Risk factors for development of atypical femoral fractures in patients on long-term oral bisphosphonate therapy.

abstract：BACKGROUND:Avoidant Restrictive Food Intake Disorder (ARFID) and Anorexia Nervosa (AN) cause significant underweight in children and young people (CYP). The association of low bone mineral density (BMD) and underweight CYP in AN is well established, but less is known about BMD in ARFID. METHODS:Retrospective case-note...

journal_title：Bone

authors： Alberts Z,Fewtrell M,Nicholls DE,Biassoni L,Easty M,Hudson LD

更新日期：2020-05-01 00:00:00

abstract：:We have tested the ability of the XCT960A to detect bone loss in OVX-rats, as well as bone gain in the proximal tibial metaphysis of healthy rats treated with hPTH(1-34). The results demonstrated that high precision can be achieved, with CV's for most measurement parameters in the range of 1.6 to 5.9% being obtained i...

journal_title：Bone

authors： Gasser JA

更新日期：1995-10-01 00:00:00

abstract：INTRODUCTION:Teriparatide is a bone formation agent that increases bone turnover and mass, resulting in an increase in bone strength and a decrease in fracture risk. METHODS:The primary purpose of this analysis was to evaluate the association between pretreatment bone turnover marker (BTM) concentrations and the absol...

journal_title：Bone

authors： Delmas PD,Licata AA,Reginster JY,Crans GG,Chen P,Misurski DA,Wagman RB,Mitlak BH

更新日期：2006-08-01 00:00:00

abstract：:Bone fragility is a concern for aged and diseased bone. Measuring bone toughness and understanding fracture properties of the bone are critical for predicting fracture risk associated with age and disease and for preclinical testing of therapies. A reference point indentation technique (BioDent) has recently been deve...

journal_title：Bone

authors： Carriero A,Bruse JL,Oldknow KJ,Millán JL,Farquharson C,Shefelbine SJ

更新日期：2014-12-01 00:00:00

abstract：:Osteonecrosis of the femoral head (ONFH) is a skeletal disorder characterized by ischemic deterioration, bone marrow edema and eventually femoral head collapse. The systemic regulation of ONFH in adult patients has not been examined. Serum proteomic is an innovative tool that potentially detects simultaneous expressio...

journal_title：Bone

authors： Wu RW,Wang FS,Ko JY,Wang CJ,Wu SL

更新日期：2008-09-01 00:00:00

abstract：:We investigated the bone remodeling activity on titanium implants with different surface roughnesses using a confocal laser scanning microscope (CLSM). Two kinds of implants were used, the machined smooth-surfaced titanium and the plasma-sprayed rough-surfaced titanium. These implants were randomly inserted in a rabbi...

journal_title：Bone

authors： Suzuki K,Aoki K,Ohya K

更新日期：1997-12-01 00:00:00

abstract：:There are increasing evidences suggesting bone marrow adiposity tissue (MAT) plays a critical role in affecting both bone quantity and quality. However, very limited studies that have investigated the association between the composition of MAT and bone mineral density (BMD). The goal of this study was to quantify MAT ...

journal_title：Bone

authors： Li X,Shet K,Xu K,Rodríguez JP,Pino AM,Kurhanewicz J,Schwartz A,Rosen CJ

更新日期：2017-12-01 00:00:00

abstract：:Genetic heterogeneity, high burden and the paucity of genetic testing for rare diseases challenge genomic healthcare for these disorders in India. Here we report our experience over the past decade, of establishing the genomic evaluation of skeletal dysplasia at a tertiary university hospital in India. Research or cli...

journal_title：Bone

authors： Uttarilli A,Shah H,Bhavani GS,Upadhyai P,Shukla A,Girisha KM

更新日期：2019-03-01 00:00:00

abstract：:Bisphosphonates are one of the most well studied groups of medications and they are bone specific. This tissue specificity is a rare property for a drug introduced into clinical practice as long as 40 years ago. Over the years, the therapeutic boundaries of bisphosphonates were explored and their safety profile has wi...

journal_title：Bone

authors： Pazianas M,Abrahamsen B

更新日期：2011-07-01 00:00:00

abstract：:Cementum, a mineralized tissue lining the surface of the tooth root, is required for formation of a functional periodontal ligament attachment during development. Additionally, during regeneration of tissues after disease, cementum is thought to play a critical role in the reparative process. Research efforts aimed to...

journal_title：Bone

authors： D'Errico JA,Ouyang H,Berry JE,MacNeil RL,Strayhorn C,Imperiale MJ,Harris NL,Goldberg H,Somerman MJ

