当前位置： SCI文献检索 > BMC IMMUNOLOGY期刊下所有文献 > Expression of lymphocyte activation markers of preterm neonates is associated with perinatal complications.

Expression of lymphocyte activation markers of preterm neonates is associated with perinatal complications.

Abstract：

BACKGROUND:Inappropriate activation of T lymphocytes plays an important role in perinatal complications. However, data on T lymphocyte activation markers of preterm infants is scarce. We investigated the association between gender, gestational and postnatal age, preeclampsia (PE), premature rupture of membranes (PROM) as well as prenatal steroid treatment (PS) and the frequency of activated T lymphocyte subsets (HLA-DR+, CD69+, CD25+, CD62L+) and major T lymphocyte subpopulations (CD4, CD8, Th1, Th2, naïve, memory) in peripheral blood during the first postnatal week in preterm infants. RESULTS:Cord blood and peripheral blood samples were collected from 43 preterm infants on the 1st, 3rd, and 7th days of life. We assessed the frequency of the above T lymphocyte subsets using flow cytometry. The 'mixed effect model' was used to analyze the effects of clinical parameters on T lymphocyte markers. The frequency of CD25+ T lymphocytes was higher in PROM. The frequency of CD4+ and CD8+ cells and the CD4+/CD8+ cell ratio was decreased in PE. The frequency of CD62L+ T lymphocytes was higher in male compared with female infants. PS did not affect the frequency of the investigated markers. CD4+ CD25+ cells had a lower frequency at birth than on day 7. Th2 lymphocytes had a lower frequency on postnatal days 1 and 3 when compared to day 7. CONCLUSIONS:Our observations indicate that alterations affecting the expression of T lymphocyte activation markers are associated with the above factors and may play a role in the development of perinatal complications.

journal_name

BMC Immunol

journal_title

BMC immunology

authors

Sava F,Toldi G,Treszl A,Hajdú J,Harmath Á,Tulassay T,Vásárhelyi B

doi

10.1186/s12865-016-0159-7

subject

Has Abstract

pub_date

2016-06-21 00:00:00

pages

19

issue

1

issn

1471-2172

pii

10.1186/s12865-016-0159-7

journal_volume

17

pub_type

杂志文章

相关文献

BMC IMMUNOLOGY文献大全
  • Co-localization of lymphoid aggregates and lymphatic networks in nose- (NALT) and lacrimal duct-associated lymphoid tissue (LDALT) of mice.

    abstract：BACKGROUND:The lymphatic vascular pattern in the head of mice has rarely been studied, due to problems of sectioning and immunostaining of complex bony structures. Therefore, the association of head lymphoid tissues with the lymphatics has remained unknown although the mouse is the most often used species in immunology...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/s12865-018-0242-3

    authors： Lohrberg M,Pabst R,Wilting J

    更新日期：2018-01-25 00:00:00

  • Porphyromonas gingivalis activates NFκB and MAPK pathways in human oral epithelial cells.

    abstract：BACKGROUND:The bacterial biofilm at the gingival margin induces a host immune reaction. In this local inflammation epithelial cells defend the host against bacterial challenge. Porphyromonas gingivalis (P. gingivalis), a keystone pathogen, infects epithelial cells. The aim of this study was to investigate the activatio...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/s12865-016-0185-5

    authors： Groeger S,Jarzina F,Domann E,Meyle J

    更新日期：2017-01-05 00:00:00

  • In vitro and in vivo protective efficacies of antibodies that neutralize the RNA N-glycosidase activity of Shiga toxin 2.

    abstract：BACKGROUND:Shiga toxin 2 (Stx2), one of two Stx liberated by Stx-producing Escherichia coli, is composed of an A subunit monomer and a B subunit pentamer, and is directly linked with hemolytic uremic syndrome in children. The pentameric B subunit binds to its cell surface receptor Gb3 for toxin internalization, and the...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/1471-2172-11-16

    authors： Jeong KI,Chapman-Bonofiglio S,Singh P,Lee J,Tzipori S,Sheoran AS

    更新日期：2010-03-24 00:00:00

  • Tumor vaccine composed of C-class CpG oligodeoxynucleotides and irradiated tumor cells induces long-term antitumor immunity.

