Optimal vitamin D status and its relationship with bone and mineral metabolism in Hong Kong Chinese.


BACKGROUND:Although 25-hydroxyvitamin D (25[OH]D) is commonly used to define vitamin D status, there is no consensus on the cutoff levels for vitamin D deficiency and insufficiency. In this study, we aimed to identify the 25(OH)D threshold that maximally suppressed parathyroid hormone (PTH) in Hong Kong Chinese population. METHODS:The study included 5276 participants (70% female) of the Hong Kong Osteoporosis Study aged 20 or above who had total 25(OH)D measured. Three-phase segmented regression was used to identify the optimal break-point between 25(OH)D and PTH. RESULTS:The prevalence of vitamin D deficiency observed was 43.8% and the prevalence of insufficient (<75nmol/L) or deficient (<50nmol/L) vitamin D levels was 90.1% in our study population. Using unadjusted three-phase segmented regression, the estimated first and second break-point of 25(OH)D on PTH suppression were 32nmol/L (95% CI: 29-35) and 89nmol/L (95% CI: 77-101) with an r2 of 0.048, whereas the estimated first and second break-point of 25(OH)D were 27nmol/L (95% CI: 24-30) and 47nmol/L (95% CI: 37-56) after adjusting for factors affecting bone and mineral metabolism. In addition, the relationship between 25(OH)D and PTH significantly differed by sex and age. CONCLUSION:The threshold for 25OHD at the point of maximal suppression of PTH estimated in this study was lower than the suggested threshold of vitamin D deficiency in the literature, perhaps due to race or assay differences, and the relationship between vitamin D and PTH changed with sex and age. Standardization in the methodology of searching for the optimal break-point is desirable so that a consensus on cutoff points can be obtained.






Leung RY,Cheung BM,Nguyen US,Kung AW,Tan KC,Cheung CL




Has Abstract


2017-04-01 00:00:00














  • The type II collagen N-propeptide, PIIBNP, inhibits cell survival and bone resorption of osteoclasts via integrin-mediated signaling.

    abstract:OBJECTIVE:Type IIB procollagen is characteristic of cartilage, comprising 50% of the extracellular matrix. The NH(2)-propeptide of type IIB collagen, PIIBNP, can kill tumor cells via binding to integrins α(V)β(3) and α(V)β(5). As osteoclasts rely on α(V)β(3) integrins for function in bone erosion, we sought to determin...


    pub_type: 杂志文章


    authors: Hayashi S,Wang Z,Bryan J,Kobayashi C,Faccio R,Sandell LJ

    更新日期:2011-10-01 00:00:00

  • ADAMTS-1 increases the three-dimensional growth of osteoblasts through type I collagen processing.

    abstract::The multi-domain neutral endopeptidase, ADAMTS-1 (a disintegrin and metalloprotease with thrombospondin repeats) is induced by parathyroid hormone (PTH) in rat osteoblasts and has therefore been suggested to be involved in initiation of bone remodeling. However, its function(s) in bone cells have not been studied. Her...


    pub_type: 杂志文章


    authors: Rehn AP,Birch MA,Karlström E,Wendel M,Lind T

    更新日期:2007-08-01 00:00:00

  • The risk of hip fractures in individuals over 50 years old with prediabetes and type 2 diabetes - A longitudinal nationwide population-based study.

    abstract:BACKGROUND:The present study aimed to investigate the association between type 2 diabetes mellitus (T2DM) and hip fractures using a large-scale nationwide population-based cohort that is representative of the Republic of Korea. We determined the risks of hip fractures in individuals with prediabetes and T2DM with diffe...


    pub_type: 杂志文章


    authors: Park HY,Han K,Kim Y,Kim YH,Sur YJ

    更新日期:2021-01-01 00:00:00

  • Clinical and biochemical characteristics of adults with hypophosphatasia attending a metabolic bone clinic.

