abstract：:The potential of whole body vibration (WBV) to maintain or enhance musculoskeletal strength during ageing is of increasing interest, with both low and high magnitude WBV having been shown to maintain or increase bone mineral density (BMD) at the lumbar spine and femoral neck. The aim of this study was to determine how...

journal_title：Bone

authors： Spain L,Yang L,Wilkinson JM,McCloskey E

更新日期：2021-03-01 00:00:00

abstract：OBJECTIVES:This study sought to identify the clinical and biochemical characteristics that would help distinguish hypophosphatasia (HPP) from other metabolic bone diseases in adult patients attending a metabolic bone clinic by comparing patients who have genetically confirmed HPP with a group of patients with low bone ...

journal_title：Bone

authors： Desborough R,Nicklin P,Gossiel F,Balasubramanian M,Walsh JS,Petryk A,Teynor M,Eastell R

更新日期：2021-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of short RNA molecules that mediate the regulation of gene activity through interactions with target mRNAs and subsequent silencing of gene expression. It has become increasingly clear the miRNAs regulate many diverse aspects of bone biology, including bone formation and bone resorption ...

journal_title：Bone

authors： Weivoda MM,Lee SK,Monroe DG

更新日期：2021-02-01 00:00:00

abstract：INTRODUCTION:Alström syndrome (ALMS) is an ultra-rare metabolic disorder caused by biallelic loss-of-function in the Alms1 gene which encodes a ubiquitously expressed centrosomal protein of the primary cilium. Although ALMS is characterised by several metabolic and hormonal dysfunctions that can lead to an increased ri...

journal_title：Bone

authors： Tahani N,Choudhary S,Boivin C,Dawson C,Gittoes N,Geberhiwot T

更新日期：2021-02-01 00:00:00

abstract：:The hips are frequently involved in inheritable diseases which affect the bones. The clinical and radiological presentation of these diseases may be very similar to common hip disorders as developmental dysplasia of the hip, osteoarthritis and avascular necrosis, so the diagnosis may be easily overlooked and treatment...

journal_title：Bone

authors： Oussoren E,Wagenmakers MAEM,Link B,van der Meijden JC,Pijnappel WWMP,Ruijter GJG,Langeveld M,van der Ploeg AT

更新日期：2021-02-01 00:00:00

abstract：:Regulation of osteoclast differentiation and function is a central element in bone homeostasis. While the role of soluble factors, such as cytokines, hormones and growth factors, in controlling osteoclast differentiation has been intensively characterized, the function of surface receptors is less well understood. Sia...

journal_title：Bone

authors： Andes FT,Adam S,Hahn M,Aust O,Frey S,Grueneboom A,Nitschke L,Schett G,Steffen U

更新日期：2021-02-01 00:00:00

abstract：:Epigenetic regulatory proteins support mammalian development, cancer, aging and tissue repair by controlling many cellular processes including stem cell self-renewal, lineage-commitment and senescence in both skeletal and non-skeletal tissues. We review here our knowledge of epigenetic regulatory protein complexes tha...

journal_title：Bone

authors： van Wijnen AJ,Bagheri L,Badreldin AA,Larson AN,Dudakovic A,Thaler R,Paradise CR,Wu Z

更新日期：2021-02-01 00:00:00

abstract：INTRODUCTION:In patients with beta thalassemia major, inadequate transfusion and chelation may compromise bone health and increase risk of fractures. The objective of this study was to describe the prevalence of fractures in Indian inadequately transfused and chelated children, adolescents and young adults with beta th...

journal_title：Bone

authors： Ekbote V,Padidela R,Khadilkar V,Ramanan V,Maheshwari A,Mughal Z,Kariki EP,Crabtree N,Khadilkar A

更新日期：2021-02-01 00:00:00

abstract：:Bone is a composite biomaterial of mineral crystals, organic matrix, and water. Each contributes to bone quality and strength and may change independently, or together, with disease progression and treatment. Even so, there is a near ubiquitous reliance on ionizing x-ray-based approaches to measure bone mineral densit...

journal_title：Bone

authors： Surowiec RK,Ram S,Idiyatullin D,Goulet R,Schlecht SH,Galban CJ,Kozloff KM

更新日期：2021-02-01 00:00:00

abstract：:Low-intensity pulsed ultrasound (LIPUS) has been used to accelerate bone fracture healing. However, the issue whether LIPUS is effective in preventing osteoporosis has not been clarified, and if so, what possible mechanisms might be responsible. Myostatin (MSTN) is a negative regulator of muscle growth, and its absenc...

