Spatial relationships between prevalent and incident spine fractures.

abstract：:Loss of bone and muscle mass are two major clinical complications among the growing list of chronic diseases that primarily affect elderly individuals. Persistent low-grade inflammation, one of the major drivers of aging, is also associated with both bone and muscle dysfunction in aging. Particularly, chronic activati...

journal_title：Bone

authors： Davis HM,Essex AL,Valdez S,Deosthale PJ,Aref MW,Allen MR,Bonetto A,Plotkin LI

更新日期：2019-07-01 00:00:00

abstract：:Recent in vitro and animal studies suggest that cholesterol and its metabolites inhibit the functional activity of osteoblasts and thereby induce reduced bone mineralization. However, scant information is available on the clinical implication of these findings with special regard to postmenopausal bone loss. Therefore...

journal_title：Bone

authors： Tankó LB,Bagger YZ,Nielsen SB,Christiansen C

更新日期：2003-01-01 00:00:00

abstract：INTRODUCTION:The GH-IGF axis has profound effects on bone metabolism and may be important in the etiology of idiopathic osteoporosis. Serum IGF-I is often low in men with osteoporosis, which may be attributable to GH hypo-secretion or hepatic GH insensitivity. We studied the GH-IGF axis in depth to look for evidence to...

journal_title：Bone

authors： Patel MB,Arden NK,Masterson LM,Phillips DI,Swaminathan R,Syddall HE,Byrne CD,Wood PJ,Cooper C,Holt RI,Hertfordshire Cohort Study Group.

更新日期：2005-12-01 00:00:00

abstract：:Global gene expression profiling has been used to study the molecular mechanisms of increased bone remodeling caused by PHPT. This disease is a model for chronic over-stimulation of target organs by PTH due to an inappropriate overproduction of the hormone. Hyperactivity of osteoblasts and osteoclasts lead to increase...

journal_title：Bone

authors： Reppe S,Stilgren L,Olstad OK,Brixen K,Nissen-Meyer LS,Gautvik KM,Abrahamsen B

更新日期：2006-07-01 00:00:00

abstract：:The use of combined antiretroviral agents during pregnancy is important to prevent mother-to-child transmission of human immunodeficiency virus (HIV). Antiretroviral treatment (ARV) is associated with reduced bone mass and altered bone metabolism in HIV-infected patients. There are no data regarding the effect of ARV ...

journal_title：Bone

authors： Mora S,Giacomet V,Viganò A,Cafarelli L,Stucchi S,Pivetti V,Manfredini V,Puzzovio M,Zuccotti G

更新日期：2012-01-01 00:00:00

abstract：:Although a critical role of COX-2 in bone repair has been established, the mechanism involved remains unclear. During early inflammatory phase of bone healing, COX-2 is produced by the surrounding inflammatory cells as well as bone/cartilage progenitors. Based on the temporal and spatial expression of COX-2 during the...

journal_title：Bone

authors： Xie C,Ming X,Wang Q,Schwarz EM,Guldberg RE,O'Keefe RJ,Zhang X

更新日期：2008-12-01 00:00:00

abstract：:Postmenopausal fractures are associated with low bone mass; however, the role of low peak bone mass in young adults in determining subsequent osteoporosis suggests that premenopausal fractures may also be relevant. We therefore sought to determine whether a self-reported previous history of premenopausal wrist and non...

journal_title：Bone

authors： Fiorano-Charlier C,Ostertag A,Aquino JP,de Vernejoul MC,Baudoin C

更新日期：2002-07-01 00:00:00

abstract：:Paramagnetic manganese can be employed as a calcium surrogate to sensitize the magnetic resonance imaging (MRI) technique to the processing of calcium during the bone formation process. At low doses, after just 48h of exposure, osteoblasts take up sufficient quantities of manganese to cause marked reductions in the wa...

journal_title：Bone

authors： Chesnick IE,Centeno JA,Todorov TI,Koenig AE,Potter K

更新日期：2011-05-01 00:00:00

abstract：:LMP1 is an intracellular scaffold protein that contains a PDZ domain and three LIM domains. LMP1 has multiple functions including regulating mesenchymal stem cell (MSC) osteogenesis. Gene delivery of LMP1 induces bone formation in vivo in heterotopic and orthotopic sites. However, little is known about the physiologic...

journal_title：Bone

authors： Lin Z,Navarro VP,Kempeinen KM,Franco LM,Jin Q,Sugai JV,Giannobile WV

更新日期：2010-07-01 00:00:00

abstract：:In an effort to elucidate the interplay between mechanical load and proteolytic gene expression in arthritic tissue degradation, we investigated cellular morphology and mRNA levels of matrix metalloproteinase-13 (MMP-13) genes under mechanical stress in human MH7A synovial cells. The cells were isolated from the knee ...

