当前位置： SCI文献检索 > BONE期刊下所有文献 > Cortical and trabecular bone at the radius and tibia in postmenopausal breast cancer patients: a Peripheral Quantitative Computed Tomography (pQCT) study.

Cortical and trabecular bone at the radius and tibia in postmenopausal breast cancer patients: a Peripheral Quantitative Computed Tomography (pQCT) study.

Abstract：

:Bone morbidity associated with antineoplastic treatment is a significant health concern for postmenopausal breast cancer patients. Trials have demonstrated that adjuvant therapy with an Aromatase Inhibitor is associated with an increase in musculoskeletal disorders and bone fractures. The objective of this study was to utilize Peripheral Quantitative Computed Tomography (pQCT) to assess in vivo trabecular and cortical volumetric bone at peripheral skeletal sites in healthy postmenopausal women and breast cancer patients prescribed Anastrozole. Fifty-eight women were recruited for this study: 27 breast cancer patients and 31 healthy control participants. pQCT measurements were taken at distal and diaphyseal sites of the radius and tibia using a Stratec XCT-2000 pQCT scanner. Bone measurement values for total density and total content at the 4% radius; total and cortical content as well as cortical density at the 20% radius; total density at the 4% tibia; and cortical density at the 38% tibia were found to be significantly lower in breast cancer patients. Moreover, the duration of time on Anastrozole showed a significant negative correlation with the following measurements: total content at the 4% radius (r=-0.36, p<0.01); total content (r=-0.33, p<0.05), cortical content (r=-0.34, p<0.05) and cortical density (r=-0.44, p<0.01) at the 20% radius; as well as cortical density (r=-0.39, p<0.01) and cortical content (r=-0.27, p<0.05) at the 38% tibia. Overall, the breast cancer patients demonstrated significantly lower values for volumetric bone density and content at the radius and tibia compared with healthy postmenopausal women. Furthermore, this novel study found adverse effects from Anastrozole treatment primarily in cortical bone.

journal_name

Bone

journal_title

Bone

authors

Szabo KA,Webber CE,Adachi JD,Tozer R,Gordon C,Papaioannou A

doi

10.1016/j.bone.2010.09.025

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

218-24

issue

2

eissn

8756-3282

issn

1873-2763

pii

S8756-3282(10)01470-5

journal_volume

48

pub_type

杂志文章

相关文献

BONE文献大全
  • Cardiovascular and skeletal safety of zoledronic acid in osteoporosis observational, matched cohort study using Danish and Swedish health registries.

    abstract：BACKGROUND:This observational safety study used national registers to compare the real world cardiovascular and skeletal safety of zoledronic acid (ZA) against oral bisphosphonates (oBP) and untreated population controls. METHODS:Propensity score matched cohort study in Sweden and Denmark. RESULTS:Matched cohort 1 in...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2020.115296

    authors： Rubin KH,Möller S,Choudhury A,Zorina O,Kalsekar S,Eriksen EF,Andersen M,Abrahamsen B

    更新日期：2020-05-01 00:00:00

  • Adaptive changes in trabecular architecture in relation to functional strain patterns and disuse.

    abstract：:Principal strains and their orientation, determined from in vivo and in situ strains recorded from the lateral cortical surface of the calcaneus of potoroos (a small marsupial) during treadmill exercise and tension applied via the Achilles tendon, were compared with the underlying trabecular architecture and its align...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/8756-3282(96)00116-0

    authors： Biewener AA,Fazzalari NL,Konieczynski DD,Baudinette RV

    更新日期：1996-07-01 00:00:00

  • A review of current murine models of multiple myeloma used to assess the efficacy of therapeutic agents on tumour growth and bone disease.

    abstract：:Pre-clinical in vivo models of multiple myeloma are essential tools for investigating the pathophysiology of multiple myeloma and for testing new therapeutic agents and strategies prior to their potential use in clinical trials. Over the last five decades, several different types of murine models of multiple myeloma h...

