Altered mRNA level of matrix metalloproteinase-13 in MH7A synovial cells under mechanical loading and unloading.

abstract：:Hormone replacement therapy is effectively used to prevent postmenopausal bone loss. Variation in response to the therapy is, however, frequently seen. In addition, the direct effects of sex steroids on isolated human bone marrow stromal cells have been reported to vary depending on the donor, but the biological mecha...

journal_title：Bone

authors： Leskelä HV,Olkku A,Lehtonen S,Mahonen A,Koivunen J,Turpeinen M,Uusitalo J,Pelkonen O,Kangas L,Selander K,Lehenkari P

更新日期：2006-11-01 00:00:00

abstract：:The study reports a theranostic nature of rno-miR-300 (miR300) in the osteoblast functioning, by influencing the signaling pathway(s), associated with osteoblast differentiation. Excessive expression of miR300 suppresses osteoblast functions. Smad3 served as a validated target for miR300, on homology-based computation...

journal_title：Bone

authors： Kaur T,John AA,Sharma C,Vashisht NK,Singh D,Kapila R,Kapila S

更新日期：2021-02-01 00:00:00

abstract：:During normal aging and menopause, cancellous bone is lost at all skeletal sites due to remodeling-related factors: negative formation balance; temporarily increased remodeling space; and osteoclastic perforations. The relative importance of the various factors in inducing bone mass loss and perforations is still cont...

journal_title：Bone

authors： Thomsen JS,Mosekilde L,Mosekilde E

更新日期：1996-11-01 00:00:00

abstract：:The effects of BPs on bone formation during mechanical loading are still unknown. In this study, we evaluated the effect of minodronate on the cortical bone response to mechanical loading applied using a 4-point bending device. We used six-month old female Wistar rats and randomized into five groups (N=10/group): Vehi...

journal_title：Bone

authors： Nagira K,Hagino H,Kameyama Y,Teshima R

更新日期：2013-03-01 00:00:00

abstract：:Osteoporosis is the consequence of altered bone metabolism resulting in the systemic reduction of bone strength and increased risk of fragility fractures. MicroRNAs (miRNAs) regulate gene expression on a post-transcriptional level and are known to take part in the control of bone formation and bone resorption. In addi...

journal_title：Bone

authors： Weilner S,Skalicky S,Salzer B,Keider V,Wagner M,Hildner F,Gabriel C,Dovjak P,Pietschmann P,Grillari-Voglauer R,Grillari J,Hackl M

更新日期：2015-10-01 00:00:00

abstract：INTRODUCTION:Trace elements are known to influence bone metabolism; however, their effects may be exacerbated in renal failure because dialysis patients are unable to excrete excess elements properly. Our study correlated bone quality in dialysis patients with levels of bone fluoride, magnesium, and aluminum. A number ...

journal_title：Bone

authors： Ng AH,Hercz G,Kandel R,Grynpas MD

更新日期：2004-01-01 00:00:00

abstract：:Identification of a reliable marker of skeletal precursor cells within calcified and soft tissues remains a major challenge for the field. To address this, we used a transgenic model in which osteoblasts can be eliminated by pharmacological treatment. Following osteoblast ablation a dramatic increase in a population o...

journal_title：Bone

authors： Kalajzic Z,Li H,Wang LP,Jiang X,Lamothe K,Adams DJ,Aguila HL,Rowe DW,Kalajzic I

更新日期：2008-09-01 00:00:00

abstract：:Cortical bone, the dominant component of the human skeleton by volume, plays a key role in protecting bones from fracture. We analyzed the cortical bone effects of teriparatide treatment in postmenopausal women with osteoporosis who had previously received long-term alendronate (ALN) therapy or were treatment naïve (T...

journal_title：Bone

authors： Ma YL,Zeng QQ,Chiang AY,Burr D,Li J,Dobnig H,Fahrleitner-Pammer A,Michalská D,Marin F,Pavo I,Stepan JJ

更新日期：2014-02-01 00:00:00

abstract：:This paper describes a new alternative for individualized mechanical analysis of bone trabecular structure. This new method closes the gap between the classic homogenization approach that is applied to macro-scale models and the modern micro-finite element method that is applied directly to micro-scale high-resolution...

journal_title：Bone

authors： Podshivalov L,Fischer A,Bar-Yoseph PZ

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:The aim was to analyse risk of forearm fractures in first- and second-generation immigrants to Sweden. METHODS:A nationwide study of individuals 20 years of age and older was conducted. Forearm fractures were defined as at least one registered diagnosis in the National Patient Register between January 1, 199...

