听力与言语-语言病理学

行为科学

医学伦理学

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  • Transmission of whole body vibration - Comparison of three vibration platforms in healthy subjects.

    abstract::The potential of whole body vibration (WBV) to maintain or enhance musculoskeletal strength during ageing is of increasing interest, with both low and high magnitude WBV having been shown to maintain or increase bone mineral density (BMD) at the lumbar spine and femoral neck. The aim of this study was to determine how...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115802

    authors: Spain L,Yang L,Wilkinson JM,McCloskey E

    更新日期:2021-03-01 00:00:00

  • Clinical and biochemical characteristics of adults with hypophosphatasia attending a metabolic bone clinic.

    abstract:OBJECTIVES:This study sought to identify the clinical and biochemical characteristics that would help distinguish hypophosphatasia (HPP) from other metabolic bone diseases in adult patients attending a metabolic bone clinic by comparing patients who have genetically confirmed HPP with a group of patients with low bone ...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115795

    authors: Desborough R,Nicklin P,Gossiel F,Balasubramanian M,Walsh JS,Petryk A,Teynor M,Eastell R

    更新日期:2021-03-01 00:00:00

  • Biological functions of chromobox (CBX) proteins in stem cell self-renewal, lineage-commitment, cancer and development.

    abstract::Epigenetic regulatory proteins support mammalian development, cancer, aging and tissue repair by controlling many cellular processes including stem cell self-renewal, lineage-commitment and senescence in both skeletal and non-skeletal tissues. We review here our knowledge of epigenetic regulatory protein complexes tha...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115659

    authors: van Wijnen AJ,Bagheri L,Badreldin AA,Larson AN,Dudakovic A,Thaler R,Paradise CR,Wu Z

    更新日期:2021-02-01 00:00:00

  • Preoperative hypoalbuminemia: Poor functional outcomes and quality of life after hip fracture surgery.

    abstract:AIMS:Hip fracture patients have severe deterioration of their quality of life and function after their injury. Markers of malnutrition such as low albumin and low body mass index (BMI) have been shown to increase mortality and complication rates but their effect on recovery of quality of life and function after hip fra...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115567

    authors: Sim SD,Sim YE,Tay K,Howe TS,Png MA,Chang CCP,Abdullah HR,Koh JSB

    更新日期:2021-02-01 00:00:00

  • Hip disease in Mucopolysaccharidoses and Mucolipidoses: A review of mechanisms, interventions and future perspectives.

    abstract::The hips are frequently involved in inheritable diseases which affect the bones. The clinical and radiological presentation of these diseases may be very similar to common hip disorders as developmental dysplasia of the hip, osteoarthritis and avascular necrosis, so the diagnosis may be easily overlooked and treatment...

    journal_title:Bone

    pub_type: 杂志文章,评审

    doi:10.1016/j.bone.2020.115729

    authors: Oussoren E,Wagenmakers MAEM,Link B,van der Meijden JC,Pijnappel WWMP,Ruijter GJG,Langeveld M,van der Ploeg AT

    更新日期:2021-02-01 00:00:00

  • MSTN is a key mediator for low-intensity pulsed ultrasound preventing bone loss in hindlimb-suspended rats.

    abstract::Low-intensity pulsed ultrasound (LIPUS) has been used to accelerate bone fracture healing. However, the issue whether LIPUS is effective in preventing osteoporosis has not been clarified, and if so, what possible mechanisms might be responsible. Myostatin (MSTN) is a negative regulator of muscle growth, and its absenc...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115610

    authors: Tang L,An S,Zhang Z,Fan X,Guo J,Sun L,Ta D

    更新日期:2021-02-01 00:00:00

  • miR300 intervenes Smad3/β-catenin/RunX2 crosstalk for therapy with an alternate function as indicative biomarker in osteoporosis.

    abstract::The study reports a theranostic nature of rno-miR-300 (miR300) in the osteoblast functioning, by influencing the signaling pathway(s), associated with osteoblast differentiation. Excessive expression of miR300 suppresses osteoblast functions. Smad3 served as a validated target for miR300, on homology-based computation...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115603

    authors: Kaur T,John AA,Sharma C,Vashisht NK,Singh D,Kapila R,Kapila S

    更新日期:2021-02-01 00:00:00

  • Very high bone mineral density in a monogenic form of obesity-associated insulin resistance.