    abstract：BACKGROUND:An ideal tumor vaccine should activate both effector and memory immune response against tumor-specific antigens. Beside the CD8+ T cells that play a central role in the generation of a protective immune response and of long-term memory, dendritic cells (DCs) are important for the induction, coordination and ...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/1471-2172-11-45

    authors： Cerkovnik P,Novakovic BJ,Stegel V,Novakovic S

    更新日期：2010-09-13 00:00:00

  • Co-inherited mutations of Fas and caspase-10 in development of the autoimmune lymphoproliferative syndrome.

    abstract：BACKGROUND:Autoimmune lymphoproliferative syndrome (ALPS) is a rare inherited disorder characterized by defective function of Fas, autoimmune manifestations that predominantly involve blood cells, polyclonal accumulation of lymphocytes in the spleen and lymph nodes with lymphoadenomegaly and/or splenomegaly, and expans...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/1471-2172-8-28

    authors： Cerutti E,Campagnoli MF,Ferretti M,Garelli E,Crescenzio N,Rosolen A,Chiocchetti A,Lenardo MJ,Ramenghi U,Dianzani U

    更新日期：2007-11-13 00:00:00

  • The DNA methyltransferase inhibitor, guadecitabine, targets tumor-induced myelopoiesis and recovers T cell activity to slow tumor growth in combination with adoptive immunotherapy in a mouse model of breast cancer.

    abstract：BACKGROUND:Myeloid derived suppressor cells (MDSCs) present a significant obstacle to cancer immunotherapy because they dampen anti-tumor cytotoxic T cell responses. Previous groups, including our own, have reported on the myelo-depletive effects of certain chemotherapy agents. We have shown previously that decitabine ...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/s12865-020-0337-5

    authors： Luker AJ,Graham LJ,Smith TM Jr,Camarena C,Zellner MP,Gilmer JS,Damle SR,Conrad DH,Bear HD,Martin RK

    更新日期：2020-02-27 00:00:00

  • Standardization and performance evaluation of mononuclear cell cytokine secretion assays in a multicenter study.

    abstract：BACKGROUND:Cryopreservation of peripheral blood mononuclear cells has been used to preserve and standardize immunologic measurements for multicenter studies, however, effects of cryopreservation on cytokine responses are incompletely understood. In designing immunologic studies for a new multicenter birth cohort study ...

    journal_title：BMC immunology

    pub_type： 杂志文章,多中心研究

    doi：10.1186/1471-2172-7-29

    authors： Shreffler WG,Visness CM,Burger M,Cruikshank WW,Lederman HM,de la Morena M,Grindle K,Calatroni A,Sampson HA,Gern JE

    更新日期：2006-12-12 00:00:00

  • The prokineticin receptor agonist Bv8 decreases IL-10 and IL-4 production in mice splenocytes by activating prokineticin receptor-1.

    abstract：BACKGROUND:Bv8, prokineticin-1, or endocrine gland-vascular endothelial growth factor, and prokineticin-2 are recently isolated peptide agonists of two G protein-coupled receptors, prokineticin receptor-1 (PROKR 1) and PROKR 2, and have been described as affecting a number of myeloid cell functions. We evaluated the im...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/1471-2172-9-60

    authors： Franchi S,Giannini E,Lattuada D,Lattanzi R,Tian H,Melchiorri P,Negri L,Panerai AE,Sacerdote P

    更新日期：2008-10-28 00:00:00

  • Investigations of immunogenic, allergenic and adjuvant properties of Cry1Ab protein after intragastric exposure in a food allergy model in mice.

    abstract：BACKGROUND:In genetically modified (GM) crops there is a risk that the inserted genes may introduce new allergens and/or adjuvants into the food and feed chain. The MON810 maize, expressing the insecticidal Cry1Ab toxin, is grown in many countries worldwide. In animal models, intranasal and intraperitoneal immunisation...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/s12865-016-0148-x

    authors： Andreassen M,Bøhn T,Wikmark OG,Bodin J,Traavik T,Løvik M,Nygaard UC

    更新日期：2016-05-04 00:00:00

  • Low-dose plasmid DNA treatment increases plasma vasopressin and regulates blood pressure in experimental endotoxemia.

