Abstract:
:Bone fragility is a concern for aged and diseased bone. Measuring bone toughness and understanding fracture properties of the bone are critical for predicting fracture risk associated with age and disease and for preclinical testing of therapies. A reference point indentation technique (BioDent) has recently been developed to determine bone's resistance to fracture in a minimally invasive way by measuring the indentation distance increase (IDI) between the first and last indentations over cyclic indentations in the same position. In this study, we investigate the relationship between fracture toughness KC and reference point indentation parameters (i.e. IDI, total indentation distance (TID) and creep indentation distance (CID)) in bones from 38 mice from six types (C57Bl/6, Balb, oim/oim, oim/+, Phospho1(-/-) and Phospho1 wild type counterpart). These mice bone are models of healthy and diseased bone spanning a range of fracture toughness from very brittle (oim/oim) to ductile (Phospho1(-/-)). Left femora were dissected, notched and tested in 3-point bending until complete failure. Contralateral femora were dissected and indented in 10 sites of their anterior and posterior shaft surface over 10 indentation cycles. IDI, TID and CID were measured. Results from this study suggest that reference point indentation parameters are not indicative of stress intensity fracture toughness in mouse bone. In particular, the IDI values at the anterior mid-diaphysis across mouse types overlapped, making it difficult to discern differences between mouse types, despite having extreme differences in stress intensity based toughness measures. When more locations of indentation were considered, the normalised IDIs could distinguish between mouse types. Future studies should investigate the relationship of the reference point indentation parameters for mouse bone in other material properties of the bone tissue in order to determine their use for measuring bone quality.
journal_name
Bonejournal_title
Boneauthors
Carriero A,Bruse JL,Oldknow KJ,Millán JL,Farquharson C,Shefelbine SJdoi
10.1016/j.bone.2014.09.020subject
Has Abstractpub_date
2014-12-01 00:00:00pages
174-9eissn
8756-3282issn
1873-2763pii
S8756-3282(14)00359-7journal_volume
69pub_type
杂志文章相关文献
BONE文献大全abstract::Bone matrix, mainly composed of type I collagen and apatite, is constantly modified during the bone remodeling process, which exposes bone cells to various proportions of mineralized collagen within bone structural units. Collagen-mineralized substrates have been shown to increase osteoblast activities. We hypothesize...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.03.010
更新日期:2010-07-01 00:00:00
abstract:PURPOSE:Vertebral fractures are associated with persistent pain, disability and mortality. However, around two thirds of women with vertebral fractures are unaware of them. We aimed to analyze which factors could mostly be associated to the presence of vertebral fractures in post-menopausal women, and evaluate the effe...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.05.007
更新日期:2018-08-01 00:00:00
abstract::In the present study, we evaluated an autologous bone graft substitute (ABGS) composed of recombinant human BMP6 (rhBMP6) dispersed within autologous blood coagulum (ABC) used as a physiological carrier for new bone formation in spine fusion sheep models. The application of ABGS included cervical cage for use in the a...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115448
更新日期:2020-09-01 00:00:00
abstract::Skeletal muscle is a highly plastic tissue that remarkably adapts to diverse stimuli including exercise, injury, disuse, and, as discussed here, aging. Humans achieve peak skeletal muscle mass and strength in mid-life and then experience a progressive decline of up to 50% by the ninth decade. The loss of muscle mass a...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2019.05.021
更新日期:2019-10-01 00:00:00
abstract::Growing evidence suggests that positive associations between fat mass (FM) and bone mineral density (BMD) are mediated by not only biomechanical but also biochemical factors. Adiponectin is a novel adipocyte-derived hormone that regulates energy homeostasis and has anti-inflammatory and anti-atherogenic effects. Unlik...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(03)00237-0
更新日期:2003-10-01 00:00:00
abstract::Daily subcutaneous administration of exogenous parathyroid hormone (PTH) promotes bone formation in patients with osteoporosis. Here we describe two novel, short-acting calcium-sensing receptor antagonists (SB-423562 and its orally bioavailable precursor, SB-423557) that elicit transient PTH release from the parathyro...