    journal_title：Bone

    pub_type： 杂志文章,评审

    doi：10.1016/j.bone.2015.04.004

    authors： Paton-Hough J,Chantry AD,Lawson MA

    更新日期：2015-08-01 00:00:00

  • Bone histomorphometry in transiliac biopsies from 48 normal, healthy men.

    abstract：:Investigators and clinicians use bone histomorphometry data from iliac bone biopsies to study bone abnormalities in diseased patients, and to understand the safety and effectiveness of pharmaceutical interventions. This requires access to a high quality normal data-set to be used for comparisons, a resource that has n...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2018.03.019

    authors： Recker RR,Akhter MP,Lappe JM,Watson P

    更新日期：2018-06-01 00:00:00

  • No vascular calcification on cardiac computed tomography spanning asfotase alfa treatment for an elderly woman with hypophosphatasia.

    abstract：:Hypophosphatasia (HPP) is the inborn-error-of-metabolism characterized enzymatically by insufficient activity of the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP) and caused by either mono- or bi-allelic loss-of-function mutation(s) of the gene ALPL that encodes this cell surface phosphomonoester phosp...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2019.02.025

    authors： Whyte MP,McAlister WH,Mumm S,Bierhals AJ

    更新日期：2019-05-01 00:00:00

  • Mechanisms of palmitate-induced lipotoxicity in osteocytes.

    abstract：BACKGROUND:Lipotoxicity is defined as cellular toxicity observed in the presence of an abnormal accumulation of fat and adipocyte-derived factors in non-fat tissues. Palmitic acid (PA), an abundant fatty acid in the bone marrow and particularly in osteoporotic bones, affects osteoblastogenesis and osteoblast function, ...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2019.06.016

    authors： Al Saedi A,Bermeo S,Plotkin L,Myers DE,Duque G

    更新日期：2019-10-01 00:00:00

  • Has reimbursement of bone mineral density testing and anti-osteoporotic treatments improved management of osteoporosis in France?

    abstract：BACKGROUND:Since July 1, 2006 bone mineral density (BMD) testing has been reimbursed for osteoporosis screening under specific clinical conditions in France. Concurrently, drug coverage has been extended to all anti-osteoporotic treatments in women with low BMD. It was thus expected that the utilisation of BMD testing ...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2010.06.026

    authors： Canoui-Poitrine F,Jaglal S,Chapurlat R,Tainturier V,Colin C,Schott AM

    更新日期：2010-10-01 00:00:00

  • Plasma cyclic AMP response to calcitonin: a potential clinical marker of bone turnover.

    abstract：:A noninvasive marker of bone turnover would be useful in predicting which patients are at risk of rapid bone loss and in monitoring response to therapy. Calcitonin (CT)-induced hypocalcemia correlates with bone turnover but has not been a clinically useful test because changes in serum calcium are small, and test dura...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/8756-3282(85)90316-3

    authors： Minkoff JR,Grant BF,Marcus R

    更新日期：1985-01-01 00:00:00

  • Computational finite element bone mechanics accurately predicts mechanical competence in the human radius of an elderly population.

    abstract：:High-resolution peripheral quantitative computed tomography (HR-pQCT) is clinically available today and provides a non-invasive measure of 3D bone geometry and micro-architecture with unprecedented detail. In combination with microarchitectural finite element (μFE) models it can be used to determine bone strength usin...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2011.02.022

    authors： Mueller TL,Christen D,Sandercott S,Boyd SK,van Rietbergen B,Eckstein F,Lochmüller EM,Müller R,van Lenthe GH

    更新日期：2011-06-01 00:00:00

  • Severe bone loss and multiple fractures in SCN8A-related epileptic encephalopathy.

    abstract：:Mutations in the SCN8A gene encoding the neuronal voltage-gated sodium channel Nav1.6 are known to be associated with epileptic encephalopathy type 13. We identified a novel de novo SCN8A mutation (p.Phe360Ala, c.1078_1079delTTinsGC, Exon 9) in a 6-year-old girl with epileptic encephalopathy accompanied by severe juve...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2017.06.025

    authors： Rolvien T,Butscheidt S,Jeschke A,Neu A,Denecke J,Kubisch C,Meisler MH,Pueschel K,Barvencik F,Yorgan T,Oheim R,Schinke T,Amling M