journal_title：Bone

authors： Sun HB,Yokota H

更新日期：2001-04-01 00:00:00

abstract：:Control of systemic inorganic phosphate (Pi) levels is crucial for osteoid mineralization. Parathyroid hormone (PTH) mediates actions on phosphate homeostasis mostly by regulating the activity of the type 2 sodium-phosphate cotransporter (Npt2), and this action requires the PDZ protein NHERF1. Osteoblasts express Npt2...

journal_title：Bone

authors： Wang B,Yang Y,Liu L,Blair HC,Friedman PA

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The treatment of complex bone loss scenarios remains challenging. This study evaluates the efficacy of ex vivo regional gene therapy using transduced human adipose-derived stem cells (ASCs) overexpressing bone morphogenetic protein-2 (BMP-2) to treat critical-sized bone defects. METHODS:Critical-sized femor...

journal_title：Bone

authors： Vakhshori V,Bougioukli S,Sugiyama O,Kang HP,Tang AH,Park SH,Lieberman JR

更新日期：2020-09-01 00:00:00

abstract：:Oestrogen deficiency-related bone loss in the ovariectomized (OVX) mouse is a common model for osteoporosis. However, a comprehensive in vivo assessment of intervention-related changes in multiple bone properties, and in multiple mouse strains, is required in order to identify an appropriate model for future evaluatio...

journal_title：Bone

authors： Roberts BC,Giorgi M,Oliviero S,Wang N,Boudiffa M,Dall'Ara E

更新日期：2019-10-01 00:00:00

abstract：:Type 1 diabetes mellitus (T1DM) has been associated with deterioration of bone microarchitecture and strength, resulting in increased fracture risk. Substantial studies have revealed the capacity of moderate-intensity static magnetic fields (SMF) on promoting osteoblastogenesis in vitro and stimulating bone growth and...

journal_title：Bone

authors： Zhang H,Gan L,Zhu X,Wang J,Han L,Cheng P,Jing D,Zhang X,Shan Q

更新日期：2018-02-01 00:00:00

abstract：:The gamma-carboxy glutamic acid (Gla)-containing protein of mammalian bone (BGP, also called osteocalcin) is a 49 amino acid polypeptide containing two to three residues of gamma-carboxyglutamic acid. BGP is synthesized by osteoblastlike cells, and plasma BGP in laboratory animals is derived principally from recently ...

journal_title：Bone

authors： Catherwood BD,Marcus R,Madvig P,Cheung AK

更新日期：1985-01-01 00:00:00

abstract：:Bone is a composite biomaterial of mineral crystals, organic matrix, and water. Each contributes to bone quality and strength and may change independently, or together, with disease progression and treatment. Even so, there is a near ubiquitous reliance on ionizing x-ray-based approaches to measure bone mineral densit...

journal_title：Bone

authors： Surowiec RK,Ram S,Idiyatullin D,Goulet R,Schlecht SH,Galban CJ,Kozloff KM

更新日期：2021-02-01 00:00:00

abstract：PURPOSE:Low trauma rib fracture (hereinafter, rib fracture) is common in the elderly, but its risk factors and mortality consequence are rarely studied. We sought to define the epidemiology of rib fracture and the association between rib fracture and postfracture mortality. METHODS:The study was part of the Dubbo Oste...

journal_title：Bone

authors： Mai HT,Tran TS,Ho-Le TP,Pham TT,Center JR,Eisman JA,Nguyen TV

更新日期：2018-11-01 00:00:00

abstract：:The purpose was to investigate whether the reduction in bone mechanical strength induced by immobilization could be prevented by a bisphosphonate compound, clodronate. The torsional breaking strength of the tibia was measured using a specially constructed torsion machine. Maximum torque capacity, maximum angle of defo...

journal_title：Bone

authors： Lepola V,Jalovaara P,Väänänen K

更新日期：1994-05-01 00:00:00

abstract：:We performed a comprehensive analysis of the relationships between histologic indices in the iliac crest (cancellous bone volume, trabecular structural indices, cortical width, and core width) and bone density in the spine, hip, and wrist in 81 patients with various metabolic bone diseases including osteoporosis, oste...

journal_title：Bone

authors： Cosman F,Schnitzer MB,McCann PD,Parisien MV,Dempster DW,Lindsay R

更新日期：1992-01-01 00:00:00

abstract：:Tumor necrosis factor (TNF) actions in target tissues are mediated by various signalling pathways. The effect of TNF to stimulate resorption in fetal rat limb bones is not inhibited by indomethacin. The current studies were designed to assess the role of cyclic AMP (cAMP) and calcium as second messengers in this prost...

journal_title：Bone

authors： Shankar G,Stern PH

更新日期：1993-11-01 00:00:00

abstract：:The R51Q mutation in sorting nexin 10 (SNX10) was shown to cause a lethal genetic disease in humans, namely autosomal recessive osteopetrosis (ARO). We describe here the first R51Q SNX10 knock-in mouse model and show that mice homozygous for this mutation exhibit massive, early-onset, and widespread osteopetrosis. The...