    abstract：BACKGROUND:Although plasmid DNA encoding an antigen from pathogens or tumor cells has been widely studied as vaccine, the use of plasmid vector (without insert) as therapeutic agent requires further investigation. RESULTS:Here, we showed that plasmid DNA (pcDNA3) at low doses inhibits the production of IL-6 and TNF-α ...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/1471-2172-13-59

    authors： Malardo T,Batalhão ME,Panunto-Castelo A,Almeida LP,Padilha E,Fontoura IC,Silva CL,Carnio EC,Coelho-Castelo AA

    更新日期：2012-11-08 00:00:00

  • Depigmented-polymerised allergoids favour regulatory over effector T cells: enhancement by 1α, 25-dihydroxyvitamin D3.

    abstract：BACKGROUND:Allergen immunotherapy (SIT) is the only treatment for allergic disease capable of modifying disease long term. To reduce the risk of anaphylaxis from SIT, allergen-extracts have been modified by polymerisation with glutaraldehyde to reduce IgE binding. It is suggested that these allergoid extracts also have...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/1471-2172-15-21

    authors： Urry ZL,Richards DF,Black C,Morales M,Carnés J,Hawrylowicz CM,Robinson DS

    更新日期：2014-05-29 00:00:00

  • Ten-color flow cytometry reveals distinct patterns of expression of CD124 and CD126 by developing thymocytes.

    abstract：BACKGROUND:We have developed a 12-parameter/10-color flow cytometric staining method for the simultaneous detection and characterization of 21 mouse thymocyte subpopulations that represent discreet stages of T cell development. To demonstrate the utility of this method, we assessed cytokine receptor expression on mouse...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/1471-2172-12-36

    authors： Tan C,Taylor AA,Coburn MZ,Marino JH,Van De Wiele CJ,Teague TK

    更新日期：2011-06-20 00:00:00

  • Immune responses in the lungs of patients with tuberculous pleural effusion without pulmonary tuberculosis.

    abstract：BACKGROUND:Tuberculous pleural effusion (TPE) is one of the most common forms of extrapulmonary tuberculosis. Because most studies of TPE focused on the pleural space, little information regarding lung parenchyma is available. We therefore aimed to investigate immune responses in the lung parenchyma of TPE patients wit...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/1471-2172-13-45

    authors： Qama D,Choi WI,Kwon KY

    更新日期：2012-08-13 00:00:00

  • CD4(+)CD25(High) Treg cells in HIV/HTLV co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factor.

    abstract：BACKGROUND:Regulatory CD4 T cells (Tregs) are critical in maintaining the homeostasis of the immune system. Quantitative or phenotypic alterations and functional impairment of Tregs have been associated with the development of pathologies including those of the central nervous system. Individuals with HIV-1/HTLV-1 co-i...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/s12865-015-0116-x

    authors： Matavele Chissumba R,Silva-Barbosa SD,Augusto Â,Maueia C,Mabunda N,Gudo ES Jr,Bhatt N,Jani I,Savino W

    更新日期：2015-09-02 00:00:00

  • Characteristics and reference ranges of CD4+T cell subpopulations among healthy adult Han Chinese in Shanxi Province, North China.

    abstract：BACKGROUND:Immunophenotyping of blood lymphocytes is an essential tool to evaluate the immune function of patients with immunodeficiency or autoimmunity. Predominately identified CD4+T cell subsets, Th1, Th2, Th17, as well as regulatory T (Treg) cells, play crucial roles in several immunological and pathological condit...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/s12865-020-00374-9

    authors： Niu HQ,Zhao XC,Li W,Xie JF,Liu XQ,Luo J,Zhao WP,Li XF

    更新日期：2020-08-03 00:00:00

  • Low frequency of CD4+CD25+ Treg in SLE patients: a heritable trait associated with CTLA4 and TGFbeta gene variants.

    abstract：BACKGROUND:CD4+CD25+ regulatory T cells play an essential role in maintaining immune homeostasis and preventing autoimmunity. Therefore, defects in Treg development, maintenance or function have been associated with several human autoimmune diseases including Systemic Lupus Erythematosus (SLE), a systemic autoimmune di...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/1471-2172-10-5

    authors： Barreto M,Ferreira RC,Lourenço L,Moraes-Fontes MF,Santos E,Alves M,Carvalho C,Martins B,Andreia R,Viana JF,Vasconcelos C,Mota-Vieira L,Ferreira C,Demengeot J,Vicente AM