journal_title：Bone

authors： Wändell P,Li X,Carlsson AC,Sundquist J,Sundquist K

更新日期：2020-09-01 00:00:00

abstract：:Eldecalcitol (ELD), a 2β-hydroxypropyloxy derivative of 1α,25 (OH) 2D3, inhibits bone resorption more potently than alfacalcidol (ALF) while maintaining osteoblastic function in an ovariectomized (OVX) osteoporosis rat model. Alendronate (ALN), which is the most common bisphosphonate used for the treatment of osteopor...

journal_title：Bone

authors： Sugimoto M,Futaki N,Harada M,Kaku S

更新日期：2013-01-01 00:00:00

abstract：:This cohort study of postmenopausal women in the United Kingdom aged ≥50years determined the incremental cost of health care and clinical outcomes in the 12months following incident, selected fractures (non-vertebral non-hip [NVNHF], vertebral [VF] and multiple [MF]). Incremental costs and outcomes of the fracture coh...

journal_title：Bone

authors： Gutiérrez L,Roskell N,Castellsague J,Beard S,Rycroft C,Abeysinghe S,Shannon P,Gitlin M,Robbins S

更新日期：2012-09-01 00:00:00

abstract：:The purpose of this study is twofold: (a) to investigate the application of transosseous low-intensity pulsed ultrasound (LiUS) on the enhancement of fracture healing and (b) to demonstrate the ability of transosseous ultrasound propagation to monitor the healing process. A midshaft tibial osteotomy model was used on ...

journal_title：Bone

authors： Malizos KN,Papachristos AA,Protopappas VC,Fotiadis DI

更新日期：2006-04-01 00:00:00

abstract：:Mandibular condylar cartilage can be distinguished from articular and growth cartilages of long bones based on several differences in morphology, physiology, and function between these structures. However, there is almost no information available on the types of genes that contribute to these differences. In this stud...

journal_title：Bone

authors： Watahiki J,Yamaguchi T,Enomoto A,Irie T,Yoshie K,Tachikawa T,Maki K

更新日期：2008-06-01 00:00:00

abstract：:The association between sports participation during adolescence and peri- and postmenopausal bone mineral density (BMD) was examined among 2025 women aged 48-58 years. Adolescent recreational and competitive sporting activities were registered with a self-administered questionnaire. Altogether, 881 (43.5%) women state...

journal_title：Bone

authors： Puntila E,Kröger H,Lakka T,Honkanen R,Tuppurainen M

更新日期：1997-10-01 00:00:00

abstract：:Impaired osteoblast and osteocyte maturation contribute to mineralization defects and excess FGF23 expression in CKD bone. Vitamin D sterols decrease osteoid accumulation and increase FGF23 expression; these agents also increase osteoblast maturation in vitro but a link between changes in bone cell maturation, bone mi...

journal_title：Bone

authors： Pereira RC,Salusky IB,Bowen RE,Freymiller EG,Wesseling-Perry K

更新日期：2019-10-01 00:00:00

abstract：INTRODUCTION:Because osteoporotic patients are prone to fractures, it must be considered whether or not patients undergoing drug therapies should discontinue treatment after sustaining a non-vertebral fracture. This study has tested the effect of novel active vitamin D3 analog, 1alpha,25-dihydroxy-2beta(3-hydroxypropox...

journal_title：Bone

authors： Cao Y,Mori S,Mashiba T,Kaji Y,Manabe T,Iwata K,Miyamoto K,Komatsubara S,Yamamoto T

更新日期：2007-01-01 00:00:00

abstract：:The R51Q mutation in sorting nexin 10 (SNX10) was shown to cause a lethal genetic disease in humans, namely autosomal recessive osteopetrosis (ARO). We describe here the first R51Q SNX10 knock-in mouse model and show that mice homozygous for this mutation exhibit massive, early-onset, and widespread osteopetrosis. The...

journal_title：Bone

authors： Stein M,Barnea-Zohar M,Shalev M,Arman E,Brenner O,Winograd-Katz S,Gerstung J,Thalji F,Kanaan M,Elinav H,Stepensky P,Geiger B,Tuckermann J,Elson A

更新日期：2020-07-01 00:00:00

abstract：:We have previously found BMD and fracture risk to be significantly associated with the MTHFR (C677T) polymorphism in healthy postmenopausal women in the first years after menopause. Since then, other cohort studies have suggested that sufficient intake of riboflavin and/or folate may have the potential to prevent deve...

journal_title：Bone

authors： Abrahamsen B,Madsen JS,Tofteng CL,Stilgren L,Bladbjerg EM,Kristensen SR,Brixen K,Mosekilde L

更新日期：2005-03-01 00:00:00

abstract：:Osteoclast differentiation and activation is controlled, at least in part, by the counterbalancing influences of osteoprotegerin ligand (OPGL) and osteoprotegerin (OPG). Nonsteroidal anti-inflammatory drugs have been shown to inhibit bone loss in vivo and bone resorption in vitro, and this is associated with a loss of...