    abstract:OBJECTIVES:This study sought to identify the clinical and biochemical characteristics that would help distinguish hypophosphatasia (HPP) from other metabolic bone diseases in adult patients attending a metabolic bone clinic by comparing patients who have genetically confirmed HPP with a group of patients with low bone ...


    pub_type: 杂志文章


    authors: Desborough R,Nicklin P,Gossiel F,Balasubramanian M,Walsh JS,Petryk A,Teynor M,Eastell R

    更新日期:2021-03-01 00:00:00

  • Reduced bone mineral density in postmenopausal women self-reporting premenopausal wrist fractures.

    abstract::Postmenopausal fractures are associated with low bone mass; however, the role of low peak bone mass in young adults in determining subsequent osteoporosis suggests that premenopausal fractures may also be relevant. We therefore sought to determine whether a self-reported previous history of premenopausal wrist and non...


    pub_type: 杂志文章


    authors: Fiorano-Charlier C,Ostertag A,Aquino JP,de Vernejoul MC,Baudoin C

    更新日期:2002-07-01 00:00:00

  • Estrogens, the menopause, and osteoporosis.

    abstract::There is a persuasive rationale from the use of hormone replacement therapy (HRT) at the time of the menopause, but there are a number of factors which limit its widespread application for osteoporosis. These relate partly to the long-term efficacy of HRT when given for a finite duration at the time of the menopause, ...


    pub_type: 杂志文章,评审


    authors: Kanis JA

    更新日期:1996-11-01 00:00:00

  • Platelets can neutralize hydrogen peroxide in an acute toxicity model with cells involved in granulation tissue formation.

    abstract::Platelets play a key role in the replacement of the blood clot with granulation tissue during the early steps of bone regeneration. We hypothesized that activated platelets can neutralize locally produced reactive oxygen species, thereby protecting cells involved in granulation tissue formation. The potential of plate...


    pub_type: 杂志文章


    authors: Kandler B,Maitz P,Fischer MB,Watzek G,Gruber R

    更新日期:2005-04-01 00:00:00

  • Lifelong risk factors for osteoporosis and fractures in elderly women with low body mass index--a population-based study.

    abstract::Low body weight is associated with an increased risk for osteoporosis and fractures, but the contribution of other lifestyle related factors have not been previously studied within lean elderly women. The present study evaluated the association between lifelong lifestyle factors and bone density, falls and postmenopau...


    pub_type: 杂志文章


    authors: Korpelainen R,Korpelainen J,Heikkinen J,Väänänen K,Keinänen-Kiukaanniemi S

    更新日期:2006-08-01 00:00:00

  • Osteonecrosis of the jaws (ONJ) in mice after extraction of teeth with periradicular disease.

    abstract::Osteonecrosis of the jaws (ONJ) is a complication of antiresorptive medications, such as denosumab or bisphosphonates, prescribed to patients with bone malignancy or osteoporosis. The most common instigating local factor in ONJ pathogenesis is tooth extraction. However, in adults the great majority of teeth are extrac...


    pub_type: 杂志文章


    authors: Soundia A,Hadaya D,Esfandi N,de Molon RS,Bezouglaia O,Dry SM,Pirih FQ,Aghaloo T,Tetradis S

    更新日期:2016-09-01 00:00:00

  • Effects of teriparatide on bone mineral density and bone turnover markers in Japanese subjects with osteoporosis at high risk of fracture in a 24-month clinical study: 12-month, randomized, placebo-controlled, double-blind and 12-month open-label phases.

    abstract::This multicenter study assessed the safety and efficacy of teriparatide 20 microg/day in Japanese men and women with osteoporosis at high risk of fracture during a 12-month, randomized, double-blind, placebo-controlled treatment period followed by second and third treatment periods (to 18 and 24 months, respectively,)...


    pub_type: 杂志文章,随机对照试验


    authors: Miyauchi A,Matsumoto T,Sugimoto T,Tsujimoto M,Warner MR,Nakamura T

    更新日期:2010-09-01 00:00:00

  • SIRT6 deficiency culminates in low-turnover osteopenia.

