当前位置： SCI文献检索 > BONE期刊下所有文献 > Apatite content of collagen materials dose-dependently increases pre-osteoblastic cell deposition of a cement line-like matrix.

Apatite content of collagen materials dose-dependently increases pre-osteoblastic cell deposition of a cement line-like matrix.

Abstract：

:Bone matrix, mainly composed of type I collagen and apatite, is constantly modified during the bone remodeling process, which exposes bone cells to various proportions of mineralized collagen within bone structural units. Collagen-mineralized substrates have been shown to increase osteoblast activities. We hypothesized that such effects may be explained by a rapid secretion of specific growth factors and/or deposition of specific matrix proteins. Using MC3T3-E1 seeded for 32h on collagen substrates complexed with various apatite contents, we found that pre-osteoblasts in contact with mineralized collagen gave rise to a dose-dependent deposit of Vascular Endothelial Growth Factor-A (VEGF-A) and RGD-containing proteins such as osteopontin (OPN) and fibronectin (FN). This RGD-matrix deposition reinforced the cell adhesion to collagen-mineralized substrates. It was also observed that, on these substrates, this matrix was elaborated concomitantly to an increased cell migration, allowing a homogeneous coverage of the sample. This particular surface activation was probably done firstly to reinforce cell survival (VEGF-A) and adhesion (OPN, FN) and secondly to recruit and prepare surfaces for subsequent bone cell activity.

journal_name

Bone

journal_title

Bone

authors

Perrier A,Dumas V,Linossier MT,Fournier C,Jurdic P,Rattner A,Vico L,Guignandon A

doi

10.1016/j.bone.2010.03.010

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

23-33

issue

1

eissn

8756-3282

issn

1873-2763

pii

S8756-3282(10)00503-X

journal_volume

47

pub_type

杂志文章

相关文献

BONE文献大全
  • The short- and long-term effects of methotrexate on the rat skeleton.

    abstract：:Both clinical and laboratory studies have shown that the chemotherapy drug, Methotrexate (MTX), has adverse short-term effects on bone. There are no studies that demonstrate the long-term response of bone to MTX. The purpose of this study was to determine the short- and long-term effects of MTX on bone volume, turnove...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/8756-3282(94)00032-u

    authors： Wheeler DL,Vander Griend RA,Wronski TJ,Miller GJ,Keith EE,Graves JE

    更新日期：1995-02-01 00:00:00

  • CSF-1 blockade impairs breast cancer osteoclastogenic potential in co-culture systems.

    abstract：:Metastatic bone disease has a major impact on the morbidity and mortality of breast cancer patients, and studies on bone metastasis biology have led to the development of the most widely used drugs for bone metastases treatment: zoledronate (Zol) and denosumab (Den). The aim of the present study was to assess the effe...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2014.06.017

    authors： Liverani C,Mercatali L,Spadazzi C,La Manna F,De Vita A,Riva N,Calpona S,Ricci M,Bongiovanni A,Gunelli E,Zanoni M,Fabbri F,Zoli W,Amadori D,Ibrahim T

    更新日期：2014-09-01 00:00:00

  • Autologous blood coagulum containing rhBMP6 induces new bone formation to promote anterior lumbar interbody fusion (ALIF) and posterolateral lumbar fusion (PLF) of spine in sheep.

    abstract：:In the present study, we evaluated an autologous bone graft substitute (ABGS) composed of recombinant human BMP6 (rhBMP6) dispersed within autologous blood coagulum (ABC) used as a physiological carrier for new bone formation in spine fusion sheep models. The application of ABGS included cervical cage for use in the a...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2020.115448

    authors： Grgurevic L,Erjavec I,Gupta M,Pecin M,Bordukalo-Niksic T,Stokovic N,Vnuk D,Farkas V,Capak H,Milosevic M,Bubic Spoljar J,Peric M,Vuckovic M,Maticic D,Windhager R,Oppermann H,Sampath TK,Vukicevic S

    更新日期：2020-09-01 00:00:00

  • Indoxyl sulfate exacerbates low bone turnover induced by parathyroidectomy in young adult rats.