journal_title：Bone

authors： Tang L,An S,Zhang Z,Fan X,Guo J,Sun L,Ta D

更新日期：2021-02-01 00:00:00

abstract：:The study reports a theranostic nature of rno-miR-300 (miR300) in the osteoblast functioning, by influencing the signaling pathway(s), associated with osteoblast differentiation. Excessive expression of miR300 suppresses osteoblast functions. Smad3 served as a validated target for miR300, on homology-based computation...

journal_title：Bone

authors： Kaur T,John AA,Sharma C,Vashisht NK,Singh D,Kapila R,Kapila S

更新日期：2021-02-01 00:00:00

abstract：AIMS:Hip fracture patients have severe deterioration of their quality of life and function after their injury. Markers of malnutrition such as low albumin and low body mass index (BMI) have been shown to increase mortality and complication rates but their effect on recovery of quality of life and function after hip fra...

journal_title：Bone

authors： Sim SD,Sim YE,Tay K,Howe TS,Png MA,Chang CCP,Abdullah HR,Koh JSB

更新日期：2021-02-01 00:00:00

abstract：:Background and Purpose Radiotherapy is known to produce long-term skeletal complications. We aim to evaluate the biomechanical effect on femoral neck bone from hypothetical eccentric loads on pre- and post-radiotherapy CT-images for patients treated for rectal cancer. MATERIAL AND METHODS:Pre- and post-radiotherapy C...

journal_title：Bone

authors： Almendros-Abellán VM,Castro-García M,Canales-Vázquez J,Berenguel-Herraiz P,Sabater S

更新日期：2021-01-26 00:00:00

abstract：:This study reports the effects of a recreational team handball exercise programme (randomised controlled trial, RCT) on bone health, postural balance and body composition in inactive postmenopausal women without previous experience of the sport. Sixty-seven postmenopausal women (68.3 ± 6.2 years, stature 156.9 ± 5.8 c...

journal_title：Bone

authors： Pereira R,Krustrup P,Castagna C,Coelho E,Santos R,Helge EW,Jørgensen NR,Magalhães J,Póvoas S

更新日期：2021-01-13 00:00:00

abstract：OBJECTIVES:This study aimed to evaluate the involvement of Angiotensin II (Ang II) in joint lesions associated with osteoarthritis (OA) in vitro and in vivo. METHODS:Chondrocyte cultures were obtained from knee joints of neonatal rats and stimulated with Ang II/MIA/ACE inhibitors. In vivo, rats treated or not with the...

journal_title：Bone

authors： de Sá GA,Dos Santos ACPM,Nogueira JM,Dos Santos DM,Amaral FA,Jorge EC,Caliari MV,Queiroz-Junior CM,Ferreira AJ

更新日期：2021-01-07 00:00:00

abstract：CONTEXT:Low energy availability causes disruption of hypothalamic gonadotropin-releasing hormone secretion leading to functional hypothalamic amenorrhea (FHA) and hypoestrogenism, which in turn contributes to decreased bone mineral density (BMD) and increased bone marrow adipose tissue (MAT). Transdermal estradiol admi...

journal_title：Bone

authors： Singhal V,Karzar NH,Bose A,Buckless C,Ackerman KE,Bredella MA,Klibanski A,Misra M

更新日期：2021-01-06 00:00:00

abstract：PURPOSE:Detraining after dedicated exercise programs might be a frequent situation in older people's exercise patterns. The aim of the present study was thus to determine the effects of 6 months of detraining after 18 months of high intensity resistance exercise (HIT-RT) on musculoskeletal outcomes in older men with sa...

journal_title：Bone

authors： Kemmler W,Kohl M,Fröhlich M,Schoene D,von Stengel S

更新日期：2021-01-01 00:00:00

abstract：:Microdeletions within 1q24 have been associated with growth deficiency, varying intellectual disability, and skeletal abnormalities. The candidate locus responsible for the various phenotypic features of this syndrome has previously been predicted to lie in the area of 1q24.3, but molecular evidence of the causative g...

journal_title：Bone

authors： Shepherdson JL,Zheng H,Amarillo IE,McAlinden A,Shinawi M

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:There is evidence that the extent of vertebral bone marrow adiposity increases caudally along the vertebral column in children and adolescents. However, no studies have examined the lipid composition of bone marrow along the vertebral column, which may uniquely influence bone acquisition and metabolism durin...

journal_title：Bone

authors： Whitney DG,Devlin MJ,Alford AI,Caird MS

更新日期：2021-01-01 00:00:00

abstract：:Bone age is used widely by pediatricians to assess the skeletal maturity of a child and predict growth potential. This entails measuring the size of secondary ossification centers (SOCs), which develop with age in the ends of long bones, which are initially cartilaginous. However, little is presently known about the d...

journal_title：Bone

authors： Xie M,Chagin AS

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:The present study aimed to investigate the association between type 2 diabetes mellitus (T2DM) and hip fractures using a large-scale nationwide population-based cohort that is representative of the Republic of Korea. We determined the risks of hip fractures in individuals with prediabetes and T2DM with diffe...

