Abstract：
:The increasing application of approaches that allow tracing of individual cells over time, together with transcriptomic and epigenomic analyses is changing the way resident stromal stem cells (mesenchymal stem cells) are viewed. Rather than being a defined, homogeneous cell population as described following in vitro expansion, in vivo, these cells are highly programmed according to their resident tissue location. This programming is evidenced by different epigenetic landscapes and gene transcription signatures in cells before any in vitro expansion. This has potentially profound implications for the heterotypic use of these cells in therapeutic tissue engineering applications.
journal_name
Bonejournal_title
Boneauthors
Yianni V,Sharpe PTdoi
10.1016/j.bone.2020.115309subject
Has Abstractpub_date
2020-05-01 00:00:00pages
115309eissn
8756-3282issn
1873-2763pii
S8756-3282(20)30089-2journal_volume
134pub_type
杂志文章相关文献
BONE文献大全abstract：:Hypercalcemia results from an imbalance between the fluxes of calcium (Ca) entering and leaving the extracellular space. The two most important influxes are the net intestinal Ca absorption and the net skeletal Ca resorption, whereas the renal excretion represents the main route of elimination. When produced in excess...
journal_title：Bone
pub_type： 杂志文章,评审
doi：
更新日期：1987-01-01 00:00:00
abstract：BACKGROUND:Roux-en-Y gastric bypass (RYGB) is a common surgical procedure for treatment of morbid obesity. RYGB induces considerable and sustained weight loss, and remission of obesity related-comorbidities. While studies have suggested negative effects of RYGB on bone health, long-term data are lacking. We aimed to ev...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2019.07.014
更新日期：2019-10-01 00:00:00
abstract：:Cancellous microanatomy, bone remodelling, and hematopoietic tissue were studied in iliac crest and femoral neck biopsies taken intraoperatively in 102 consecutive patients with displaced intracapsular fractures. About half of the femoral biopsies had osteopenia, and most showed replacement of hematopoietic tissue by ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(91)90047-m
更新日期：1991-01-01 00:00:00
abstract：:Acceleration of remodeling activity after menopause leads to bone loss and fragility, however, whether this is associated with modifications of bone matrix quality has been less studied. The impact of variation in bone remodeling rate on bone matrix has been studied mainly in pathologies or anti-osteoporotic treatment...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2019.08.003
更新日期：2019-11-01 00:00:00
abstract：:Bisphosphonates are widely used to treat children with osteogenesis imperfecta (OI), a bone fragility disorder that is most often caused by mutations in COL1A1 or COL1A2. However, it is unclear whether this treatment decreases the risk of developing scoliosis. We retrospectively evaluated spine radiographs and charts ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2016.02.018
更新日期：2016-05-01 00:00:00
abstract：OBJECTIVE:While the importance of cortical structure quantification is increasingly underscored by recent literature, conventional analysis techniques obscure potentially important regional variations in cortical structure. The objective of this study was to characterize the spatial variability in cortical geometry and...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2012.10.031
更新日期：2013-02-01 00:00:00
abstract：:The underlying causes of maxillary bone loss during lactation remain poorly understood. We evaluated the impact of lactation on physiological and mechanically-induced alveolar bone remodeling. Nulliparous non-lactating (N-LAC) and 21-day lactating (LAC) mice underwent mechanically-induced bone remodeling by orthodonti...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2018.01.032
更新日期：2018-05-01 00:00:00
abstract：:Low-turnover bone disease is one of the bone abnormalities observed in patients with chronic kidney disease (CKD) and is recognized to be associated with low serum parathyroid hormone (PTH) level and skeletal resistance to PTH. Indoxyl sulfate (IS) is a representative uremic toxin that accumulates in the blood as rena...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2015.06.010
更新日期：2015-10-01 00:00:00
abstract：:Alagille syndrome (ALGS) is an autosomal dominant disorder attributed to mutations in the Notch signaling pathway. Children with ALGS are at increased risk for fragility fracture of unknown etiology. Our objective was to characterize bone mass, geometry, and microarchitecture in children with ALGS. This was a cross-se...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2020.115576
