Abstract：
:In order to evaluate the effects of uremia and low levels of dietary phosphorus on bone, male Sprague-Dawley rats weighing 320 +/- 20 g (12 weeks old) were subjected to either a two-step, subtotal nephrectomy or sham-operation (SO), and then fed a custom diet with either normal calcium (0.5%) and normal phosphorus (0.3%) (NCNP), or normal calcium and low phosphorus (0.03%). When compared to the NCNP SO group after seven days, only uremic rats fed low phosphorus diets developed osteomalacia characterized by an increase in the osteoid thickness, surface and volume, a prolonged osteoid maturation time, and a decreased bone formation rate. No other groups developed these changes. This osteomalacia was also associated with hypophosphatemia, a reduced serum PTH and an elevation in the serum 1,25(OH)2D3. It was concluded that while neither this degree of uremia nor the low phosphorus diets alone had any significant effect, the combination of uremia and low dietary phosphorus resulted in the initiation of osteomalacia. This animal model should prove useful in investigations dealing with the influence of uremia on the mineralization process.
journal_name
Bonejournal_title
Boneauthors
Lieuallen WG,Weisbrode SE,Horst RL,Nagode LAdoi
10.1016/8756-3282(90)90070-fsubject
Has Abstractpub_date
1990-01-01 00:00:00pages
41-6issue
1eissn
8756-3282issn
1873-2763pii
8756-3282(90)90070-Fjournal_volume
11pub_type
杂志文章相关文献
BONE文献大全abstract：BACKGROUND:Avoidant Restrictive Food Intake Disorder (ARFID) and Anorexia Nervosa (AN) cause significant underweight in children and young people (CYP). The association of low bone mineral density (BMD) and underweight CYP in AN is well established, but less is known about BMD in ARFID. METHODS:Retrospective case-note...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2020.115307
更新日期：2020-05-01 00:00:00
abstract：:On the basis of previous investigations indicating that the distribution of osteonic and interstitial lamellae in a normal femur depends on its mechanical properties, a procedure has been devised to provide information on the distribution of lamellae in human femora diaphyses deformed by bending. To achieve this, exac...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(87)90009-3
更新日期：1987-01-01 00:00:00
abstract：:Progressive osseous heteroplasia (POH) is a rare autosomal dominant disorder of mesenchymal differentiation characterized by progressive heterotopic ossification (HO) of dermis, deep connective tissues and skeletal muscle. Usually, initial bone formation occurs during infancy as primary osteoma cutis (OC) then progres...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2013.06.015
更新日期：2013-10-01 00:00:00
abstract：:While increasing age, decreasing body mass index (BMI), and physical inactivity are known to increase hip fracture risk, whether these factors have similar effects on other common fractures is not well established. We used prospectively-collected data from a large cohort to examine the role of these factors on the ris...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2012.03.014
更新日期：2012-06-01 00:00:00
abstract：:Estrogen and calcium deficiencies increase both bone resorption and formation, whereas immobilization mainly decreases bone formation. How these functionally different risk factors for bone loss interact in cancellous bone undergoing modeling or remodeling activity is not well understood. Mature (6-month-old) female r...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(97)00070-7
更新日期：1997-07-01 00:00:00
abstract：:The effects of glucocorticoid (GC) excess, thyrotoxicosis, and hypothyroidism on linear growth indicate that growth plate chondrocytes are exquisitely sensitive to GC and thyroid hormone (T(3)). Murine ATDC5 cells undergo chondrogenesis in vitro and were used to evaluate the effects of dexamethasone (Dex) and T(3) on ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(02)00855-4
更新日期：2002-10-01 00:00:00
abstract：:Bone morbidity associated with antineoplastic treatment is a significant health concern for postmenopausal breast cancer patients. Trials have demonstrated that adjuvant therapy with an Aromatase Inhibitor is associated with an increase in musculoskeletal disorders and bone fractures. The objective of this study was t...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2010.09.025
更新日期：2011-02-01 00:00:00
abstract：:Ectonucleotide phosphatase/phosphodiesterase 1 (ENPP1) deficiency results in either lethal arterial calcifications ('Generalized Arterial Calcification of Infancy' - GACI), phosphate wasting rickets ('Autosomal Recessive Hypophosphatemic Rickets type 2' - ARHR2), early onset osteoporosis, or progressive spinal rigidit...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2020.115656