    abstract::Deficiency of Sirtuin 6 (SIRT6), a chromatin-related deacetylase, in mice reveals severe premature aging phenotypes including osteopenia. However, the underlying molecular mechanisms of SIRT6 in bone metabolism are unknown. Here we show that SIRT6 deficiency in mice produces low-turnover osteopenia caused by impaired ...


    pub_type: 杂志文章


    authors: Sugatani T,Agapova O,Malluche HH,Hruska KA

    更新日期:2015-12-01 00:00:00

  • Differences in the microarchitectural features of the lateral collapsed lesion between osteonecrosis and subchondral insufficiency fracture of the femoral head.

    abstract:BACKGROUND:Like osteonecrosis of the femoral head (ONFH), subchondral insufficiency fracture of the femoral head (SIF) causes femoral head collapse. However, little is known about the differences between the two diseases regarding the morphological features of the collapsed lesion. We tested the hypothesis that the mor...


    pub_type: 杂志文章


    authors: Kawano K,Motomura G,Ikemura S,Yamaguchi R,Baba S,Xu M,Nakashima Y

    更新日期:2020-12-01 00:00:00

  • Pharmacological inhibition of tankyrase induces bone loss in mice by increasing osteoclastogenesis.

    abstract::Tankyrase is a poly (ADP-ribose) polymerase that leads to ubiquitination and degradation of target proteins. Since tankyrase inhibitors suppress the degradation of AXIN protein, a negative regulator of the canonical Wnt pathway, they effectively act as Wnt inhibitors. Small molecule tankyrase inhibitors are being inve...


    pub_type: 杂志文章


    authors: Fujita S,Mukai T,Mito T,Kodama S,Nagasu A,Kittaka M,Sone T,Ueki Y,Morita Y

    更新日期:2018-01-01 00:00:00

  • Heterogeneity of trabecular and cortical postmenopausal bone loss: a longitudinal study with pQCT.

    abstract::Eighty-one women were studied longitudinally to measure trabecular bone mineral density (BMDTrab) and cortical bone mineral density (BMDCorti) in the distal radius by peripheral quantitative computed tomography (pQCT) at intervals of about 1 year and to calculate the rate of percent change/year. Fifty-three women were...


    pub_type: 杂志文章


    authors: Hernández ER,Revilla M,Seco-Durban C,Villa LF,Cortés J,Rico H

    更新日期:1997-03-01 00:00:00

  • Determinants of ovine compact bone viscoelastic properties: effects of architecture, mineralization, and remodeling.

    abstract::Significant decreases in ovine compact bone viscoelastic properties (specifically, stress-rate sensitivity, and damping efficiency) are associated with three years of ovariectomy and are particularly evident at higher frequencies [Proc. Orthop. Res. Soc. 27 (2002) 89]. It is unclear what materials or architectural fea...


    pub_type: 杂志文章


    authors: Les CM,Spence CA,Vance JL,Christopherson GT,Patel B,Turner AS,Divine GW,Fyhrie DP

    更新日期:2004-09-01 00:00:00

  • Bone and muscle: Interactions beyond mechanical.

    abstract::The musculoskeletal system is significantly more complex than portrayed by traditional reductionist approaches that have focused on and studied the components of this system separately. While bone and skeletal muscle are the two largest tissues within this system, this system also includes tendons, ligaments, cartilag...


    pub_type: 杂志文章,评审


    authors: Brotto M,Bonewald L

    更新日期:2015-11-01 00:00:00

  • Trabecular bone score (TBS): Method and applications.

    abstract::Trabecular bone score (TBS) is a texture index derived from standard lumbar spine dual energy X-ray absorptiometry (DXA) images and provides information about the underlying bone independent of the bone mineral density (BMD). Several salient observations have emerged. Numerous studies have examined the relationship be...


    pub_type: 杂志文章


    authors: Martineau P,Leslie WD

    更新日期:2017-11-01 00:00:00

  • Quantification of remodeling parameter sensitivity--assessed by a computer simulation model.