    abstract：:Low-turnover bone disease is one of the bone abnormalities observed in patients with chronic kidney disease (CKD) and is recognized to be associated with low serum parathyroid hormone (PTH) level and skeletal resistance to PTH. Indoxyl sulfate (IS) is a representative uremic toxin that accumulates in the blood as rena...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2015.06.010

    authors： Hirata J,Hirai K,Asai H,Matsumoto C,Inada M,Miyaura C,Yamato H,Watanabe-Akanuma M

    更新日期：2015-10-01 00:00:00

  • In vivo trabecular microcracks in human vertebral bone.

    abstract：:Human vertebral cancellous bone from white males (N = 19), black males (N = 16), white females (N = 12), and black females (N = 17) was examined histologically for the presence, numerical density, and morphology of in vivo microscopic cracking (microdamage). Two patterns of microcracks, linear and cross-hatched, were ...

    journal_title：Bone

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/8756-3282(96)88871-5

    authors： Wenzel TE,Schaffler MB,Fyhrie DP

    更新日期：1996-08-01 00:00:00

  • Low bone turnover levels predict increased risk of cancer.

    abstract：BACKGROUND:Several epidemiological studies have shown an association between bone mineral density (BMD) and risk of breast cancer in postmenopausal women, but it remains unknown whether bone turnover is associated with increased risk of cancer. The aim of this study was to investigate if markers of bone formation and r...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2019.05.032

    authors： Bager CL,Bay F,Christiansen C,Karsdal M

    更新日期：2019-10-01 00:00:00

  • Identification of the type II Na(+)-Pi cotransporter (Npt2) in the osteoclast and the skeletal phenotype of Npt2-/- mice.

    abstract：:We previously reported that a type II sodium phosphate (Na(+)-Pi) cotransporter (Npt2) protein is expressed in osteoclasts and that Pi limitation decreases osteoclast-mediated bone resorption in vitro. We also demonstrated that mice homozygous for the disrupted Npt2 gene (Npt2-/-) exhibit a unique age-dependent bone p...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/s8756-3282(01)00601-9

    authors： Gupta A,Tenenhouse HS,Hoag HM,Wang D,Khadeer MA,Namba N,Feng X,Hruska KA

    更新日期：2001-11-01 00:00:00

  • Characterisation of cytosolic FK506 binding protein 12 and its role in modulating expression of Cbfa1 and osterix in ROS 17/2.8 cells.

    abstract：:FK506 is a commonly used immunosuppressant that mediates its action by exclusively interacting with the cytosolic immunophilin, FK506 binding protein 12 (FKBP12). Although FK506-induced acute osteoporosis is now well recognised, its precise mode of action in osteoblasts remains unclear. Therefore, in the present study...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2004.09.021

    authors： Varanasi SS,Datta HK

    更新日期：2005-02-01 00:00:00

  • Uniaxial cyclic stretch induces osteogenic differentiation and synthesis of bone morphogenetic proteins of spinal ligament cells derived from patients with ossification of the posterior longitudinal ligaments.

    abstract：:Ossification of the posterior longitudinal ligament of the spine (OPLL) is characterized by ectopic bone formation in the spinal ligaments. Mechanical stress, which acts on the posterior ligaments, is thought to be an important factor in the progression of OPLL. To elucidate this mechanism, we investigated the effects...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/s8756-3282(03)00204-7

    authors： Tanno M,Furukawa KI,Ueyama K,Harata S,Motomura S

    更新日期：2003-10-01 00:00:00

  • Peripheral quantitative computed tomography measures are associated with adult fracture risk: the Hertfordshire Cohort Study.

    abstract：:Peripheral quantitative computed tomography (pQCT) captures novel aspects of bone geometry that may contribute to fracture risk and offers the ability to measure both volumetric bone mineral density (vBMD) and a separation of trabecular and cortical compartments of bone, but longitudinal data relating measures obtaine...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2014.03.040

    authors： Dennison EM,Jameson KA,Edwards MH,Denison HJ,Aihie Sayer A,Cooper C

    更新日期：2014-07-01 00:00:00

  • Screening for GNAS genetic and epigenetic alterations in progressive osseous heteroplasia: first Italian series.