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:WNT signaling plays a major role in bone and cartilage metabolism. Impaired WNT/β-catenin signaling leads to early-onset osteoporosis, but specific features in bone and other tissues remain inadequately characterized. We have identified two large Finnish families with early-onset osteoporosis due to a hetero...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2017.04.001
更新日期：2017-08-01 00:00:00
abstract：INTRODUCTION:Sex steroids have distinct effects on bone growth and maintenance in men and women, mediated through their respective steroid receptors. Though most evidence is derived from animal studies, several concepts have been confirmed in humans by detection of specific mutations. In this report we describe changes...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2009.04.198
更新日期：2009-08-01 00:00:00
abstract：:Hypercalcemia results from an imbalance between the fluxes of calcium (Ca) entering and leaving the extracellular space. The two most important influxes are the net intestinal Ca absorption and the net skeletal Ca resorption, whereas the renal excretion represents the main route of elimination. When produced in excess...
journal_title：Bone
pub_type： 杂志文章,评审
doi：
更新日期：1987-01-01 00:00:00
abstract：:The direct effects of physical activity on long bones are already recognized. However, little information is available regarding distant osseous sites, such as maxillary bone. We evaluated the influence of physical training on alveolar bone quality, with and without mechanically-induced load during orthodontic tooth m...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2020.115496
更新日期：2020-09-01 00:00:00
abstract：:In some types of low-trauma fractures of older adults the number and incidence of fractures are stabilizing or even decreasing. However, very little population-based information is available concerning the nationwide numbers, incidences and especially secular trends of low-trauma fractures of the distal humerus. There...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2009.11.025
更新日期：2010-05-01 00:00:00
abstract：:An emerging strategy in the regeneration and repair of bone is to use stem cells, including bone marrow mesenchymal stem cells, which are the most investigated and reliable source for tissue engineering, as well as circulating skeletal stem/progenitor cells, which are receiving abundant attention in regenerative medic...
journal_title：Bone
pub_type： 杂志文章,评审
doi：10.1016/j.bone.2008.05.001
更新日期：2008-09-01 00:00:00
abstract：:Biochemical bone turnover markers (BTMs) provide important information on the diagnosis, therapy and monitoring of metabolic bone diseases including osteoporosis. One goal of antiresorptive therapy in women is to decrease biochemical BTMs to the lower half of reference intervals for healthy pre-menopausal counterparts...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2010.07.017
更新日期：2010-10-01 00:00:00
abstract：:If muscle force is a primary source for triggering bone adaptation, with disuse and reloading, bone changes should follow muscle changes. We examined the timing and magnitude of changes in muscle cross-sectional area (MCSA) and bone architecture in response to muscle inactivity following botulinum toxin (BTX) injectio...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2009.10.016
更新日期：2010-01-01 00:00:00
abstract：:Women with prevalent fractures have an increased risk of developing additional, incident fractures. This article examines the relation between the location of prevalent fractures within the spine and the risk of subsequent vertebral fractures. The subjects were 721 Japanese-American women of mean age 69.5 +/- 5.3 (SD)...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(98)00176-8
更新日期：1999-03-01 00:00:00
abstract：:Ginsenoside Rh2 is one of the most active components of red ginseng, controlling cancer and other metabolic diseases including osteoclast differentiation. However, the molecular mechanism underlying the inhibition of osteoclast differentiation by ginsenoside Rh2 remains poorly understood. In the present study, it was ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2012.03.022
更新日期：2012-06-01 00:00:00
abstract：:There is a lot of interest for how and how much osteoclasts resorb bone. However, little is known about the mechanism which controls the orientation and the duration of a resorptive event, thereby determining the specific geometry of a cavitation. Here we show that the relative rate of collagenolysis vs. demineralizat...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2013.06.007
更新日期：2013-09-01 00:00:00
abstract：:We previously reported that calcium intake enhanced the leg bone response to physical activity of preschool children in a 12-month randomized trial of calcium supplementation and physical activity. To determine whether the intervention-induced changes in leg bone mineral content and size were maintained through the su...