journal_title：Bone

authors： O'Brien EA,Williams JH,Marshall MJ

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVE:To compare the effects of TNF-α and IL-17A on osteogenic differentiation of isolated fibroblast-like synoviocytes (FLS) from healthy donors, osteoarthritis (OA) and rheumatoid arthritis (RA) patients. METHODS:FLS were cultured in osteogenic medium, with and without TNF-α and/or IL-17A. Extracellular matrix m...

journal_title：Bone

authors： Lavocat F,Osta B,Miossec P

更新日期：2016-06-01 00:00:00

abstract：:MLO-A5 cells are a fully differentiated osteoblastic cell line with the ability to rapidly synthesise mineralised extracellular matrix (ECM). We used MLO-A5 cells to develop a system for studying the mechanical modulation of bone matrix formation in 3D using a cyclic compressive loading stimulus. Polyurethane (PU) ope...

journal_title：Bone

authors： Sittichockechaiwut A,Scutt AM,Ryan AJ,Bonewald LF,Reilly GC

更新日期：2009-05-01 00:00:00

abstract：:Colony-stimulating factor-1 (CSF-1) induces osteoclast spreading that requires activation of c-Src and phosphatidyl inositol 3-kinase (PI3-K), both of which are recruited to activated c-Fms, the CSF-1 receptor. The present report provides evidence that the hemopoietic guanine nucleotide exchange factor (GEF), Vav, and...

journal_title：Bone

authors： Sakai H,Chen Y,Itokawa T,Yu KP,Zhu ML,Insogna K

更新日期：2006-12-01 00:00:00

abstract：:Short-term changes in biochemical markers of bone turnover (bone markers) have been suggested as predictors of long-term response in bone mass during antiresorptive treatment. In the Danish cohort (n = 306) of the Early Postmenopausal Intervention Cohort (EPIC) Study (n = 1609) of oral alendronate (ALN) for prevention...

journal_title：Bone

authors： Ravn P,Thompson DE,Ross PD,Christiansen C

更新日期：2003-07-01 00:00:00

abstract：:The temporal expression of bone microsomal casein kinase II, osteopontin, bone sialoprotein, alkaline phosphatase, and the accumulation of a solid calcium-inorganic orthophosphate mineral phase, have been charted from day 2 to day 21 during the repair of calvarial defects in rats induced by the implantation of decalci...

journal_title：Bone

authors： Wang J,Glimcher MJ,Mah J,Zhou HY,Salih E

更新日期：1998-06-01 00:00:00

abstract：:In order to evaluate the effects of uremia and low levels of dietary phosphorus on bone, male Sprague-Dawley rats weighing 320 +/- 20 g (12 weeks old) were subjected to either a two-step, subtotal nephrectomy or sham-operation (SO), and then fed a custom diet with either normal calcium (0.5%) and normal phosphorus (0....

journal_title：Bone

authors： Lieuallen WG,Weisbrode SE,Horst RL,Nagode LA

更新日期：1990-01-01 00:00:00

abstract：:Osteopetrotic bone shows dissociation between bone mineral density (BMD) and bone strength. In this study, volumetric BMD; preferential orientation of the extracellular matrix (ECM), which is composed of collagen fibers and apatite crystals as bone material quality; and mechanical properties of the src-/- osteopetroti...

journal_title：Bone

authors： Ishimoto T,Sato B,Lee JW,Nakano T

更新日期：2017-10-01 00:00:00

abstract：:This study reports the effects of a recreational team handball exercise programme (randomised controlled trial, RCT) on bone health, postural balance and body composition in inactive postmenopausal women without previous experience of the sport. Sixty-seven postmenopausal women (68.3 ± 6.2 years, stature 156.9 ± 5.8 c...

journal_title：Bone

authors： Pereira R,Krustrup P,Castagna C,Coelho E,Santos R,Helge EW,Jørgensen NR,Magalhães J,Póvoas S

更新日期：2021-01-13 00:00:00

abstract：:The present study was designed to evaluate the relationships between ultrasonic backscatter, density, and microarchitecture of cancellous bone. The slopes of the frequency-dependent attenuation coefficient (nBUA), ultrasound bone velocity (UBV), the frequency-averaged backscatter coefficient (BUB) were measured in 25 ...

journal_title：Bone

authors： Chaffaî S,Peyrin F,Nuzzo S,Porcher R,Berger G,Laugier P

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that low birth weight twins have a higher risk of osteoportotic fracture in later life, we investigated the association between fetal IGF axis and type-1 collagen markers of bone turnover in monochorionic (MC) twins with or without discordant birth weight of >or=20%. METHODS:Maternal a...

journal_title：Bone

authors： Bajoria R,Sooranna SR,Ward S,Chatterjee R

更新日期：2006-06-01 00:00:00