    abstract：:Progressive osseous heteroplasia (POH) is a rare autosomal dominant disorder of mesenchymal differentiation characterized by progressive heterotopic ossification (HO) of dermis, deep connective tissues and skeletal muscle. Usually, initial bone formation occurs during infancy as primary osteoma cutis (OC) then progres...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2013.06.015

    authors： Elli FM,Barbieri AM,Bordogna P,Ferrari P,Bufo R,Ferrante E,Giardino E,Beck-Peccoz P,Spada A,Mantovani G

    更新日期：2013-10-01 00:00:00

  • High resolution computed tomography of the vertebrae yields accurate information on trabecular distances if processed by 3D fuzzy segmentation approaches.

    abstract：INTRODUCTION:The structure of trabecular bone represents an aspect of bone properties that affects vertebral bone strength independently of bone mineral density [M. Kleerekoper, A. Villanueva, J. Stanciu, D. Rao, and A. Parfitt. The role of three-dimensional trabecular microstructure in the pathogenesis of vertebral co...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2008.08.131

    authors： Krebs A,Graeff C,Frieling I,Kurz B,Timm W,Engelke K,Glüer CC

    更新日期：2009-01-01 00:00:00

  • Prevention of glucocorticoid induced-apoptosis of osteoblasts and osteocytes by protecting against endoplasmic reticulum (ER) stress in vitro and in vivo in female mice.

    abstract：:Endoplasmic reticulum (ER) stress is associated with increased reactive oxygen species (ROS), results from accumulation of misfolded/unfolded proteins, and can trigger apoptosis. ER stress is alleviated by phosphorylation of eukaryotic translation initiation factor 2α (eIF2α), which inhibits protein translation allowi...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2014.12.012

    authors： Sato AY,Tu X,McAndrews KA,Plotkin LI,Bellido T

    更新日期：2015-04-01 00:00:00

  • A novel autologous bone graft substitute comprised of rhBMP6 blood coagulum as carrier tested in a randomized and controlled Phase I trial in patients with distal radial fractures.

    abstract：:Bone morphogenetic proteins (BMPs) are known to induce new bone formation in vivo but treating trabecular bone defects with a BMP based therapeutic remains controversial. Here, we evaluated the safety and efficacy of a novel Autologous Bone Graft Substitute (ABGS) comprised of recombinant human BMP6 (rhBMP6) dispersed...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2020.115551

    authors： Durdevic D,Vlahovic T,Pehar S,Miklic D,Oppermann H,Bordukalo-Niksic T,Gavrankapetanovic I,Jamakosmanovic M,Milosevic M,Martinovic S,Sampath TK,Peric M,Grgurevic L,Vukicevic S

    更新日期：2020-11-01 00:00:00

  • Type 2 diabetes impairs angiogenesis and osteogenesis in calvarial defects: MicroCT study in ZDF rats.

    abstract：OBJECTIVES:The present study was motivated by the fact that bone regeneration in the compromised vascular microenvironment of T2DM is challenging and the factors that determine the adverse bone regeneration outcomes are poorly understood. For this purpose the effect of T2DM on osteogenic and angiogenic healing potentia...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2018.04.009

    authors： Caliaperoumal G,Souyet M,Bensidhoum M,Petite H,Anagnostou F

    更新日期：2018-07-01 00:00:00

  • WISE-2005: bed-rest induced changes in bone mineral density in women during 60 days simulated microgravity.

    abstract：:To better understand the effects of prolonged bed-rest in women, 24 healthy women aged 25 to 40 years participated in 60-days of strict 6° head-down tilt bed-rest (WISE-2005). Subjects were assigned to either a control group (CON, n=8) which performed no countermeasure, an exercise group (EXE, n=8) undertaking a combi...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2011.06.021

    authors： Beller G,Belavý DL,Sun L,Armbrecht G,Alexandre C,Felsenberg D

    更新日期：2011-10-01 00:00:00

  • Bone mineral density of the total body and forearm in premenopausal black and white women.