journal_title：Bone
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.bone.2004.08.012
更新日期：2004-12-01 00:00:00
abstract：:Parathyroid hormone (PTH) and tumor necrosis factoralpha (TNFalpha) are bone resorptive agents that upregulate interleukin-6 (IL-6) and RANKL production by osteoblasts. IL-6 mRNA expression induced by PTH is rapid and transient in osteoblasts both in vitro and in vivo. This study found that IL-6 secretion induced by P...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2005.10.007
更新日期：2006-04-01 00:00:00
abstract：PURPOSE:The accepted mechanism explaining the accelerated growth following periosteal resection is that the periosteum serves as a mechanical restraint to restrict physeal growth. To test the veracity of this mechanism we first utilized Second Harmonic Generation (SHG) imaging to measure differences of periosteal fiber...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2016.08.021
更新日期：2016-11-01 00:00:00
abstract：:Osteoclasts form when hematopoietic cells are stimulated by macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-kappaB ligand (RANKL) or tumor necrosis factor-alpha (TNFalpha). Osteoclast precursors derive from M-CSF-dependent proliferating hematopoietic cells but cannot yet be purified from mixe...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(01)00654-8
更新日期：2002-01-01 00:00:00
abstract：:Aging is associated with gradual bone loss in men and premenopausal women, with an accelerated rate of loss after menopause in women. Although many studies have investigated bone loss due to surgically induced estrogen depletion, little is known regarding normal age-related changes in bone mass in animal models. We us...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(00)00452-x
更新日期：2001-03-01 00:00:00
abstract：:The uncarboxylated form of the osteoblast-specific secreted molecule osteocalcin is a hormone favoring glucose handling and increasing energy expenditure. As a result, the absence of osteocalcin leads to glucose intolerance in mice, while genetically modified mice with an increase in uncarboxylated osteocalcin are pro...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2011.04.017
更新日期：2012-02-01 00:00:00
abstract：:The purpose was to investigate whether the reduction in bone mechanical strength induced by immobilization could be prevented by a bisphosphonate compound, clodronate. The torsional breaking strength of the tibia was measured using a specially constructed torsion machine. Maximum torque capacity, maximum angle of defo...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(94)90302-6
更新日期：1994-05-01 00:00:00
abstract：:With the increased burden of low back pain (LBP) in our globally aging population there is a need to develop preclinical models of LBP that capture clinically relevant features of physiological aging, degeneration, and disability. Here we assess the validity of using a mouse model system for age-related LBP by charact...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2019.03.037
更新日期：2019-06-01 00:00:00
abstract：:Increases in local and systemic bone resorption are hallmarks of rheumatoid arthritis (RA). Osteoclasts are implicated in these processes and their enhanced differentiation may contribute to bone destruction. We observed that in vitro osteoclastogenesis varies among healthy individuals and hypothesized that increased ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2010.10.167
更新日期：2011-03-01 00:00:00
abstract：:Osteocytes form over 90% of the bone cells and are postulated to be mechanosensors responsible for regulating the function of osteoclasts and osteoblasts in bone modeling and remodeling. Physical activity results in mechanical loading on the bones. Osteocytes are thought to be the main mechanosensory cells in bone. Up...
journal_title：Bone
pub_type： 杂志文章,评审
doi：10.1016/j.bone.2020.115328
更新日期：2020-08-01 00:00:00
abstract：:Loss of bone and muscle mass are two major clinical complications among the growing list of chronic diseases that primarily affect elderly individuals. Persistent low-grade inflammation, one of the major drivers of aging, is also associated with both bone and muscle dysfunction in aging. Particularly, chronic activati...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2019.04.012
更新日期：2019-07-01 00:00:00
