Angiotensin II triggers knee joint lesions in experimental osteoarthritis.

abstract：:Osteogenesis occurs in striking interaction with angiogenesis. There is growing evidence that endothelial cells are involved in the modulation of osteoblast differentiation. We hypothesized that primary human umbilical vein endothelial cells (HUVEC) should be able to modulate primary human osteoprogenitors (HOP) funct...

journal_title：Bone

authors： Guillotin B,Bareille R,Bourget C,Bordenave L,Amédée J

更新日期：2008-06-01 00:00:00

abstract：:Exercise during growth can be important for attaining optimal bone mass. High-intensity long-duration protocols, however, can have detrimental effects on immature bone morphology and mechanics. The underlying mechanisms are poorly understood. Here, we quantified the mechanical environment of the middiaphyseal rooster ...

journal_title：Bone

authors： Judex S,Zernicke RF

更新日期：2000-02-01 00:00:00

abstract：:Several Biophosphonates have been used as therapeutic agents for Paget's bone disease. (Chloro-4 phenyl)thiomethylene-bisphosphonate (CIPsMBP) has recently been shown to have significant antiosteoclastic activity while an affect of CIPsMBP on mineralization was only observed at high doses. We tested this drug for 6 mo...

journal_title：Bone

authors： Reginster JY,Jeugmans-Huynen AM,Albert A,Denis D,Deroisy R,Lecart MP,Fontaine MA,Collette J,Franchimont P

更新日期：1988-01-01 00:00:00

abstract：:A mildly elevated homocysteine (Hcy) level is a novel and potentially modifiable risk factor for age-related osteoporotic fractures. Elevated Hcy levels can have a nutritional cause, such as inadequate intake of folate, riboflavin, pyridoxine or cobalamin, which serve as cofactors or substrates for the enzymes involve...

journal_title：Bone

authors： Yazdanpanah N,Zillikens MC,Rivadeneira F,de Jong R,Lindemans J,Uitterlinden AG,Pols HA,van Meurs JB

更新日期：2007-12-01 00:00:00

abstract：:This cohort study of postmenopausal women in the United Kingdom aged ≥50years determined the incremental cost of health care and clinical outcomes in the 12months following incident, selected fractures (non-vertebral non-hip [NVNHF], vertebral [VF] and multiple [MF]). Incremental costs and outcomes of the fracture coh...

journal_title：Bone

authors： Gutiérrez L,Roskell N,Castellsague J,Beard S,Rycroft C,Abeysinghe S,Shannon P,Gitlin M,Robbins S

更新日期：2012-09-01 00:00:00

abstract：:A more accurate understanding of the molecular mechanisms and signaling pathways underpinning human mesenchymal stem cell (MSC) plasticity and differentiation properties is pivotal for accomplishing solid and diligent translation of MSC-based experimental therapeutics and clinical trials to broad clinical practice. In...

journal_title：Bone

authors： Ishiy FAA,Fanganiello RD,Kobayashi GS,Kague E,Kuriki PS,Passos-Bueno MR

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The association between beta-blockers (BB) and fracture risk is controversial, due largely to conflicting findings from previous studies. The present study sought to evaluate the effect of BB on fracture risk by using a Bayesian meta-analysis approach. METHODS AND RESULTS:We systematically retrieved 13 obse...

journal_title：Bone

authors： Yang S,Nguyen ND,Eisman JA,Nguyen TV

更新日期：2012-11-01 00:00:00

abstract：:Whether glucocorticoids directly enhance or interrupt osteoclastogenesis is still a controversial subject. In this study, we ascertained the dose-dependent positive effects of glucocorticoids on osteoclastogenesis in vivo and in vitro as well as investigated the mechanism in vitro. As the dose of glucocorticoids incre...

journal_title：Bone

authors： Shi J,Wang L,Zhang H,Jie Q,Li X,Shi Q,Huang Q,Gao B,Han Y,Guo K,Liu J,Yang L,Luo Z

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:NF-κB essential modulator (NEMO), encoded by IKBKG, is necessary for activation of the ubiquitous transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). Animal studies suggest NEMO is required for NF-κB mediated bone homeostasis, but this has not been thoroughly studied ...

journal_title：Bone

authors： Frost M,Tencerova M,Andreasen CM,Andersen TL,Ejersted C,Svaneby D,Qui W,Kassem M,Zarei A,McAlister WH,Veis DJ,Whyte MP,Frederiksen AL

更新日期：2019-04-01 00:00:00

abstract：:Although ovariectomized cynomolgus monkeys are used extensively for studies examining perimenopausal changes in the skeleton, very little is known about the changes that occur naturally during growth and aging in these animals. To evaluate the changes in bone during growth and aging in female cynomolgus monkeys, 29 mo...