    abstract：:This study was conducted to report and compare bone mineral density (BMD) of the total body and distal forearm, as measured by X-ray absorptiometry, in 65 black and 73 white premenopausal women between the ages of 20 and 40. The black women had higher current and recalled body weights, a higher percent body fat, and m...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/8756-3282(95)00050-n

    authors： Harris SS,Wood MJ,Dawson-Hughes B

    更新日期：1995-04-01 00:00:00

  • An orally active calcium-sensing receptor antagonist that transiently increases plasma concentrations of PTH and stimulates bone formation.

    abstract：:Daily subcutaneous administration of exogenous parathyroid hormone (PTH) promotes bone formation in patients with osteoporosis. Here we describe two novel, short-acting calcium-sensing receptor antagonists (SB-423562 and its orally bioavailable precursor, SB-423557) that elicit transient PTH release from the parathyro...

    journal_title：Bone

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.bone.2009.09.028

    authors： Kumar S,Matheny CJ,Hoffman SJ,Marquis RW,Schultz M,Liang X,Vasko JA,Stroup GB,Vaden VR,Haley H,Fox J,DelMar EG,Nemeth EF,Lago AM,Callahan JF,Bhatnagar P,Huffman WF,Gowen M,Yi B,Danoff TM,Fitzpatrick LA

    更新日期：2010-02-01 00:00:00

  • Microcracks in subchondral bone plate is linked to less cartilage damage.

    abstract：OBJECTIVES:Osteoarthritis (OA) is a disease of the whole joint characterized by cartilage loss and subchondral bone remodeling. The role of microcracks in cartilage integrity and subchondral bone homeostasis is not fully understood. The main goal of this work was to evaluate microcrack density in both calcified cartila...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2019.03.011

    authors： Zarka M,Hay E,Ostertag A,Marty C,Chappard C,Oudet F,Engelke K,Laredo JD,Cohen-Solal M

    更新日期：2019-06-01 00:00:00

  • Improvement of cancellous bone microstructure in patients on teriparatide following alendronate pretreatment.

    abstract：:An increase in procollagen type I amino-terminal propeptide (PINP) early after teriparatide initiation was shown to correlate with increased lumbar spine areal BMD and is a good predictor of the anabolic response to teriparatide. Few data exist correlating PINP and bone microstructure, and no data exist in patients on...

    journal_title：Bone

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.bone.2016.05.004

    authors： Fahrleitner-Pammer A,Burr D,Dobnig H,Stepan JJ,Petto H,Li J,Krege JH,Pavo I

    更新日期：2016-08-01 00:00:00

  • Changes in marrow adipose tissue in relation to changes in bone parameters following estradiol replacement in adolescent and young adult females with functional hypothalamic amenorrhea.

    abstract：CONTEXT:Low energy availability causes disruption of hypothalamic gonadotropin-releasing hormone secretion leading to functional hypothalamic amenorrhea (FHA) and hypoestrogenism, which in turn contributes to decreased bone mineral density (BMD) and increased bone marrow adipose tissue (MAT). Transdermal estradiol admi...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2021.115841

    authors： Singhal V,Karzar NH,Bose A,Buckless C,Ackerman KE,Bredella MA,Klibanski A,Misra M

    更新日期：2021-01-06 00:00:00

  • Hypercalcemia of malignancy: pathophysiology and treatment.

    abstract：:Hypercalcemia is a relatively common terminal complication of malignancy. In the majority of the patients it is due to excessive bone resorption, secondary either to local destruction by metastases or by the activity of several paracrine and/or endocrine factors. Increased renal tubular reabsorption of calcium plays a...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/s8756-3282(09)80010-0

    authors： Adami S,Rossini M

    更新日期：1992-01-01 00:00:00

  • Longitudinal patient-reported mobility assessment in fibrodysplasia ossificans progressiva (FOP).

    abstract：BACKGROUND:Fibrodysplasia ossificans progressiva (FOP) is a rare, disabling genetic disorder characterized by episodic soft tissue swelling (flare-ups) that leads to progressive heterotopic ossification and restricted joint mobility. METHODS:Here we present the first longitudinal patient-reported mobility assessment (...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2017.06.005

    authors： Kaplan FS,Al Mukaddam M,Pignolo RJ

    更新日期：2018-04-01 00:00:00

  • Assessment of compliance with osteoporosis treatment and its consequences in a managed care population.

