Abstract：
:Investigators and clinicians use bone histomorphometry data from iliac bone biopsies to study bone abnormalities in diseased patients, and to understand the safety and effectiveness of pharmaceutical interventions. This requires access to a high quality normal data-set to be used for comparisons, a resource that has not been adequate to date. The objective of this work is to present static and dynamic bone histomorphometry data from transilial bone biopsies performed on 48 healthy males, evenly distributed between ages 45 and 75. In addition, we compared these results with results from our earlier study in normal postmenopausal women (Recker et al., 1988 [1]). The data include bone density and anthropometric measurements, micro-CT, and a collection of serum biochemical measurements. We found that several of the histomorphometry variables were correlated with serum measurements, i.e. serum testosterone and sex hormone-binding globulin (SHBG). Micro-CT variables were correlated with the static histomorphometry variables, and were very similar. Age-related changes were observed for both histomorphometry and Micro-CT, but were surprisingly small in most cases. Comparisons with our previously reported histomorphometry data from normal women were surprisingly similar, but there was a significant age by gender interaction in the wall thickness (W.Th) measurements, i.e. there was a small increase in this variable with age in men, and a significant decline with age in women. The population selected for this study, and the prior study in normal women, were carefully chosen so as to rule out the presence of clinical, life-style or other confounding factors. While the cohort chosen herein was a convenience sample, and not a population-based sample, we believe it can be used as a reference standard with proper precautions in its interpretation and in its comparisons with diseased populations.
journal_name
Bonejournal_title
Boneauthors
Recker RR,Akhter MP,Lappe JM,Watson Pdoi
10.1016/j.bone.2018.03.019subject
Has Abstractpub_date
2018-06-01 00:00:00pages
109-115eissn
8756-3282issn
1873-2763pii
S8756-3282(18)30138-8journal_volume
111pub_type
杂志文章相关文献
BONE文献大全abstract：:Old age-associated osteoporosis is related to diminished bone blood flow and impaired nitric oxide (NO)-mediated vasodilation of the bone vasculature. Endurance exercise training restores the age-associated reduction of vasodilation in numerous vascular beds, as well as improving bone properties. The purpose of this s...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2009.10.029
更新日期：2010-03-01 00:00:00
abstract：:Formoterol, a beta2-adrenergic agonist has been shown in ovariectomized rat models to have anabolic effects on bone. However, those studies did not determine whether the effect of formoterol was by a direct action on bone cells themselves or indirectly via anabolic action on muscle. To address the question of whether ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(98)00026-x
更新日期：1998-05-01 00:00:00
abstract：:Androgen receptor (AR) is expressed throughout the osteoblast lineage. Two different AR transgenic families (AR2.3-tg and AR3.6-tg mice) demonstrating overlapping and distinct expression profiles were employed to assess the effects of enhanced androgen sensitivity to ameliorate hypogonadal loss. Two different paradigm...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2012.08.111
更新日期：2012-11-01 00:00:00
abstract：:Localized proton spectra of the human lumbar vertebral body were recorded in vivo at 1.5 T, using the STEAM (stimulated echo acquisition mode) pulse sequence. Thirty-seven patients (18 men, 19 women) were examined, ranging in age from 21 to 68 years (mean = 40, SD = 13). The fat fraction of the bone marrow was calcula...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(93)90239-7
更新日期：1993-03-01 00:00:00
abstract：:Glucocorticoids (GC) are used for the treatment of a wide spectrum of diseases because of their potent anti-inflammatory and immunosuppressive effects, and they are serious and common causes of secondary osteoporosis. Administration of intermittent parathyroid hormone (PTH) may induce formation of new bone and may cou...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2006.01.142
更新日期：2006-08-01 00:00:00
abstract：:On the basis of studies with bone-seeking isotopes, it is generally believed that the metabolic activity of osteoblasts of the trabecular bone is greater than that of the osteoblasts of the cortex. This implies that the oxidative activity, which provides the energy for biosyntheses, will also be greater in the former ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(89)90061-6