journal_title：Bone

authors： Lees CJ,Ramsay H

更新日期：1999-01-01 00:00:00

abstract：:Bone can be viewed as a nano-fibrous composite with complex hierarchical structures. Its deformation and fracture behaviors depend on both the local structure and the type of stress applied. In contrast to the extensive studies on bone fracture under compression and tension, there is a lack of knowledge on the fractur...

journal_title：Bone

authors： Tang T,Ebacher V,Cripton P,Guy P,McKay H,Wang R

更新日期：2015-02-01 00:00:00

abstract：:Oral bisphosphonates are established therapeutics for postmenopausal osteoporosis. Alternative, simplified dosing regimens that improve tolerability and promote convenience may be advantageous. Ibandronate is a highly potent, nitrogen-containing bisphosphonate that can be administered as a convenient intravenous (i.v....

journal_title：Bone

authors： Adami S,Felsenberg D,Christiansen C,Robinson J,Lorenc RS,Mahoney P,Coutant K,Schimmer RC,Delmas PD

更新日期：2004-05-01 00:00:00

abstract：:The effects of pregnancy and lactation on bone histomorphometry have been studied extensively in rats and dogs. However, these models differ greatly in reproductive physiology compared with women. The purpose of this study was to evaluate histomorphometric changes in iliac crest bone biopsies taken from cynomolgus mon...

journal_title：Bone

authors： Lees CJ,Jerome CP

更新日期：1998-05-01 00:00:00

abstract：:Bisphosphonates (BPs) are the first-line therapy for osteoporosis. In recent years, atypical femoral fractures (AFF) have been described in patients on BPs therapy. However, the relationship between BPs and AFF remains to be clarified. We evaluated clinical and hormonal characteristics of AFF patients, in order to det...

journal_title：Bone

authors： Franceschetti P,Bondanelli M,Caruso G,Ambrosio MR,Lorusso V,Zatelli MC,Massari L,Degli Uberti EC

更新日期：2013-10-01 00:00:00

abstract：:The increasing application of approaches that allow tracing of individual cells over time, together with transcriptomic and epigenomic analyses is changing the way resident stromal stem cells (mesenchymal stem cells) are viewed. Rather than being a defined, homogeneous cell population as described following in vitro e...

journal_title：Bone

authors： Yianni V,Sharpe PT

更新日期：2020-05-01 00:00:00

abstract：:Due to the rising life expectancy, bone diseases (e.g. osteoporosis, osteoarthritis) and trauma (e.g. fracture) have become an important socio-economic burden. Accurate visualization and quantification of the bone microstructure in vivo is seen as an important step to enhance diagnosis and treatment. Micro-computed to...

journal_title：Bone

authors： Mys K,Stockmans F,Vereecke E,van Lenthe GH

更新日期：2018-09-01 00:00:00

abstract：:It is well established that short-term clearance of an intravenous calcium load in vivo reflects bone uptake. Using results from isotope-dilution experiments with 42Ca, a 3-h test has been developed to measure a quantity, gamma, related to bone accretion. This test is proposed as a useful, clinically applicable measur...

journal_title：Bone

authors： Goans RE,Abrams SA,Vieira NE,Marini JC,Perez MD,Yergey AL

更新日期：1995-01-01 00:00:00

abstract：:CCN2/connective tissue growth factor (CCN2/CTGF) is known to promote both the proliferation and differentiation of chondrocytes, which actions are mediated by ERK and p38 MAPK, respectively. In this study, we first re-evaluated the involvement of multiple MAPKs therein and found that JNK also mediated such CCN2 signal...

journal_title：Bone

authors： Yosimichi G,Kubota S,Nishida T,Kondo S,Yanagita T,Nakao K,Takano-Yamamoto T,Takigawa M

更新日期：2006-06-01 00:00:00

abstract：CONTEXT:Low energy availability causes disruption of hypothalamic gonadotropin-releasing hormone secretion leading to functional hypothalamic amenorrhea (FHA) and hypoestrogenism, which in turn contributes to decreased bone mineral density (BMD) and increased bone marrow adipose tissue (MAT). Transdermal estradiol admi...

journal_title：Bone

authors： Singhal V,Karzar NH,Bose A,Buckless C,Ackerman KE,Bredella MA,Klibanski A,Misra M

更新日期：2021-01-06 00:00:00

abstract：:Bisphosphonates (BP), especially alendronate and risedronate, are the drugs most commonly used for osteoporosis treatment, being incorporated into the skeleton where they inhibit bone resorption and are thereafter slowly released during bone turnover. However, there are few data on the release of BP in patients who ha...

journal_title：Bone

authors： Peris P,Torra M,Olivares V,Reyes R,Monegal A,Martínez-Ferrer A,Guañabens N

