Effect of 1 alpha-hydroxyvitamin D3 on osteoporosis induced by immobilization combined with ovariectomy in rats.

abstract：:The correlation between bone mineral density and vertebral strength is not based on mechanical principles and thus the method cannot reflect the effects of subtle geometric features and densitometric inhomogeneities that may substantially affect vertebral strength. Finite element models derived from quantitative compu...

journal_title：Bone

authors： Crawford RP,Cann CE,Keaveny TM

更新日期：2003-10-01 00:00:00

abstract：:Tumor necrosis factor (TNF) actions in target tissues are mediated by various signalling pathways. The effect of TNF to stimulate resorption in fetal rat limb bones is not inhibited by indomethacin. The current studies were designed to assess the role of cyclic AMP (cAMP) and calcium as second messengers in this prost...

journal_title：Bone

authors： Shankar G,Stern PH

更新日期：1993-11-01 00:00:00

abstract：:Hormone replacement therapy is effectively used to prevent postmenopausal bone loss. Variation in response to the therapy is, however, frequently seen. In addition, the direct effects of sex steroids on isolated human bone marrow stromal cells have been reported to vary depending on the donor, but the biological mecha...

journal_title：Bone

authors： Leskelä HV,Olkku A,Lehtonen S,Mahonen A,Koivunen J,Turpeinen M,Uusitalo J,Pelkonen O,Kangas L,Selander K,Lehenkari P

更新日期：2006-11-01 00:00:00

abstract：:The degree of mineralization of bone matrix is an important factor in determining the mechanical competence of bone. The remodeling and modeling activities of bone cells together with the time course of mineralization of newly formed bone matrix generate a characteristic bone mineralization density distribution (BMDD)...

journal_title：Bone

authors： Roschger P,Gupta HS,Berzlanovich A,Ittner G,Dempster DW,Fratzl P,Cosman F,Parisien M,Lindsay R,Nieves JW,Klaushofer K

更新日期：2003-03-01 00:00:00

abstract：:Osteoarthritis (OA) occurs naturally in cynomolgus macaques. The purposes of the present study were to: 1) develop histological measurement schemes to measure the cross-sectional area of axial and abaxial osteophytes in the proximal tibia; 2) determine the effects of long-term estrogen replacement therapy (ERT) on ost...

journal_title：Bone

authors： Olson EJ,Lindgren BR,Carlson CS

更新日期：2007-08-01 00:00:00

abstract：:Administration of perioperative antibiotic prophylaxis is a routine procedure in orthopedic surgery. Besides systemic prophylaxis, only few techniques are established for local application of antibiotics to reduce infection related to orthopedic implants. The aim of this study was to evaluate the efficacy of locally v...

journal_title：Bone

authors： Lucke M,Wildemann B,Sadoni S,Surke C,Schiller R,Stemberger A,Raschke M,Haas NP,Schmidmaier G

更新日期：2005-05-01 00:00:00

abstract：:Bone is a composite biomaterial of mineral crystals, organic matrix, and water. Each contributes to bone quality and strength and may change independently, or together, with disease progression and treatment. Even so, there is a near ubiquitous reliance on ionizing x-ray-based approaches to measure bone mineral densit...

journal_title：Bone

authors： Surowiec RK,Ram S,Idiyatullin D,Goulet R,Schlecht SH,Galban CJ,Kozloff KM

更新日期：2021-02-01 00:00:00

abstract：:Large, cylindrical implants of a porous calcium phosphate ceramic ("hydroxyapatite" starting material, HAC) were used to replace far greater than critical-sized sections of the midshaft of sheep tibiae and retrieved at 2 and 9 months; external fixation was used in the first 5 months. Excellent clinical function of the...

journal_title：Bone

authors： Boyde A,Corsi A,Quarto R,Cancedda R,Bianco P

更新日期：1999-06-01 00:00:00

abstract：:Aging is associated with gradual bone loss in men and premenopausal women, with an accelerated rate of loss after menopause in women. Although many studies have investigated bone loss due to surgically induced estrogen depletion, little is known regarding normal age-related changes in bone mass in animal models. We us...

journal_title：Bone

authors： Black A,Tilmont EM,Handy AM,Scott WW,Shapses SA,Ingram DK,Roth GS,Lane MA

更新日期：2001-03-01 00:00:00

abstract：:Teeth with intact crowns rarely split or fracture, despite decades of cyclic loading and occasional unexpected overload. This is largely attributed to the presence of dentine, since cracking and fracture of enamel have been frequently reported. Dentine is similar to bone, comprising mineralised collagen fibres as a ma...