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:To estimate the cost-effectiveness of strontium ranelate in the treatment of postmenopausal osteoporotic women aged over 75 years. MATERIALS AND METHODS:A validated Markov microsimulation model with a Belgian payer's perspective estimated the cost per quality-adjusted life-year (QALY) of a 3-year strontium r...

journal_title：Bone

authors： Hiligsmann M,Bruyère O,Reginster JY

更新日期：2010-02-01 00:00:00

abstract：:In patients with osteoporosis, alendronate treatment causes an increase in bone mineral density (BMD) and a decrease in fracture incidence. Alendronate acts by changing the bone remodeling process. Changes in bone remodeling resulting in decreased remodeling space, increased bone balance per remodeling cycle, and incr...

journal_title：Bone

authors： Hernandez CJ,Beaupré GS,Marcus R,Carter DR

更新日期：2001-12-01 00:00:00

abstract：:The Sost gene encodes Sclerostin, an inhibitor of Wnt-signaling, generally considered a main response gene to mechanical loading in bone. Several papers describe that unloading leads to upregulation of Sost, which in turn may lead to loss of bone. These studies were based on whole bone homogenates or cortical bone. By...

journal_title：Bone

authors： Macias BR,Aspenberg P,Agholme F

更新日期：2013-04-01 00:00:00

abstract：:Bone metastases and skeletal complications are major causes of morbidity in prostate cancer patients. Despite the osteoblastic appearance of bone metastases on imaging studies, patients have elevated serum and urinary markers of bone resorption, indicative of high osteoclast activity. Increased osteoclast activity is ...

journal_title：Bone

authors： Lee RJ,Saylor PJ,Smith MR

更新日期：2011-01-01 00:00:00

abstract：:Osteoporosis is a major public health problem in Western countries and is projected to have a similar impact in the Middle East. It has been suggested that peak bone mineral density (BMD), a major determinant of osteoporotic fractures later in life, may be lower in this part of the world compared with the Western worl...

journal_title：Bone

authors： El-Hajj Fuleihan G,Baddoura R,Awada H,Salam N,Salamoun M,Rizk P

更新日期：2002-10-01 00:00:00

abstract：PURPOSE:In the Fracture Prevention Trial, the risks of any nonvertebral fracture (relative risk [RR] 0.65, P=0.04) and any fragility nonvertebral fracture (RR 0.47, P=0.02) were significantly reduced in the teriparatide 20 μg/day (teriparatide) versus placebo group. The purpose of this analysis was to examine the effic...

journal_title：Bone

authors： Krege JH,Wan X

更新日期：2012-01-01 00:00:00

abstract：:It is well established that short-term clearance of an intravenous calcium load in vivo reflects bone uptake. Using results from isotope-dilution experiments with 42Ca, a 3-h test has been developed to measure a quantity, gamma, related to bone accretion. This test is proposed as a useful, clinically applicable measur...

journal_title：Bone

authors： Goans RE,Abrams SA,Vieira NE,Marini JC,Perez MD,Yergey AL

更新日期：1995-01-01 00:00:00

abstract：:The striking predilection of temporomandibular disorders (TMD) in women, especially during gonad-intact puberty or reproductive years, indicates that oestrogen plays an important role in the progression of TMD, but the underlying mechanism remains unclear. In this study, unilateral anterior crossbite (UAC) was used to...

journal_title：Bone

authors： Ye T,Sun D,Mu T,Chu Y,Miao H,Zhang M,Yang H,Liu Q,Lu L,Xing X,Yu S

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVES:The present study was motivated by the fact that bone regeneration in the compromised vascular microenvironment of T2DM is challenging and the factors that determine the adverse bone regeneration outcomes are poorly understood. For this purpose the effect of T2DM on osteogenic and angiogenic healing potentia...

journal_title：Bone

authors： Caliaperoumal G,Souyet M,Bensidhoum M,Petite H,Anagnostou F

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Dietary acid charge enhances bone loss. Bicarbonate or alkali diet decreases bone resorption in humans. We compared the effect of an alkaline mineral water, rich in bicarbonate, with that of an acid one, rich in calcium only, on bone markers, in young women with a normal calcium intake. METHODS:This study c...

journal_title：Bone

authors： Wynn E,Krieg MA,Aeschlimann JM,Burckhardt P

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:There is evidence that the extent of vertebral bone marrow adiposity increases caudally along the vertebral column in children and adolescents. However, no studies have examined the lipid composition of bone marrow along the vertebral column, which may uniquely influence bone acquisition and metabolism durin...