journal_title:Bone
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.bone.2009.09.028
更新日期:2010-02-01 00:00:00
abstract:INTRODUCTION:The elderly population is growing fast worldwide, and therefore, investigation of health outcomes peculiar to these individuals is a public health priority nowadays. The decade between 2000 and 2010 is denominated as the Bone and Joint Decade, and researchers are encouraged to quantity the burden of muscul...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.04.002
更新日期:2005-08-01 00:00:00
abstract::Vertebral fracture risk is a heritable complex trait. The aim of this study was to identify genetic susceptibility factors for osteoporotic vertebral fractures applying a genome-wide association study (GWAS) approach. The GWAS discovery was based on the Rotterdam Study, a population-based study of elderly Dutch indivi...
journal_title:Bone
pub_type: 杂志文章
doi:
更新日期:2014-02-01 00:00:00
abstract::Bone has the unique capacity to heal without the formation of a fibrous scar, likely because several of the cellular and molecular processes governing bone healing recapitulate the events during skeletal development. A critical component in bone healing is the timely appearance of blood vessels in the fracture callus....
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2014.09.017
更新日期:2015-01-01 00:00:00
abstract::This study describes the early interface reaction of cancellous bone to a nanocrystalline hydroxyapatite cement containing type I collagen (HA/Coll) and its modifications with sodium citrate (CI), calcium carbonate (CA), phosphoserine (P) and phosphoserine plus RGD-peptide (RGD). Cylindrical implants of HA/Coll and it...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2006.11.019
更新日期:2007-04-01 00:00:00
abstract::Bisphosphonates play an important role in the treatment of metabolic bone diseases such as osteoporosis. In addition to their anti-resorptive activity by triggering osteoclast apoptosis, nitrogen-containing bisphosphonates (N-BP) may also influence osteogenic differentiation, which might rely on their capacity to inhi...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.03.020
更新日期:2018-06-01 00:00:00
abstract::Iliac crest bone biopsies from 62 patients (42 women, 20 men; median age 59 years; range 17-79 years) with primary hyperparathyroidism (PHP) were examined. Static and structural parameters were compared with 30 age- and sex-matched normal controls. Eighteen sex-matched younger controls were used for evaluation of the ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(93)90207-q
更新日期:1993-09-01 00:00:00
abstract::SOST encodes sclerostin, an inhibitor of bone formation that antagonizes canonical Wnt signaling. Variations of SOST expression have an impact on bone mineral density (BMD) and bone strength. We hypothesized that genetic and epigenetic DNA modifications have an impact on SOST gene expression. By analyzing 43 bone samp...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2016.08.004
更新日期:2016-11-01 00:00:00
abstract::There is increasing evidence that osteogenic cells are present not only in bone marrow (BM) but also in peripheral blood (PB). Since staining for alkaline phosphatase (AP) identifies osteoprogenitor cells in BM, we sought to further characterize BM versus PB hematopoietic lineage negative (lin-)/AP+ cells and to compa...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.03.018
更新日期:2010-07-01 00:00:00
abstract::The aim of the study was to compare the effects on bone mass and turnover of continuous vs. intermittent clodronate administration on 120 postmenopausal women (average age 61 years) with low bone mass (femoral neck bone mineral density [BMD] of at least -1 SD or more, T-score), with another 30 women as a control group...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(99)00273-2
更新日期:2000-03-01 00:00:00
abstract::Short-term changes in biochemical markers of bone turnover (bone markers) have been suggested as predictors of long-term response in bone mass during antiresorptive treatment. In the Danish cohort (n = 306) of the Early Postmenopausal Intervention Cohort (EPIC) Study (n = 1609) of oral alendronate (ALN) for prevention...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(03)00168-6
更新日期:2003-07-01 00:00:00
abstract::The traditional view of osteoporotic fractures is that they result from a reduction in bone mass combined with alterations in the micro-architecture. Apart from the effects of bone remodeling, the material properties of the remaining bone are thought to be unaffected. To test this, we compared the degree of matrix min...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2004.05.025
更新日期:2004-10-01 00:00:00
abstract::Using immunohistology with two specific antisera raised against N-terminal parathyroid hormone-related protein (PTHrP) and in situ hybridization (riboprobe to common coding exon), evidence is provided for the expression of PTHrP by mouse, rabbit, and human osteoclasts derived from several in vitro and in vivo sources....
