A nonhuman primate model of age-related bone loss: a longitudinal study in male and premenopausal female rhesus monkeys.

abstract：:Ossification of the posterior longitudinal ligament of the spine (OPLL) is characterized by ectopic bone formation in the spinal ligaments. Mechanical stress, which acts on the posterior ligaments, is thought to be an important factor in the progression of OPLL. To elucidate this mechanism, we investigated the effects...

journal_title：Bone

authors： Tanno M,Furukawa KI,Ueyama K,Harata S,Motomura S

更新日期：2003-10-01 00:00:00

abstract：:Recent studies have established that generalized loss of trabecular bone occurs in the growing rat following day-to-day inflammatory irritation for a period of 3 wk. We can now demonstrate that there are similar effects on bone in milder but more prolonged chronic inflammation (14 wk). Thus, there were significant dec...

journal_title：Bone

authors： Pfeilschifter J,Minne HW,Enzmann E,Krempien B,Ziegler R

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Since July 1, 2006 bone mineral density (BMD) testing has been reimbursed for osteoporosis screening under specific clinical conditions in France. Concurrently, drug coverage has been extended to all anti-osteoporotic treatments in women with low BMD. It was thus expected that the utilisation of BMD testing ...

journal_title：Bone

authors： Canoui-Poitrine F,Jaglal S,Chapurlat R,Tainturier V,Colin C,Schott AM

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:Autosomal recessive osteopetrosis (ARO) is a rare congenital disorder of defective bone resorption. The inability of osteoclasts to resorb bone compromises the development of bone marrow cavity, and ultimately, leads to defective hematopoiesis and death within the first decade. The only curative treatment cur...

journal_title：Bone

authors： Maximova N,Zennaro F,Gregori M,Boz G,Zanon D,Mbalaviele G

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:Osteocalcin (OC) is the most abundant non-collagenous bone protein and is determinant for bone mineralization. We aimed to compare OC bone expression and serum factors related to its carboxylation in hip fragility fracture and osteoarthritis patients. We also aimed to identify which of these factors were a...

journal_title：Bone

authors： Rodrigues AM,Caetano-Lopes J,Vale AC,Vidal B,Lopes A,Aleixo I,Polido-Pereira J,Sepriano A,Perpétuo IP,Monteiro J,Vaz MF,Fonseca JE,Canhão H

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:High-resolution peripheral quantitative computed tomography (HR-pQCT) represents a three-dimensional tool for the screening of osteoporosis patients i.e., regarding fracture risk. The purpose of this study was to determine the baseline and follow-up bone microarchitecture in relation to incident fracture ris...

journal_title：Bone

authors： Butscheidt S,Rolvien T,Vettorazzi E,Frieling I

更新日期：2018-09-01 00:00:00

abstract：INTRODUCTION:High plasma homocysteine (Hcy) levels have been associated with increased risk of fracture. Since Hcy has been shown to induce apoptosis in many cell types, including vascular endothelial cells, we hypothesized that Hcy would have a similar apoptotic effect on osteoblasts, leading to osteoporosis by reduci...

journal_title：Bone

authors： Kim DJ,Koh JM,Lee O,Kim NJ,Lee YS,Kim YS,Park JY,Lee KU,Kim GS

更新日期：2006-09-01 00:00:00

abstract：:Recent increasing evidence supports a role for neuronal type signaling in bone. Specifically glutamate receptors have been found in cells responsible for bone remodeling, namely the osteoblasts and the osteoclasts. While most studies have focused on ionotropic glutamate receptors, the relevance of the metabotropic glu...

journal_title：Bone

authors： Musante I,Mattinzoli D,Otescu LA,Bossi S,Ikehata M,Gentili C,Cangemi G,Gatti C,Emionite L,Messa P,Ravazzolo R,Rastaldi MP,Riccardi D,Puliti A

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:While the importance of cortical structure quantification is increasingly underscored by recent literature, conventional analysis techniques obscure potentially important regional variations in cortical structure. The objective of this study was to characterize the spatial variability in cortical geometry and...

journal_title：Bone

authors： Kazakia GJ,Nirody JA,Bernstein G,Sode M,Burghardt AJ,Majumdar S

更新日期：2013-02-01 00:00:00

abstract：:High fat diets can have detrimental effects on the skeleton as well as cause intestinal dysbiosis. Exercise prevents high fat (HF) diet-induced obesity and also improves bone density and prevents the intestinal dysbiosis that promotes energy storage. Previous studies indicate a link between intestinal microbial balanc...

journal_title：Bone

authors： McCabe LR,Irwin R,Tekalur A,Evans C,Schepper JD,Parameswaran N,Ciancio M

