Ex vivo regional gene therapy with human adipose-derived stem cells for bone repair.

abstract：:Thanatophoric dysplasia (TD) is a lethal human bone dysplasia characterized by severe dwarfism. It pathogenesis is thought to involve an abnormal ossifying fibrous tissue that disrupts the skeletal growth plate. We employed a combined morphologic, immunohistochemical and biochemical approach to better define the natur...

journal_title：Bone

authors： Horton WA,Hood OJ,Machado MA,Ahmed S,Griffey ES

更新日期：1988-01-01 00:00:00

abstract：:Diabetes is associated with a number of lower extremity orthopedic conditions and complications including fractures, Charcot neuroarthropathy, plantar ulcers, and infection. These complications are of significant clinical concern in terms of morbidity, mortality, and socioeconomic costs. A review of each condition is ...

journal_title：Bone

authors： Gehling DJ,Lecka-Czernik B,Ebraheim NA

更新日期：2016-01-01 00:00:00

abstract：:Myostatin (GDF8) is a negative regulator of skeletal muscle growth and mice lacking myostatin show a significant increase in muscle mass and bone density compared to normal mice. In order to further define the role of myostatin in regulating bone mass we sought to determine if loss of myostatin function significantly ...

journal_title：Bone

authors： Hamrick MW,Shi X,Zhang W,Pennington C,Thakore H,Haque M,Kang B,Isales CM,Fulzele S,Wenger KH

更新日期：2007-06-01 00:00:00

abstract：:Several Biophosphonates have been used as therapeutic agents for Paget's bone disease. (Chloro-4 phenyl)thiomethylene-bisphosphonate (CIPsMBP) has recently been shown to have significant antiosteoclastic activity while an affect of CIPsMBP on mineralization was only observed at high doses. We tested this drug for 6 mo...

journal_title：Bone

authors： Reginster JY,Jeugmans-Huynen AM,Albert A,Denis D,Deroisy R,Lecart MP,Fontaine MA,Collette J,Franchimont P

更新日期：1988-01-01 00:00:00

abstract：:Bone can be viewed as a nano-fibrous composite with complex hierarchical structures. Its deformation and fracture behaviors depend on both the local structure and the type of stress applied. In contrast to the extensive studies on bone fracture under compression and tension, there is a lack of knowledge on the fractur...

journal_title：Bone

authors： Tang T,Ebacher V,Cripton P,Guy P,McKay H,Wang R

更新日期：2015-02-01 00:00:00

abstract：:Bone age is used widely by pediatricians to assess the skeletal maturity of a child and predict growth potential. This entails measuring the size of secondary ossification centers (SOCs), which develop with age in the ends of long bones, which are initially cartilaginous. However, little is presently known about the d...

journal_title：Bone

authors： Xie M,Chagin AS

更新日期：2021-01-01 00:00:00

abstract：:To define structure-activity relationships for bisphosphonate activity, we examined the bone binding and antiresorptive properties of heterocycle-containing analogs of risedronate, a pyridylbisphosphonate, in cultures of mouse fetal bone explants. Our studies indicated that hydroxybisphosphonates with the nitrogen mol...

journal_title：Bone

authors： van Beek ER,Löwik CW,Ebetino FH,Papapoulos SE

更新日期：1998-11-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of short RNA molecules that mediate the regulation of gene activity through interactions with target mRNAs and subsequent silencing of gene expression. It has become increasingly clear the miRNAs regulate many diverse aspects of bone biology, including bone formation and bone resorption ...

journal_title：Bone

authors： Weivoda MM,Lee SK,Monroe DG

更新日期：2021-02-01 00:00:00

abstract：:Amelogenin is the major enamel protein produced by ameloblasts. Its expression has been shown to be down-regulated in ameloblasts of vitamin-D-deficient (-D) rats. The potential expression and localization of amelogenin in odontoblasts and its regulation by vitamin D were investigated in this study. RT-PCR and semi-qu...

journal_title：Bone

authors： Papagerakis P,MacDougall M,Hotton D,Bailleul-Forestier I,Oboeuf M,Berdal A

更新日期：2003-03-01 00:00:00

abstract：:Second generation antipsychotics (SGAs) have been linked to metabolic and bone disorders in clinical studies, but the mechanisms of these side effects remain unclear. Additionally, no studies have examined whether SGAs cause bone loss in mice. Using in vivo and in vitro modeling we examined the effects of risperidone,...

journal_title：Bone

authors： Motyl KJ,Dick-de-Paula I,Maloney AE,Lotinun S,Bornstein S,de Paula FJ,Baron R,Houseknecht KL,Rosen CJ

更新日期：2012-02-01 00:00:00

abstract：INTRODUCTION:Teriparatide is a bone formation agent that increases bone turnover and mass, resulting in an increase in bone strength and a decrease in fracture risk. METHODS:The primary purpose of this analysis was to evaluate the association between pretreatment bone turnover marker (BTM) concentrations and the absol...