journal_title：Bone

authors： Park HY,Han K,Kim Y,Kim YH,Sur YJ

更新日期：2021-01-01 00:00:00

abstract：:Ectonucleotide phosphatase/phosphodiesterase 1 (ENPP1) deficiency results in either lethal arterial calcifications ('Generalized Arterial Calcification of Infancy' - GACI), phosphate wasting rickets ('Autosomal Recessive Hypophosphatemic Rickets type 2' - ARHR2), early onset osteoporosis, or progressive spinal rigidit...

journal_title：Bone

authors： Maulding ND,Kavanagh D,Zimmerman K,Coppola G,Carpenter TO,Jue NK,Braddock DT

更新日期：2021-01-01 00:00:00

abstract：:Metastatic cancer is lethal and patients who suffer bone metastases fare especially poorly. Bone-specific metastatic progression in prostate and breast cancers is a highly observed example of organ-specific metastasis, or organotropism. Though research has delineated the sequential steps of the metastatic cascade, the...

journal_title：Bone

authors： Mallin MM,Pienta KJ,Amend SR

更新日期：2020-12-03 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Fibroblast growth factor 23 (FGF23) participates in phosphate, calcium and vitamin D metabolism. In children these interactions and modifying factors are largely unknown. PARTICIPANTS AND METHODS:This study evaluates temporal changes and modifiers of FGF23 concentrations from 12 to 24 months,...

journal_title：Bone

authors： Enlund-Cerullo M,Hauta-Alus H,Valkama S,Rosendahl J,Andersson S,Mäkitie O,Holmlund-Suila E

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Like osteonecrosis of the femoral head (ONFH), subchondral insufficiency fracture of the femoral head (SIF) causes femoral head collapse. However, little is known about the differences between the two diseases regarding the morphological features of the collapsed lesion. We tested the hypothesis that the mor...

journal_title：Bone

authors： Kawano K,Motomura G,Ikemura S,Yamaguchi R,Baba S,Xu M,Nakashima Y

更新日期：2020-12-01 00:00:00

abstract：:Alagille syndrome (ALGS) is an autosomal dominant disorder attributed to mutations in the Notch signaling pathway. Children with ALGS are at increased risk for fragility fracture of unknown etiology. Our objective was to characterize bone mass, geometry, and microarchitecture in children with ALGS. This was a cross-se...

journal_title：Bone

authors： Kindler JM,Mitchell EL,Piccoli DA,Grimberg A,Leonard MB,Loomes KM,Zemel BS

更新日期：2020-12-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are known to induce new bone formation in vivo but treating trabecular bone defects with a BMP based therapeutic remains controversial. Here, we evaluated the safety and efficacy of a novel Autologous Bone Graft Substitute (ABGS) comprised of recombinant human BMP6 (rhBMP6) dispersed...

journal_title：Bone

authors： Durdevic D,Vlahovic T,Pehar S,Miklic D,Oppermann H,Bordukalo-Niksic T,Gavrankapetanovic I,Jamakosmanovic M,Milosevic M,Martinovic S,Sampath TK,Peric M,Grgurevic L,Vukicevic S

更新日期：2020-11-01 00:00:00

abstract：:The incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are well known for their insulinotropic effects and they are thought to affect bone homeostasis as mediators in the so-called entero-osseous axis. We examined the contributions of endogenous GIP and GLP-1, resp...

journal_title：Bone

authors： Helsted MM,Gasbjerg LS,Lanng AR,Bergmann NC,Stensen S,Hartmann B,Christensen MB,Holst JJ,Vilsbøll T,Rosenkilde MM,Knop FK

更新日期：2020-11-01 00:00:00

abstract：:In elderly subjects and in particular in those with osteoporosis the evidence on age related volume changes of the hip is still very limited. Even less is known about bone changes of the femoral head. The aim of this study is to explore associations of bone size of the femoral head and neck with age in postmenopausal ...

journal_title：Bone

authors： Su Y,Wang L,Liu X,Yang M,Yi C,Liu Y,Huang P,Guo Z,Yu A,Cheng X,Wu X,Blake GM,Engelke K

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:The treatment of complex bone loss scenarios remains challenging. This study evaluates the efficacy of ex vivo regional gene therapy using transduced human adipose-derived stem cells (ASCs) overexpressing bone morphogenetic protein-2 (BMP-2) to treat critical-sized bone defects. METHODS:Critical-sized femor...

journal_title：Bone

authors： Vakhshori V,Bougioukli S,Sugiyama O,Kang HP,Tang AH,Park SH,Lieberman JR