更新日期：2019-01-01 00:00:00

abstract：:Osteocytes have been implicated in the control of bone formation. However, the signal transduction pathways that regulate the biological function of osteocytes are poorly defined. Limited evidence suggests an important role for the Gs/cAMP pathway in osteocyte function. In the present study, we explored the hypothesis...

journal_title：Bone

authors： Kao RS,Abbott MJ,Louie A,O'Carroll D,Lu W,Nissenson R

更新日期：2013-08-01 00:00:00

abstract：:Intracortical remodeling in the adult skeleton removes and replaces areas of compact bone that have sustained microdamage. Although studies have been performed in animal species in which there is an existing baseline of remodeling activity, laboratory rodents have been considered to have limited suitability as models ...

journal_title：Bone

authors： Bentolila V,Boyce TM,Fyhrie DP,Drumb R,Skerry TM,Schaffler MB

更新日期：1998-09-01 00:00:00

abstract：:Mouse serum alkaline phosphatase (ALP) is frequently measured and interpreted in mammalian bone research. However, little is known about the circulating ALPs in mice and their relation to human ALP isozymes and isoforms. Mouse ALP was extracted from liver, kidney, intestine, and bone from vertebra, femur and calvaria ...

journal_title：Bone

authors： Halling Linder C,Englund UH,Narisawa S,Millán JL,Magnusson P

更新日期：2013-04-01 00:00:00

abstract：:Several animal studies have showed that gelatin may be effective for minimizing bone loss in OVX rats with established osteopenia. To gain insight into how cod bone gelatin administration affects bone loss after ovariectomy, studies were carried out focusing on bone quality and the molecular mechanisms. Eighty-four fe...

journal_title：Bone

authors： Han X,Xu Y,Wang J,Pei X,Yang R,Li N,Li Y

更新日期：2009-05-01 00:00:00

abstract：:The aim of this study was to provide insight into the bone mineral status and biochemical markers of bone metabolism in a Chinese population from Shenyang, in the north of China, where hip fracture incidence is low. A total of 194 healthy men and women, aged 25-35 years and 65-75 years, were studied. Bone mineral dens...

journal_title：Bone

authors： Yan L,Prentice A,Zhou B,Zhang H,Wang X,Stirling DM,Laidlaw A,Han Y,Laskey A

更新日期：2002-02-01 00:00:00

abstract：:Large, cylindrical implants of a porous calcium phosphate ceramic ("hydroxyapatite" starting material, HAC) were used to replace far greater than critical-sized sections of the midshaft of sheep tibiae and retrieved at 2 and 9 months; external fixation was used in the first 5 months. Excellent clinical function of the...

journal_title：Bone

authors： Boyde A,Corsi A,Quarto R,Cancedda R,Bianco P

更新日期：1999-06-01 00:00:00

abstract：:GM1 gangliosidosis is a lysosomal storage disorder caused by mutations in GLB1 encoding a lysosomal β-galactosidase. This disease is a continuum from the severe infantile form with rapid neurological decline to the chronic adult form, which is not life-limiting. The intermediate or type 2 form can be further classifie...

journal_title：Bone

authors： Ferreira CR,Regier DS,Yoon R,Pan KS,Johnston JM,Yang S,Spranger JW,Tifft CJ

更新日期：2020-02-01 00:00:00

abstract：INTRODUCTION:Because osteoporotic patients are prone to fractures, it must be considered whether or not patients undergoing drug therapies should discontinue treatment after sustaining a non-vertebral fracture. This study has tested the effect of novel active vitamin D3 analog, 1alpha,25-dihydroxy-2beta(3-hydroxypropox...

journal_title：Bone

authors： Cao Y,Mori S,Mashiba T,Kaji Y,Manabe T,Iwata K,Miyamoto K,Komatsubara S,Yamamoto T

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:The RANKL-OPG axis is a key regulator of osteoclastogenesis and bone turnover activity. Its contribution to bone resorption under altered mechanical states, however, has not been fully elucidated. Here we examined the role of OPG in regulating mechanically induced bone modeling in a rat model of orthodonti...

journal_title：Bone

authors： Dunn MD,Park CH,Kostenuik PJ,Kapila S,Giannobile WV

更新日期：2007-09-01 00:00:00

abstract：:One year of treatment with bisphosphonates at 5x the dose used for post-menopausal osteoporosis significantly increases failure load and microdamage, and decreases toughness at multiple skeletal sites in intact female beagles. The goal of this study was to determine if similar changes occur with doses equivalent to th...

journal_title：Bone

authors： Allen MR,Iwata K,Phipps R,Burr DB

更新日期：2006-10-01 00:00:00

abstract：:Osteonecrosis of the jaws (ONJ) is a complication of antiresorptive medications, such as denosumab or bisphosphonates, prescribed to patients with bone malignancy or osteoporosis. The most common instigating local factor in ONJ pathogenesis is tooth extraction. However, in adults the great majority of teeth are extrac...