    更新日期：2009-01-27 00:00:00

  • Pneumococcal vaccination responses in adults with subnormal IgG subclass concentrations.

    abstract：BACKGROUND:We sought to compare Pneumovax®23 responses in adults with subnormal IgG subclass concentrations. We studied adults with normal total IgG, frequent/severe respiratory infection, and subnormal IgG1, IgG3, or IgG1 + IgG3 before and after Pneumovax®23. We defined response as serotype-specific IgG > 1.3 μg/mL an...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/s12865-019-0310-3

    authors： Parker AR,Skold M,Harding S,Barton JC,Bertoli LF,Barton JC

    更新日期：2019-08-20 00:00:00

  • Modulation of neutrophil function by the tripeptide feG.

    abstract：BACKGROUND:Neutrophils are critical in the defense against potentially harmful microorganisms, but their excessive and inappropriate activation can contribute significantly to tissue damage and a worsening pathology. Through the release of endocrine factors submandibular glands contribute to achieving a balance in neut...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/1471-2172-4-3

    authors： Mathison RD,Befus AD,Davison JS,Woodman RC

    更新日期：2003-03-04 00:00:00

  • Limiting prolonged inflammation during proliferation and remodeling phases of wound healing in streptozotocin-induced diabetic rats supplemented with camel undenatured whey protein.

    abstract：BACKGROUND:Impaired diabetic wound healing occurs as a consequence of excessive reactive oxygen species (ROS) and inflammatory cytokine production. We previously found that whey protein (WP) was able to normally regulate the ROS and inflammatory cytokines during the inflammatory phase (first day) in streptozotocin (STZ...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/1471-2172-14-31

    authors： Ebaid H,Ahmed OM,Mahmoud AM,Ahmed RR

    更新日期：2013-07-25 00:00:00

  • Genomic locus on chromosome 1 regulates susceptibility to spontaneous arthritis in mice deficiency of IL-1RA.

    abstract：BACKGROUND:To understand the role of genetic factors on chromosome 1 in the regulation of spontaneous arthritis in mice deficient in IL-1 receptor antagonist protein (IL_1RA), we previously used speed congenic breeding to transfer the QTL region from DBA/1(-/-) mice that are resistant to spontaneous arthritis into BALB...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/s12865-014-0057-9

    authors： Deng N,Jiao Y,Cao Y,Liu X,Ma Y,Hasty KA,Brand DD,Stuart JM,Gu W

    更新日期：2014-12-09 00:00:00

  • Activation of tonsil dendritic cells with immuno-adjuvants.

    abstract：BACKGROUND:Dendritic cells (DC) play the key role in directing antigen-specific immune responses and manipulating their function may be a useful tool for immunotherapy. The balance between immune stimulation and tolerance is particularly important at mucosal interfaces, where discrimination between dangerous pathogens ...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/1471-2172-9-10

    authors： Polak ME,Borthwick NJ,Gabriel FG,Jager MJ,Cree IA

    更新日期：2008-03-18 00:00:00

  • Gallin; an antimicrobial peptide member of a new avian defensin family, the ovodefensins, has been subject to recent gene duplication.

    abstract：BACKGROUND:Egg white must provide nutrients and protection to the developing avian embryo. One way in which this is achieved is an arsenal of antimicrobial proteins and peptides which are essentially extensions of the innate immune system. Gallin is a recently identified member of a family of peptides that are found in...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/1471-2172-11-12

    authors： Gong D,Wilson PW,Bain MM,McDade K,Kalina J,Hervé-Grépinet V,Nys Y,Dunn IC

    更新日期：2010-03-12 00:00:00

  • Prothymosin α and a prothymosin α-derived peptide enhance T(H)1-type immune responses against defined HER-2/neu epitopes.

    abstract：BACKGROUND:Active cancer immunotherapies are beginning to yield clinical benefit, especially those using peptide-pulsed dendritic cells (DCs). Different adjuvants, including Toll-like receptor (TLR) agonists, commonly co-administered to cancer patients as part of a DC-based vaccine, are being widely tested in the clini...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/1471-2172-14-43

    authors： Ioannou K,Derhovanessian E,Tsakiri E,Samara P,Kalbacher H,Voelter W,Trougakos IP,Pawelec G,Tsitsilonis OE