更新日期：2020-09-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) were first described over 50 years ago as potent inducers of ectopic bone formation when administrated subcutaneously. Preclinical studies have extensively examined the osteoinductive properties of BMPs in vitro and new bone formation in vivo. BMPs (BMP-2, BMP-7) have been used in or...

journal_title：Bone

authors： Kamiya N,Atsawasuwan P,Joiner DM,Waldorff EI,Goldstein S,Yamauchi M,Mishina Y

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:The aim was to analyse risk of forearm fractures in first- and second-generation immigrants to Sweden. METHODS:A nationwide study of individuals 20 years of age and older was conducted. Forearm fractures were defined as at least one registered diagnosis in the National Patient Register between January 1, 199...

journal_title：Bone

authors： Wändell P,Li X,Carlsson AC,Sundquist J,Sundquist K

更新日期：2020-09-01 00:00:00

abstract：:The direct effects of physical activity on long bones are already recognized. However, little information is available regarding distant osseous sites, such as maxillary bone. We evaluated the influence of physical training on alveolar bone quality, with and without mechanically-induced load during orthodontic tooth m...

journal_title：Bone

authors： Pereira LJ,Macari S,Coimbra CC,Pereira TDSF,Barrioni BR,Gomez RS,Silva TA,Paiva SM

更新日期：2020-09-01 00:00:00

abstract：:Inflammation is an important part of the fracture repair process which requires osteogenic cells to interact with innate immune cells such as macrophages. All murine macrophages express the F4/80 cell surface marker but they may be further subdivided into two main phenotypes: M1 (proinflammatory) or M2 (anti-inflammat...

journal_title：Bone

authors： Hozain S,Cottrell J

更新日期：2020-09-01 00:00:00

abstract：:In the present study, we evaluated an autologous bone graft substitute (ABGS) composed of recombinant human BMP6 (rhBMP6) dispersed within autologous blood coagulum (ABC) used as a physiological carrier for new bone formation in spine fusion sheep models. The application of ABGS included cervical cage for use in the a...

journal_title：Bone

authors： Grgurevic L,Erjavec I,Gupta M,Pecin M,Bordukalo-Niksic T,Stokovic N,Vnuk D,Farkas V,Capak H,Milosevic M,Bubic Spoljar J,Peric M,Vuckovic M,Maticic D,Windhager R,Oppermann H,Sampath TK,Vukicevic S

更新日期：2020-09-01 00:00:00

abstract：:The ligands that comprise the Transforming Growth Factor β superfamily highly govern the development of the embryonic growth plate. Members of this superfamily activate canonical TGFβ and/or BMP (Bone Morphogenetic Protein) signaling pathways. How these pathways interact with one another is an area of active investiga...

journal_title：Bone

authors： Wang W,Rigueur D,Lyons KM

更新日期：2020-08-01 00:00:00

abstract：:Impaired fracture healing in patients with obesity-associated type 2 diabetes (T2D) is a significant unmet clinical problem that affects millions of people worldwide. However, the underlying causes are poorly understood. Additionally, limited clinical information is available on how pre-diabetic hyperglycemia in obese...

journal_title：Bone

authors： Khajuria DK,Soliman M,Elfar JC,Lewis GS,Abraham T,Kamal F,Elbarbary RA

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:Rheumatoid arthritis (RA) is accompanied by potential risk of bone mineral loss. In this study, we developed a screening index for the osteoporosis related level of bone mineral density loss for RA patients as a substitute to the dual-energy X-ray absorptiometry (DXA) method. METHODS:X-ray pictures of both s...

journal_title：Bone

authors： Yoshii I,Akita K

更新日期：2020-08-01 00:00:00

abstract：:Bone morphogenetic protein (BMP) signaling in osteoblasts plays critical roles in skeletal development and bone homeostasis. Our previous studies showed loss of function of BMPR1A, one of the type 1 receptors for BMPs, in osteoblasts results in increased trabecular bone mass in long bones due to an imbalance between b...

journal_title：Bone

authors： Zhang H,Zhang Y,Terajima M,Romanowicz G,Liu Y,Omi M,Bigelow E,Joiner DM,Waldorff EI,Zhu P,Raghavan M,Lynch M,Kamiya N,Zhang R,Jepsen KJ,Goldstein S,Morris MD,Yamauchi M,Kohn DH,Mishina Y

更新日期：2020-08-01 00:00:00

abstract：:Osteocytes form over 90% of the bone cells and are postulated to be mechanosensors responsible for regulating the function of osteoclasts and osteoblasts in bone modeling and remodeling. Physical activity results in mechanical loading on the bones. Osteocytes are thought to be the main mechanosensory cells in bone. Up...

journal_title：Bone

authors： Ganesh T,Laughrey LE,Niroobakhsh M,Lara-Castillo N

更新日期：2020-08-01 00:00:00