更新日期：2020-12-01 00:00:00
abstract：:Recent increasing evidence supports a role for neuronal type signaling in bone. Specifically glutamate receptors have been found in cells responsible for bone remodeling, namely the osteoblasts and the osteoclasts. While most studies have focused on ionotropic glutamate receptors, the relevance of the metabotropic glu...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2016.10.025
更新日期：2017-01-01 00:00:00
abstract：UNLABELLED:We evaluated the effect of glucocorticoids (GC) and growth hormone (GH) on cortical and cancellous bone turnover in adult rats using random vertical sections giving valid measurements of bone surfaces and bone formation parameters. GH administration could reverse GC-induced osteopenia and low bone turnover o...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2004.07.015
更新日期：2005-01-01 00:00:00
abstract：:Bone tissue undergoes permanent and lifelong remodeling with a concerted action of bone-building osteoblasts and bone-resorbing osteoclasts. A precise cooperation between those two cell types is critical in the complex process of bone renewal. Galectin-3 is a member of the β-galactoside-binding lectin family playing m...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2017.08.013
更新日期：2017-12-01 00:00:00
abstract：:The interrelationship between mediators of hormone action (cAMP and calcium) and induction of ornithine decarboxylase (ODC) activity was investigated in bone and bone cells. Stimuli that enhanced the cAMP level in both osteoblastlike (BL) and osteoclastlike (CL) cells and in intact calvaria only induced ODC activity i...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(85)90405-3
更新日期：1985-01-01 00:00:00
abstract：:Cancer chemotherapy often causes significant bone loss, marrow adiposity and haematopoietic defects, yet the underlying mechanisms and recovery potential remain unclear. Wnt/β-catenin signalling is integral to the regulation of osteogenesis, adipogenesis and haematopoiesis; using a rat model, the current study investi...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2012.03.027
更新日期：2012-06-01 00:00:00
abstract：:Bone losses are common as a consequence of unloading and also in patients with chronic obstructive pulmonary disease (COPD). Although hypoxia has been implicated as an important factor to drive bone loss, its interaction with unloading remains unresolved. The objective therefore was to assess whether human bone loss c...
journal_title：Bone
pub_type： 临床试验,杂志文章
doi：10.1016/j.bone.2016.07.013
更新日期：2016-10-01 00:00:00
abstract：:Hypercalcemia is a relatively common terminal complication of malignancy. In the majority of the patients it is due to excessive bone resorption, secondary either to local destruction by metastases or by the activity of several paracrine and/or endocrine factors. Increased renal tubular reabsorption of calcium plays a...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(09)80010-0
更新日期：1992-01-01 00:00:00
abstract：:Glucocorticoids (GC) are used for the treatment of a wide spectrum of diseases because of their potent anti-inflammatory and immunosuppressive effects, and they are serious and common causes of secondary osteoporosis. Administration of intermittent parathyroid hormone (PTH) may induce formation of new bone and may cou...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2006.01.142
更新日期：2006-08-01 00:00:00
abstract：:Leptin, a small polypeptide hormone secreted by the adipocytes, controls body weight and gonadal function by binding to a special receptor located in the hypothalamus. Observational studies have demonstrated a controversial association between leptin and bone mineral density (BMD), and functional studies of the relati...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2019.05.006
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVES:Osteoporosis results in loss of bone mass and microarchitectural deterioration. Dental radiographs potentially offer a means of screening for osteoporosis as they are commonly made on adults. Spatial frequency analyses are well suited to detect subtle changes in image patterns. We hypothesize that individual...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2004.03.002
更新日期：2004-08-01 00:00:00