更新日期：1989-01-01 00:00:00
abstract：:We compared the distribution of a cysteine proteinase inhibitor, cystatin C, with that of cathepsin K in osteoclasts of the mouse tibia by immunolight and immunoelectron microscopy. Light microscopically, strong immunoreactivity for cystatin C was found extracellularly along the resorption lacuna and intracellularly i...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(01)00466-5
更新日期：2001-07-01 00:00:00
abstract：:We examined the effects of estrogen and calcium supplementation upon bone loss among a cohort of Japanese-American women. The women averaged 64 years of age (age range 45-81) and 14 years postmenopause at their initial examination in 1981. They returned at 1-3-year intervals for subsequent examinations, most recently ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(95)00249-9
更新日期：1995-10-01 00:00:00
abstract：:A 57 year old white male with oncogenous osteomalacia due to a mixed mesenchymal tumor was evaluated by sequential histologic and metabolic studies over a period of 33 mos prior to identifying the location of the tumor. On the basis of these studies we conclude: (i) disorders of the enterohepatic circulation and/or ac...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(88)90025-7
更新日期：1988-01-01 00:00:00
abstract：:Understanding the cellular basis of osteoblastic cell-biomaterial interaction is crucial to the analysis of the mechanism of osseointegration, a requirement of long-term orthopedic implant stability. Clinically, the amount of bone ingrowth is variable, and cellular parameters that influence ingrowth have yet to be cle...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(99)00077-0
更新日期：1999-05-01 00:00:00
abstract：:The effects of imaging parameters and special configuration of objects within the reconstruction space on the micro computed tomography (μCT) based mineral density have been explored, and a series of density correction curves have been presented. A manufacturer-provided calibration phantom (0, 100, 200, 400, 800 mg HA...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2011.10.004
更新日期：2012-03-01 00:00:00
abstract：:End plate chondrocyte degeneration is a major cause of intervertebral disc degeneration. Mechanical biophysical forces, including intermittent cyclic mechanical tension (ICMT), exacerbate end plate chondrocyte degeneration. However, the underlying molecular mechanism of mechanical stretch-induced end plate chondrocyte...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2019.115052
更新日期：2019-11-01 00:00:00
abstract：:Conventional methods used to image and quantify microdamage accumulation in bone are limited to histological sections, which are inherently invasive, destructive, two-dimensional, and tedious. These limitations inhibit investigation of microdamage accumulation with respect to volumetric spatial variation in mechanical...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2010.10.160
更新日期：2011-03-01 00:00:00
abstract：:Recently, the involvement of immune responses in metabolic bone disease and/or local bone destruction has received much attention. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), a member of the immunoglobulin (Ig) superfamily, negatively regulates T cell activation. The deficiency of CTLA-4 induces profound ost...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2004.06.018
更新日期：2004-11-01 00:00:00
abstract：:In recent years, great interest in combined treatment of parathyroid hormone (PTH) with anti-resorptive therapy has emerged. PTH has been suggested to aid bridging of atrophic fractures and improve strength in closed fracture models. Bisphosphonate treatments typically result in a larger woven bone callus that is slow...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2016.08.012
更新日期：2016-11-01 00:00:00
abstract：:The hypocalcemic and hypophosphatemic effect of salmon calcitonin (sCT) given by intranasal (i.n.) spray to 12 patients with histological confirmed primary hyperparathyroidism (1 degree HPT) was studied. The concentration of ionized calcium in whole blood (B-Ca++), serum phosphate (S-P), magnesium (S-Mg), plasma sCT (...
journal_title：Bone
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/8756-3282(91)90016-c
更新日期：1991-01-01 00:00:00
abstract：:The adult human skeleton is a multifunctional organ undergoing constant remodeling through the opposing activities of the bone-resorbing osteoclast and the bone-forming osteoblast. The exquisite balance between bone resorption and bone formation is responsible for bone homeostasis in healthy adults. However, evidence ...