    abstract:INTRODUCTION:Alström syndrome (ALMS) is an ultra-rare metabolic disorder caused by biallelic loss-of-function in the Alms1 gene which encodes a ubiquitously expressed centrosomal protein of the primary cilium. Although ALMS is characterised by several metabolic and hormonal dysfunctions that can lead to an increased ri...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115756

    authors: Tahani N,Choudhary S,Boivin C,Dawson C,Gittoes N,Geberhiwot T

    更新日期:2021-02-01 00:00:00

  • Increased prevalence of fractures in inadequately transfused and chelated Indian children and young adults with beta thalassemia major.

    abstract:INTRODUCTION:In patients with beta thalassemia major, inadequate transfusion and chelation may compromise bone health and increase risk of fractures. The objective of this study was to describe the prevalence of fractures in Indian inadequately transfused and chelated children, adolescents and young adults with beta th...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115649

    authors: Ekbote V,Padidela R,Khadilkar V,Ramanan V,Maheshwari A,Mughal Z,Kariki EP,Crabtree N,Khadilkar A

    更新日期:2021-02-01 00:00:00

  • The human sialic acid-binding immunoglobulin-like lectin Siglec-9 and its murine homolog Siglec-E control osteoclast activity and bone resorption.

    abstract::Regulation of osteoclast differentiation and function is a central element in bone homeostasis. While the role of soluble factors, such as cytokines, hormones and growth factors, in controlling osteoclast differentiation has been intensively characterized, the function of surface receptors is less well understood. Sia...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115665

    authors: Andes FT,Adam S,Hahn M,Aust O,Frey S,Grueneboom A,Nitschke L,Schett G,Steffen U

    更新日期:2021-02-01 00:00:00

  • miRNAs in osteoclast biology.

    abstract::MicroRNAs (miRNAs) are a class of short RNA molecules that mediate the regulation of gene activity through interactions with target mRNAs and subsequent silencing of gene expression. It has become increasingly clear the miRNAs regulate many diverse aspects of bone biology, including bone formation and bone resorption ...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115757

    authors: Weivoda MM,Lee SK,Monroe DG

    更新日期:2021-02-01 00:00:00

  • In vivo quantitative imaging biomarkers of bone quality and mineral density using multi-band-SWIFT magnetic resonance imaging.

    abstract::Bone is a composite biomaterial of mineral crystals, organic matrix, and water. Each contributes to bone quality and strength and may change independently, or together, with disease progression and treatment. Even so, there is a near ubiquitous reliance on ionizing x-ray-based approaches to measure bone mineral densit...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115615

    authors: Surowiec RK,Ram S,Idiyatullin D,Goulet R,Schlecht SH,Galban CJ,Kozloff KM

    更新日期:2021-02-01 00:00:00

  • Alterations in femoral neck strength following pelvic irradiation. A finite element analysis of simulated eccentric forces using bone density data derived from CT.

    abstract::Background and Purpose Radiotherapy is known to produce long-term skeletal complications. We aim to evaluate the biomechanical effect on femoral neck bone from hypothetical eccentric loads on pre- and post-radiotherapy CT-images for patients treated for rectal cancer. MATERIAL AND METHODS:Pre- and post-radiotherapy C...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2021.115865

    authors: Almendros-Abellán VM,Castro-García M,Canales-Vázquez J,Berenguel-Herraiz P,Sabater S

    更新日期:2021-01-26 00:00:00

  • Effects of recreational team handball on bone health, postural balance and body composition in inactive postmenopausal women - A randomised controlled trial.

    abstract::This study reports the effects of a recreational team handball exercise programme (randomised controlled trial, RCT) on bone health, postural balance and body composition in inactive postmenopausal women without previous experience of the sport. Sixty-seven postmenopausal women (68.3 ± 6.2 years, stature 156.9 ± 5.8 c...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2021.115847

    authors: Pereira R,Krustrup P,Castagna C,Coelho E,Santos R,Helge EW,Jørgensen NR,Magalhães J,Póvoas S