journal_title：Bone

authors： Fleck C,Burke M,Ganzosch G,Müller C,Currey JD,Zaslansky P

更新日期：2020-03-01 00:00:00

abstract：:The long-term protective effect of stronger back muscles on the spine was determined in 50 healthy white postmenopausal women, aged 58-75 years, 8 years after they had completed a 2 year randomized, controlled trial. Twenty-seven subjects had performed progressive, resistive back-strengthening exercises for 2 years an...

journal_title：Bone

authors： Sinaki M,Itoi E,Wahner HW,Wollan P,Gelzcer R,Mullan BP,Collins DA,Hodgson SF

更新日期：2002-06-01 00:00:00

abstract：:High bone mass (HBM), detected in 0.2% of DXA scans, is characterised by a mild skeletal dysplasia largely unexplained by known genetic mutations. We conducted the first systematic assessment of the skeletal phenotype in unexplained HBM using pQCT in our unique HBM population identified from screening routine UK NHS D...

journal_title：Bone

authors： Gregson CL,Sayers A,Lazar V,Steel S,Dennison EM,Cooper C,Smith GD,Rittweger J,Tobias JH

更新日期：2013-01-01 00:00:00

abstract：:Bisphosphonates are widely used in the treatment of osteoporosis and contribute to the reduction of bone fractures. Ibandronate (IBN) is a highly potent, nitrogen-containing bisphosphonate, which is administered orally or intravenously at extended dosing intervals. Vitamin D or active vitamin D3 derivatives are also u...

journal_title：Bone

authors： Sakai S,Takeda S,Sugimoto M,Shimizu M,Shimonaka Y,Yogo K,Hashimoto J,Bauss F,Endo K

更新日期：2015-12-01 00:00:00

abstract：:Oral glucocorticoids (GC) preserve muscle strength and prolong walking in boys with Duchenne muscular dystrophy (DMD). Although vertebral fractures have been reported in boys taking GC, fracture rates for different GC regimes have not been investigated. The aim of this pragmatic longitudinal study was to compare growt...

journal_title：Bone

authors： Crabtree NJ,Adams JE,Padidela R,Shaw NJ,Högler W,Roper H,Hughes I,Daniel A,Mughal MZ

更新日期：2018-11-01 00:00:00

abstract：:Osteocytes can participate in systemic mineral homeostasis through perilacunar maintenance and remodeling, where changes to osteocyte lacunar morphology may affect bone structural integrity, tissue strains, and osteocyte mechanosensitivity. Though aging is associated with both decreased bone quality and altered minera...

journal_title：Bone

authors： Heveran CM,Rauff A,King KB,Carpenter RD,Ferguson VL

更新日期：2018-05-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of short RNA molecules that mediate the regulation of gene activity through interactions with target mRNAs and subsequent silencing of gene expression. It has become increasingly clear the miRNAs regulate many diverse aspects of bone biology, including bone formation and bone resorption ...

journal_title：Bone

authors： Weivoda MM,Lee SK,Monroe DG

更新日期：2021-02-01 00:00:00

abstract：PURPOSE:To compare the power of FRAX® without bone mineral density (BMD) and simpler screening tools (OST, ORAI, OSIRIS, SCORE and age alone) in predicting fractures. METHODS:This study was a prospective, population-based study performed in Denmark comprising 3614 women aged 40-90 years, who returned a questionnaire c...

journal_title：Bone

authors： Rubin KH,Abrahamsen B,Friis-Holmberg T,Hjelmborg JV,Bech M,Hermann AP,Barkmann R,Glüer CC,Brixen K

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVES:This study aimed to evaluate the involvement of Angiotensin II (Ang II) in joint lesions associated with osteoarthritis (OA) in vitro and in vivo. METHODS:Chondrocyte cultures were obtained from knee joints of neonatal rats and stimulated with Ang II/MIA/ACE inhibitors. In vivo, rats treated or not with the...

journal_title：Bone

authors： de Sá GA,Dos Santos ACPM,Nogueira JM,Dos Santos DM,Amaral FA,Jorge EC,Caliari MV,Queiroz-Junior CM,Ferreira AJ

更新日期：2021-01-07 00:00:00

abstract：:We investigated the role of 3,5,3'-tri-iodothyronine (T3) in regulating differentiation of osteoprogenitor cells and also studied the effects of the glucocorticoid hormone dexamethasone (Dex) on the T3-induced effects on osteoprogenitor populations. This was done by determining the effects of either hormone alone, or ...

journal_title：Bone

authors： Ishida H,Bellows CG,Aubin JE,Heersche JN

更新日期：1995-05-01 00:00:00

abstract：:Conventional methods used to image and quantify microdamage accumulation in bone are limited to histological sections, which are inherently invasive, destructive, two-dimensional, and tedious. These limitations inhibit investigation of microdamage accumulation with respect to volumetric spatial variation in mechanical...