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(97)00278-0
更新日期:1998-03-01 00:00:00
abstract::Oral bisphosphonates are established therapeutics for postmenopausal osteoporosis. Alternative, simplified dosing regimens that improve tolerability and promote convenience may be advantageous. Ibandronate is a highly potent, nitrogen-containing bisphosphonate that can be administered as a convenient intravenous (i.v....
journal_title:Bone
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.bone.2004.01.007
更新日期:2004-05-01 00:00:00
abstract::We present a three-dimensional mineralizing model based on a hollow fiber bioreactor (HFBR) inoculated with primary osteoblasts isolated from embryonic chick calvaria. Using non-invasive magnetic resonance microscopy (MRM), the growth and development of the mineralized tissue around the individual fibers were monitore...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2006.10.020
更新日期:2007-04-01 00:00:00
abstract::Women with prevalent fractures have an increased risk of developing additional, incident fractures. This article examines the relation between the location of prevalent fractures within the spine and the risk of subsequent vertebral fractures. The subjects were 721 Japanese-American women of mean age 69.5 +/- 5.3 (SD)...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(98)00176-8
更新日期:1999-03-01 00:00:00
abstract::The effect of low-dose 1 alpha-hydroxyvitamin D3 [1 alpha(OH)D3] on experimental osteoporosis in rats induced by a combination of hemicordotomy and ovariectomy was evaluated. 1 alpha(OH)D3 (0.1 microgram/kg 1 alpha(OH)D3 three times a week) increased the femur score and photo-density. The administration of 1 alpha(OH)...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(87)90066-4
更新日期:1987-01-01 00:00:00
abstract::High-resolution peripheral quantitative computed tomography (HR-pQCT) is clinically available today and provides a non-invasive measure of 3D bone geometry and micro-architecture with unprecedented detail. In combination with microarchitectural finite element (μFE) models it can be used to determine bone strength usin...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.02.022
更新日期:2011-06-01 00:00:00
abstract::Skeleton is the most common organ targeted by breast cancer cells, especially from estrogen receptor alpha (ER)-positive neoplasms. Metastatic cells can stimulate directly or indirectly osteoclast-mediated bone resorption. Tumor-induced osteolysis is often extensive and leads to the release of large quantities of calc...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2004.03.021
更新日期:2004-08-01 00:00:00
abstract::We have previously shown that in osteoblasts Sox2 expression can be induced by Fgfs, and can inhibit Wnt signaling and differentiation. Furthermore, in mice in which Sox2 is conditionally deleted in the osteoblastic lineage, bones are osteopenic, and Sox2 inactivation in cultured osteoblasts leads to a loss of prolife...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.06.008
更新日期:2011-10-01 00:00:00
abstract::In some types of low-trauma fractures of older adults the number and incidence of fractures are stabilizing or even decreasing. However, very little population-based information is available concerning the nationwide numbers, incidences and especially secular trends of low-trauma fractures of the distal humerus. There...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.11.025
更新日期:2010-05-01 00:00:00
abstract::Low-trauma fractures of older women are a major public health problem. Nevertheless, nationwide information on recent trends of proximal humeral fractures is sparse. We assessed the current trend in the number and rate (per 100,000 persons) of low-trauma fractures of the proximal humerus among 80-year-old or older wom...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2008.12.007
更新日期:2009-04-01 00:00:00
abstract::Trabecular bone fracture represents a major health problem, therefore the improvement of its assessment is mandatory for the reduction of the economic and social burden. The micro-structure of the trabecular bone was found to have an important effect on trabecular mechanical behavior. Nonetheless, the high variability...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.12.007
更新日期:2014-03-01 00:00:00
abstract::Both bone density and quality are important determinants of bone strength. Bone quality is prescribed by matrix characteristic including collagen cross-linking and bone structural characteristics and is important in reinforcement of bone strength. We investigated the effects of alfacalcidol (ALF), a prodrug of calcitr...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.12.008
更新日期:2010-04-01 00:00:00
abstract:INTRODUCTION:Heterotopic ossification (HO), or the abnormal formation of bone in soft tissue, occurs in over 60% of major burn injuries and blast traumas. A significant need exists to improve the current diagnostic modalities for HO which are inadequate to diagnose and intervene on HO at early time-points. Raman spectr...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.01.002
更新日期:2013-05-01 00:00:00