    更新日期:2021-01-13 00:00:00

  • Angiotensin II triggers knee joint lesions in experimental osteoarthritis.

    abstract:OBJECTIVES:This study aimed to evaluate the involvement of Angiotensin II (Ang II) in joint lesions associated with osteoarthritis (OA) in vitro and in vivo. METHODS:Chondrocyte cultures were obtained from knee joints of neonatal rats and stimulated with Ang II/MIA/ACE inhibitors. In vivo, rats treated or not with the...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2021.115842

    authors: de Sá GA,Dos Santos ACPM,Nogueira JM,Dos Santos DM,Amaral FA,Jorge EC,Caliari MV,Queiroz-Junior CM,Ferreira AJ

    更新日期:2021-01-07 00:00:00

  • Changes in marrow adipose tissue in relation to changes in bone parameters following estradiol replacement in adolescent and young adult females with functional hypothalamic amenorrhea.

    abstract:CONTEXT:Low energy availability causes disruption of hypothalamic gonadotropin-releasing hormone secretion leading to functional hypothalamic amenorrhea (FHA) and hypoestrogenism, which in turn contributes to decreased bone mineral density (BMD) and increased bone marrow adipose tissue (MAT). Transdermal estradiol admi...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2021.115841

    authors: Singhal V,Karzar NH,Bose A,Buckless C,Ackerman KE,Bredella MA,Klibanski A,Misra M

    更新日期:2021-01-06 00:00:00

  • Genetic pathways disrupted by ENPP1 deficiency provide insight into mechanisms of osteoporosis, osteomalacia, and paradoxical mineralization.

    abstract::Ectonucleotide phosphatase/phosphodiesterase 1 (ENPP1) deficiency results in either lethal arterial calcifications ('Generalized Arterial Calcification of Infancy' - GACI), phosphate wasting rickets ('Autosomal Recessive Hypophosphatemic Rickets type 2' - ARHR2), early onset osteoporosis, or progressive spinal rigidit...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115656

    authors: Maulding ND,Kavanagh D,Zimmerman K,Coppola G,Carpenter TO,Jue NK,Braddock DT

    更新日期:2021-01-01 00:00:00

  • The risk of hip fractures in individuals over 50 years old with prediabetes and type 2 diabetes - A longitudinal nationwide population-based study.

    abstract:BACKGROUND:The present study aimed to investigate the association between type 2 diabetes mellitus (T2DM) and hip fractures using a large-scale nationwide population-based cohort that is representative of the Republic of Korea. We determined the risks of hip fractures in individuals with prediabetes and T2DM with diffe...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115691

    authors: Park HY,Han K,Kim Y,Kim YH,Sur YJ

    更新日期:2021-01-01 00:00:00

  • The epiphyseal secondary ossification center: Evolution, development and function.

    abstract::Bone age is used widely by pediatricians to assess the skeletal maturity of a child and predict growth potential. This entails measuring the size of secondary ossification centers (SOCs), which develop with age in the ends of long bones, which are initially cartilaginous. However, little is presently known about the d...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115701

    authors: Xie M,Chagin AS

    更新日期:2021-01-01 00:00:00

  • Delineation of the 1q24.3 microdeletion syndrome provides further evidence for the potential role of non-coding RNAs in regulating the skeletal phenotype.

    abstract::Microdeletions within 1q24 have been associated with growth deficiency, varying intellectual disability, and skeletal abnormalities. The candidate locus responsible for the various phenotypic features of this syndrome has previously been predicted to lie in the area of 1q24.3, but molecular evidence of the causative g...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115705

    authors: Shepherdson JL,Zheng H,Amarillo IE,McAlinden A,Shinawi M

    更新日期:2021-01-01 00:00:00

  • Pattern of bone marrow lipid composition measures along the vertebral column: A descriptive study of adolescents with idiopathic scoliosis.