    abstract::During normal aging and menopause, cancellous bone is lost at all skeletal sites due to remodeling-related factors: negative formation balance; temporarily increased remodeling space; and osteoclastic perforations. The relative importance of the various factors in inducing bone mass loss and perforations is still cont...


    pub_type: 杂志文章


    authors: Thomsen JS,Mosekilde L,Mosekilde E

    更新日期:1996-11-01 00:00:00

  • A homozygous intronic branch-point deletion in the ALPL gene causes infantile hypophosphatasia.

    abstract::Hypophosphatasia (HPP) is a multi-systemic inborn disease with an extraordinary spectrum of severity, ranging from the absence of mineralization to high lethality and it involves different organs including bone, muscle, kidney, lung, gastrointestinal tract and the nervous system. The disease is characterized by low le...


    pub_type: 杂志文章


    authors: Mentrup B,Girschick H,Jakob F,Hofmann C

    更新日期:2017-01-01 00:00:00

  • Plasma cyclic AMP response to calcitonin: a potential clinical marker of bone turnover.

    abstract::A noninvasive marker of bone turnover would be useful in predicting which patients are at risk of rapid bone loss and in monitoring response to therapy. Calcitonin (CT)-induced hypocalcemia correlates with bone turnover but has not been a clinically useful test because changes in serum calcium are small, and test dura...


    pub_type: 杂志文章


    authors: Minkoff JR,Grant BF,Marcus R

    更新日期:1985-01-01 00:00:00

  • Phenotypic characterization of Grm1crv4 mice reveals a functional role for the type 1 metabotropic glutamate receptor in bone mineralization.

    abstract::Recent increasing evidence supports a role for neuronal type signaling in bone. Specifically glutamate receptors have been found in cells responsible for bone remodeling, namely the osteoblasts and the osteoclasts. While most studies have focused on ionotropic glutamate receptors, the relevance of the metabotropic glu...


    pub_type: 杂志文章


    authors: Musante I,Mattinzoli D,Otescu LA,Bossi S,Ikehata M,Gentili C,Cangemi G,Gatti C,Emionite L,Messa P,Ravazzolo R,Rastaldi MP,Riccardi D,Puliti A

    更新日期:2017-01-01 00:00:00

  • Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE-ASARM motif: a model for impaired mineralization in X-linked rickets (HYP).

    abstract::Matrix Extracellular Phospho-glycoprotEin (MEPE) and proteases are elevated and PHEX is defective in HYP. PHEX prevents proteolysis of MEPE and release of a protease-resistant MEPE-ASARM peptide, an inhibitor of mineralization (minhibin). Thus, in HYP, mutated PHEX may contribute to increased ASARM peptide release. Mo...


    pub_type: 杂志文章


    authors: Rowe PS,Garrett IR,Schwarz PM,Carnes DL,Lafer EM,Mundy GR,Gutierrez GE

    更新日期:2005-01-01 00:00:00

  • Cortical thickness relative to the transverse diameter of third metacarpal bone reflects bone mineral density in patients with rheumatoid arthritis.

    abstract:OBJECTIVE:Rheumatoid arthritis (RA) is accompanied by potential risk of bone mineral loss. In this study, we developed a screening index for the osteoporosis related level of bone mineral density loss for RA patients as a substitute to the dual-energy X-ray absorptiometry (DXA) method. METHODS:X-ray pictures of both s...


    pub_type: 杂志文章


    authors: Yoshii I,Akita K

    更新日期:2020-08-01 00:00:00

  • The study of GPX3 methylation in patients with Kashin-Beck Disease and its mechanism in chondrocyte apoptosis.

    abstract:OBJECTIVE:Selenium deficiency is a risk factor for Kashin-Beck Disease (KBD), an endemic osteoarthropathy. Although promoter hypermethylation of glutathione peroxidase 3 (GPX3) (a selenoprotein) has been identified in several cancers, little is known about promoter methylation and expression of GPX3 and their relation ...