    更新日期：2017-10-01 00:00:00

  • Stronger back muscles reduce the incidence of vertebral fractures: a prospective 10 year follow-up of postmenopausal women.

    abstract：:The long-term protective effect of stronger back muscles on the spine was determined in 50 healthy white postmenopausal women, aged 58-75 years, 8 years after they had completed a 2 year randomized, controlled trial. Twenty-seven subjects had performed progressive, resistive back-strengthening exercises for 2 years an...

    journal_title：Bone

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s8756-3282(02)00739-1

    authors： Sinaki M,Itoi E,Wahner HW,Wollan P,Gelzcer R,Mullan BP,Collins DA,Hodgson SF

    更新日期：2002-06-01 00:00:00

  • Use of oral bisphosphonates and risk of hospital admission with osteonecrosis of the jaw: Large prospective cohort study in UK women.

    abstract：:About 1 in 10 postmenopausal UK women are currently prescribed oral bisphosphonates, but there are concerns about their adverse effects. Osteonecrosis of the jaw is a recognised uncommon but important side effect of intravenous bisphosphonates, but epidemiological evidence on risk of osteonecrosis of the jaw associate...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2019.04.003

    authors： Wotton CJ,Green J,Brown A,Armstrong MEG,Floud S,Beral V,Reeves GK,Million Women Study collaborators.

    更新日期：2019-07-01 00:00:00

  • The beneficial effect of icaritin on osteoporotic bone is dependent on the treatment initiation timing in adult ovariectomized rats.

    abstract：BACKGROUND:Epimedium-derived flavonoids (EFs) have a potential to treat established osteoporosis in postmenopausal women. However, one of the main disadvantages of the compound is the high volume and dosage during long-term administration period. Meanwhile, the beneficial effect of EFs on osteoporotic bone depends grea...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2013.02.012

    authors： Peng S,Zhang G,Zhang BT,Guo B,He Y,Bakker AJ,Pan X,Zhen W,Hung L,Qin L,Leung WN

    更新日期：2013-07-01 00:00:00

  • Meta-analysis of walking for preservation of bone mineral density in postmenopausal women.

    abstract：:Whilst exercise is recommended for optimum bone health in adult women, there are few systematic reviews of the efficacy of walking as singular exercise therapy for postmenopausal bone loss. The aim of this study was to assess the effects of prescribed walking programmes on bone mineral density (BMD) at the hip and spi...

    journal_title：Bone

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.bone.2008.05.012

    authors： Martyn-St James M,Carroll S

    更新日期：2008-09-01 00:00:00

  • Extracellular matrix-integrin interactions in osteoblast function and tissue remodeling.

    abstract：:Previous work with cultured primary cells, from our group and from other laboratories, has shown that signals from extracellular matrix, transduced by integrins, play critical roles in regulating gene expression, tissue-specific differentiation, and survival of primary osteoblasts and fibroblasts. This summary will fo...

    journal_title：Bone

    pub_type： 杂志文章,评审

    doi：10.1016/s8756-3282(99)00106-4

    authors： Damsky CH

    更新日期：1999-07-01 00:00:00

  • Development of a molecular test of Paget's disease of bone.

    abstract：:Depending on populations, 15 to 40% of patients have a familial form of Paget's disease of bone (PDB), which is transmitted in an autosomal-dominant mode of inheritance with incomplete penetrance. To date, only SQSTM1 gene mutations have been linked to the disease. Several single nucleotide polymorphisms (SNPs) have b...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2016.01.007

    authors： Guay-Bélanger S,Simonyan D,Bureau A,Gagnon E,Albert C,Morissette J,Siris ES,Orcel P,Brown JP,Michou L

    更新日期：2016-03-01 00:00:00

  • Genome-wide association study for radiographic vertebral fractures: a potential role for the 16q24 BMD locus.

    abstract：:Vertebral fracture risk is a heritable complex trait. The aim of this study was to identify genetic susceptibility factors for osteoporotic vertebral fractures applying a genome-wide association study (GWAS) approach. The GWAS discovery was based on the Rotterdam Study, a population-based study of elderly Dutch indivi...