    abstract:BACKGROUND:There is evidence that the extent of vertebral bone marrow adiposity increases caudally along the vertebral column in children and adolescents. However, no studies have examined the lipid composition of bone marrow along the vertebral column, which may uniquely influence bone acquisition and metabolism durin...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115702

    authors: Whitney DG,Devlin MJ,Alford AI,Caird MS

    更新日期:2021-01-01 00:00:00

  • Detraining effects after 18 months of high intensity resistance training on osteosarcopenia in older men-Six-month follow-up of the randomized controlled Franconian Osteopenia and Sarcopenia Trial (FrOST).

    abstract:PURPOSE:Detraining after dedicated exercise programs might be a frequent situation in older people's exercise patterns. The aim of the present study was thus to determine the effects of 6 months of detraining after 18 months of high intensity resistance exercise (HIT-RT) on musculoskeletal outcomes in older men with sa...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115772

    authors: Kemmler W,Kohl M,Fröhlich M,Schoene D,von Stengel S

    更新日期:2021-01-01 00:00:00

  • Cancer cell foraging to explain bone-specific metastatic progression.

    abstract::Metastatic cancer is lethal and patients who suffer bone metastases fare especially poorly. Bone-specific metastatic progression in prostate and breast cancers is a highly observed example of organ-specific metastasis, or organotropism. Though research has delineated the sequential steps of the metastatic cascade, the...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115788

    authors: Mallin MM,Pienta KJ,Amend SR

    更新日期:2020-12-03 00:00:00

  • Differences in the microarchitectural features of the lateral collapsed lesion between osteonecrosis and subchondral insufficiency fracture of the femoral head.

    abstract:BACKGROUND:Like osteonecrosis of the femoral head (ONFH), subchondral insufficiency fracture of the femoral head (SIF) causes femoral head collapse. However, little is known about the differences between the two diseases regarding the morphological features of the collapsed lesion. We tested the hypothesis that the mor...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115585

    authors: Kawano K,Motomura G,Ikemura S,Yamaguchi R,Baba S,Xu M,Nakashima Y

    更新日期:2020-12-01 00:00:00

  • Fibroblast growth factor 23 concentrations and modifying factors in children from age 12 to 24 months.

    abstract:BACKGROUND AND OBJECTIVES:Fibroblast growth factor 23 (FGF23) participates in phosphate, calcium and vitamin D metabolism. In children these interactions and modifying factors are largely unknown. PARTICIPANTS AND METHODS:This study evaluates temporal changes and modifiers of FGF23 concentrations from 12 to 24 months,...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115629

    authors: Enlund-Cerullo M,Hauta-Alus H,Valkama S,Rosendahl J,Andersson S,Mäkitie O,Holmlund-Suila E

    更新日期:2020-12-01 00:00:00

  • Bone geometry and microarchitecture deficits in children with Alagille syndrome.

    abstract::Alagille syndrome (ALGS) is an autosomal dominant disorder attributed to mutations in the Notch signaling pathway. Children with ALGS are at increased risk for fragility fracture of unknown etiology. Our objective was to characterize bone mass, geometry, and microarchitecture in children with ALGS. This was a cross-se...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115576

    authors: Kindler JM,Mitchell EL,Piccoli DA,Grimberg A,Leonard MB,Loomes KM,Zemel BS

    更新日期:2020-12-01 00:00:00

  • A novel autologous bone graft substitute comprised of rhBMP6 blood coagulum as carrier tested in a randomized and controlled Phase I trial in patients with distal radial fractures.

    abstract::Bone morphogenetic proteins (BMPs) are known to induce new bone formation in vivo but treating trabecular bone defects with a BMP based therapeutic remains controversial. Here, we evaluated the safety and efficacy of a novel Autologous Bone Graft Substitute (ABGS) comprised of recombinant human BMP6 (rhBMP6) dispersed...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115551

    authors: Durdevic D,Vlahovic T,Pehar S,Miklic D,Oppermann H,Bordukalo-Niksic T,Gavrankapetanovic I,Jamakosmanovic M,Milosevic M,Martinovic S,Sampath TK,Peric M,Grgurevic L,Vukicevic S

    更新日期:2020-11-01 00:00:00

  • The role of endogenous GIP and GLP-1 in postprandial bone homeostasis.