journal_title：Bone

authors： Landrigan MD,Li J,Turnbull TL,Burr DB,Niebur GL,Roeder RK

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the morphological changes that take place in the subchondral bone and calcified cartilage zone in the experimental anterior cruciate ligament (ACL) dog model of osteoarthritis (OA) and analyze concomitant changes in the level of MMP-13 and cathepsin K, as well as examine the therapeutic effects of...

journal_title：Bone

authors： Pelletier JP,Boileau C,Brunet J,Boily M,Lajeunesse D,Reboul P,Laufer S,Martel-Pelletier J

更新日期：2004-03-01 00:00:00

abstract：:Pre-clinical in vivo models of multiple myeloma are essential tools for investigating the pathophysiology of multiple myeloma and for testing new therapeutic agents and strategies prior to their potential use in clinical trials. Over the last five decades, several different types of murine models of multiple myeloma h...

journal_title：Bone

authors： Paton-Hough J,Chantry AD,Lawson MA

更新日期：2015-08-01 00:00:00

abstract：:One hundred Sprague-Dawley rats were ovariectomized (OVX) or sham-operated (Sham) at the age of 12 weeks. Eight or six animals from each group were sacrificed at the following time points: 0, 2, 4, 8, 16, 28, and 40 weeks. Mechanical testing of the bones showed that the maximal load of the femoral neck remained at the...

journal_title：Bone

authors： Peng ZQ,Väänänen HK,Zhang HX,Tuukkanen J

更新日期：1997-03-01 00:00:00

abstract：:Glucocorticoids (GC) are used for the treatment of a wide spectrum of diseases because of their potent anti-inflammatory and immunosuppressive effects, and they are serious and common causes of secondary osteoporosis. Administration of intermittent parathyroid hormone (PTH) may induce formation of new bone and may cou...

journal_title：Bone

authors： Oxlund H,Ortoft G,Thomsen JS,Danielsen CC,Ejersted C,Andreassen TT

更新日期：2006-08-01 00:00:00

abstract：:Eighty-one women were studied longitudinally to measure trabecular bone mineral density (BMDTrab) and cortical bone mineral density (BMDCorti) in the distal radius by peripheral quantitative computed tomography (pQCT) at intervals of about 1 year and to calculate the rate of percent change/year. Fifty-three women were...

journal_title：Bone

authors： Hernández ER,Revilla M,Seco-Durban C,Villa LF,Cortés J,Rico H

更新日期：1997-03-01 00:00:00

abstract：:We have tested the ability of the XCT960A to detect bone loss in OVX-rats, as well as bone gain in the proximal tibial metaphysis of healthy rats treated with hPTH(1-34). The results demonstrated that high precision can be achieved, with CV's for most measurement parameters in the range of 1.6 to 5.9% being obtained i...

journal_title：Bone

authors： Gasser JA

更新日期：1995-10-01 00:00:00

abstract：:Recent studies have shown that treatment with bisphosphonates could be effective against the myelomatous skeletal deterioration. However, the mechanisms of action of these drugs in multiple myeloma (MM) have been poorly studied. In the present study, 11 patients with MM and bone lesions were treated orally with 30 mg/...

journal_title：Bone

authors： Roux C,Ravaud P,Cohen-Solal M,de Vernejoul MC,Guillemant S,Cherruau B,Delmas P,Dougados M,Amor B

更新日期：1994-01-01 00:00:00

abstract：:Bone losses are common as a consequence of unloading and also in patients with chronic obstructive pulmonary disease (COPD). Although hypoxia has been implicated as an important factor to drive bone loss, its interaction with unloading remains unresolved. The objective therefore was to assess whether human bone loss c...

journal_title：Bone

authors： Rittweger J,Debevec T,Frings-Meuthen P,Lau P,Mittag U,Ganse B,Ferstl PG,Simpson EJ,Macdonald IA,Eiken O,Mekjavic IB

更新日期：2016-10-01 00:00:00

abstract：:The effects of imaging parameters and special configuration of objects within the reconstruction space on the micro computed tomography (μCT) based mineral density have been explored, and a series of density correction curves have been presented. A manufacturer-provided calibration phantom (0, 100, 200, 400, 800 mg HA...

journal_title：Bone

authors： Entezari V,Vartanians V,Zurakowski D,Patel N,Fajardo RJ,Müller R,Snyder BD,Nazarian A

更新日期：2012-03-01 00:00:00

abstract：:The last step of the osteoclast differentiation process is cell fusion. Most efforts to understand the fusion mechanism have focused on the identification of molecules involved in the fusion process. Surprisingly, the basic fusion modalities, which are well known for fusion of other cell types, are not known for the o...

journal_title：Bone

authors： Søe K,Hobolt-Pedersen AS,Delaisse JM

更新日期：2015-04-01 00:00:00