    abstract：OBJECTIVE:To evaluate non-compliance with osteoporosis medications as well as its implications for health and economic outcomes in actual practice. STUDY DESIGN:Data on demographics, prescription drug dispensing, physician services and hospitalizations were obtained from a US managed care database for women with osteo...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2005.10.022

    authors： Huybrechts KF,Ishak KJ,Caro JJ

    更新日期：2006-06-01 00:00:00

  • The effect of fluoride treatment on bone mineral crystals in the rat.

    abstract：:In order to investigate the effect of fluoride on bone mineral crystals, we gave groups of female rats 8 mM NaF/L water and distilled water to control groups. The rats were sacrificed at six weeks, three months, and six months. The fluor content of the bone was determined by neutron activation. X-ray diffraction showe...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/8756-3282(92)90085-b

    authors： Grynpas MD,Rey C

    更新日期：1992-01-01 00:00:00

  • Gastrodin: an ancient Chinese herbal medicine as a source for anti-osteoporosis agents via reducing reactive oxygen species.

    abstract：:Increased levels of reactive oxygen species (ROS) are a crucial pathogenic factor of osteoporosis. Gastrodin, isolated from the traditional Chinese herbal agent Gastrodia elata, is a potent antioxidant. We hypothesized that gastrodin demonstrates protective effects against osteoporosis by partially reducing reactive o...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2014.12.059

    authors： Huang Q,Shi J,Gao B,Zhang HY,Fan J,Li XJ,Fan JZ,Han YH,Zhang JK,Yang L,Luo ZJ,Liu J

    更新日期：2015-04-01 00:00:00

  • Neurofibromin and its inactivation of Ras are prerequisites for osteoblast functioning.

    abstract：:Skeletal problems and osteoporosis occur in up to 50% affected neurofibromatosis type 1 (NF1) humans. Inactivation of neurofibromin results in deregulation of Ras signal transduction. Little is known of bone biology in humans with NF1. The goal of our work was to determine if loss-of-function of Nf1 gene was associate...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2005.01.022

    authors： Yu X,Chen S,Potter OL,Murthy SM,Li J,Pulcini JM,Ohashi N,Winata T,Everett ET,Ingram D,Clapp WD,Hock JM

    更新日期：2005-05-01 00:00:00

  • A new open-source tool for measuring 3D osteocyte lacunar geometries from confocal laser scanning microscopy reveals age-related changes to lacunar size and shape in cortical mouse bone.

    abstract：:Osteocytes can participate in systemic mineral homeostasis through perilacunar maintenance and remodeling, where changes to osteocyte lacunar morphology may affect bone structural integrity, tissue strains, and osteocyte mechanosensitivity. Though aging is associated with both decreased bone quality and altered minera...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2018.01.018

    authors： Heveran CM,Rauff A,King KB,Carpenter RD,Ferguson VL

    更新日期：2018-05-01 00:00:00

  • Mechanical vibration inhibits osteoclast formation by reducing DC-STAMP receptor expression in osteoclast precursor cells.

    abstract：:It is well known that physical inactivity leads to loss of muscle mass, but it also causes bone loss. Mechanistically, osteoclastogenesis and bone resorption have recently been shown to be regulated by vibration. However, the underlying mechanism behind the inhibition of osteoclast formation is yet unknown. Therefore,...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2013.08.020

    authors： Kulkarni RN,Voglewede PA,Liu D

    更新日期：2013-12-01 00:00:00

  • Muscle and bone follow similar temporal patterns of recovery from muscle-induced disuse due to botulinum toxin injection.

    abstract：:If muscle force is a primary source for triggering bone adaptation, with disuse and reloading, bone changes should follow muscle changes. We examined the timing and magnitude of changes in muscle cross-sectional area (MCSA) and bone architecture in response to muscle inactivity following botulinum toxin (BTX) injectio...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2009.10.016

    authors： Manske SL,Boyd SK,Zernicke RF

    更新日期：2010-01-01 00:00:00