    abstract::The incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are well known for their insulinotropic effects and they are thought to affect bone homeostasis as mediators in the so-called entero-osseous axis. We examined the contributions of endogenous GIP and GLP-1, resp...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115553

    authors: Helsted MM,Gasbjerg LS,Lanng AR,Bergmann NC,Stensen S,Hartmann B,Christensen MB,Holst JJ,Vilsbøll T,Rosenkilde MM,Knop FK

    更新日期:2020-11-01 00:00:00

  • Lack of periosteal apposition in the head and neck of femur after menopause in Chinese women with high risk for hip fractures - A cross-sectional study with QCT.

    abstract::In elderly subjects and in particular in those with osteoporosis the evidence on age related volume changes of the hip is still very limited. Even less is known about bone changes of the femoral head. The aim of this study is to explore associations of bone size of the femoral head and neck with age in postmenopausal ...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115545

    authors: Su Y,Wang L,Liu X,Yang M,Yi C,Liu Y,Huang P,Guo Z,Yu A,Cheng X,Wu X,Blake GM,Engelke K

    更新日期:2020-10-01 00:00:00

  • Controversy of physiological vs. pharmacological effects of BMP signaling: Constitutive activation of BMP type IA receptor-dependent signaling in osteoblast lineage enhances bone formation and resorption, not affecting net bone mass.

    abstract::Bone morphogenetic proteins (BMPs) were first described over 50 years ago as potent inducers of ectopic bone formation when administrated subcutaneously. Preclinical studies have extensively examined the osteoinductive properties of BMPs in vitro and new bone formation in vivo. BMPs (BMP-2, BMP-7) have been used in or...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115513

    authors: Kamiya N,Atsawasuwan P,Joiner DM,Waldorff EI,Goldstein S,Yamauchi M,Mishina Y

    更新日期:2020-09-01 00:00:00

  • Ex vivo regional gene therapy with human adipose-derived stem cells for bone repair.

    abstract:BACKGROUND:The treatment of complex bone loss scenarios remains challenging. This study evaluates the efficacy of ex vivo regional gene therapy using transduced human adipose-derived stem cells (ASCs) overexpressing bone morphogenetic protein-2 (BMP-2) to treat critical-sized bone defects. METHODS:Critical-sized femor...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115524

    authors: Vakhshori V,Bougioukli S,Sugiyama O,Kang HP,Tang AH,Park SH,Lieberman JR

    更新日期:2020-09-01 00:00:00

  • CDllb+ targeted depletion of macrophages negatively affects bone fracture healing.

    abstract::Inflammation is an important part of the fracture repair process which requires osteogenic cells to interact with innate immune cells such as macrophages. All murine macrophages express the F4/80 cell surface marker but they may be further subdivided into two main phenotypes: M1 (proinflammatory) or M2 (anti-inflammat...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115479

    authors: Hozain S,Cottrell J

    更新日期:2020-09-01 00:00:00

  • Distal forearm fractures in immigrant groups: A national Swedish study.

    abstract:OBJECTIVE:The aim was to analyse risk of forearm fractures in first- and second-generation immigrants to Sweden. METHODS:A nationwide study of individuals 20 years of age and older was conducted. Forearm fractures were defined as at least one registered diagnosis in the National Patient Register between January 1, 199...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115508

    authors: Wändell P,Li X,Carlsson AC,Sundquist J,Sundquist K

    更新日期:2020-09-01 00:00:00

  • Aerobic and resistance training improve alveolar bone quality and interferes with bone-remodeling during orthodontic tooth movement in mice.

    abstract::The direct effects of physical activity on long bones are already recognized. However, little information is available regarding distant osseous sites, such as maxillary bone. We evaluated the influence of physical training on alveolar bone quality, with and without mechanically-induced load during orthodontic tooth m...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115496

    authors: Pereira LJ,Macari S,Coimbra CC,Pereira TDSF,Barrioni BR,Gomez RS,Silva TA,Paiva SM