更新日期：2011-10-01 00:00:00

abstract：:A predictable animal model with skeletal remodeling characteristics similar to those of humans is needed to facilitate the understanding of the mechanism of postmenopausal osteoporosis. We have utilized the ovariohysterectomized (Ovh) dog to examine cellular and biochemical responses to estrogen depletion and PTH stim...

journal_title：Bone

authors： Shen V,Dempster DW,Birchman R,Mellish RW,Church E,Kohn D,Lindsay R

更新日期：1992-01-01 00:00:00

abstract：:Osteocytes play an important role in signaling within bone. Communication of osteocytes with each other and with bone lining cells may have a function in mineral homeostasis and mechanotransduction. However, very little is known of the expression of ion channels in these cells. Using the whole-cell patch-clamp techniq...

journal_title：Bone

authors： Gu Y,Preston MR,El Haj AJ,Howl JD,Publicover SJ

更新日期：2001-01-01 00:00:00

abstract：:Bone loss represents a major unsolved problem in rheumatoid arthritis (RA). The skeletal complications of RA consist of focal bone erosions and periarticular osteoporosis at sites of active inflammation, and generalized bone loss with reduced bone mass. New evidence indicates that osteoclasts are key mediators of all ...

journal_title：Bone

authors： Romas E,Gillespie MT,Martin TJ

更新日期：2002-02-01 00:00:00

abstract：:This study describes the early interface reaction of cancellous bone to a nanocrystalline hydroxyapatite cement containing type I collagen (HA/Coll) and its modifications with sodium citrate (CI), calcium carbonate (CA), phosphoserine (P) and phosphoserine plus RGD-peptide (RGD). Cylindrical implants of HA/Coll and it...

journal_title：Bone

authors： Schneiders W,Reinstorf A,Pompe W,Grass R,Biewener A,Holch M,Zwipp H,Rammelt S

更新日期：2007-04-01 00:00:00

abstract：:Hypertension and osteoporosis are two major chronic diseases affecting the elderly. A cross-sectional study of 3887 Chinese men (n = 1958) and women (n = 1929) was used to explore the association between angiotensin converting enzyme inhibitor (ACEI) use and bone mineral density (BMD). The participants were aged 65 ye...

journal_title：Bone

authors： Lynn H,Kwok T,Wong SY,Woo J,Leung PC

更新日期：2006-04-01 00:00:00

abstract：:Impaired osteoblast and osteocyte maturation contribute to mineralization defects and excess FGF23 expression in CKD bone. Vitamin D sterols decrease osteoid accumulation and increase FGF23 expression; these agents also increase osteoblast maturation in vitro but a link between changes in bone cell maturation, bone mi...

journal_title：Bone

authors： Pereira RC,Salusky IB,Bowen RE,Freymiller EG,Wesseling-Perry K

更新日期：2019-10-01 00:00:00

abstract：:Recent studies have indicated a role for a MECOM allele in susceptibility to osteoporotic fractures in humans. We have generated a mutation in Mecom in mouse (termed ME(m1)) via lacZ knock-in into the upstream transcription start site for the gene, resulting in disruption of Mds1 and Mds1-Evi1 transcripts, but not of ...

journal_title：Bone

authors： Juneja SC,Vonica A,Zeiss C,Lezon-Geyda K,Yatsula B,Sell DR,Monnier VM,Lin S,Ardito T,Eyre D,Reynolds D,Yao Z,Awad HA,Yu H,Wilson M,Honnons S,Boyce BF,Xing L,Zhang Y,Perkins AS

更新日期：2014-03-01 00:00:00

abstract：:Alendronate has been shown to reduce bone turnover and increase bone mass. However, little is known about the duration of the effect on bone after treatment withdrawal. The aim of this study was to investigate the long-term effects on bone mineral density (BMD) and bone turnover of various alendronate regimens after t...

journal_title：Bone

authors： Bagger YZ,Tankó LB,Alexandersen P,Ravn P,Christiansen C

更新日期：2003-09-01 00:00:00

abstract：:Patients with coxarthrosis (cOA) have a reduced incidence of intracapsular femoral neck fracture, suggesting that cOA offers protection. The distribution of bone in the femoral neck was compared in cases of coxarthrosis and postmortem controls to assess the possibility that disease-associated changes might contribute ...

journal_title：Bone

authors： Jordan GR,Loveridge N,Bell KL,Power J,Dickson GR,Vedi S,Rushton N,Clarke MT,Reeve J

更新日期：2003-01-01 00:00:00

abstract：:Cancellous microanatomy, bone remodelling, and hematopoietic tissue were studied in iliac crest and femoral neck biopsies taken intraoperatively in 102 consecutive patients with displaced intracapsular fractures. About half of the femoral biopsies had osteopenia, and most showed replacement of hematopoietic tissue by ...

journal_title：Bone

authors： Eventov I,Frisch B,Cohen Z,Hammel I

更新日期：1991-01-01 00:00:00