcel JM,Bielsa S,Toubes ME,Álvarez-Dobaño JM,Valdés L

更新日期：2018-06-01 00:00:00

abstract：INTRODUCTION:Cystic Fibrosis is among the first diseases to have general population genetic screening tests and one of the most common indications of prenatal and preimplantation genetic diagnosis for single gene disorders. During the past twenty years, thanks to the evolution of diagnostic techniques, our knowledge of...

journal_title：Expert review of respiratory medicine

authors： Bergougnoux A,Taulan-Cadars M,Claustres M,Raynal C

更新日期：2018-05-01 00:00:00

abstract：INTRODUCTION:Interstitial lung diseases (ILD) include a broad range of diffuse parenchymal lung disorders of known and unknown etiologies. Patients with ILD can experience acute exacerbations (AE) which are associated with extremely high morbidity and mortality. Little is known about the etiology of AEs, and whether in...

journal_title：Expert review of respiratory medicine

authors： Azadeh N,Moua T,Baqir M,Ryu JH

更新日期：2018-04-01 00:00:00

abstract：INTRODUCTION:There is an ongoing need for additional interventions in idiopathic pulmonary fibrosis (IPF) as antifibrotic drugs currently available only inhibit and do not stall disease progression. Vitamin K is a co-factor for the activation of coagulation factors. However, it is also required to activate proteins wit...

journal_title：Expert review of respiratory medicine

authors： De Brouwer B,Piscaer I,Von Der Thusen JH,Grutters JC,Schutgens RE,Wouters EF,Janssen R

更新日期：2018-03-01 00:00:00

abstract：INTRODUCTION:Cardiorespiratory physiotherapy is an evidence-based practice that has evolved alongside changes in medical and surgical management, analgesia, the ageing society and increasing comorbidities of our patient populations. Continued research provides the profession with the ability to adapt to meet the changi...

journal_title：Expert review of respiratory medicine

authors： Denehy L,Granger CL,El-Ansary D,Parry SM

更新日期：2018-03-01 00:00:00

abstract：INTRODUCTION:The Global Initiative for Asthma (GINA) annual report summarizes the latest evidence for asthma management. GINA recommends stepwise pharmacological treatment, advocating inhaled corticosteroids (ICS) plus rapid, long-acting β2-agonists (LABA) delivered in a single inhaler for maintenance and relief at Ste...

journal_title：Expert review of respiratory medicine

authors： Lin J,Zhou X,Wang C,Liu C,Cai S,Huang M

更新日期：2018-03-01 00:00:00

abstract：INTRODUCTION:Lymphangioleiomyomatosis (LAM) is a destructive lung disease affecting primarily women. LAM is caused by inactivating mutations in the tuberous sclerosis complex (TSC) genes, resulting in hyperactivation of mechanistic/mammalian target of rapamycin complex 1 (mTORC1). Over the past five years, there have b...

journal_title：Expert review of respiratory medicine

authors： Nijmeh J,El-Chemaly S,Henske EP

更新日期：2018-02-01 00:00:00

abstract：INTRODUCTION:Malignant pleural effusion (MPE) is a feature of metastatic cancer associated with significant morbidity and cost. The typical management of MPE is systemic chemotherapy and mechanical intervention. Vascular endothelial growth factor (VEGF), an inducer of vascular permeability, has been shown to mediate fl...

journal_title：Expert review of respiratory medicine

authors： Sabang RL,Gandhiraj D,Fanucchi M,Epelbaum O

更新日期：2018-02-01 00:00:00

abstract：INTRODUCTION:The use of beta-blockers in chronic obstructive pulmonary disease (COPD) is controversial, primarily due to concerns that they may worsen lung function and attenuate bronchodilator response. Areas covered: This review summarizes the reasons for and against the use of beta-blockers in COPD by evaluating the...

journal_title：Expert review of respiratory medicine

authors： Leitao Filho FS,Alotaibi NM,Yamasaki K,Ngan DA,Sin DD

更新日期：2018-02-01 00:00:00

abstract：INTRODUCTION:Optimal management of malignant pleural effusion (MPE) is important in the care of patients with advanced cancer. Surgical (especially video-assisted thoracoscopic surgery (VATS)) and non-surgical strategies are available. Clinicians should be aware of the evidence supporting the use of different modalitie...

journal_title：Expert review of respiratory medicine

authors： Fitzgerald DB,Koegelenberg CFN,Yasufuku K,Lee YCG

更新日期：2018-01-01 00:00:00

abstract：INTRODUCTION:Asthmatic patients show a large heterogeneity in response to asthma medication. Rapidly evolving genotyping technologies have led to the identification of various genetic variants associated with treatment outcomes. Areas covered: This review focuses on the current knowledge of genetic variants influencing...

journal_title：Expert review of respiratory medicine

authors： Vijverberg SJH,Farzan N,Slob EMA,Neerincx AH,Maitland-van der Zee AH

更新日期：2018-01-01 00:00:00