    journal_title：Bone

    pub_type： 杂志文章

    doi：

    authors： Oei L,Estrada K,Duncan EL,Christiansen C,Liu CT,Langdahl BL,Obermayer-Pietsch B,Riancho JA,Prince RL,van Schoor NM,McCloskey E,Hsu YH,Evangelou E,Ntzani E,Evans DM,Alonso N,Husted LB,Valero C,Hernandez JL,Lewis JR,

    更新日期：2014-02-01 00:00:00

  • Evaluation of bioreactor-cultivated bone by magnetic resonance microscopy and FTIR microspectroscopy.

    abstract：:We present a three-dimensional mineralizing model based on a hollow fiber bioreactor (HFBR) inoculated with primary osteoblasts isolated from embryonic chick calvaria. Using non-invasive magnetic resonance microscopy (MRM), the growth and development of the mineralized tissue around the individual fibers were monitore...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2006.10.020

    authors： Chesnick IE,Avallone FA,Leapman RD,Landis WJ,Eidelman N,Potter K

    更新日期：2007-04-01 00:00:00

  • Phenotyping and genotyping of skeletal dysplasias: Evolution of a center and a decade of experience in India.

    abstract：:Genetic heterogeneity, high burden and the paucity of genetic testing for rare diseases challenge genomic healthcare for these disorders in India. Here we report our experience over the past decade, of establishing the genomic evaluation of skeletal dysplasia at a tertiary university hospital in India. Research or cli...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2018.10.026

    authors： Uttarilli A,Shah H,Bhavani GS,Upadhyai P,Shukla A,Girisha KM

    更新日期：2019-03-01 00:00:00

  • Circulating sclerostin is elevated in short-term and reduced in long-term SCI.

    abstract：:Spinal cord injury (SCI) causes profound bone loss due to muscle paralysis resulting in the inability to walk. Sclerostin, a Wnt signaling pathway antagonist produced by osteocytes, is a potent inhibitor of bone formation. Short-term studies in rodent models have demonstrated increased sclerostin in response to mechan...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2012.04.019

    authors： Battaglino RA,Sudhakar S,Lazzari AA,Garshick E,Zafonte R,Morse LR

    更新日期：2012-09-01 00:00:00

  • Treatment with eldecalcitol positively affects mineralization, microdamage, and collagen crosslinks in primate bone.

    abstract：:Eldecalcitol (ELD), an active form of vitamin D analog approved for the treatment of osteoporosis in Japan, increases lumbar spine bone mineral density (BMD), suppresses bone turnover markers, and reduces fracture risk in patients with osteoporosis. We have previously reported that treatment with ELD for 6 months impr...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2014.11.025

    authors： Saito M,Grynpas MD,Burr DB,Allen MR,Smith SY,Doyle N,Amizuka N,Hasegawa T,Kida Y,Marumo K,Saito H

    更新日期：2015-04-01 00:00:00

  • Very high bone mineral density in a monogenic form of obesity-associated insulin resistance.

    abstract：INTRODUCTION:Alström syndrome (ALMS) is an ultra-rare metabolic disorder caused by biallelic loss-of-function in the Alms1 gene which encodes a ubiquitously expressed centrosomal protein of the primary cilium. Although ALMS is characterised by several metabolic and hormonal dysfunctions that can lead to an increased ri...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2020.115756

    authors： Tahani N,Choudhary S,Boivin C,Dawson C,Gittoes N,Geberhiwot T

    更新日期：2021-02-01 00:00:00

  • The effects of uremia and dietary phosphorus on the bone of rats.

    abstract：:In order to evaluate the effects of uremia and low levels of dietary phosphorus on bone, male Sprague-Dawley rats weighing 320 +/- 20 g (12 weeks old) were subjected to either a two-step, subtotal nephrectomy or sham-operation (SO), and then fed a custom diet with either normal calcium (0.5%) and normal phosphorus (0....