abstract：:To define structure-activity relationships for bisphosphonate activity, we examined the bone binding and antiresorptive properties of heterocycle-containing analogs of risedronate, a pyridylbisphosphonate, in cultures of mouse fetal bone explants. Our studies indicated that hydroxybisphosphonates with the nitrogen mol...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(98)00120-3
更新日期：1998-11-01 00:00:00
abstract：:A noninvasive marker of bone turnover would be useful in predicting which patients are at risk of rapid bone loss and in monitoring response to therapy. Calcitonin (CT)-induced hypocalcemia correlates with bone turnover but has not been a clinically useful test because changes in serum calcium are small, and test dura...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(85)90316-3
更新日期：1985-01-01 00:00:00
abstract：:Control of systemic inorganic phosphate (Pi) levels is crucial for osteoid mineralization. Parathyroid hormone (PTH) mediates actions on phosphate homeostasis mostly by regulating the activity of the type 2 sodium-phosphate cotransporter (Npt2), and this action requires the PDZ protein NHERF1. Osteoblasts express Npt2...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2012.10.001
更新日期：2013-01-01 00:00:00
abstract：:Approximately 5% of all military recruits incur stress fracture injuries during intense physical training, predominately in the lower extremity. We compared young men and women with stress fracture injury (subjects) to a matched group of uninjured volunteers (controls) during a summer training program at the United St...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2004.05.014
更新日期：2004-09-01 00:00:00
abstract：:The topological changes in vertebral cancellous bone were estimated in vertebrae from calcium-restricted ovariectomized Sinclair S-1 minipigs, a recently described animal model of cancellous osteopenia. Connectivity was estimated using unbiased stereological principles in disector pairs of sections from the first lumb...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(95)00116-u
更新日期：1995-06-01 00:00:00
abstract：:The present review summarizes the pathogenic mechanisms leading to hip fracture based on epidemiological, experimental, and controlled clinical studies. The estimated lifetime risk of hip fracture is about 14% in postmenopausal women and 6% in men. The incidence of hip fractures increases exponentially with aging, but...
journal_title：Bone
pub_type： 杂志文章,评审
doi：10.1016/8756-3282(95)00382-7
更新日期：1996-01-01 00:00:00
abstract：:Epigenetic regulatory proteins support mammalian development, cancer, aging and tissue repair by controlling many cellular processes including stem cell self-renewal, lineage-commitment and senescence in both skeletal and non-skeletal tissues. We review here our knowledge of epigenetic regulatory protein complexes tha...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2020.115659
更新日期：2021-02-01 00:00:00
abstract：:The parathyroid hormone (PTH) signaling pathways that effect changes in osteoblast gene expression also alter the organization of the cytoskeletal proteins. PTH regulates the expression of nucleoskeletal proteins, such as nuclear mitotic apparatus protein (NuMA) and topoisomerase II-alpha. NuMA is a structural compone...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(97)00300-1
更新日期：1998-04-01 00:00:00
abstract：:Treatment with parathyroid hormone 1-84 (PTH) or teriparatide increases osteonal remodeling and decreases bone mineral density (BMD) at cortical (Ct) bone sites but may also increase bone size. Decreases in BMD and increases in size exert opposing effects on bone strength. In adult ovariectomized (OVX) rhesus monkeys,...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2007.04.197
更新日期：2007-09-01 00:00:00
abstract：:Old age-associated osteoporosis is related to diminished bone blood flow and impaired nitric oxide (NO)-mediated vasodilation of the bone vasculature. Endurance exercise training restores the age-associated reduction of vasodilation in numerous vascular beds, as well as improving bone properties. The purpose of this s...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2009.10.029
更新日期：2010-03-01 00:00:00
abstract：:Biochemical bone turnover markers (BTMs) provide important information on the diagnosis, therapy and monitoring of metabolic bone diseases including osteoporosis. One goal of antiresorptive therapy in women is to decrease biochemical BTMs to the lower half of reference intervals for healthy pre-menopausal counterparts...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2010.07.017
更新日期：2010-10-01 00:00:00