    更新日期:2020-09-01 00:00:00

  • Autologous blood coagulum containing rhBMP6 induces new bone formation to promote anterior lumbar interbody fusion (ALIF) and posterolateral lumbar fusion (PLF) of spine in sheep.

    abstract::In the present study, we evaluated an autologous bone graft substitute (ABGS) composed of recombinant human BMP6 (rhBMP6) dispersed within autologous blood coagulum (ABC) used as a physiological carrier for new bone formation in spine fusion sheep models. The application of ABGS included cervical cage for use in the a...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115448

    authors: Grgurevic L,Erjavec I,Gupta M,Pecin M,Bordukalo-Niksic T,Stokovic N,Vnuk D,Farkas V,Capak H,Milosevic M,Bubic Spoljar J,Peric M,Vuckovic M,Maticic D,Windhager R,Oppermann H,Sampath TK,Vukicevic S

    更新日期:2020-09-01 00:00:00

  • TGFβ as a gatekeeper of BMP action in the developing growth plate.

    abstract::The ligands that comprise the Transforming Growth Factor β superfamily highly govern the development of the embryonic growth plate. Members of this superfamily activate canonical TGFβ and/or BMP (Bone Morphogenetic Protein) signaling pathways. How these pathways interact with one another is an area of active investiga...

    journal_title:Bone

    pub_type: 杂志文章,评审

    doi:10.1016/j.bone.2020.115439

    authors: Wang W,Rigueur D,Lyons KM

    更新日期:2020-08-01 00:00:00

  • Aberrant structure of fibrillar collagen and elevated levels of advanced glycation end products typify delayed fracture healing in the diet-induced obesity mouse model.

    abstract::Impaired fracture healing in patients with obesity-associated type 2 diabetes (T2D) is a significant unmet clinical problem that affects millions of people worldwide. However, the underlying causes are poorly understood. Additionally, limited clinical information is available on how pre-diabetic hyperglycemia in obese...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115436

    authors: Khajuria DK,Soliman M,Elfar JC,Lewis GS,Abraham T,Kamal F,Elbarbary RA

    更新日期:2020-08-01 00:00:00

  • Loss of BMP signaling mediated by BMPR1A in osteoblasts leads to differential bone phenotypes in mice depending on anatomical location of the bones.

    abstract::Bone morphogenetic protein (BMP) signaling in osteoblasts plays critical roles in skeletal development and bone homeostasis. Our previous studies showed loss of function of BMPR1A, one of the type 1 receptors for BMPs, in osteoblasts results in increased trabecular bone mass in long bones due to an imbalance between b...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115402

    authors: Zhang H,Zhang Y,Terajima M,Romanowicz G,Liu Y,Omi M,Bigelow E,Joiner DM,Waldorff EI,Zhu P,Raghavan M,Lynch M,Kamiya N,Zhang R,Jepsen KJ,Goldstein S,Morris MD,Yamauchi M,Kohn DH,Mishina Y

    更新日期:2020-08-01 00:00:00

  • Multiscale finite element modeling of mechanical strains and fluid flow in osteocyte lacunocanalicular system.

    abstract::Osteocytes form over 90% of the bone cells and are postulated to be mechanosensors responsible for regulating the function of osteoclasts and osteoblasts in bone modeling and remodeling. Physical activity results in mechanical loading on the bones. Osteocytes are thought to be the main mechanosensory cells in bone. Up...

    journal_title:Bone

    pub_type: 杂志文章,评审

    doi:10.1016/j.bone.2020.115328

    authors: Ganesh T,Laughrey LE,Niroobakhsh M,Lara-Castillo N

    更新日期:2020-08-01 00:00:00

  • Cortical thickness relative to the transverse diameter of third metacarpal bone reflects bone mineral density in patients with rheumatoid arthritis.

    abstract:OBJECTIVE:Rheumatoid arthritis (RA) is accompanied by potential risk of bone mineral loss. In this study, we developed a screening index for the osteoporosis related level of bone mineral density loss for RA patients as a substitute to the dual-energy X-ray absorptiometry (DXA) method. METHODS:X-ray pictures of both s...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115405

    authors: Yoshii I,Akita K

    更新日期:2020-08-01 00:00:00

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