    更新日期：2013-09-22 00:00:00

  • Streptococcus sanguinis-induced cytokine and matrix metalloproteinase-1 release from platelets.

    abstract：BACKGROUND:Streptococcus sanguinis (S.sanguinis), a predominant bacterium in the human oral cavity, has been widely associated with the development of infective endocarditis. Platelets play both a haemostatic function and can influence both innate and adaptive immune responses. Previous studies have shown that S.sangui...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/1471-2172-15-15

    authors： Cognasse F,Hamzeh-Cognasse H,Chabert A,Jackson E,Arthaud CA,Garraud O,McNicol A

    更新日期：2014-04-22 00:00:00

  • Interleukin-10 production by tumor infiltrating macrophages plays a role in Human Papillomavirus 16 tumor growth.

    abstract：BACKGROUND:Human Papillomavirus, HPV, is the main etiological factor for cervical cancer. Different studies show that in women infected with HPV there is a positive correlation between lesion grade and number of infiltrating macrophages, as well as with IL-10 higher expression. Using a HPV16 associated tumor model in m...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/1471-2172-11-27

    authors： Bolpetti A,Silva JS,Villa LL,Lepique AP

    更新日期：2010-06-07 00:00:00

  • The innate interferon gamma response of BALB/c and C57BL/6 mice to in vitro Burkholderia pseudomallei infection.

    abstract：BACKGROUND:Burkholderia pseudomallei is the causative agent for melioidosis. For many bacterial infections, cytokine dysregulation is one of the contributing factors to the severe clinical outcomes in the susceptible hosts. The C57BL/6 and BALB/c mice have been established as a differential model of susceptibility in m...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/1471-2172-7-19

    authors： Koo GC,Gan YH

    更新日期：2006-08-18 00:00:00

  • High glucose concentrations induce TNF-α production through the down-regulation of CD33 in primary human monocytes.

    abstract：BACKGROUND:CD33 is a membrane receptor containing a lectin domain and a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) that is able to inhibit cytokine production. CD33 is expressed by monocytes, and reduced expression of CD33 correlates with augmented production of inflammatory cytokines, such as IL...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/1471-2172-13-19

    authors： Gonzalez Y,Herrera MT,Soldevila G,Garcia-Garcia L,Fabián G,Pérez-Armendariz EM,Bobadilla K,Guzmán-Beltrán S,Sada E,Torres M

    更新日期：2012-04-14 00:00:00

  • Subsets of mononuclear phagocytes are enriched in the inflamed colons of patients with IBD.

    abstract：BACKGROUND:Myeloid cells, especially mononuclear phagocytes, which include monocytes, macrophages and dendritic cells (DC), play vital roles in innate immunity, and in the initiation and maintenance of adaptive immunity. While T cell-associated activation pathways and cytokines have been identified and evaluated in inf...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/s12865-019-0322-z

    authors： Liu H,Dasgupta S,Fu Y,Bailey B,Roy C,Lightcap E,Faustin B

    更新日期：2019-11-12 00:00:00

  • Detection of IL-9 producing T cells in the PBMCs of allergic asthmatic patients.

    abstract：BACKGROUND:Interleukin-9 (IL-9) was reported as an active participant in the pathogenesis of allergic asthma. This study aimed to investigate the major source ofIL-9 and its effect on interferon γ (IFN-γ) and immunoglobulin (Ig) secretion by B cells. METHODS:We isolated peripheral blood mononuclear cells from children...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/s12865-017-0220-1

    authors： Jia L,Wang Y,Li J,Li S,Zhang Y,Shen J,Tan W,Wu C

    更新日期：2017-07-19 00:00:00

  • Eosinophils may play regionally disparate roles in influencing IgA(+) plasma cell numbers during large and small intestinal inflammation.

    abstract：BACKGROUND:Eosinophils are innate immune cells present in the intestine during steady state conditions. An intestinal eosinophilia is a hallmark of many infections and an accumulation of eosinophils is also observed in the intestine during inflammatory disorders. Classically the function of eosinophils has been associa...

    journal_title：BMC immunology

    pub_type： 杂志文章

    doi：10.1186/s12865-016-0153-0

    authors： Forman R,Bramhall M,Logunova L,Svensson-Frej M,Cruickshank SM,Else KJ

    更新日期：2016-05-31 00:00:00