journal_title：Bone
pub_type： 杂志文章,评审
doi：10.1016/j.bone.2017.08.008
更新日期：2018-10-01 00:00:00
abstract：:Treatment with parathyroid hormone 1-84 (PTH) or teriparatide increases osteonal remodeling and decreases bone mineral density (BMD) at cortical (Ct) bone sites but may also increase bone size. Decreases in BMD and increases in size exert opposing effects on bone strength. In adult ovariectomized (OVX) rhesus monkeys,...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2007.04.197
更新日期：2007-09-01 00:00:00
abstract：BACKGROUND:Vertebral fracture (VF) is the most common osteoporotic fracture in postmenopausal women, although most VFs are subclinical. Prevalent VFs are a significant predictor of subsequent fracture and therefore, identification of VF improves the identification of those with high fracture risk. The aim of present st...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2020.115358
更新日期：2020-07-01 00:00:00
abstract：:Bone fragility is a concern for aged and diseased bone. Measuring bone toughness and understanding fracture properties of the bone are critical for predicting fracture risk associated with age and disease and for preclinical testing of therapies. A reference point indentation technique (BioDent) has recently been deve...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2014.09.020
更新日期：2014-12-01 00:00:00
abstract：:A mildly elevated homocysteine (Hcy) level is a novel and potentially modifiable risk factor for age-related osteoporotic fractures. Elevated Hcy levels can have a nutritional cause, such as inadequate intake of folate, riboflavin, pyridoxine or cobalamin, which serve as cofactors or substrates for the enzymes involve...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2007.08.021
更新日期：2007-12-01 00:00:00
abstract：:This study describes the early interface reaction of cancellous bone to a nanocrystalline hydroxyapatite cement containing type I collagen (HA/Coll) and its modifications with sodium citrate (CI), calcium carbonate (CA), phosphoserine (P) and phosphoserine plus RGD-peptide (RGD). Cylindrical implants of HA/Coll and it...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2006.11.019
更新日期：2007-04-01 00:00:00
abstract：:Leptin has been suggested to mediate a variety of actions, including bone development, via its ubiquitously expressed receptor (Ob-Rb). In this study, we investigated the role of leptin in endochondral ossification at the growth plate. The growth plates of wild-type and ob/ob mice were analyzed. Effects of leptin on c...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2005.05.009
更新日期：2005-11-01 00:00:00
abstract：BACKGROUND:Prior research on the ability of bisphosphonates to prevent fractures and related health care utilization has been based on high levels of compliance achievable in clinical trial settings. This study was undertaken to assess rates of osteoporotic fractures and health care utilization as a function of bisphos...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2007.07.009
更新日期：2007-11-01 00:00:00
abstract：:The purpose of this study is twofold: (a) to investigate the application of transosseous low-intensity pulsed ultrasound (LiUS) on the enhancement of fracture healing and (b) to demonstrate the ability of transosseous ultrasound propagation to monitor the healing process. A midshaft tibial osteotomy model was used on ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2005.10.012
更新日期：2006-04-01 00:00:00
abstract：:The tooth root is essential for normal tooth physiological function. Studies on mice with mutations or targeted gene deletions revealed that osteoclasts (OCs) play an important role in tooth root development. However, knowledge on the cellular and molecular mechanism underlying how OCs mediate root formation is limite...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2017.12.026
更新日期：2018-09-01 00:00:00
abstract：:Prenatal dexamethasone exposure (PDE) induces developmental toxicities of multi-organs and susceptibility to multi-diseases in offspring. However, the effects of PDE on osteoarthritis susceptibility in adult offspring and its mechanism have not been reported. In the present study, we treated pregnant Wistar rats with ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2020.115245
更新日期：2020-04-01 00:00:00
abstract：INTRODUCTION:The GH-IGF axis has profound effects on bone metabolism and may be important in the etiology of idiopathic osteoporosis. Serum IGF-I is often low in men with osteoporosis, which may be attributable to GH hypo-secretion or hepatic GH insensitivity. We studied the GH-IGF axis in depth to look for evidence to...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2005.06.016
更新日期：2005-12-01 00:00:00
abstract：:We examined the effect of nicotine on cellular proliferation, as measured by [3H]thymidine (TdR) incorporation and cell count, and on alkaline phosphatase activity in UMR 106-01 rat osteoblastic osteosarcoma cells. The cells were cultured with varying concentrations of nicotine in serum-free medium for 2 to 72 hours. ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(91)90077-v
更新日期：1991-01-01 00:00:00
abstract：:Parathyroid hormone (PTH) and tumor necrosis factoralpha (TNFalpha) are bone resorptive agents that upregulate interleukin-6 (IL-6) and RANKL production by osteoblasts. IL-6 mRNA expression induced by PTH is rapid and transient in osteoblasts both in vitro and in vivo. This study found that IL-6 secretion induced by P...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2005.10.007
更新日期：2006-04-01 00:00:00