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/8756-3282(90)90070-f

    authors： Lieuallen WG,Weisbrode SE,Horst RL,Nagode LA

    更新日期：1990-01-01 00:00:00

  • Alendronate has a residual effect on bone mass in postmenopausal Danish women up to 7 years after treatment withdrawal.

    abstract：:Alendronate has been shown to reduce bone turnover and increase bone mass. However, little is known about the duration of the effect on bone after treatment withdrawal. The aim of this study was to investigate the long-term effects on bone mineral density (BMD) and bone turnover of various alendronate regimens after t...

    journal_title：Bone

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s8756-3282(03)00112-1

    authors： Bagger YZ,Tankó LB,Alexandersen P,Ravn P,Christiansen C

    更新日期：2003-09-01 00:00:00

  • Does the mechanical milieu associated with high-speed running lead to adaptive changes in diaphyseal growing bone?

    abstract：:Exercise during growth can be important for attaining optimal bone mass. High-intensity long-duration protocols, however, can have detrimental effects on immature bone morphology and mechanics. The underlying mechanisms are poorly understood. Here, we quantified the mechanical environment of the middiaphyseal rooster ...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/s8756-3282(99)00256-2

    authors： Judex S,Zernicke RF

    更新日期：2000-02-01 00:00:00

  • Focal changes in blood supply during normal epiphyseal growth are central in the pathogenesis of osteochondrosis in pigs.

    abstract：:Cartilage canals are temporary vessel-containing structures within the growth cartilage. The canals gradually regress with age in a process designated chondrification, where the content of the canals is replaced by cartilage. The process of chondrification is considered physiological; however, premature regression has...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2004.08.016

    authors： Ytrehus B,Ekman S,Carlson CS,Teige J,Reinholt FP

    更新日期：2004-12-01 00:00:00

  • Histomorphometric evaluation of the influence of the diabetic metabolic state on bone defect healing depending on the defect size in spontaneously diabetic BB/OK rats.

    abstract：:Insulin-dependent type 1 diabetes mellitus (IDDM) has been shown to alter the properties of bone and impair bone repair in both humans and animals. The objective of this study was the detailed histomorphometric evaluation of the influence of the diabetic metabolic state on bone formation and remodeling during bone def...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2004.03.011

    authors： Follak N,Klöting I,Wolf E,Merk H

    更新日期：2004-07-01 00:00:00

  • Effect of a general school-based physical activity intervention on bone mineral content and density: a cluster-randomized controlled trial.

    abstract：BACKGROUND:Specific physical loading leads to enhanced bone development during childhood. A general physical activity program mimicking a real-life situation was successful at increasing general physical health in children. Yet, it is not clear whether it can equally increase bone mineral mass. We performed a cluster-r...

    journal_title：Bone

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.bone.2010.11.018

    authors： Meyer U,Romann M,Zahner L,Schindler C,Puder JJ,Kraenzlin M,Rizzoli R,Kriemler S

    更新日期：2011-04-01 00:00:00

  • Evidence for a role of p38 MAP kinase in expression of alkaline phosphatase during osteoblastic cell differentiation.

    abstract：:In the present study, we investigate the implication of the mitogen-activated protein kinases (MAPKs) Erk, p38, and JNK in mediating the effect of fetal calf serum (FCS) on the differentiation of MC3T3-E1 osteoblast-like cells. Erk is stimulated by FCS in proliferating, early-differentiating, as well as in mature cell...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/s8756-3282(01)00660-3

    authors： Suzuki A,Guicheux J,Palmer G,Miura Y,Oiso Y,Bonjour JP,Caverzasio J

    更新日期：2002-01-01 00:00:00

  • Clinical and biochemical characteristics of adults with hypophosphatasia attending a metabolic bone clinic.

    abstract：OBJECTIVES:This study sought to identify the clinical and biochemical characteristics that would help distinguish hypophosphatasia (HPP) from other metabolic bone diseases in adult patients attending a metabolic bone clinic by comparing patients who have genetically confirmed HPP with a group of patients with low bone ...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2020.115795

    authors： Desborough R,Nicklin P,Gossiel F,Balasubramanian M,Walsh JS,Petryk A,Teynor M,Eastell R

    更新日期：2021-03-01 00:00:00