journal_title：Bone

authors： Whitney DG,Devlin MJ,Alford AI,Caird MS

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:The treatment of complex bone loss scenarios remains challenging. This study evaluates the efficacy of ex vivo regional gene therapy using transduced human adipose-derived stem cells (ASCs) overexpressing bone morphogenetic protein-2 (BMP-2) to treat critical-sized bone defects. METHODS:Critical-sized femor...

journal_title：Bone

authors： Vakhshori V,Bougioukli S,Sugiyama O,Kang HP,Tang AH,Park SH,Lieberman JR

更新日期：2020-09-01 00:00:00

abstract：:Postmenopausal osteoporosis is characterized by a reduction in the numbers of sinusoidal and arterial capillaries in the bone marrow and reduced bone perfusion suggesting a role of vascular component in the pathogenesis of osteoporosis. Previous studies have shown that bone formation and angiogenesis are positively co...

journal_title：Bone

authors： Zhao Q,Shen X,Zhang W,Zhu G,Qi J,Deng L

更新日期：2012-03-01 00:00:00

abstract：:Skeletal muscle is a highly plastic tissue that remarkably adapts to diverse stimuli including exercise, injury, disuse, and, as discussed here, aging. Humans achieve peak skeletal muscle mass and strength in mid-life and then experience a progressive decline of up to 50% by the ninth decade. The loss of muscle mass a...

journal_title：Bone

authors： Aversa Z,Zhang X,Fielding RA,Lanza I,LeBrasseur NK

更新日期：2019-10-01 00:00:00

abstract：:Endochondral bone growth is abnormal in 6 of the 11 types of mucopolysaccharidoses (MPS) disorders; resulting in short stature, reduced size of the thoracic cavity and compromised manual dexterity. Current therapies for MPS have had a limited effect on bone growth and to improve these therapies or develop adjunct appr...

journal_title：Bone

authors： Jiang Z,Derrick-Roberts ALK,Reichstein C,Byers S

更新日期：2020-03-01 00:00:00

abstract：:Ordinary measurements of the wall thickness (the end result of the osteoblastic work) of trabecular bone packets (completed remodeling sites) describe the average thickness of walls formed during the previous two to three years. If the bone biopsy is obtained shortly after onset of disease or initiation of treatment, ...

journal_title：Bone

authors： Steiniche T,Eriksen EF,Kudsk H,Mosekilde L,Melsen F

更新日期：1992-01-01 00:00:00

abstract：:Epigenetic regulatory proteins support mammalian development, cancer, aging and tissue repair by controlling many cellular processes including stem cell self-renewal, lineage-commitment and senescence in both skeletal and non-skeletal tissues. We review here our knowledge of epigenetic regulatory protein complexes tha...

journal_title：Bone

authors： van Wijnen AJ,Bagheri L,Badreldin AA,Larson AN,Dudakovic A,Thaler R,Paradise CR,Wu Z

更新日期：2021-02-01 00:00:00

abstract：:Vitamin D deficiency may depress bone formation but its effect on bone resorption is not well defined. As an index of bone resorption, the activity of acid phosphatase, a lysosomal enzyme found in osteoclasts, was quantitated in situ from a bone tissue smear preparation. Activity of the enzyme, measured by integrative...

journal_title：Bone

authors： Silverton SF,Kaye M

更新日期：1987-01-01 00:00:00

abstract：:The fundamental elements of tissue regeneration are cells, biochemical signals and the three-dimensional microenvironment. In the described approach, biomineralized-collagen biomaterial functions as a scaffold and provides biochemical stimuli for tissue regeneration. In addition superparamagnetic nanoparticles were us...

journal_title：Bone

authors： Panseri S,Russo A,Sartori M,Giavaresi G,Sandri M,Fini M,Maltarello MC,Shelyakova T,Ortolani A,Visani A,Dediu V,Tampieri A,Marcacci M

更新日期：2013-10-01 00:00:00

abstract：:Molecular mechanism of mechanical stress-induced bone formation remains unclear. We demonstrate that mechanical unloading suppresses and reloading enhances Interleukin (IL)-11 gene expression in the hindlimb of mice in vivo. Mechanical stress to osteoblasts by fluid shear stress (FSS) in vitro rapidly and transiently ...

journal_title：Bone

authors： Kido S,Kuriwaka-Kido R,Imamura T,Ito Y,Inoue D,Matsumoto T

更新日期：2009-12-01 00:00:00