journal_title：Bone

authors： Soundia A,Hadaya D,Esfandi N,de Molon RS,Bezouglaia O,Dry SM,Pirih FQ,Aghaloo T,Tetradis S

更新日期：2016-09-01 00:00:00

abstract：:Studies were carried out to characterize the effects of cyclosporines and FK506 on the formation and survival of osteoclasts deriving from mouse bone marrow cultures. Cyclosporin A (CsA), cyclosporin B (CsB), cyclosporin H (CsH), and FK506 all inhibited receptor activator of NFkappaB ligand (RANKL)-stimulated tartrate...

journal_title：Bone

authors： Igarashi K,Hirotani H,Woo JT,Stern PH

更新日期：2004-07-01 00:00:00

abstract：:Osteocytes are cells buried in the bone matrix. They largely contribute to the regulation of bone remodeling in response to mechanical and microenvironmental changes. Much has been recognized in recent years regarding the role of osteocytes in bone homeostasis, nevertheless their ability to directly contribute to mine...

journal_title：Bone

authors： Teti A,Zallone A

更新日期：2009-01-01 00:00:00

abstract：:Hypophosphatasia (HPP) is caused by loss-of-function mutation(s) within the gene TNSALP that encodes the "tissue-nonspecific" isoenzyme of alkaline phosphatase (TNSALP). In HPP, inorganic pyrophosphate, an inhibitor of mineralization and substrate for TNSALP, accumulates extracellularly often leading to rickets or ost...

journal_title：Bone

authors： Whyte MP,Zhang F,Wenkert D,McAlister WH,Mack KE,Benigno MC,Coburn SP,Wagy S,Griffin DM,Ericson KL,Mumm S

更新日期：2015-06-01 00:00:00

abstract：:Depending on populations, 15 to 40% of patients have a familial form of Paget's disease of bone (PDB), which is transmitted in an autosomal-dominant mode of inheritance with incomplete penetrance. To date, only SQSTM1 gene mutations have been linked to the disease. Several single nucleotide polymorphisms (SNPs) have b...

journal_title：Bone

authors： Guay-Bélanger S,Simonyan D,Bureau A,Gagnon E,Albert C,Morissette J,Siris ES,Orcel P,Brown JP,Michou L

更新日期：2016-03-01 00:00:00

abstract：:The proliferation inhibitor of the macrolide class, everolimus, is a drug shown to be effective in the prevention of organ transplant rejection and to have a potential in the treatment of rheumatoid arthritis and certain cancers. As these diseases or their current treatments are associated with bone loss, we examined ...

journal_title：Bone

authors： Kneissel M,Luong-Nguyen NH,Baptist M,Cortesi R,Zumstein-Mecker S,Kossida S,O'Reilly T,Lane H,Susa M

更新日期：2004-11-01 00:00:00

abstract：:The neuropeptide Y system has emerged as one of the major neural signalling pathways regulating bone homeostasis. Absence of Y1 receptor signalling from bone forming osteoblasts is responsible for an enhancement on bone mass in mice, suggesting that pharmacological blockade of Y1 receptors may offer a novel anabolic t...

journal_title：Bone

authors： Sousa DM,Baldock PA,Enriquez RF,Zhang L,Sainsbury A,Lamghari M,Herzog H

更新日期：2012-07-01 00:00:00

abstract：:Osteogenesis imperfecta (OI) is a heritable collagen-related bone dysplasia, characterized by brittle bones with increased fracture risk that presents most severely in children. Anti-resorptive bisphosphonates are frequently used to treat pediatric OI and controlled clinical trials have shown that bisphosphonate thera...

journal_title：Bone

authors： Sinder BP,Salemi JD,Ominsky MS,Caird MS,Marini JC,Kozloff KM

更新日期：2015-02-01 00:00:00

abstract：:Peak bone mass (PBM) is an important determinant of osteoporosis. Circulating monocytes serve as early progenitors of osteoclasts and produce important molecules for bone metabolism. To search for genes functionally important for PBM variation, we performed a whole genome gene differential expression study of circulat...

journal_title：Bone

authors： Lei SF,Wu S,Li LM,Deng FY,Xiao SM,Jiang C,Chen Y,Jiang H,Yang F,Tan LJ,Sun X,Zhu XZ,Liu MY,Liu YZ,Chen XD,Deng HW

更新日期：2009-05-01 00:00:00

abstract：:On the basis of previous investigations indicating that the distribution of osteonic and interstitial lamellae in a normal femur depends on its mechanical properties, a procedure has been devised to provide information on the distribution of lamellae in human femora diaphyses deformed by bending. To achieve this, exac...

journal_title：Bone

authors： Ascenzi A,Improta S,Portigliatti Barbos M,Carando S,Boyde A

更新日期：1987-01-01 00:00:00