journal_title：Bone

authors： Delmas PD,Licata AA,Reginster JY,Crans GG,Chen P,Misurski DA,Wagman RB,Mitlak BH

更新日期：2006-08-01 00:00:00

abstract：:The ovariectomized (OVX) rat is a well established model for osteoporosis research. The recent development of in vivo micro-computed tomography (micro-CT) provides new possibilities to monitor individual bone changes over time. The purpose of this study was to establish the normal time course of bone loss in the OVX r...

journal_title：Bone

authors： Boyd SK,Davison P,Müller R,Gasser JA

更新日期：2006-10-01 00:00:00

abstract：:Despite the potential biological importance of sympathetic activity in human bone metabolism, its effects on bone microarchitecture, a key determinant of bone quality, has not been thoroughly studied. In the present study, we investigated the lumbar spine trabecular bone score (TBS) as an indicator of skeletal deterio...

journal_title：Bone

authors： Kim BJ,Kwak MK,Kim JS,Lee SH,Koh JM

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:Selenium deficiency is a risk factor for Kashin-Beck Disease (KBD), an endemic osteoarthropathy. Although promoter hypermethylation of glutathione peroxidase 3 (GPX3) (a selenoprotein) has been identified in several cancers, little is known about promoter methylation and expression of GPX3 and their relation ...

journal_title：Bone

authors： Han L,Yang X,Sun W,Li Z,Ren H,Li B,Zhang R,Zhang D,Shi Z,Liu J,Cao J,Zhang J,Xiong Y

更新日期：2018-12-01 00:00:00

abstract：:Analysis of tissue from a 34-years-old male patient from Austrian origin with a history of multiple fractures associated with painful episodes over the carpal, tarsal and at the end of the long bones respectively is presented. Radiographic images and axial 3DCT scans showed widespread defects in trabecular bone archit...

journal_title：Bone

authors： Shboul M,Roschger P,Ganger R,Paschalis L,Rokidi S,Zandieh S,Behunova J,Muschitz C,Fahrleitner-Pammer A,Ng AYJ,Tohari S,Venkatesh B,Bonnard C,Reversade B,Klaushofer K,Al Kaissi A

更新日期：2019-06-01 00:00:00

abstract：:Osteocytes can participate in systemic mineral homeostasis through perilacunar maintenance and remodeling, where changes to osteocyte lacunar morphology may affect bone structural integrity, tissue strains, and osteocyte mechanosensitivity. Though aging is associated with both decreased bone quality and altered minera...

journal_title：Bone

authors： Heveran CM,Rauff A,King KB,Carpenter RD,Ferguson VL

更新日期：2018-05-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are known to induce new bone formation in vivo but treating trabecular bone defects with a BMP based therapeutic remains controversial. Here, we evaluated the safety and efficacy of a novel Autologous Bone Graft Substitute (ABGS) comprised of recombinant human BMP6 (rhBMP6) dispersed...

journal_title：Bone

authors： Durdevic D,Vlahovic T,Pehar S,Miklic D,Oppermann H,Bordukalo-Niksic T,Gavrankapetanovic I,Jamakosmanovic M,Milosevic M,Martinovic S,Sampath TK,Peric M,Grgurevic L,Vukicevic S

更新日期：2020-11-01 00:00:00

abstract：:We hypothesized that estrogen deficiency induces changes in bone vascularization which might be involved in bone loss mechanisms. First, we studied gene expression of angiogenic (vascular endothelial growth factor (VEGF), fibroblast growth factor-2 (FGF-2)) and vasodilator (endothelial nitric oxide synthase (ecNOS), n...

journal_title：Bone

authors： Mekraldi S,Lafage-Proust MH,Bloomfield S,Alexandre C,Vico L

更新日期：2003-06-01 00:00:00

abstract：:On the basis of studies with bone-seeking isotopes, it is generally believed that the metabolic activity of osteoblasts of the trabecular bone is greater than that of the osteoblasts of the cortex. This implies that the oxidative activity, which provides the energy for biosyntheses, will also be greater in the former ...

journal_title：Bone

authors： Dodds RA,Emery RJ,Klenerman L,Chayen J,Bitensky L

更新日期：1989-01-01 00:00:00

abstract：:The topological changes in vertebral cancellous bone were estimated in vertebrae from calcium-restricted ovariectomized Sinclair S-1 minipigs, a recently described animal model of cancellous osteopenia. Connectivity was estimated using unbiased stereological principles in disector pairs of sections from the first lumb...

journal_title：Bone

authors： Boyce RW,Ebert DC,Youngs TA,Paddock CL,Mosekilde L,Stevens ML,Gundersen HJ