    pub_type: 杂志文章


    authors: Han L,Yang X,Sun W,Li Z,Ren H,Li B,Zhang R,Zhang D,Shi Z,Liu J,Cao J,Zhang J,Xiong Y

    更新日期:2018-12-01 00:00:00

  • The human sialic acid-binding immunoglobulin-like lectin Siglec-9 and its murine homolog Siglec-E control osteoclast activity and bone resorption.

    abstract::Regulation of osteoclast differentiation and function is a central element in bone homeostasis. While the role of soluble factors, such as cytokines, hormones and growth factors, in controlling osteoclast differentiation has been intensively characterized, the function of surface receptors is less well understood. Sia...


    pub_type: 杂志文章


    authors: Andes FT,Adam S,Hahn M,Aust O,Frey S,Grueneboom A,Nitschke L,Schett G,Steffen U

    更新日期:2021-02-01 00:00:00

  • Increase in vertebral body size in postmenopausal women with osteoporosis.

    abstract::Bone geometry plays a prominent role in bone strength. Cross-sectional studies have shown that advancing age is associated with increasing diameter of long bones, related to both periostal apposition and endosteal resorption. However, there are few data provided by prospective studies, especially concerning the change...


    pub_type: 杂志文章


    authors: Briot K,Kolta S,Fechtenbaum J,Said-Nahal R,Benhamou CL,Roux C

    更新日期:2010-08-01 00:00:00

  • Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis.

    abstract::Levels of HtrA1 protein in cartilage have been reported to elevate in joints of human osteoarthritis patients. To understand roles of HtrA1 in normal osteogenesis as well as in pathogenesis of arthritis, we examine HtrA1 expression pattern during bone and cartilage development and in articular cartilage affected by ex...


    pub_type: 杂志文章


    authors: Tsuchiya A,Yano M,Tocharus J,Kojima H,Fukumoto M,Kawaichi M,Oka C

    更新日期:2005-09-01 00:00:00

  • Glucocorticoids: Dose-related effects on osteoclast formation and function via reactive oxygen species and autophagy.

    abstract::Whether glucocorticoids directly enhance or interrupt osteoclastogenesis is still a controversial subject. In this study, we ascertained the dose-dependent positive effects of glucocorticoids on osteoclastogenesis in vivo and in vitro as well as investigated the mechanism in vitro. As the dose of glucocorticoids incre...


    pub_type: 杂志文章


    authors: Shi J,Wang L,Zhang H,Jie Q,Li X,Shi Q,Huang Q,Gao B,Han Y,Guo K,Liu J,Yang L,Luo Z

    更新日期:2015-10-01 00:00:00

  • Peroxisome proliferator activated receptor-gamma (PPARgamma) represses thyroid hormone signaling in growth plate chondrocytes.

    abstract::Peroxisome proliferator activated receptors (PPARs) are DNA-binding nuclear hormone receptors that are upregulated in response to high fat diets. PPARs are structurally related to the type II nuclear receptors, including the thyroid hormone receptors (TRs). To investigate if PPARs modulate TR-mediated terminal differe...


    pub_type: 杂志文章


    authors: Wang L,Shao YY,Ballock RT

    更新日期:2005-09-01 00:00:00

  • A novel autologous bone graft substitute comprised of rhBMP6 blood coagulum as carrier tested in a randomized and controlled Phase I trial in patients with distal radial fractures.

    abstract::Bone morphogenetic proteins (BMPs) are known to induce new bone formation in vivo but treating trabecular bone defects with a BMP based therapeutic remains controversial. Here, we evaluated the safety and efficacy of a novel Autologous Bone Graft Substitute (ABGS) comprised of recombinant human BMP6 (rhBMP6) dispersed...


    pub_type: 杂志文章


    authors: Durdevic D,Vlahovic T,Pehar S,Miklic D,Oppermann H,Bordukalo-Niksic T,Gavrankapetanovic I,Jamakosmanovic M,Milosevic M,Martinovic S,Sampath TK,Peric M,Grgurevic L,Vukicevic S

    更新日期:2020-11-01 00:00:00