journal_title：Bone

authors： Stein M,Barnea-Zohar M,Shalev M,Arman E,Brenner O,Winograd-Katz S,Gerstung J,Thalji F,Kanaan M,Elinav H,Stepensky P,Geiger B,Tuckermann J,Elson A

更新日期：2020-07-01 00:00:00

abstract：:Although vitamin D supplementation is a fundamental part of osteoporosis treatment, many patients do not regularly take adequate amounts. A once-weekly (OW) alendronate (ALN) preparation that includes 2800 IU of vitamin D3 in a single combination tablet (ALN+D2800) is available for treating patients and ensuring intak...

journal_title：Bone

authors： Binkley N,Ringe JD,Reed JI,Ljunggren O,Holick MF,Minne HW,Liu M,Lamotta A,West JA,Santora AC

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:X-linked hypophosphatemia (XLH) causes rickets, osteomalacia, skeletal deformities and growth impairment, due to elevated fibroblast growth factor 23 and hypophosphatemia. Conventional therapy requires high doses of phosphate salts combined with active vitamin D analogues. Risks of this regimen include nephr...

journal_title：Bone

authors： DeLacey S,Liu Z,Broyles A,El-Azab SA,Guandique CF,James BC,Imel EA

更新日期：2019-10-01 00:00:00

abstract：:Ectonucleotide phosphatase/phosphodiesterase 1 (ENPP1) deficiency results in either lethal arterial calcifications ('Generalized Arterial Calcification of Infancy' - GACI), phosphate wasting rickets ('Autosomal Recessive Hypophosphatemic Rickets type 2' - ARHR2), early onset osteoporosis, or progressive spinal rigidit...

journal_title：Bone

authors： Maulding ND,Kavanagh D,Zimmerman K,Coppola G,Carpenter TO,Jue NK,Braddock DT

更新日期：2021-01-01 00:00:00

abstract：:Matrix Extracellular Phospho-glycoprotEin (MEPE) and proteases are elevated and PHEX is defective in HYP. PHEX prevents proteolysis of MEPE and release of a protease-resistant MEPE-ASARM peptide, an inhibitor of mineralization (minhibin). Thus, in HYP, mutated PHEX may contribute to increased ASARM peptide release. Mo...

journal_title：Bone

authors： Rowe PS,Garrett IR,Schwarz PM,Carnes DL,Lafer EM,Mundy GR,Gutierrez GE

更新日期：2005-01-01 00:00:00

abstract：:Based on the fact that the klotho-deficient mouse exhibits multiple aging phenotypes, including osteopenia and subchondral sclerosis of joints, we explored the possibility of whether human klotho gene polymorphism is associated with two major age-related skeletal disorders: osteoporosis and spondylosis. Analysis of th...

journal_title：Bone

authors： Ogata N,Matsumura Y,Shiraki M,Kawano K,Koshizuka Y,Hosoi T,Nakamura K,Kuro-O M,Kawaguchi H

更新日期：2002-07-01 00:00:00

abstract：:Administration of perioperative antibiotic prophylaxis is a routine procedure in orthopedic surgery. Besides systemic prophylaxis, only few techniques are established for local application of antibiotics to reduce infection related to orthopedic implants. The aim of this study was to evaluate the efficacy of locally v...

journal_title：Bone

authors： Lucke M,Wildemann B,Sadoni S,Surke C,Schiller R,Stemberger A,Raschke M,Haas NP,Schmidmaier G

更新日期：2005-05-01 00:00:00

abstract：:It is known that marrow fat content increases in a variety of osteoporoses. This study sought to clarify this phenomenon by combining bone and marrow histomorphometry, and to determine (1) whether the marrow fat increase follows or precedes diminishment of bone volume, and (2) whether the increase in fat volume is due...

journal_title：Bone

authors： Martin RB,Zissimos SL

更新日期：1991-01-01 00:00:00

abstract：:To facilitate an understanding of the dependence of ultrasound velocity and attenuation upon the material and structural properties of cancellous bone, several theoretical concepts for ultrasound propagation have been adapted or developed, including the Biot theory and several scattering theories. Biot theory consider...

journal_title：Bone

authors： Haire TJ,Langton CM

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:Although 25-hydroxyvitamin D (25[OH]D) is commonly used to define vitamin D status, there is no consensus on the cutoff levels for vitamin D deficiency and insufficiency. In this study, we aimed to identify the 25(OH)D threshold that maximally suppressed parathyroid hormone (PTH) in Hong Kong Chinese populat...

journal_title：Bone

authors： Leung RY,Cheung BM,Nguyen US,Kung AW,Tan KC,Cheung CL

更新日期：2017-04-01 00:00:00