更新日期：1995-06-01 00:00:00

abstract：:General dental practitioners use a vast amount of panoramic radiography in their routine clinical work, but valuable information about patients' osteoporotic status is not collected. There are many reasons for this, but one of the prime reasons must be the disruption involved in clinical routine with lengthy manual ra...

journal_title：Bone

authors： Devlin H,Allen PD,Graham J,Jacobs R,Karayianni K,Lindh C,van der Stelt PF,Harrison E,Adams JE,Pavitt S,Horner K

更新日期：2007-04-01 00:00:00

abstract：:Several animal studies have showed that gelatin may be effective for minimizing bone loss in OVX rats with established osteopenia. To gain insight into how cod bone gelatin administration affects bone loss after ovariectomy, studies were carried out focusing on bone quality and the molecular mechanisms. Eighty-four fe...

journal_title：Bone

authors： Han X,Xu Y,Wang J,Pei X,Yang R,Li N,Li Y

更新日期：2009-05-01 00:00:00

abstract：:It is well known that porosity has an inverse relationship with the mechanical properties of bones. We examined cortical and trabecular porosity of antlers, and mineral composition, thickness and mechanical properties in the cortical wall. Samples belonged to two deer populations: a captive population of an experiment...

journal_title：Bone

authors： Landete-Castillejos T,Currey JD,Ceacero F,García AJ,Gallego L,Gomez S

更新日期：2012-01-01 00:00:00

abstract：:Achondroplasia (ACH) and thanatophoric dysplasia (TD) are human skeletal disorders of increasing severity accounted for by mutations in the fibroblast growth factor receptor 3 (FGFR3). Attempts to elucidate the molecular signaling pathways leading to these phenotypes through mouse model engineering have provided relev...

journal_title：Bone

authors： Legeai-Mallet L,Benoist-Lasselin C,Munnich A,Bonaventure J

更新日期：2004-01-01 00:00:00

abstract：:Vitamin K is a cofactor for γ-glutamyl carboxylase, which is an essential enzyme for the γ-carboxylation of vitamin K-dependent proteins such as osteocalcin and matrix Gla protein. Although it has been suggested that vitamin K plays an important role in the improvement of bone metabolism, the relationship between diet...

journal_title：Bone

authors： Sogabe N,Maruyama R,Baba O,Hosoi T,Goseki-Sone M

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:The accepted mechanism explaining the accelerated growth following periosteal resection is that the periosteum serves as a mechanical restraint to restrict physeal growth. To test the veracity of this mechanism we first utilized Second Harmonic Generation (SHG) imaging to measure differences of periosteal fiber...

journal_title：Bone

authors： Chaudhary R,Lee MS,Mubyana K,Duenwald-Kuehl S,Johnson L,Kaiser J,Vanderby R Jr,Eliceiri KW,Corr DT,Chin MS,Li WJ,Campagnola PJ,Halanski MA

更新日期：2016-11-01 00:00:00

abstract：:This multicenter study assessed the safety and efficacy of teriparatide 20 microg/day in Japanese men and women with osteoporosis at high risk of fracture during a 12-month, randomized, double-blind, placebo-controlled treatment period followed by second and third treatment periods (to 18 and 24 months, respectively,)...

journal_title：Bone

authors： Miyauchi A,Matsumoto T,Sugimoto T,Tsujimoto M,Warner MR,Nakamura T

更新日期：2010-09-01 00:00:00

abstract：:Ginsenoside Rh2 is one of the most active components of red ginseng, controlling cancer and other metabolic diseases including osteoclast differentiation. However, the molecular mechanism underlying the inhibition of osteoclast differentiation by ginsenoside Rh2 remains poorly understood. In the present study, it was ...

journal_title：Bone

authors： He L,Lee J,Jang JH,Lee SH,Nan MH,Oh BC,Lee SG,Kim HH,Soung NK,Ahn JS,Kim BY

更新日期：2012-06-01 00:00:00

abstract：:We investigated the function of Ca2+ in the activation of phosphatidylcholine (PC)-hydrolyzing phospholipase D (PLD) in osteoblast-like MC3T3-E1 cells. Fetal calf serum (FCS) stimulated the formation of choline in a dose-dependent manner in the range between 0.6% and 10%. The effect of a combination of FCS and 12-O-te...

journal_title：Bone

authors： Tokuda H,Suzuki A,Watanabe-Tomita Y,Shinoda J,Imamura Y,Oiso Y,Igata A,Kozawa O

更新日期：1996-10-01 00:00:00

abstract：:The rat model has previously been used to test the effect of ovariectomy and of PTH administration on vertebral bone mass, size, and biomechanical competence. In this study, we used the same "biomechanical rat model" to assess the effect of long-term exercise on vertebral bone mass and quality and also on femoral bone...

journal_title：Bone

authors： Mosekilde L,Danielsen CC,Søgaard CH,Thorling E

更新日期：1994-05-01 00:00:00